ATE547080T1 - Vorrichtungen zur intraokularen arzneimittelabgabe - Google Patents

Vorrichtungen zur intraokularen arzneimittelabgabe

Info

Publication number
ATE547080T1
ATE547080T1 AT08014292T AT08014292T ATE547080T1 AT E547080 T1 ATE547080 T1 AT E547080T1 AT 08014292 T AT08014292 T AT 08014292T AT 08014292 T AT08014292 T AT 08014292T AT E547080 T1 ATE547080 T1 AT E547080T1
Authority
AT
Austria
Prior art keywords
delivery
devices
drug delivery
substances
therapeutic agent
Prior art date
Application number
AT08014292T
Other languages
English (en)
Inventor
Signe Varner
Eugene Dejuan
Terry Shelly
Aaron Barnes
Mark Humayun
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22859147&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE547080(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Application granted granted Critical
Publication of ATE547080T1 publication Critical patent/ATE547080T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831—Material properties
    • A61B2017/00867—Material properties shape memory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Prostheses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
AT08014292T 2000-08-30 2001-06-22 Vorrichtungen zur intraokularen arzneimittelabgabe ATE547080T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22893400P 2000-08-30 2000-08-30

Publications (1)

Publication Number Publication Date
ATE547080T1 true ATE547080T1 (de) 2012-03-15

Family

ID=22859147

Family Applications (2)

Application Number Title Priority Date Filing Date
AT01950424T ATE404140T1 (de) 2000-08-30 2001-06-22 Vorrichtung zur intraokularen wirkstoffverabreichung
AT08014292T ATE547080T1 (de) 2000-08-30 2001-06-22 Vorrichtungen zur intraokularen arzneimittelabgabe

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT01950424T ATE404140T1 (de) 2000-08-30 2001-06-22 Vorrichtung zur intraokularen wirkstoffverabreichung

Country Status (11)

Country Link
US (3) US6719750B2 (de)
EP (2) EP1313415B1 (de)
JP (1) JP4471568B2 (de)
AT (2) ATE404140T1 (de)
AU (3) AU2001271417B2 (de)
CA (1) CA2420038C (de)
DE (1) DE60135352D1 (de)
DK (1) DK1313415T3 (de)
ES (1) ES2312456T3 (de)
PT (1) PT1313415E (de)
WO (1) WO2002017831A2 (de)

Families Citing this family (296)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW586934B (en) * 1997-05-19 2004-05-11 Sumitomo Pharma Immunopotentiating composition
US9295581B2 (en) * 1999-01-05 2016-03-29 Second Sight Medical Products, Inc. Medical tack with a variable effective length
US7943162B2 (en) * 1999-10-21 2011-05-17 Alcon, Inc. Drug delivery device
US6416777B1 (en) * 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
US6719750B2 (en) * 2000-08-30 2004-04-13 The Johns Hopkins University Devices for intraocular drug delivery
CA2432438C (en) * 2001-01-09 2011-04-26 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
US7181287B2 (en) * 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
US6875165B2 (en) * 2001-02-22 2005-04-05 Retinalabs, Inc. Method of radiation delivery to the eye
WO2002100318A2 (en) 2001-06-12 2002-12-19 Johns Hopkins University School Of Medicine Reservoir device for intraocular drug delivery
EP1441799B1 (de) * 2001-06-18 2006-10-11 Durect Corporation Vorrichtung zur abgabe von mikrodosen eines medikaments in das ohr
CN100349562C (zh) * 2001-07-23 2007-11-21 爱尔康公司 眼部药物输送装置
MXPA03011609A (es) * 2001-07-23 2004-07-01 Alcon Inc Dispositivo de entrega de droga oftalmica.
WO2003061625A2 (en) * 2002-01-18 2003-07-31 Snyder Michael E Sustained release ophthalmological device and method of making and using the same
US7108685B2 (en) * 2002-04-15 2006-09-19 Boston Scientific Scimed, Inc. Patch stabilization of rods for treatment of cardiac muscle
WO2003092665A2 (en) * 2002-05-02 2003-11-13 Massachusetts Eye And Ear Infirmary Ocular drug delivery systems and use thereof
DK1519681T3 (da) * 2002-07-09 2007-04-10 Aecc Entpr Ltd Fremgangsmåde til billeddannelse af den relative bevægelse af skeletstykker
US7008403B1 (en) * 2002-07-19 2006-03-07 Cognitive Ventures Corporation Infusion pump and method for use
WO2004026347A2 (en) * 2002-09-17 2004-04-01 Iscience Surgical Corporation Apparatus and method for surgical bypass of aqueous humor
AU2003279055A1 (en) * 2002-09-29 2004-04-19 Surmodics, Inc. Methods for treatment and/or prevention of retinal disease
US7326238B1 (en) * 2002-09-30 2008-02-05 Abbott Cardiovascular Systems Inc. Method and apparatus for treating vulnerable plaque
US20060265043A1 (en) * 2002-09-30 2006-11-23 Evgenia Mandrusov Method and apparatus for treating vulnerable plaque
US7008411B1 (en) * 2002-09-30 2006-03-07 Advanced Cardiovascular Systems, Inc. Method and apparatus for treating vulnerable plaque
WO2004073551A2 (en) * 2003-02-18 2004-09-02 Massachusetts Eye And Ear Infirmary Transscleral drug delivery device and related methods
AU2004237774B2 (en) * 2003-05-02 2009-09-10 Surmodics, Inc. Implantable controlled release bioactive agent delivery device
US8246974B2 (en) * 2003-05-02 2012-08-21 Surmodics, Inc. Medical devices and methods for producing the same
US20040225250A1 (en) 2003-05-05 2004-11-11 Michael Yablonski Internal shunt and method for treating glaucoma
US20040265356A1 (en) * 2003-06-30 2004-12-30 Bausch & Lomb Incorporated Drug delivery device
KR20060082792A (ko) * 2003-07-10 2006-07-19 알콘, 인코퍼레이티드 안과용 약물 전달 장치
DK1660057T3 (da) * 2003-08-27 2012-08-20 Ophthotech Corp Kombinationsterapi til behandling af neovaskulære øjenlidelser
CN102144961A (zh) * 2003-09-18 2011-08-10 参天制药株式会社 经巩膜递送
US20050181018A1 (en) * 2003-09-19 2005-08-18 Peyman Gholam A. Ocular drug delivery
US7291125B2 (en) * 2003-11-14 2007-11-06 Transcend Medical, Inc. Ocular pressure regulation
AU2004296205B2 (en) * 2003-12-05 2009-11-12 Innfocus, Llc Glaucoma implant device
US20050148948A1 (en) * 2003-12-19 2005-07-07 Caputa Steven G. Sutureless ophthalmic drug delivery system and method
IL159818A0 (en) * 2004-01-12 2004-06-20 Nulens Ltd Intraocular structure
US7976520B2 (en) * 2004-01-12 2011-07-12 Nulens Ltd. Eye wall anchored fixtures
US20050222613A1 (en) * 2004-02-05 2005-10-06 Edwin Ryan Wound closure device and method for vitrectomy
ATE488269T1 (de) 2004-02-12 2010-12-15 Neovista Inc Gerät für die intraokulare brachytherapie
US7563222B2 (en) * 2004-02-12 2009-07-21 Neovista, Inc. Methods and apparatus for intraocular brachytherapy
US20060083772A1 (en) * 2004-04-06 2006-04-20 Dewitt David M Coating compositions for bioactive agents
US7541048B2 (en) * 2004-04-06 2009-06-02 Surmodics, Inc. Coating compositions for bioactive agents
US20100173866A1 (en) * 2004-04-29 2010-07-08 Iscience Interventional Corporation Apparatus and method for ocular treatment
ZA200609408B (en) * 2004-04-29 2008-02-27 Iscience Interventional Corp Apparatus and method for surgical enhancement of aqueous humor drainage
EP1740255A4 (de) * 2004-04-29 2009-03-25 Iscience Interventional Corp Gerät und verfahren für die augenbehandlung
US8119154B2 (en) * 2004-04-30 2012-02-21 Allergan, Inc. Sustained release intraocular implants and related methods
US20050244471A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Estradiol derivative and estratopone containing sustained release intraocular implants and related methods
US20050267520A1 (en) 2004-05-12 2005-12-01 Modesitt D B Access and closure device and method
WO2006002366A2 (en) * 2004-06-24 2006-01-05 Surmodics, Inc. Biodegradable ocular devices, methods and systems
AU2005269988B2 (en) * 2004-07-02 2012-02-02 Mati Therapeutics Inc. Treatment medium delivery device and methods for delivery
US20060110428A1 (en) * 2004-07-02 2006-05-25 Eugene Dejuan Methods and devices for the treatment of ocular conditions
US7678133B2 (en) 2004-07-10 2010-03-16 Arstasis, Inc. Biological tissue closure device and method
US7117870B2 (en) * 2004-07-26 2006-10-10 Clarity Corporation Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same
US9138228B2 (en) 2004-08-11 2015-09-22 Emory University Vascular conduit device and system for implanting
US20060034891A1 (en) * 2004-08-12 2006-02-16 Laurie Lawin Biodegradable controlled release bioactive agent delivery device
US8246569B1 (en) 2004-08-17 2012-08-21 California Institute Of Technology Implantable intraocular pressure drain
MX2007006214A (es) * 2004-11-24 2008-04-16 Therakine Ltd Un implante para suministro de farmaco intraocular.
CA2589761A1 (en) * 2004-12-07 2006-06-15 Surmodics, Inc. Coatings with crystallized active agent(s) and methods
WO2006068898A1 (en) * 2004-12-22 2006-06-29 Bausch & Lomb Incorporated Reusable drug delivery device
US20060147491A1 (en) * 2005-01-05 2006-07-06 Dewitt David M Biodegradable coating compositions including multiple layers
US20060198868A1 (en) * 2005-01-05 2006-09-07 Dewitt David M Biodegradable coating compositions comprising blends
EP1883398A4 (de) * 2005-02-01 2012-06-06 Osteobiologics Inc Verfahren und vorrichtung zur selektiven zugabe eines bioaktiven wirkstoffes zu einem mehrphasenimplantat
BRPI0608152A2 (pt) * 2005-02-09 2009-11-10 Macusight Inc formulações para tratamento ocular
US8663639B2 (en) * 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
US20060233858A1 (en) * 2005-03-08 2006-10-19 Allergan, Inc. Systems and methods providing targeted intraocular drug delivery
US20070077270A1 (en) * 2005-03-28 2007-04-05 Clemson University Delivery devices and methods for long-term, targeted delivery of therapeutic agents to the eye and ear
CA2601864A1 (en) * 2005-04-08 2006-10-19 Surmodics, Inc. Sustained release implants and methods for subretinal delivery of bioactive agents to treat or prevent retinal disease
US20060259008A1 (en) * 2005-04-27 2006-11-16 Allergan, Inc. Apparatus and methods useful for intravitreal injection of drugs
US20060258994A1 (en) * 2005-05-12 2006-11-16 Avery Robert L Implantable delivery device for administering pharmacological agents to an internal portion of a body
US8241325B2 (en) * 2005-05-12 2012-08-14 Arstasis, Inc. Access and closure device and method
CN101198301A (zh) * 2005-05-18 2008-06-11 苏尔莫迪克斯公司 用于非线性医用装置的插入器械
US20080207499A1 (en) * 2005-06-29 2008-08-28 Gaetano Barile Rage-related methods for treating and preventing diabetic retinopathy
US8109913B2 (en) * 2005-07-11 2012-02-07 Dsm Ip Assets B.V. Coiled wire for the controlled release of drugs to the eye
US8663673B2 (en) 2005-07-29 2014-03-04 Surmodics, Inc. Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
US20070060887A1 (en) * 2005-08-22 2007-03-15 Marsh David A Ophthalmic injector
US20070212397A1 (en) * 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
US8241656B2 (en) * 2005-09-21 2012-08-14 Surmodics, Inc Articles including natural biodegradable polysaccharides and uses thereof
DE602006011764D1 (de) * 2005-09-21 2010-03-04 Surmodics Inc In situ okklusionszusammensetzungen mit natürlichen biologisch abbaubaren polysacchariden
US20080167600A1 (en) * 2005-09-26 2008-07-10 Peyman Gholam A Device for delivery of an agent to the eye and other sites
AU2006311577B2 (en) 2005-11-09 2013-02-07 Zalicus Inc. Methods, compositions, and kits for the treatment of medical conditions
CN101505830A (zh) 2005-11-15 2009-08-12 内奥维斯塔公司 用于眼内近距离治疗的方法和器具
WO2007059144A1 (en) * 2005-11-15 2007-05-24 Surmodics, Inc. Ultrasonic nozzles for applying two-component coatings
AU2006320535B2 (en) 2005-11-29 2010-09-23 Glaxosmithkline Llc Treatment method
US8663674B2 (en) * 2006-01-13 2014-03-04 Surmodics, Inc. Microparticle containing matrices for drug delivery
WO2007084582A2 (en) * 2006-01-17 2007-07-26 Forsight Labs, Llc Drug delivery treatment device
PT2526910E (pt) 2006-01-17 2015-11-18 Transcend Medical Inc Dispositivo para tratamento de glaucoma
GB0600903D0 (en) * 2006-01-17 2006-02-22 Cancer Rec Tech Ltd Treatment of cancer
CN101389295B (zh) * 2006-01-17 2010-11-10 纽镜有限公司 眼球内药物分配器
KR20140093764A (ko) 2006-02-09 2014-07-28 산텐 세이야꾸 가부시키가이샤 안정한 제제와 그 제조 및 사용 방법
ATE497797T1 (de) 2006-03-14 2011-02-15 Univ Southern California Mems-vorrichtung zur wirkstofffreisetzung
CN103127100A (zh) * 2006-03-23 2013-06-05 参天制药株式会社 用于与血管通透性有关的疾病或病症的制剂和方法
US8676293B2 (en) * 2006-04-13 2014-03-18 Aecc Enterprises Ltd. Devices, systems and methods for measuring and evaluating the motion and function of joint structures and associated muscles, determining suitability for orthopedic intervention, and evaluating efficacy of orthopedic intervention
US7981096B2 (en) * 2006-05-12 2011-07-19 David Castillejos Optic nerve head implant and medication delivery system
US7862540B2 (en) * 2006-05-17 2011-01-04 Alcon Research, Ltd. Ophthalmic injection device using shape memory alloy
US7871399B2 (en) * 2006-05-17 2011-01-18 Alcon Research, Ltd. Disposable ophthalmic injection device
US7887521B2 (en) * 2006-05-17 2011-02-15 Alcon Research, Ltd. Ophthalmic injection system
US7811252B2 (en) * 2006-05-17 2010-10-12 Alcon Research, Ltd. Dosage control device
US7674243B2 (en) * 2006-05-17 2010-03-09 Alcon Inc. Ophthalmic injection device using piezoelectric array
US20070270750A1 (en) * 2006-05-17 2007-11-22 Alcon, Inc. Drug delivery device
US20070268340A1 (en) * 2006-05-17 2007-11-22 Bruno Dacquay Ophthalmic Injection System and Method Using Piezoelectric Array
US20070293873A1 (en) * 2006-06-19 2007-12-20 Allergan, Inc. Apparatus and methods for implanting particulate ocular implants
US8668676B2 (en) * 2006-06-19 2014-03-11 Allergan, Inc. Apparatus and methods for implanting particulate ocular implants
US8968782B2 (en) * 2006-06-28 2015-03-03 Surmodics, Inc. Combination degradable and non-degradable matrices for active agent delivery
US7638344B2 (en) * 2006-06-28 2009-12-29 Surmodics, Inc. Active agent eluting matrices with particulates
US8911496B2 (en) 2006-07-11 2014-12-16 Refocus Group, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
US9039761B2 (en) 2006-08-04 2015-05-26 Allergan, Inc. Ocular implant delivery assemblies with distal caps
WO2008022258A2 (en) * 2006-08-16 2008-02-21 Surmodics, Inc. Methods and materials for increasing the adhesion of elution control matrices to substrates
WO2008027371A2 (en) * 2006-08-29 2008-03-06 Surmodics, Inc. Low profile bioactive agent delivery device
US20080075753A1 (en) * 2006-09-25 2008-03-27 Chappa Ralph A Multi-layered coatings and methods for controlling elution of active agents
US20080097379A1 (en) * 2006-09-26 2008-04-24 Alcon Manufacturing, Ltd. Ophthalmic injection method
US20080125712A1 (en) * 2006-09-26 2008-05-29 Alcon Manufacturing, Ltd. Ophthalmic injection system
US20080097390A1 (en) * 2006-09-27 2008-04-24 Alcon Manufacturing, Ltd. Spring actuated delivery system
WO2008088593A2 (en) * 2006-09-27 2008-07-24 Surmodics, Inc. Additives and methods for enhancing active agent elution kinetics
JP5694664B2 (ja) * 2006-09-29 2015-04-01 サーモディクス，インコーポレイティド 生分解性眼用インプラント及び眼の病気を治療する方法
US20080281292A1 (en) * 2006-10-16 2008-11-13 Hickingbotham Dyson W Retractable Injection Port
MX2009003207A (es) * 2006-10-16 2009-05-11 Alcon Res Ltd Metodo de operacion de pieza manual oftalmica con extremo desechable.
US9022970B2 (en) * 2006-10-16 2015-05-05 Alcon Research, Ltd. Ophthalmic injection device including dosage control device
AU2007347736A1 (en) * 2006-10-16 2008-09-04 Alcon Research, Ltd. Universal rechargeable limited reuse assembly for ophthalmic hand piece
US7831309B1 (en) 2006-12-06 2010-11-09 University Of Southern California Implants based on bipolar metal oxide semiconductor (MOS) electronics
US20090005869A1 (en) * 2006-12-15 2009-01-01 University Of Virginia Patent Foundation Device which Attaches into a Joint and Carries a Payload of Controlled Release Drugs and Related Method thereof
US20080147021A1 (en) * 2006-12-15 2008-06-19 Jani Dharmendra M Drug delivery devices
US20080145406A1 (en) * 2006-12-18 2008-06-19 Alcon Manufacturing Ltd. Devices and methods for ophthalmic drug delivery
US7846123B2 (en) 2007-04-24 2010-12-07 Emory University Conduit device and system for implanting a conduit device in a tissue wall
US20080265343A1 (en) * 2007-04-26 2008-10-30 International Business Machines Corporation Field effect transistor with inverted t shaped gate electrode and methods for fabrication thereof
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
US8672870B2 (en) 2007-07-17 2014-03-18 Transcend Medical, Inc. Ocular implant with hydrogel expansion capabilities
US7740619B2 (en) 2007-08-01 2010-06-22 Alcon Research, Ltd. Spring driven ophthalmic injection device with safety actuator lockout feature
US20090036842A1 (en) * 2007-08-03 2009-02-05 Raffi Pinedjian Consumable Activation Lever For Injection Device
US20090099481A1 (en) 2007-10-10 2009-04-16 Adam Deitz Devices, Systems and Methods for Measuring and Evaluating the Motion and Function of Joints and Associated Muscles
US20090105744A1 (en) * 2007-10-17 2009-04-23 Modesitt D Bruce Methods for forming tracts in tissue
JP5330401B2 (ja) 2007-11-08 2013-10-30 アリメラ・サイエンシーズ，インコーポレーテッド 眼のための埋め込み装置、及びその装置を備えるキット
EP2242464B2 (de) 2007-12-20 2017-03-01 University Of Southern California Vorrichtung zur abgabe von therapeutika
EP2727616B1 (de) 2008-01-03 2017-04-26 University Of Southern California Implantierbare Wirkstofffreisetzungsvorrichtungen sowie Geräte und Verfahren zum Auffüllen der Vorrichtungen
US9056201B1 (en) 2008-01-07 2015-06-16 Salutaris Medical Devices, Inc. Methods and devices for minimally-invasive delivery of radiation to the eye
US8608632B1 (en) 2009-07-03 2013-12-17 Salutaris Medical Devices, Inc. Methods and devices for minimally-invasive extraocular delivery of radiation and/or pharmaceutics to the posterior portion of the eye
US9873001B2 (en) 2008-01-07 2018-01-23 Salutaris Medical Devices, Inc. Methods and devices for minimally-invasive delivery of radiation to the eye
US10022558B1 (en) 2008-01-07 2018-07-17 Salutaris Medical Devices, Inc. Methods and devices for minimally-invasive delivery of radiation to the eye
US8602959B1 (en) 2010-05-21 2013-12-10 Robert Park Methods and devices for delivery of radiation to the posterior portion of the eye
WO2009089288A1 (en) * 2008-01-07 2009-07-16 Salutaris Md Methods and devices for minimally-invasive extraocular delivery of radiation to the posterior portion of the eye
CA2711490A1 (en) * 2008-01-14 2009-07-23 Surmodics, Inc. Devices and methods for elution of nucleic acid delivery complexes
JP2011510750A (ja) 2008-01-29 2011-04-07 クライマン、ギルバート・エイチ 薬物送達デバイス、キット及びそれらの方法
US20100152646A1 (en) * 2008-02-29 2010-06-17 Reshma Girijavallabhan Intravitreal injection device and method
US20090227938A1 (en) * 2008-03-05 2009-09-10 Insitu Therapeutics, Inc. Wound Closure Devices, Methods of Use, and Kits
US20090263449A1 (en) * 2008-04-09 2009-10-22 Surmodics, Inc. Delivery of nucleic acid complexes from materials including negatively charged groups
US8496954B2 (en) * 2008-04-18 2013-07-30 Surmodics, Inc. Coating systems for the controlled delivery of hydrophilic bioactive agents
WO2009137689A2 (en) * 2008-05-07 2009-11-12 Surmodics, Inc. Delivery of nucleic acid complexes from particles
EP2323716B1 (de) * 2008-05-08 2015-03-04 MiniPumps, LLC Arzneiabgabepumpen
MX2010012212A (es) * 2008-05-08 2011-09-27 Minipumps Llc Dispositivos implantables para suministro de fármacos, y áparato y métodos para llenar los dispositivos.
US9333297B2 (en) 2008-05-08 2016-05-10 Minipumps, Llc Drug-delivery pump with intelligent control
WO2009137780A2 (en) * 2008-05-08 2009-11-12 Replenish Pumps, Llc Implantable pumps and cannulas therefor
CA2724327A1 (en) 2008-06-04 2009-12-10 Neovista, Inc. Handheld radiation delivery system for advancing a radiation source wire
ES2640867T3 (es) 2008-06-25 2017-11-07 Novartis Ag Implante ocular con capacidad de cambio de forma
CA2731493A1 (en) * 2008-07-21 2010-01-28 Arstasis, Inc. Devices and methods for forming tracts in tissue
CN102159126A (zh) * 2008-07-21 2011-08-17 阿尔斯塔西斯公司 在组织中形成管道的装置、方法和成套用具
US8459310B2 (en) * 2008-07-24 2013-06-11 Surmodics, Inc. Systems and methods for filling medical device lumen
EP2367527A2 (de) 2008-11-26 2011-09-28 SurModics, Inc. Implantierbare okulare arzneimittelabgabevorrichtung und verfahren
JP2012512725A (ja) * 2008-12-19 2012-06-07 キュー エル ティー インク． 物質送達用涙点インプラントおよび物質送達方法
JP2012514493A (ja) * 2009-01-02 2012-06-28 アルコン リサーチ， リミテッド その場で再充填可能な眼用移植物
USD691270S1 (en) 2009-01-07 2013-10-08 Salutaris Medical Devices, Inc. Fixed-shape cannula for posterior delivery of radiation to an eye
USD691269S1 (en) 2009-01-07 2013-10-08 Salutaris Medical Devices, Inc. Fixed-shape cannula for posterior delivery of radiation to an eye
USD691268S1 (en) 2009-01-07 2013-10-08 Salutaris Medical Devices, Inc. Fixed-shape cannula for posterior delivery of radiation to eye
USD691267S1 (en) 2009-01-07 2013-10-08 Salutaris Medical Devices, Inc. Fixed-shape cannula for posterior delivery of radiation to eye
US8545554B2 (en) * 2009-01-16 2013-10-01 Allergan, Inc. Intraocular injector
US20100191177A1 (en) * 2009-01-23 2010-07-29 Iscience Interventional Corporation Device for aspirating fluids
US8425473B2 (en) 2009-01-23 2013-04-23 Iscience Interventional Corporation Subretinal access device
EP2548538B1 (de) * 2009-01-28 2020-04-01 Alcon Inc. Implantationssysteme für augenimplantate mit steifheitseigenschaften
US20100191168A1 (en) 2009-01-29 2010-07-29 Trustees Of Tufts College Endovascular cerebrospinal fluid shunt
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
SG173167A1 (en) * 2009-01-29 2011-08-29 Forsight Labs Llc Posterior segment drug delivery
US8409606B2 (en) 2009-02-12 2013-04-02 Incept, Llc Drug delivery through hydrogel plugs
US8911495B2 (en) 2009-03-16 2014-12-16 Endoshape, Inc. Reliably retained shape memory ophthalmological implants
US8372036B2 (en) 2009-05-06 2013-02-12 Alcon Research, Ltd. Multi-layer heat assembly for a drug delivery device
JP2012526640A (ja) * 2009-05-15 2012-11-01 アルスタシス，インコーポレイテッド 組織に経路を形成する装置、方法及びキット
CA2763522A1 (en) 2009-06-02 2010-12-09 Surmodics, Inc. Silane-functionalized hydrophobic .alpha.(1.fwdarw.-4)glucopyranose polymers and polymeric matrices for implantation or injection
JP5695035B2 (ja) 2009-06-03 2015-04-01 フォーサイト・ビジョン５・インコーポレイテッドＦｏｒｓｉｇｈｔ Ｖｉｓｉｏｎ５，Ｉｎｃ． 前眼部薬物供給
US20110152770A1 (en) 2009-07-30 2011-06-23 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
WO2011022484A1 (en) * 2009-08-18 2011-02-24 Replenish Pumps. Llc Electrolytic drug-delivery pump with adaptive control
US20110054445A1 (en) * 2009-09-02 2011-03-03 Board Of Regents, The University Of Texas System Devices and Methods for Treatment of Eye Disease
US8257295B2 (en) 2009-09-21 2012-09-04 Alcon Research, Ltd. Intraocular pressure sensor with external pressure compensation
US8545431B2 (en) * 2009-09-21 2013-10-01 Alcon Research, Ltd. Lumen clearing valve for glaucoma drainage device
US8721580B2 (en) * 2009-09-21 2014-05-13 Alcon Research, Ltd. Power saving glaucoma drainage device
US8419673B2 (en) 2009-09-21 2013-04-16 Alcon Research, Ltd. Glaucoma drainage device with pump
CN102665573B (zh) * 2009-09-22 2015-09-16 阿尔斯塔西斯公司 用于在组织中形成管道的装置
WO2011038236A2 (en) 2009-09-25 2011-03-31 Ortho Kinematics, Inc. Systems and devices for an integrated imaging system with real-time feedback loops and methods therefor
US8932616B2 (en) 2009-09-30 2015-01-13 Surmodics, Inc. Hydrophobic polysaccharides with silyl ether linkages having enhanced degradation and medical articles made therefrom
US20120232102A1 (en) 2009-09-30 2012-09-13 Chun-Fang Xu Methods Of Administration And Treatment
US20110166555A1 (en) * 2009-09-30 2011-07-07 Jianbo Zhou Carrier for an insertable medical device, insertion tools, methods of use, and kits
EP2496304A4 (de) * 2009-11-02 2013-04-17 Salutaris Medical Devices Inc Verfahren und vorrichtungen zur verabreichung minimal invasiver extraokularer strahlung
US20110105990A1 (en) * 2009-11-04 2011-05-05 Silvestrini Thomas A Zonal drug delivery device and method
US8177747B2 (en) 2009-12-22 2012-05-15 Alcon Research, Ltd. Method and apparatus for drug delivery
US8529492B2 (en) 2009-12-23 2013-09-10 Trascend Medical, Inc. Drug delivery devices and methods
US20110159098A1 (en) * 2009-12-30 2011-06-30 Surmodics, Inc. Stabilization and delivery of nucleic acid complexes
US20110184310A1 (en) * 2010-01-27 2011-07-28 Joe Denton Brown Method of heating a shape memory alloy of a surgical instrument
US10166142B2 (en) 2010-01-29 2019-01-01 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
JP2013524275A (ja) 2010-04-03 2013-06-17 ドシ，プラフル 薬剤を含む医療機器、その製造方法とその使用方法
US10413506B2 (en) 2010-04-03 2019-09-17 Praful Doshi Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia
SG185383A1 (en) 2010-04-30 2012-12-28 Alexion Pharma Inc Anti-c5a antibodies and methods for using the antibodies
JP5907966B2 (ja) 2010-08-05 2016-04-26 フォーサイト・ビジョン フォー・インコーポレーテッド 埋め込み型治療デバイス
AU2011285548B2 (en) 2010-08-05 2014-02-06 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
EP2600930B1 (de) 2010-08-05 2021-02-17 ForSight Vision4, Inc. Injektionsapparat zur verabreichung von medikamenten
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
WO2012058274A2 (en) 2010-10-26 2012-05-03 Surmodics, Inc. Coatings and methods for controlled elution of hydrophilic active agents
US20140033800A1 (en) 2010-11-11 2014-02-06 Forsight Vision4, Inc. Methods and apparatus to determine diffusion properties of porous structures for drug delivery
WO2012068549A2 (en) 2010-11-19 2012-05-24 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
US8901092B2 (en) 2010-12-29 2014-12-02 Surmodics, Inc. Functionalized polysaccharides for active agent delivery
WO2012103546A2 (en) 2011-01-28 2012-08-02 Apica Cardiovascular Limited Systems for sealing a tissue wall puncture
WO2012106422A2 (en) 2011-02-01 2012-08-09 Georgia Tech Research Corporation Systems for implanting and using a conduit within a tissue wall
US10286146B2 (en) 2011-03-14 2019-05-14 Minipumps, Llc Implantable drug pumps and refill devices therefor
US9919099B2 (en) 2011-03-14 2018-03-20 Minipumps, Llc Implantable drug pumps and refill devices therefor
US9603997B2 (en) 2011-03-14 2017-03-28 Minipumps, Llc Implantable drug pumps and refill devices therefor
EP2691127B1 (de) 2011-03-27 2021-01-13 Microsert Ltd Implantierbare miniatur-arzneimittelabgabevorrichtungen und einführsystem zur einführung solcher vorrichtungen
EP4249059A3 (de) 2011-06-28 2023-11-29 ForSight Vision4, Inc. Vorrichtung zum sammeln einer flüssigkeitsprobe aus einer reservoirkammer einer therapeutischen vorrichtung für das auge
WO2013027107A1 (en) * 2011-08-23 2013-02-28 Simcha Milo Device for creating temporary access and then closure
AU2012308317B2 (en) * 2011-09-14 2017-01-05 Forsight Vision5, Inc. Ocular insert apparatus and methods
CN103796573A (zh) * 2011-09-15 2014-05-14 优瑟夫·雅阿科比 一种治疗耳病的系统和方法
CA2848385C (en) 2011-09-16 2021-10-26 Forsight Vision4, Inc. Methods and apparatus to exchange a fluid of an implantable device
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
US8585631B2 (en) 2011-10-18 2013-11-19 Alcon Research, Ltd. Active bimodal valve system for real-time IOP control
US8579848B2 (en) 2011-12-09 2013-11-12 Alcon Research, Ltd. Active drainage systems with pressure-driven valves and electronically-driven pump
US8840578B2 (en) 2011-12-09 2014-09-23 Alcon Research, Ltd. Multilayer membrane actuators
US9622910B2 (en) 2011-12-12 2017-04-18 Alcon Research, Ltd. Active drainage systems with dual-input pressure-driven values
US9125721B2 (en) 2011-12-13 2015-09-08 Alcon Research, Ltd. Active drainage systems with dual-input pressure-driven valves
US9339187B2 (en) 2011-12-15 2016-05-17 Alcon Research, Ltd. External pressure measurement system and method for an intraocular implant
US9241829B2 (en) 2011-12-20 2016-01-26 Abbott Medical Optics Inc. Implantable intraocular drug delivery apparatus, system and method
US10010448B2 (en) 2012-02-03 2018-07-03 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
US10085633B2 (en) 2012-04-19 2018-10-02 Novartis Ag Direct visualization system for glaucoma treatment
US9241832B2 (en) 2012-04-24 2016-01-26 Transcend Medical, Inc. Delivery system for ocular implant
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US20130317481A1 (en) 2012-05-25 2013-11-28 Arstasis, Inc. Vascular access configuration
US20130317438A1 (en) 2012-05-25 2013-11-28 Arstasis, Inc. Vascular access configuration
US10010513B2 (en) 2012-05-25 2018-07-03 Novartis Ag Aqueous pharmaceutical composition containing a biologic therapeutic agent and guanidine or a guanidine derivative and an injection including the composition
US9827401B2 (en) 2012-06-01 2017-11-28 Surmodics, Inc. Apparatus and methods for coating medical devices
US9308355B2 (en) 2012-06-01 2016-04-12 Surmodies, Inc. Apparatus and methods for coating medical devices
WO2014043698A2 (en) 2012-09-17 2014-03-20 Transcend Medical, Inc. Expanding ocular implant devices and methods
US11090468B2 (en) 2012-10-25 2021-08-17 Surmodics, Inc. Apparatus and methods for coating medical devices
HUE046128T2 (hu) 2012-10-26 2020-02-28 Forsight Vision5 Inc Szemészeti rendszer gyógyszer szembe való késleltetett kibocsátására
US9763829B2 (en) 2012-11-14 2017-09-19 Novartis Ag Flow promoting ocular implant
US9295389B2 (en) 2012-12-17 2016-03-29 Novartis Ag Systems and methods for priming an intraocular pressure sensor in an intraocular implant
US9572712B2 (en) 2012-12-17 2017-02-21 Novartis Ag Osmotically actuated fluidic valve
US9528633B2 (en) 2012-12-17 2016-12-27 Novartis Ag MEMS check valve
EP2948104B1 (de) 2013-01-25 2019-07-24 Apica Cardiovascular Limited Systeme für perkutanen zugang sowie stabilisierung und verschluss von organen
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US9968603B2 (en) 2013-03-14 2018-05-15 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
JP6444973B2 (ja) 2013-03-15 2018-12-26 オプティメディカ・コーポレイションＯｐｔｉｍｅｄｉｃａ Ｃｏｒｐｏｒａｔｉｏｎ マイクロフェムト切開方法及びシステム
JP6302992B2 (ja) 2013-03-15 2018-03-28 エーピーケー アドバンスド メディカル テクノロジーズ，インコーポレイテッド 組織壁に移植するためのコネクタ
EP4302736A3 (de) 2013-03-28 2024-04-03 ForSight Vision4, Inc. Ophthalmisches implantat zur abgabe von therapeutischen substanzen
US9987163B2 (en) 2013-04-16 2018-06-05 Novartis Ag Device for dispensing intraocular substances
KR20230152151A (ko) 2013-07-12 2023-11-02 이베릭 바이오, 인크. 안과적 질환을 치료하거나 예방하기 위한 방법
US9226851B2 (en) 2013-08-24 2016-01-05 Novartis Ag MEMS check valve chip and methods
US9289324B2 (en) 2013-08-26 2016-03-22 Novartis Ag Externally adjustable passive drainage device
US9283115B2 (en) 2013-08-26 2016-03-15 Novartis Ag Passive to active staged drainage device
US11219552B2 (en) 2013-09-06 2022-01-11 The Regents Of The University Of Colorado, A Body Corporate Intraocular filter device and methods of using same
US10518002B2 (en) * 2013-09-06 2019-12-31 The Regents Of The University Of Colorado, A Body Corporate Intraocular drug delivery and filter device and methods of using same
EP3094365B1 (de) 2014-01-15 2021-12-08 Tufts Medical Center, Inc. Endovaskulärer shunt für rückenmarksflüssigkeit
US9737696B2 (en) 2014-01-15 2017-08-22 Tufts Medical Center, Inc. Endovascular cerebrospinal fluid shunt
NZ711451A (en) 2014-03-07 2016-05-27 Alexion Pharma Inc Anti-c5 antibodies having improved pharmacokinetics
US9681983B2 (en) 2014-03-13 2017-06-20 Novartis Ag Debris clearance system for an ocular implant
US9603742B2 (en) 2014-03-13 2017-03-28 Novartis Ag Remote magnetic driven flow system
USD760381S1 (en) 2014-06-25 2016-06-28 Donald Fox Orbital injection cannula
KR102416726B1 (ko) 2014-07-15 2022-07-05 포사이트 비젼4, 인크. 안구 이식물 전달 디바이스 및 방법
JP2017524034A (ja) 2014-08-08 2017-08-24 フォーサイト・ビジョン フォー・インコーポレーテッドＦｏｒｓｉｇｈｔ Ｖｉｓｉｏｎ４， Ｉｎｃ． 受容体型チロシンキナーゼ阻害剤の安定で可溶な製剤およびその調製の方法
WO2016070147A1 (en) 2014-10-31 2016-05-06 Cerevasc, Llc Methods and systems for treating hydrocephalus
US10485909B2 (en) 2014-10-31 2019-11-26 Thoratec Corporation Apical connectors and instruments for use in a heart wall
AU2015346450B2 (en) 2014-11-10 2020-01-30 Forsight Vision4, Inc. Expandable drug delivery devices and method of use
US9655777B2 (en) 2015-04-07 2017-05-23 Novartis Ag System and method for diagphragm pumping using heating element
US20160296532A1 (en) 2015-04-13 2016-10-13 Forsight Vision5, Inc. Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent
US20160354161A1 (en) 2015-06-05 2016-12-08 Ortho Kinematics, Inc. Methods for data processing for intra-operative navigation systems
US10182939B2 (en) 2015-09-16 2019-01-22 Novartis Ag Hydraulic injector and methods for intra-ocular lens insertion
US10272230B2 (en) 2015-10-30 2019-04-30 Cerevasc, Llc Systems and methods for treating hydrocephalus
CA3005238A1 (en) 2015-11-20 2017-05-26 Forsight Vision4, Inc. Porous structures for extended release drug delivery devices
CA3006303C (en) 2015-11-25 2023-11-14 Incept, Llc Shape changing drug delivery devices and methods
BR112018070383A2 (pt) 2016-04-05 2019-02-05 Forsight Vision4 Inc dispositivos para aplicação de fármaco oculares implantáveis
USD814637S1 (en) 2016-05-11 2018-04-03 Salutaris Medical Devices, Inc. Brachytherapy device
USD815285S1 (en) 2016-05-11 2018-04-10 Salutaris Medical Devices, Inc. Brachytherapy device
USD814638S1 (en) 2016-05-11 2018-04-03 Salutaris Medical Devices, Inc. Brachytherapy device
USD808528S1 (en) 2016-08-31 2018-01-23 Salutaris Medical Devices, Inc. Holder for a brachytherapy device
USD808529S1 (en) 2016-08-31 2018-01-23 Salutaris Medical Devices, Inc. Holder for a brachytherapy device
EA202090247A1 (ru) 2017-07-14 2020-05-12 Цитомкс Терапьютикс, Инк. Антитела против cd166 и их применения
DK3658184T3 (da) 2017-07-27 2023-11-27 Alexion Pharma Inc Højkoncentrerede anti-c5-antistofformuleringer
CN107519532B (zh) * 2017-08-25 2020-10-02 唐山市工人医院 一种弹性假体材料及其制备方法
CA3082891A1 (en) 2017-11-21 2019-05-31 Forsight Vision4, Inc. Fluid exchange apparatus for expandable port delivery system and methods of use
EP3501433A1 (de) * 2017-12-21 2019-06-26 Universiteit Maastricht Vorrichtung zur handhabung eines stabförmigen elements zum einfügen in oder entfernen aus dem auge eines patienten
EP3762083A1 (de) 2018-03-08 2021-01-13 CereVasc, Inc. Systeme und verfahren zur minimal-invasiven wirkstoffabgabe an einen subarachnoidraum
WO2019226516A1 (en) 2018-05-24 2019-11-28 Celanese EVA Performance Polymers Corporation Implantable device for sustained release of a macromolecular drug compound
JP2021524840A (ja) 2018-05-24 2021-09-16 セラニーズ・イーブイエイ・パフォーマンス・ポリマーズ・エルエルシー 高分子薬剤化合物の持続放出用の埋め込み型デバイス
US20200100941A1 (en) 2018-08-25 2020-04-02 Thad Anthony Labbe Ophthalmic surgical instruments for removal of lens materials and methods of use
WO2020112816A1 (en) 2018-11-29 2020-06-04 Surmodics, Inc. Apparatus and methods for coating medical devices
EP3893899A2 (de) 2018-12-12 2021-10-20 Kite Pharma, Inc. Chimäre antigen-rezeptoren und car-t-zellen und verwendungsverfahren
CN109431678B (zh) * 2018-12-17 2021-05-28 中国医学科学院北京协和医院 经巩膜药物传输系统
US11819590B2 (en) 2019-05-13 2023-11-21 Surmodics, Inc. Apparatus and methods for coating medical devices
WO2021217024A1 (en) 2020-04-24 2021-10-28 Millennium Pharmaceuticals, Inc. Anti-cd19 antibodies and uses thereof
EP4281144A1 (de) 2021-01-22 2023-11-29 Shifamed Holdings, LLC Einstellbare rangiersysteme mit plattenanordnungen und zugehörige systeme und verfahren
EP4320149A1 (de) 2021-04-09 2024-02-14 Takeda Pharmaceutical Company Limited Gegen komplementfaktor d gerichtete antikörper und verwendungen davon
CA3216770A1 (en) 2021-04-26 2022-11-03 Tomoki Yoshihara Anti-clec12a antibodies and uses thereof
WO2022232035A1 (en) 2021-04-26 2022-11-03 Millennium Pharmaceuticals, Inc. Anti-adgre2 antibodies and uses thereof
IL311837A (en) 2021-10-20 2024-05-01 Takeda Pharmaceuticals Co BCMA designated preparations and methods for their use
USD1033637S1 (en) 2022-01-24 2024-07-02 Forsight Vision4, Inc. Fluid exchange device

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US273410A (en) * 1883-03-06 Gelatine eye-disk
US3416530A (en) * 1966-03-02 1968-12-17 Richard A. Ness Eyeball medication dispensing tablet
US4069307A (en) * 1970-10-01 1978-01-17 Alza Corporation Drug-delivery device comprising certain polymeric materials for controlled release of drug
US4144317A (en) * 1975-05-30 1979-03-13 Alza Corporation Device consisting of copolymer having acetoxy groups for delivering drugs
US4014334A (en) * 1976-02-02 1977-03-29 Alza Corporation Laminated osmotic system for dispensing beneficial agent
US4206756A (en) * 1977-03-23 1980-06-10 Murray Grossan Jet ear irrigation system
US4300557A (en) 1980-01-07 1981-11-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for treating intraocular malignancies
US4304765A (en) * 1980-10-14 1981-12-08 Alza Corporation Ocular insert housing steroid in two different therapeutic forms
US4678466A (en) * 1981-06-25 1987-07-07 Rosenwald Peter L Internal medication delivery method and vehicle
US4451254A (en) * 1982-03-15 1984-05-29 Eli Lilly And Company Implant system
CA1232814A (en) 1983-09-16 1988-02-16 Hidetoshi Sakamoto Guide wire for catheter
US4892736A (en) * 1983-10-07 1990-01-09 The Forsyth Dental Infirmary For Children Intra-pocket drug delivery devices for treatment of periodontal diseases
US4764377A (en) * 1983-10-07 1988-08-16 The Forsyth Dental Infirmary For Children Intra-pocket drug delivery devices for treatment of periodontal diseases
US4701180A (en) * 1986-02-19 1987-10-20 Kelly L Thomas Implanted anchor and insert with analog display
US4665905A (en) 1986-06-09 1987-05-19 Brown Charles S Dynamic elbow and knee extension brace
US5322691A (en) 1986-10-02 1994-06-21 Sohrab Darougar Ocular insert with anchoring protrusions
US5989579A (en) * 1986-10-02 1999-11-23 Escalon Medical Corp. Ocular insert with anchoring protrusions
JP2868817B2 (ja) 1987-12-17 1999-03-10 ユナイテッド・ステーツ・サージカル・コーポレーション 反復カーボネート単位を含むホモポリマーおよびコポリマーから製造された医療用具
US4853224A (en) 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US4936825A (en) * 1988-04-11 1990-06-26 Ungerleider Bruce A Method for reducing intraocular pressure caused by glaucoma
US5098443A (en) 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
KR0185215B1 (ko) * 1990-11-30 1999-05-01 요시다 쇼오지 서방성 안구삽입용 약제
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US5364343A (en) * 1991-03-06 1994-11-15 D.D. S.R.L. Irrigation device for use in ear canals for therapeutic or hygienic purposes
US5246867A (en) * 1992-01-17 1993-09-21 University Of Maryland At Baltimore Determination and quantification of saccharides by luminescence lifetimes and energy transfer
US5178635A (en) 1992-05-04 1993-01-12 Allergan, Inc. Method for determining amount of medication in an implantable device
US5578075B1 (en) * 1992-11-04 2000-02-08 Daynke Res Inc Minimally invasive bioactivated endoprosthesis for vessel repair
US5464650A (en) 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
US5716981A (en) * 1993-07-19 1998-02-10 Angiogenesis Technologies, Inc. Anti-angiogenic compositions and methods of use
ATE420628T1 (de) 1993-07-19 2009-01-15 Angiotech Pharm Inc Anti-angiogene mittel und verfahren zu deren verwendung
US5443505A (en) * 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5466233A (en) * 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
US5472436A (en) 1994-07-26 1995-12-05 Fremstad; Daria A. Ocular appliance for delivering medication
US5582616A (en) 1994-08-05 1996-12-10 Origin Medsystems, Inc. Surgical helical fastener with applicator
US5725493A (en) * 1994-12-12 1998-03-10 Avery; Robert Logan Intravitreal medicine delivery
US5551427A (en) * 1995-02-13 1996-09-03 Altman; Peter A. Implantable device for the effective elimination of cardiac arrhythmogenic sites
US5605696A (en) 1995-03-30 1997-02-25 Advanced Cardiovascular Systems, Inc. Drug loaded polymeric material and method of manufacture
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US6120536A (en) 1995-04-19 2000-09-19 Schneider (Usa) Inc. Medical devices with long term non-thrombogenic coatings
US5837313A (en) 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
IL113723A (en) * 1995-05-14 2002-11-10 Optonol Ltd Intraocular implant
US5773019A (en) * 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US5904144A (en) 1996-03-22 1999-05-18 Cytotherapeutics, Inc. Method for treating ophthalmic diseases
ZA97976B (en) 1996-04-05 1997-08-18 Alza Corp Uniform drug delivery theraphy.
US5928662A (en) 1996-07-31 1999-07-27 Phillips; Andrew F. Ocular drug delivery device
ZA978537B (en) * 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
US5997517A (en) 1997-01-27 1999-12-07 Sts Biopolymers, Inc. Bonding layers for medical device surface coatings
PT973499E (pt) 1997-03-31 2003-12-31 Alza Corp Sistema de administracao difusor implantavel
US5879697A (en) 1997-04-30 1999-03-09 Schneider Usa Inc Drug-releasing coatings for medical devices
US6110483A (en) 1997-06-23 2000-08-29 Sts Biopolymers, Inc. Adherent, flexible hydrogel and medicated coatings
US6248345B1 (en) 1997-07-02 2001-06-19 Euro-Celtique, S.A. Prolonged anesthesia in joints and body spaces
WO1999007418A2 (en) 1997-08-11 1999-02-18 Allergan Sales, Inc. Sterile bioerodible implant device with improved biocompatability and method
US6306166B1 (en) 1997-08-13 2001-10-23 Scimed Life Systems, Inc. Loading and release of water-insoluble drugs
US5972027A (en) * 1997-09-30 1999-10-26 Scimed Life Systems, Inc Porous stent drug delivery system
KR100289471B1 (ko) 1998-01-19 2001-09-17 김충섭 휀타닐계마취제의이식형서방성제제
JP3406903B2 (ja) * 1998-04-27 2003-05-19 サーモディックス，インコーポレイティド 生物活性剤を放出するコーティング
US20020188037A1 (en) * 1999-04-15 2002-12-12 Chudzik Stephen J. Method and system for providing bioactive agent release coating
US6013099A (en) * 1998-04-29 2000-01-11 Medtronic, Inc. Medical device for delivering a water-insoluble therapeutic salt or substance
JP2002518141A (ja) * 1998-06-22 2002-06-25 ネオヴェイシス インコーポレイテッド 組織内の血流を増大させる方法、インプラントおよび配給システム
US6153252A (en) * 1998-06-30 2000-11-28 Ethicon, Inc. Process for coating stents
WO2000002564A1 (en) 1998-07-10 2000-01-20 The University Of Sydney Prophylactic treatments of neovascularisation in macular degeneration
US6378526B1 (en) * 1998-08-03 2002-04-30 Insite Vision, Incorporated Methods of ophthalmic administration
US6399655B1 (en) * 1998-12-22 2002-06-04 Johns Hopkins University, School Of Medicine Method for the prophylactic treatment of cataracts
US20040121014A1 (en) * 1999-03-22 2004-06-24 Control Delivery Systems, Inc. Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6217895B1 (en) * 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6309660B1 (en) 1999-07-28 2001-10-30 Edwards Lifesciences Corp. Universal biocompatible coating platform for medical devices
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US6264971B1 (en) 1999-11-04 2001-07-24 Btg International Limited Ocular insert
US6706023B1 (en) * 1999-12-03 2004-03-16 Bionix Development Corporation Device for irrigation of a blind orifice
US6245100B1 (en) 2000-02-01 2001-06-12 Cordis Corporation Method for making a self-expanding stent-graft
US7077848B1 (en) 2000-03-11 2006-07-18 John Hopkins University Sutureless occular surgical methods and instruments for use in such methods
WO2001068766A2 (en) * 2000-03-13 2001-09-20 The Dow Chemical Company Flame retardant, high impact monovinylidene aromatic polymer composition
US6478776B1 (en) * 2000-04-05 2002-11-12 Biocardia, Inc. Implant delivery catheter system and methods for its use
US6638239B1 (en) * 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US6375972B1 (en) * 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US6451373B1 (en) * 2000-08-04 2002-09-17 Advanced Cardiovascular Systems, Inc. Method of forming a therapeutic coating onto a surface of an implantable prosthesis
US6719750B2 (en) 2000-08-30 2004-04-13 The Johns Hopkins University Devices for intraocular drug delivery
KR20030045847A (ko) 2000-10-31 2003-06-11 쿡 인코포레이티드 코팅된 이식형 의료 장치
EP1355588B1 (de) 2000-12-22 2007-08-15 Avantec Vascular Corporation Vorrichtung zur Abgabe von therapeutischen Wirkstoffen
US6471980B2 (en) * 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US6713081B2 (en) * 2001-03-15 2004-03-30 The United States Of America As Represented By The Department Of Health And Human Services Ocular therapeutic agent delivery devices and methods for making and using such devices
US20040022853A1 (en) * 2001-04-26 2004-02-05 Control Delivery Systems, Inc. Polymer-based, sustained release drug delivery system
WO2002100318A2 (en) * 2001-06-12 2002-12-19 Johns Hopkins University School Of Medicine Reservoir device for intraocular drug delivery
US7485113B2 (en) * 2001-06-22 2009-02-03 Johns Hopkins University Method for drug delivery through the vitreous humor
US20030158598A1 (en) * 2001-09-17 2003-08-21 Control Delivery Systems, Inc. System for sustained-release delivery of anti-inflammatory agents from a coated medical device
US6764470B2 (en) * 2001-12-03 2004-07-20 Roland P. Dimick Ear plug medication administration device
WO2004014447A1 (en) * 2002-08-13 2004-02-19 Medtronic, Inc. Active agent delivery system including a poly(ethylene-co-(meth)acrylate), medical device, and method
AU2003279055A1 (en) 2002-09-29 2004-04-19 Surmodics, Inc. Methods for treatment and/or prevention of retinal disease
US7654997B2 (en) * 2004-04-21 2010-02-02 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitus and other disorders of the ears, nose and/or throat

Also Published As

Publication number Publication date
AU2007200057B2 (en) 2008-09-18
ATE404140T1 (de) 2008-08-15
WO2002017831A2 (en) 2002-03-07
EP1313415A2 (de) 2003-05-28
EP1992317B1 (de) 2012-02-29
WO2002017831A3 (en) 2002-07-11
AU2001271417B2 (en) 2006-10-05
JP2004524866A (ja) 2004-08-19
PT1313415E (pt) 2008-11-25
US20040133155A1 (en) 2004-07-08
CA2420038A1 (en) 2002-03-07
EP1992317A3 (de) 2009-01-21
JP4471568B2 (ja) 2010-06-02
ES2312456T3 (es) 2009-03-01
US20050059956A1 (en) 2005-03-17
DK1313415T3 (da) 2008-10-13
AU2007200057A1 (en) 2007-01-25
EP1313415B1 (de) 2008-08-13
US6719750B2 (en) 2004-04-13
US8096972B2 (en) 2012-01-17
US20020026176A1 (en) 2002-02-28
AU7141701A (en) 2002-03-13
DE60135352D1 (de) 2008-09-25
CA2420038C (en) 2010-11-09
EP1992317A2 (de) 2008-11-19

Similar Documents

Publication Publication Date Title
ATE547080T1 (de) Vorrichtungen zur intraokularen arzneimittelabgabe
EP1404297A4 (de) Reservoirvorrichtung für die intraokulare arzneimittelabgabe
EP1284727A4 (de) Intrakorporale medikamente zur photodynamischen behandlung von erkrankungen
FR12C0067I1 (fr) Implant oculaire biodegradable
TNSN08079A1 (en) Pharmaceutical compositions for the treatment of inner ear disorders
HUP0401568A2 (hu) Periokuláris vagy subconjunctivális adagolásra alkalmas szemészeti depó készítmények
DE60230393D1 (de) Bioaktive okklusionsspirale
ATE504308T1 (de) Antimikrobielle kationische peptide und diese enthaltende formulierungen
GB0108592D0 (en) Therapeutic agents
ATE300306T1 (de) Pharmazeutische zusammensetzung zur ophtalmologischen und rhinologischen anwendung
GB0223040D0 (en) Therapeutic compounds
WO2004050140A3 (en) Medical devices for delivery of therapeutic agents
HUP0203590A2 (hu) Gyógyszerkészítmény a csonttömeg csökkenésével járó betegségek kezelésére
HK1085386A1 (en) Pharmaceuticals comprising shikonins active constituent
MXPA04000124A (es) Composicion farmaceutica para la terapia de cistitis intersticial.
HK1069785A1 (en) Superoxide dismutase mimics for the treatment of ocular disorders and diseases
DE60140318D1 (de) Konfiguration implantierter vorrichtungen
WO2001039792A3 (en) The use of caspase 9 inhibitors to treat ocular neural pathology
EP1297849A4 (de) Heilmittel für zur behandlung von erkrankungen des sehnervs und so weiter
DE60231785D1 (de) Gelierbare, biokompatible und implantierbare zusammensetzung
MXPA04001255A (es) Uso de compuesto para el tratamiento de condiciones que resultan de lesion al nervio corneo despues de lasik y otras cirugias oculares o trauma.
MXPA05005460A (es) Contraste de ultrasonido que usa xantenos halogenados.
CA2567140A1 (en) Methods and apparatus for delivery of ocular implants
LT2002105A (en) Novel use of siberian fir oil
UA89858C2 (ru) Фармацевтические композиции, предназначенные для лечения нарушений внутреннего уха