MX2007006214A - Un implante para suministro de farmaco intraocular. - Google Patents
Un implante para suministro de farmaco intraocular.Info
- Publication number
- MX2007006214A MX2007006214A MX2007006214A MX2007006214A MX2007006214A MX 2007006214 A MX2007006214 A MX 2007006214A MX 2007006214 A MX2007006214 A MX 2007006214A MX 2007006214 A MX2007006214 A MX 2007006214A MX 2007006214 A MX2007006214 A MX 2007006214A
- Authority
- MX
- Mexico
- Prior art keywords
- implant
- end portion
- opening
- drug delivery
- intraocular drug
- Prior art date
Links
- 239000007943 implant Substances 0.000 title abstract 5
- 238000012377 drug delivery Methods 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000011343 solid material Substances 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
- A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Un implante para suministro de farmaco intraocular para el tratamiento de enfermedades inflamatorias o degenerativas. En una modalidad, el implante incluye una porcion de cuerpo que tiene una primera porcion de extremo y una segunda porcion de extremo opuesta y que define una cavidad con una primera abertura en la primera porcion de extremo, y una segunda abertura opuesta en la segunda porcion de extremo, y un material solido recibido en la cavidad, en donde el material solido comprende un material de deposito y una cantidad efectiva de por lo menos un compuesto o agente terapeutico. Cuando el implante se implanta en un ojo de un sujeto vivo, la cantidad efectiva de por lo menos un compuesto o agente terapeutico se libera al medio ambiente del implante a traves de por lo menos una de la primera abertura y la segunda abertura opuesta durante un periodo prolongado de tiempo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63075104P | 2004-11-24 | 2004-11-24 | |
PCT/US2005/041330 WO2006057859A1 (en) | 2004-11-24 | 2005-11-16 | An implant for intraocular drug delivery |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007006214A true MX2007006214A (es) | 2008-04-16 |
Family
ID=36498302
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007006214A MX2007006214A (es) | 2004-11-24 | 2005-11-16 | Un implante para suministro de farmaco intraocular. |
Country Status (12)
Country | Link |
---|---|
US (2) | US20060110429A1 (es) |
EP (1) | EP1827462A4 (es) |
JP (1) | JP2008521489A (es) |
KR (1) | KR20080016780A (es) |
CN (1) | CN101132800A (es) |
AU (1) | AU2005309854A1 (es) |
BR (1) | BRPI0518582A2 (es) |
CA (1) | CA2588449A1 (es) |
IL (1) | IL183424A0 (es) |
MX (1) | MX2007006214A (es) |
RU (1) | RU2007123604A (es) |
WO (1) | WO2006057859A1 (es) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
US7976520B2 (en) * | 2004-01-12 | 2011-07-12 | Nulens Ltd. | Eye wall anchored fixtures |
US20050232972A1 (en) | 2004-04-15 | 2005-10-20 | Steven Odrich | Drug delivery via punctal plug |
US7922702B2 (en) | 2004-07-02 | 2011-04-12 | Qlt Inc. | Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such a delivery device |
CN101132800A (zh) * | 2004-11-24 | 2008-02-27 | 席拉坎有限责任公司 | 一种用于眼内药物释出的植入体 |
US20080199460A1 (en) * | 2005-09-01 | 2008-08-21 | Schering Corporation | Use of IL-23 and IL-17 antagonists to treat autoimmune ocular inflammatory disease |
AU2007293169A1 (en) * | 2006-02-02 | 2008-03-13 | Allergan, Inc. | Compositions and methods for the treatment of ophthalmic disease |
US8795711B2 (en) | 2006-03-31 | 2014-08-05 | Mati Therapeutics Inc. | Drug delivery methods, structures, and compositions for nasolacrimal system |
BRPI0621761A2 (pt) * | 2006-06-12 | 2011-12-20 | Therakine Ltd | solução oftálmica e uso de uma solução salina, e uma quantidade eficaz de pelo menos um agente terapêutico |
US9173773B2 (en) * | 2006-06-21 | 2015-11-03 | Johnson & Johnson Vision Care, Inc. | Punctal plugs for the delivery of active agents |
US9474645B2 (en) * | 2006-06-21 | 2016-10-25 | Johnson & Johnson Vision Care, Inc. | Punctal plugs for the delivery of active agents |
US20080045911A1 (en) * | 2006-06-21 | 2008-02-21 | Borgia Maureen J | Punctal plugs for the delivery of active agents |
AU2007272963B2 (en) | 2006-07-11 | 2013-05-23 | Refocus Group, Inc. | Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods |
US8911496B2 (en) | 2006-07-11 | 2014-12-16 | Refocus Group, Inc. | Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods |
WO2008045564A2 (en) * | 2006-10-12 | 2008-04-17 | Epix Delaware, Inc. | Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor |
WO2008073295A2 (en) * | 2006-12-07 | 2008-06-19 | Surmodics, Inc. | Latent stabilization of bioactive agents releasable from implantable medical articles |
AU2007339929A1 (en) * | 2006-12-26 | 2008-07-10 | Qlt Inc. | Drug delivery implants for inhibition of optical defects |
EP2205193A2 (en) | 2007-09-07 | 2010-07-14 | QLT Plug Delivery, Inc. | Lacrimal implant detection |
DK2207529T3 (en) | 2007-09-07 | 2015-03-09 | Mati Therapeutics Inc | PHARMACEUTICAL cores for the sustained release of therapeutic agents |
KR20100050566A (ko) | 2007-09-07 | 2010-05-13 | 큐엘티 플러그 딜리버리, 인코포레이티드 | 눈물 임플랜트 및 이에 관련된 방법 |
RU2010128543A (ru) | 2007-12-11 | 2012-01-20 | Сайтопатфайндер, Инк. (Jp) | Карбоксамидные соединения и их применение в качестве агонистов хемокиновых рецепторов |
US20110053852A1 (en) * | 2007-12-21 | 2011-03-03 | Paul Klotman | Use of podocan protein in treating cardiovascular diseases |
CA3069576A1 (en) | 2008-01-09 | 2009-07-16 | The Schepens Eye Research Institute, Inc. | Therapeutic compositions for treatment of ocular inflammatory disorders |
JP2011509944A (ja) * | 2008-01-14 | 2011-03-31 | サーモディクス,インコーポレイティド | 核酸送達複合体の溶出のための装置及び方法 |
CN104623741A (zh) | 2008-04-30 | 2015-05-20 | 马缇医疗股份有限公司 | 复合泪管植入物及相关方法 |
WO2009137689A2 (en) * | 2008-05-07 | 2009-11-12 | Surmodics, Inc. | Delivery of nucleic acid complexes from particles |
JP2011520805A (ja) | 2008-05-09 | 2011-07-21 | キューエルティー プラグ デリバリー,インク. | 緑内障および高眼圧症治療のための活性剤の持続送達 |
US10064819B2 (en) | 2008-05-12 | 2018-09-04 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
JP5591226B2 (ja) | 2008-05-12 | 2014-09-17 | ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション | 眼内薬物送達装置および関連する方法 |
US9877973B2 (en) | 2008-05-12 | 2018-01-30 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
US9095404B2 (en) | 2008-05-12 | 2015-08-04 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
EP2315571A4 (en) * | 2008-07-16 | 2013-05-01 | Surmodics Pharmaceuticals Inc | METHOD FOR PRODUCING MICROPARTICLES WITH BIOACTIVE PEPTIDES |
CA2744245A1 (en) * | 2008-11-19 | 2010-05-27 | Refocus Group, Inc. | Artificial intraocular lens, altered natural crystalline lens, or refilled natural crystalline lens capsule with one or more scleral prostheses for improved performance |
US20120014970A1 (en) * | 2009-01-09 | 2012-01-19 | Reza Dana | Therapeutic Compositions for Treatment of Corneal Disorders |
EP2385839B1 (en) * | 2009-01-09 | 2014-11-26 | The Schepens Eye Research Institute, Inc. | Therapeutic compositions for treatment of corneal disorders |
WO2010093945A2 (en) | 2009-02-13 | 2010-08-19 | Glaukos Corporation | Uveoscleral drug delivery implant and methods for implanting the same |
MX2011008875A (es) | 2009-02-23 | 2011-09-26 | Quadra Logic Tech Inc | Implantes lagrimales y metodos relacionados. |
US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
JP5844258B2 (ja) * | 2009-08-27 | 2016-01-13 | バイオメット、バイオロジクス、リミテッド、ライアビリティー、カンパニーBiomet Biologics, Llc | インターロイキン−1受容体アンタゴニストの生産のための植込み型装置 |
EP3470421B9 (en) | 2010-07-29 | 2023-10-04 | Buzzard Pharmaceuticals AB | Chimeric il-1 receptor type i antagonists |
US9668915B2 (en) | 2010-11-24 | 2017-06-06 | Dose Medical Corporation | Drug eluting ocular implant |
US8901092B2 (en) | 2010-12-29 | 2014-12-02 | Surmodics, Inc. | Functionalized polysaccharides for active agent delivery |
EP2711013A4 (en) * | 2011-05-18 | 2015-03-04 | Ajinomoto Kk | IMMUNSTIMULANDS FOR ANIMALS, FEED THEREFOR AND MANUFACTURING PROCESS THEREFOR |
US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
CN103889401B (zh) | 2011-08-29 | 2017-10-13 | Qlt公司 | 持续释放递送活性剂以治疗青光眼和高眼压 |
US9974685B2 (en) | 2011-08-29 | 2018-05-22 | Mati Therapeutics | Drug delivery system and methods of treating open angle glaucoma and ocular hypertension |
RU2642664C2 (ru) | 2011-11-18 | 2018-01-25 | Ридженерон Фармасьютикалз, Инк. | Полимерные белковые микрочастицы |
US9474715B2 (en) | 2011-11-30 | 2016-10-25 | Andreas Voigt | Polymeric drug-delivery material, method for manufacturing thereof and method for delivery of a drug-delivery composition |
KR101969594B1 (ko) * | 2012-05-11 | 2019-04-16 | 서강대학교산학협력단 | 안내 약물 전달 임플란트 |
RS61391B1 (sr) * | 2012-06-08 | 2021-02-26 | Alkermes Pharma Ireland Ltd | Ligandi modifikovani primenom cirkularnog permutiranja kao agonisti i antagonisti |
RU2015143521A (ru) | 2013-03-13 | 2017-04-19 | Илэвэн Байотерапьютикс, Инк. | Лекарственные формы химерных цитокинов для глазной доставки |
US10517759B2 (en) | 2013-03-15 | 2019-12-31 | Glaukos Corporation | Glaucoma stent and methods thereof for glaucoma treatment |
CA2920653A1 (en) * | 2013-08-08 | 2015-02-12 | Loma Linda University Medical Center | Systems and methods for the treatment of bladder cancer |
TW201609145A (zh) * | 2013-12-25 | 2016-03-16 | 參天製藥股份有限公司 | 注射劑及形成緩釋(depot)之方法 |
JP6655610B2 (ja) | 2014-05-29 | 2020-02-26 | グローコス コーポレーション | 制御された薬物送達機能を備えるインプラント及びそれを使用する方法 |
FR3028410A1 (fr) | 2014-11-18 | 2016-05-20 | Pierre Coulon | Implant capsulaire multifonctionnel |
US11925578B2 (en) | 2015-09-02 | 2024-03-12 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
WO2017037685A1 (en) * | 2015-09-04 | 2017-03-09 | University Of The Witwatersrand, Johannesburg | Biodegradable implant |
US11173130B2 (en) | 2015-09-24 | 2021-11-16 | Massachusetts Eye And Ear Infirmary | Drug delivery system and methods of use |
US11564833B2 (en) | 2015-09-25 | 2023-01-31 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
EA036623B1 (ru) * | 2015-10-16 | 2020-12-01 | Ридженерон Фармасьютикалз, Инк. | Стабильные белковые композиции |
CN105497991B (zh) * | 2016-01-07 | 2018-08-31 | 北京大学第三医院 | 聚羟基脂肪酸酯pha在制备治疗青光眼的产品中的应用 |
WO2017120479A1 (en) | 2016-01-07 | 2017-07-13 | The Schepens Eye Research Institute, Inc. | Therapeutics for ocular immunoinflammatory diseases |
US11318043B2 (en) | 2016-04-20 | 2022-05-03 | Dose Medical Corporation | Bioresorbable ocular drug delivery device |
WO2018175237A1 (en) * | 2017-03-23 | 2018-09-27 | Particle Sciences, Inc. | Implantable and removable drug delivery device |
IT201700101582A1 (it) * | 2017-09-12 | 2019-03-12 | Milano Politecnico | Dispositivo per rilascio intraoculare |
EP3843676A1 (en) * | 2018-08-29 | 2021-07-07 | W.L. Gore & Associates, Inc. | Drug therapy delivery systems and methods |
US11678983B2 (en) | 2018-12-12 | 2023-06-20 | W. L. Gore & Associates, Inc. | Implantable component with socket |
IT201900003597A1 (it) * | 2019-03-12 | 2020-09-12 | Milano Politecnico | Dispositivo per il rilascio controllato |
Family Cites Families (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3977404A (en) * | 1975-09-08 | 1976-08-31 | Alza Corporation | Osmotic device having microporous reservoir |
US5269812A (en) * | 1986-05-16 | 1993-12-14 | White Thomas C | Methods and devices employed in replacement of the corneal endothelium |
US5139518A (en) * | 1986-05-16 | 1992-08-18 | White Thomas C | Methods employed in replacement of the corneal endothelium |
US4863457A (en) * | 1986-11-24 | 1989-09-05 | Lee David A | Drug delivery device |
DK0454044T3 (da) * | 1990-04-25 | 1996-04-22 | Hoechst Ag | Farmakologisk præparat indeholdende polyelektrolytkomplekser på mikropartikelform og mindst et virksomt stof |
US5041081A (en) * | 1990-05-18 | 1991-08-20 | Odrich Ronald B | Ocular implant for controlling glaucoma |
US5830508A (en) * | 1992-08-06 | 1998-11-03 | Deo Corporation | Composition for treating dry eye |
US5707643A (en) * | 1993-02-26 | 1998-01-13 | Santen Pharmaceutical Co., Ltd. | Biodegradable scleral plug |
US5622965A (en) * | 1993-03-12 | 1997-04-22 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | 4-hydroxy-3-nitro-1,2-dihydroquinolin-2-ones and the use thereof as excitatory amino acid and glycine receptor antagonists |
JPH08512056A (ja) * | 1993-06-30 | 1996-12-17 | ジェネンテク・インコーポレイテッド | リポソームの製造法 |
US5466233A (en) * | 1994-04-25 | 1995-11-14 | Escalon Ophthalmics, Inc. | Tack for intraocular drug delivery and method for inserting and removing same |
US5885795A (en) * | 1994-04-26 | 1999-03-23 | The Children's Medical Center Corporation | Methods of expressing angiostatic protein |
US5837682A (en) * | 1996-03-08 | 1998-11-17 | The Children's Medical Center Corporation | Angiostatin fragments and method of use |
US5945403A (en) * | 1997-05-30 | 1999-08-31 | The Children's Medical Center Corporation | Angiostatin fragments and method of use |
US5639725A (en) * | 1994-04-26 | 1997-06-17 | Children's Hospital Medical Center Corp. | Angiostatin protein |
US6107045A (en) * | 1994-06-30 | 2000-08-22 | Oklahoma Medical Research Foundation | Antibodies to lipoproteins and apolipoproteins and methods of use thereof |
US6063396A (en) * | 1994-10-26 | 2000-05-16 | Houston Biotechnology Incorporated | Methods and compositions for the modulation of cell proliferation and wound healing |
US6063116A (en) * | 1994-10-26 | 2000-05-16 | Medarex, Inc. | Modulation of cell proliferation and wound healing |
US5900245A (en) * | 1996-03-22 | 1999-05-04 | Focal, Inc. | Compliant tissue sealants |
US5972326A (en) * | 1995-04-18 | 1999-10-26 | Galin; Miles A. | Controlled release of pharmaceuticals in the anterior chamber of the eye |
US5612027A (en) * | 1995-04-18 | 1997-03-18 | Galin; Miles A. | Controlled release of miotic and mydriatic drugs in the anterior chamber |
US5861372A (en) * | 1996-02-22 | 1999-01-19 | The Children's Medical Center Corporation | Aggregate angiostatin and method of use |
US5837240A (en) * | 1995-04-28 | 1998-11-17 | Oravax-Merieux Co. | Multimeric, recombinant urease vaccine |
US5968058A (en) * | 1996-03-27 | 1999-10-19 | Optonol Ltd. | Device for and method of implanting an intraocular implant |
EP0842209B1 (en) * | 1995-07-28 | 2006-10-11 | Genzyme Corporation | Multiblock biodegradable hydrogels for use as controlled release agents for drugs and tissue treatment agents |
US5773019A (en) * | 1995-09-27 | 1998-06-30 | The University Of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
AR009439A1 (es) * | 1996-12-23 | 2000-04-12 | Novartis Ag | Un articulo que comprende un sustrato con un recubrimiento polimerico primario que porta grupos reactivos predominantemente en su superficie, unmetodo para preparar dicho articulo, un articulo que posee un recubrimiento de tipo hibrido y una lente de contacto |
DE69816980T2 (de) * | 1997-03-31 | 2004-07-22 | Alza Corp., Palo Alto | Implantierbares diffusionabgabesystem |
US6224893B1 (en) * | 1997-04-11 | 2001-05-01 | Massachusetts Institute Of Technology | Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering |
US6638621B2 (en) * | 2000-08-16 | 2003-10-28 | Lyotropic Therapeutics, Inc. | Coated particles, methods of making and using |
US6186148B1 (en) * | 1998-02-04 | 2001-02-13 | Kiyoshi Okada | Prevention of posterior capsular opacification |
CA2320515A1 (en) * | 1998-02-13 | 1999-08-19 | Human Genome Sciences, Inc. | Therapeutic uses of keratinocyte growth factor-2 |
US7101575B2 (en) * | 1998-03-19 | 2006-09-05 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Production of nanocapsules and microcapsules by layer-wise polyelectrolyte self-assembly |
WO1999047253A1 (en) * | 1998-03-19 | 1999-09-23 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Fabrication of multilayer-coated particles and hollow shells via electrostatic self-assembly of nanocomposite multilayers on decomposable colloidal templates |
US20020099438A1 (en) * | 1998-04-15 | 2002-07-25 | Furst Joseph G. | Irradiated stent coating |
EP1098696B2 (de) * | 1998-07-15 | 2010-07-14 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Polyelektrolythüllen auf biologischen templaten |
EP1098642B1 (en) * | 1998-07-27 | 2007-04-04 | Johns Hopkins University | Diamino-propanol-compounds for treating ischemia |
EP1107791B8 (en) * | 1998-09-04 | 2007-11-07 | Scios Inc. | Hydrogel compositions for the controlled release administration of growth factors |
US6630457B1 (en) * | 1998-09-18 | 2003-10-07 | Orthogene Llc | Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same |
IT1302534B1 (it) * | 1998-12-21 | 2000-09-05 | Fidia Advanced Biopolymers Srl | Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per |
US6395029B1 (en) * | 1999-01-19 | 2002-05-28 | The Children's Hospital Of Philadelphia | Sustained delivery of polyionic bioactive agents |
US6217895B1 (en) * | 1999-03-22 | 2001-04-17 | Control Delivery Systems | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
FR2791552B1 (fr) * | 1999-04-02 | 2001-10-19 | Georges Baikoff | Implant pour la correction de la presbytie des yeux phaques |
US6312725B1 (en) * | 1999-04-16 | 2001-11-06 | Cohesion Technologies, Inc. | Rapid gelling biocompatible polymer composition |
JP4970678B2 (ja) * | 1999-06-10 | 2012-07-11 | マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ | 多層コーティングによる結晶のカプセル化 |
US6331313B1 (en) * | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
US6204270B1 (en) * | 1999-11-12 | 2001-03-20 | Eyal S. Ron | Ophthalmic and mucosal preparations |
DE60041978D1 (de) * | 1999-11-15 | 2009-05-20 | Biocure Inc | Auf äussere bedingungen ansprechende polymere hohle partikel |
US6267954B1 (en) * | 1999-11-24 | 2001-07-31 | Universite De Paris V Rene-Descartes | Intraocular transplantation of encapsulated cells |
DE10001172A1 (de) * | 2000-01-13 | 2001-07-26 | Max Planck Gesellschaft | Templatieren von Feststoffpartikeln mit Polymermultischichten |
US20030186386A1 (en) * | 2000-02-11 | 2003-10-02 | Hansen Christian Karsten | Interleukin 10 |
US6375972B1 (en) * | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
EP1286634B1 (en) * | 2000-05-19 | 2007-11-07 | Michael S. Berlin | Laser delivery system and method of use for the eye |
US20040170665A1 (en) * | 2000-06-02 | 2004-09-02 | Allergan, Inc. | Intravitreal botulinum toxin implant |
US6458275B1 (en) * | 2000-06-05 | 2002-10-01 | Harvard Apparatus, Inc. | Multi-well equilibrium dialysis system |
ES2312456T3 (es) * | 2000-08-30 | 2009-03-01 | Johns Hopkins University | Dispositivos para suministro intraocular de farmacos. |
AU2002248284A1 (en) * | 2000-11-01 | 2002-08-06 | Allergan, Inc. | Compositions for treatment of ocular neovascularization |
WO2002053130A2 (en) * | 2001-01-03 | 2002-07-11 | Bausch & Lomb Incorporated | Sustained release drug delivery devices with coated drug cores |
US6713081B2 (en) * | 2001-03-15 | 2004-03-30 | The United States Of America As Represented By The Department Of Health And Human Services | Ocular therapeutic agent delivery devices and methods for making and using such devices |
US6849271B2 (en) * | 2001-04-27 | 2005-02-01 | Verion, Inc. | Microcapsule matrix microspheres, absorption-enhancing pharmaceutical compositions and methods |
US20030211464A1 (en) * | 2001-05-02 | 2003-11-13 | Charles Pidgeon | Method and compositions for drug discovery |
JP4531290B2 (ja) * | 2001-05-18 | 2010-08-25 | 大日本印刷株式会社 | 保護拡散フィルム、面光源装置及び液晶表示装置 |
US20040062768A1 (en) * | 2001-06-05 | 2004-04-01 | Advanced Biotherapy, Inc. | Compositions and methods for treating hyperimmune response in the eye |
EP2316394B1 (en) * | 2001-06-12 | 2016-11-23 | The Johns Hopkins University | Reservoir device for intraocular drug delivery |
CA2456806C (en) * | 2001-08-08 | 2011-10-18 | Brown University Research Foundation | Methods for micronization of hydrophobic drugs |
WO2003039404A2 (en) * | 2001-11-09 | 2003-05-15 | Eyetech Pharmaceuticals | Methods for treating ocular neovascular diseases |
CA2473355C (en) * | 2002-01-18 | 2012-01-03 | Michael E. Snyder | Sustained release ophthalmological device and method of making and using the same |
CN1732022A (zh) * | 2002-12-30 | 2006-02-08 | 血管技术国际股份公司 | 含有丝的支架移植物 |
AR043356A1 (es) * | 2003-01-24 | 2005-07-27 | Control Delivery Sys Inc | Dispositvo de liberacion sostenida para la administracion ocular de inhibidores de la anhidrasa carbonica y uso de inhibidores de la anhidrasa carbonica para su preparacion |
US7241455B2 (en) * | 2003-04-08 | 2007-07-10 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices containing radiation-crosslinked polymer for controlled delivery of a therapeutic agent |
US7332470B2 (en) * | 2003-04-15 | 2008-02-19 | The Regents Of The University Of California | Methods and compositions for treating ocular disease |
US6923996B2 (en) * | 2003-05-06 | 2005-08-02 | Scimed Life Systems, Inc. | Processes for producing polymer coatings for release of therapeutic agent |
US7364585B2 (en) * | 2003-08-11 | 2008-04-29 | Boston Scientific Scimed, Inc. | Medical devices comprising drug-loaded capsules for localized drug delivery |
CN101132800A (zh) * | 2004-11-24 | 2008-02-27 | 席拉坎有限责任公司 | 一种用于眼内药物释出的植入体 |
-
2005
- 2005-11-16 CN CNA2005800470557A patent/CN101132800A/zh active Pending
- 2005-11-16 EP EP05851665A patent/EP1827462A4/en not_active Withdrawn
- 2005-11-16 RU RU2007123604/142007123604/14A patent/RU2007123604A/ru not_active Application Discontinuation
- 2005-11-16 WO PCT/US2005/041330 patent/WO2006057859A1/en active Application Filing
- 2005-11-16 MX MX2007006214A patent/MX2007006214A/es active IP Right Grant
- 2005-11-16 AU AU2005309854A patent/AU2005309854A1/en not_active Abandoned
- 2005-11-16 BR BRPI0518582-3A patent/BRPI0518582A2/pt not_active IP Right Cessation
- 2005-11-16 CA CA002588449A patent/CA2588449A1/en not_active Abandoned
- 2005-11-16 KR KR1020077014438A patent/KR20080016780A/ko not_active Application Discontinuation
- 2005-11-16 JP JP2007543173A patent/JP2008521489A/ja active Pending
- 2005-11-16 US US11/280,377 patent/US20060110429A1/en not_active Abandoned
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2007
- 2007-05-24 IL IL183424A patent/IL183424A0/en unknown
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2009
- 2009-03-18 US US12/406,876 patent/US20090214619A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20090214619A1 (en) | 2009-08-27 |
JP2008521489A (ja) | 2008-06-26 |
KR20080016780A (ko) | 2008-02-22 |
AU2005309854A1 (en) | 2006-06-01 |
US20060110429A1 (en) | 2006-05-25 |
RU2007123604A (ru) | 2008-12-27 |
WO2006057859A1 (en) | 2006-06-01 |
CA2588449A1 (en) | 2006-06-01 |
EP1827462A1 (en) | 2007-09-05 |
CN101132800A (zh) | 2008-02-27 |
BRPI0518582A2 (pt) | 2008-11-25 |
IL183424A0 (en) | 2008-04-13 |
EP1827462A4 (en) | 2012-01-04 |
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