US20070270750A1 - Drug delivery device - Google Patents

Drug delivery device Download PDF

Info

Publication number
US20070270750A1
US20070270750A1 US11/435,906 US43590606A US2007270750A1 US 20070270750 A1 US20070270750 A1 US 20070270750A1 US 43590606 A US43590606 A US 43590606A US 2007270750 A1 US2007270750 A1 US 2007270750A1
Authority
US
United States
Prior art keywords
handpiece
tip
drug
delivery device
drug delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/435,906
Inventor
Bruno Dacquay
Michael A. Zica
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Priority to US11/435,906 priority Critical patent/US20070270750A1/en
Assigned to ALCON, INC. reassignment ALCON, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DACQUAY, BRUNO, ZICA, MICHAEL A.
Priority claimed from US11/688,573 external-priority patent/US7811252B2/en
Priority claimed from US11/751,981 external-priority patent/US7674243B2/en
Priority claimed from US11/752,064 external-priority patent/US7862540B2/en
Priority claimed from US11/751,934 external-priority patent/US20070268340A1/en
Priority claimed from US11/752,011 external-priority patent/US20070270768A1/en
Priority claimed from US11/832,333 external-priority patent/US7815603B2/en
Priority claimed from US11/832,301 external-priority patent/US7887521B2/en
Publication of US20070270750A1 publication Critical patent/US20070270750A1/en
Application status is Abandoned legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/10Blood pumps; Artificial hearts; Devices for mechanical circulatory assistance, e.g. intra-aortic balloon pumps
    • A61M1/1037Pumps having flexible elements, e.g. with membranes, diaphragms, or bladder pumps
    • A61M1/1046Drive systems therefor, e.g. mechanically, electromechanically or skeletal muscle drive means
    • A61M1/1053Drive systems therefor, e.g. mechanically, electromechanically or skeletal muscle drive means using non-rotary electrical means
    • A61M1/1058Piezoelectric means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14546Front-loading type injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/02General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0266Shape memory materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3331Pressure; Flow
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/82Internal energy supply devices
    • A61M2205/8206Internal energy supply devices battery-operated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/82Internal energy supply devices
    • A61M2205/8262Internal energy supply devices connectable to external power source, e.g. connecting to automobile battery through the cigarette lighter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00Anatomical parts of the body
    • A61M2210/06Head
    • A61M2210/0612Eyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/48Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for varying, regulating, indicating or limiting injection pressure
    • A61M5/484Regulating injection pressure

Abstract

A syringe-like device having a drug dispensing tip connected to a motorized handpiece. The tip may be packaged pre-loaded with an amount of a liquid or phase transition drug or may be shipped empty and loaded with a liquid or phase transition drug by the user. The motorized handpiece contains suitable sensors and controllers for precisely actuating the tip for the controlled delivery of the liquid or phase transition drug in the tip. The handpiece by contain an internal power source, such as a battery, or may be connected to an external power source and/or control unit.

Description

  • The present invention generally pertains to the delivery of ophthalmically acceptable pharmaceutically active agents to the back of the eye and more particularly to an apparatus for delivery of precise amounts of a liquid or phase transition drug under controlled back pressure and flow conditions.
  • BACKGROUND OF THE INVENTION
  • Age related macular degeneration (ARMD) is the leading cause of blindness in the elderly. It attacks the center of vision and blurs it, making reading, driving, and other detailed tasks difficult or impossible. Current estimates reveal that approximately forty percent of the population over age 75, and approximately twenty percent of the population over age 60, suffer from some degree of macular degeneration. In “wet” ARMD, the type that most often causes blindness, newly formed choroidal blood vessels (CNV) leak fluid and cause progressive damage to the retina. Two main methods of treatment are currently being performed, (a) photocoagulation and (b) the use of angiogenesis inhibitors.
  • Photocoagulation can be harmful to the retina and is impractical when the CNV is in proximity of the fovea. Furthermore, photocoagulation often results in recurrent CNV over time.
  • Angiogenesis inhibitors may be administered orally, by intraocular injections, by extraocular sub-Tennon injections, or by local implants. In the sub-Tenon injection method, a physician disposes the tip of a curved needle externally around the eye near the macula, and releases a precise amount of the drug. However, a concern with sub-Tenon delivery is that the drug must be administered slowly and under relatively low pressure so as to be retained in the tissue rather than leaking back out, around the needle.
  • Therefore, a need exists in the field of ophthalmology for an improved apparatus for controlled delivery of a drug to the human eye.
  • BRIEF SUMMARY OF THE INVENTION
  • The present invention improves upon the prior art by providing a syringe-like device having a drug dispensing tip connected to a motorized handpiece. The tip may be packaged pre-loaded with an amount of a liquid or phase transition drug or may be shipped empty and loaded with a liquid or phase transition drug by the user. The motorized handpiece contains suitable sensors and controllers for precisely actuating the tip for the controlled delivery of the liquid or phase transition drug in the tip. The handpiece may contain an internal power source, such as a battery, or may be connected to an external power source and/or control unit.
  • Accordingly, one objective of the present invention is to provide a syringe-like device having a drug dispensing tip.
  • Another objective of the present invention is to provide a device for the delivery of a drug to the human eye and having a drug dispensing tip actuated by a motorized handpiece.
  • Yet another objective of the present invention is to provide a drug delivery device wherein the flow rate of the drug being delivered can be controlled.
  • Yet another objective of the present invention is to provide a drug delivery device wherein the amount of the drug being delivered can be controlled.
  • These and other advantages and objectives of the present invention will become apparent from the detailed description and claims that follow.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is an enlarged, schematical view of a first embodiment of the drug deliver device of the present invention.
  • FIG. 2 is an enlarged, schematical view of a second embodiment of the drug deliver device of the present invention.
  • DETAILED DESCRIPTION OF THE INVENTION
  • As best seen in FIG. 1, drug delivery device 10 of the present invention generally comprises tip 12 and handpiece 14. Tip 12 generally contains delivery cannula or needle 16 and body 18. Needle 16 may be any suitably sized needle of conventional construction. Body 18 generally is of a construction similar to a standard hypodermic syringe, e.g., cylindrical and tubular, made from glass, metal or a suitable plastic. Body 18 is sized and shaped to hold a suitable amount of a liquid or phase transition drug. Handpiece 14 generally is sized and shape similar to body 18, e.g., cylindrical, and has distal end 20 adapted to allow tip 12 to be mechanically connected to handpiece 14. Handpiece 14 contains drive mechanism 22, with associated driver electronics 24, to push plunger 21 in body 18 to force the liquid or phase transition drug contained in body 18 out needle 16. Suitable drive mechanisms include, for example, piezoelectric linear motors, such motors being well-known in the art (as described in U.S. Pat. No. 6,940,209 (Henderson)), and available from sources such as New Scale Technologies, Inc., Victor, N.Y. In the embodiment illustrated in FIG. 1, power for driver 22 and control electronics 24 is provided from power source 26, such as a battery, located internal to handpiece 14. Such a construction allows for very precise and controlled movement of plunger 21. In addition, electronics 24 can provide a feedback mechanism that senses the back pressure being exerted against the expression of the drug out of needle 16 and make appropriate adjustments to the speed and direction of motor 22.
  • As best seen in FIG. 2, drug delivery device 110 of the present invention may also generally comprise tip 112 and handpiece 114. Tip 112 generally contains delivery cannula or needle 116 and body 118. Needle 116 may be any suitably sized needle of conventional construction. Body 118 is generally is of construction similar to a standard hypodermic syringe, e.g., cylindrical and tubular, made from glass, metal or a suitable plastic. Body 118 is sized and shaped to hold a suitable amount of a liquid or phase transition drug. Handpiece 114 generally is sized and shaped similar to body 118, e.g., cylindrical, and has distal end 120 adapted so allow tip 112 to be mechanically connected to handpiece 114. Handpiece 114 contains drive mechanism 122, with associated driver electronics 124, to push plunger 121 in body 118 to force the liquid or phase transition drug contained in body 118 out needle 116. In the embodiment illustrated in FIG. 2, control electronics 124 are located external to handpiece 114 and power and control signals are provided to drive mechanism 122 through cable 123. Power for driver 122 and electronics 124 is provided from external source 126 through electrical cable 128. Such a construction allows for a smaller handpiece 114.
  • This description is given for purposes of illustration and explanation. It will be apparent to those skilled in the relevant art that changes and modifications may be made to the invention described above without departing from its scope or spirit.

Claims (6)

1. A drug delivery device, comprising:
a) a handpiece;
b) a tip having a body, the body being removably attached to the handpiece;
c) a cannula generally located on the body opposite the handpiece;
d) a plunger located in the tip body; and
e) a drive mechanism located in the handpiece, the drive mechanism providing movement of the plunger when the tip is connected to the handpiece.
2. The drug delivery device of claim 1 wherein the drive mechanism comprises a piezoelectric linear motor.
3. The drug delivery device of claim 1 wherein the handpiece further comprises an internal power source for the drive mechanism.
4. The drug delivery device of claim 1 wherein the handpiece further comprises internal control electronics for the drive mechanism.
5. The drug delivery device of claim 1 further comprising external control electronics for the drive mechanism.
6. The drug delivery device of claim 1 wherein the handpiece further comprises an external power source for the drive mechanism.
US11/435,906 2006-05-17 2006-05-17 Drug delivery device Abandoned US20070270750A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/435,906 US20070270750A1 (en) 2006-05-17 2006-05-17 Drug delivery device

Applications Claiming Priority (30)

Application Number Priority Date Filing Date Title
US11/435,906 US20070270750A1 (en) 2006-05-17 2006-05-17 Drug delivery device
US11/688,573 US7811252B2 (en) 2006-05-17 2007-03-20 Dosage control device
EP07108293A EP1857130A1 (en) 2006-05-17 2007-05-15 Drug delivery device
CA 2588519 CA2588519A1 (en) 2006-05-17 2007-05-15 Drug delivery device
TW096117365A TW200744558A (en) 2006-05-17 2007-05-16 Drug delivery device
MX2007005846A MX2007005846A (en) 2006-05-17 2007-05-16 Drug delivery device.
BRPI0702340 BRPI0702340A (en) 2006-05-17 2007-05-16 drug delivery device
JP2007131544A JP2007307376A (en) 2006-05-17 2007-05-17 Drug delivery device
KR1020070048065A KR20070111394A (en) 2006-05-17 2007-05-17 Drug delivery device
IL18329507A IL183295D0 (en) 2006-05-17 2007-05-17 Drug delivery device
ARP070102129 AR061002A1 (en) 2006-05-17 2007-05-17 Drug delivery device
CN 200710104927 CN101073682A (en) 2006-05-17 2007-05-17 Medicine conveying device
AU2007202216A AU2007202216A1 (en) 2006-05-17 2007-05-17 Drug delivery device
US11/752,011 US20070270768A1 (en) 2006-05-17 2007-05-22 Mechanical Linkage Mechanism For Ophthalmic Injection Device
US11/751,981 US7674243B2 (en) 2006-05-17 2007-05-22 Ophthalmic injection device using piezoelectric array
US11/752,064 US7862540B2 (en) 2006-05-17 2007-05-22 Ophthalmic injection device using shape memory alloy
US11/751,934 US20070268340A1 (en) 2006-05-17 2007-05-22 Ophthalmic Injection System and Method Using Piezoelectric Array
US11/762,844 US7762981B2 (en) 2006-05-17 2007-06-14 Temperature release mechanism for injection device
US11/777,408 US8821440B2 (en) 2006-05-17 2007-07-13 Dual thermal coefficient dispensing chamber
US11/832,333 US7815603B2 (en) 2006-05-17 2007-08-01 Ophthalmic injection method
US11/832,301 US7887521B2 (en) 2006-05-17 2007-08-01 Ophthalmic injection system
US11/832,364 US20070270744A1 (en) 2006-05-17 2007-08-01 Limited Reuse Assembly For Ophthalmic Injection Device
US11/832,243 US7871399B2 (en) 2006-05-17 2007-08-01 Disposable ophthalmic injection device
US11/833,668 US7887517B2 (en) 2006-05-17 2007-08-03 Drug casting
US11/833,471 US20080021412A1 (en) 2006-05-17 2007-08-03 Plunger Linkage and Seal For Ophthalmic Medical Device
US11/833,518 US20080021419A1 (en) 2006-05-17 2007-08-03 Plunger Linkage Method For Ophthalmic Medical Device
PCT/US2007/080505 WO2008105954A2 (en) 2006-05-17 2007-10-05 Disposable ophthalmic injection device
PCT/US2007/080673 WO2008105956A2 (en) 2006-05-17 2007-10-08 Ophthalmic injection method
US12/443,898 US8118790B2 (en) 2006-05-17 2007-10-09 Battery operated surgical hand piece with disposable end
US12/109,079 US20080197035A1 (en) 2006-05-17 2008-04-24 Sharps Container System for Two Piece Injection Device

Related Child Applications (15)

Application Number Title Priority Date Filing Date
US58162906A Continuation-In-Part 2006-10-16 2006-10-16
US92149706P Continuation-In-Part 2006-10-16 2006-10-16
US11/688,573 Continuation-In-Part US7811252B2 (en) 2006-05-17 2007-03-20 Dosage control device
US11/752,064 Continuation-In-Part US7862540B2 (en) 2006-05-17 2007-05-22 Ophthalmic injection device using shape memory alloy
US11/762,844 Continuation-In-Part US7762981B2 (en) 2006-05-17 2007-06-14 Temperature release mechanism for injection device
US11/777,408 Continuation-In-Part US8821440B2 (en) 2006-05-17 2007-07-13 Dual thermal coefficient dispensing chamber
US11/832,333 Continuation-In-Part US7815603B2 (en) 2006-05-17 2007-08-01 Ophthalmic injection method
US11/832,364 Continuation-In-Part US20070270744A1 (en) 2006-05-17 2007-08-01 Limited Reuse Assembly For Ophthalmic Injection Device
US11/832,243 Continuation-In-Part US7871399B2 (en) 2006-05-17 2007-08-01 Disposable ophthalmic injection device
US11/832,301 Continuation-In-Part US7887521B2 (en) 2006-05-17 2007-08-01 Ophthalmic injection system
US11/833,471 Continuation-In-Part US20080021412A1 (en) 2006-05-17 2007-08-03 Plunger Linkage and Seal For Ophthalmic Medical Device
US11/833,518 Continuation-In-Part US20080021419A1 (en) 2006-05-17 2007-08-03 Plunger Linkage Method For Ophthalmic Medical Device
US11/833,668 Continuation-In-Part US7887517B2 (en) 2006-05-17 2007-08-03 Drug casting
US12/443,898 Continuation-In-Part US8118790B2 (en) 2006-05-17 2007-10-09 Battery operated surgical hand piece with disposable end
US12/109,079 Continuation-In-Part US20080197035A1 (en) 2006-05-17 2008-04-24 Sharps Container System for Two Piece Injection Device

Publications (1)

Publication Number Publication Date
US20070270750A1 true US20070270750A1 (en) 2007-11-22

Family

ID=38420664

Family Applications (7)

Application Number Title Priority Date Filing Date
US11/435,906 Abandoned US20070270750A1 (en) 2006-05-17 2006-05-17 Drug delivery device
US11/762,844 Expired - Fee Related US7762981B2 (en) 2006-05-17 2007-06-14 Temperature release mechanism for injection device
US11/777,408 Active 2030-07-10 US8821440B2 (en) 2006-05-17 2007-07-13 Dual thermal coefficient dispensing chamber
US11/833,518 Abandoned US20080021419A1 (en) 2006-05-17 2007-08-03 Plunger Linkage Method For Ophthalmic Medical Device
US11/833,668 Active 2028-09-28 US7887517B2 (en) 2006-05-17 2007-08-03 Drug casting
US11/833,471 Abandoned US20080021412A1 (en) 2006-05-17 2007-08-03 Plunger Linkage and Seal For Ophthalmic Medical Device
US12/109,079 Abandoned US20080197035A1 (en) 2006-05-17 2008-04-24 Sharps Container System for Two Piece Injection Device

Family Applications After (6)

Application Number Title Priority Date Filing Date
US11/762,844 Expired - Fee Related US7762981B2 (en) 2006-05-17 2007-06-14 Temperature release mechanism for injection device
US11/777,408 Active 2030-07-10 US8821440B2 (en) 2006-05-17 2007-07-13 Dual thermal coefficient dispensing chamber
US11/833,518 Abandoned US20080021419A1 (en) 2006-05-17 2007-08-03 Plunger Linkage Method For Ophthalmic Medical Device
US11/833,668 Active 2028-09-28 US7887517B2 (en) 2006-05-17 2007-08-03 Drug casting
US11/833,471 Abandoned US20080021412A1 (en) 2006-05-17 2007-08-03 Plunger Linkage and Seal For Ophthalmic Medical Device
US12/109,079 Abandoned US20080197035A1 (en) 2006-05-17 2008-04-24 Sharps Container System for Two Piece Injection Device

Country Status (12)

Country Link
US (7) US20070270750A1 (en)
EP (1) EP1857130A1 (en)
JP (1) JP2007307376A (en)
KR (1) KR20070111394A (en)
CN (1) CN101073682A (en)
AR (1) AR061002A1 (en)
AU (1) AU2007202216A1 (en)
BR (1) BRPI0702340A (en)
CA (1) CA2588519A1 (en)
IL (1) IL183295D0 (en)
MX (1) MX2007005846A (en)
TW (1) TW200744558A (en)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060229570A1 (en) * 2002-09-11 2006-10-12 Becton, Dickinson And Company Injector device with force lock-out and injection rate limiting mechanisms
US20070293820A1 (en) * 2006-05-17 2007-12-20 Bruno Dacquay Disposable Ophthalmic Injection Device
US20080015545A1 (en) * 2006-05-17 2008-01-17 Robert Sanchez Dual Thermal Coefficient Dispensing Chamber
US20080281292A1 (en) * 2006-10-16 2008-11-13 Hickingbotham Dyson W Retractable Injection Port
US20100030136A1 (en) * 2006-10-16 2010-02-04 Bruno Dacquay Ophthalmic Injection Device Including Dosage Control Device
US7887521B2 (en) 2006-05-17 2011-02-15 Alcon Research, Ltd. Ophthalmic injection system
US8177747B2 (en) 2009-12-22 2012-05-15 Alcon Research, Ltd. Method and apparatus for drug delivery
US8372036B2 (en) 2009-05-06 2013-02-12 Alcon Research, Ltd. Multi-layer heat assembly for a drug delivery device
US20130053816A1 (en) * 2011-07-25 2013-02-28 Tandem Diabetes Care, Inc. Multi-reservoir infusion pump systems and methods
US8403888B2 (en) 2010-04-15 2013-03-26 Teneo Innovations Inc. Device and electronic controller for syringe piston control
US9750871B2 (en) 2012-05-17 2017-09-05 Tandem Diabetes Care, Inc. Pump device with multiple medicament reservoirs
US9962486B2 (en) 2013-03-14 2018-05-08 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US10182939B2 (en) 2015-09-16 2019-01-22 Novartis Ag Hydraulic injector and methods for intra-ocular lens insertion

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
GB0418389D0 (en) * 2004-08-18 2004-09-22 Liversidge Barry P Injection apparatus
US8361026B2 (en) * 2005-02-01 2013-01-29 Intelliject, Inc. Apparatus and methods for self-administration of vaccines and other medicaments
US20070212397A1 (en) * 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
US20090104945A1 (en) * 2007-10-17 2009-04-23 Sony Ericsson Mobile Communications Ab handsfree cable for use with an electronic device
BRPI0820176A2 (en) 2007-11-08 2015-06-16 Alimera Sciences Inc Device for ocular implantation.
US20090227979A1 (en) * 2008-03-07 2009-09-10 Sanchez Jr Robert J Drug Level Sensor for Injection Device
GB0805521D0 (en) * 2008-03-27 2008-04-30 The Technology Partnership Plc Dispensing system
CN101574550B (en) 2008-05-06 2013-02-13 德昌电机(深圳)有限公司 The injection device
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
US8399006B2 (en) 2009-01-29 2013-03-19 Forsight Vision4, Inc. Posterior segment drug delivery
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
AU2011285545B2 (en) * 2010-08-05 2014-03-13 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US9492315B2 (en) 2010-08-05 2016-11-15 Forsight Vision4, Inc. Implantable therapeutic device
KR101092074B1 (en) * 2011-02-22 2011-12-12 문창수 Syringe for topical anesthesia
CN107252510A (en) * 2011-05-06 2017-10-17 赛诺菲-安万特德国有限公司 Locking component with varying cross-section
GB2490721B (en) * 2011-05-12 2017-03-01 Owen Mumford Ltd Injection devices
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
WO2013003620A2 (en) 2011-06-28 2013-01-03 Forsight Vision4, Inc. Diagnostic methods and apparatus
EP2739252A4 (en) 2011-08-05 2015-08-12 Forsight Vision4 Inc Small molecule delivery with implantable therapeutic device
EP2755600A4 (en) 2011-09-16 2015-09-16 Forsight Vision4 Inc Fluid exchange apparatus and methods
GB2526948A (en) 2012-12-27 2015-12-09 Kaleo Inc Systems for locating and interacting with medicament delivery devices
CA2905496A1 (en) 2013-03-14 2014-06-25 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
EP2978393A1 (en) 2013-03-28 2016-02-03 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
EP2810675A1 (en) * 2013-06-04 2014-12-10 Bioftalmik, S.L. Injector for intraocular injection
CA2957548A1 (en) 2014-08-08 2016-02-11 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
KR20170068570A (en) 2014-11-18 2017-06-19 일라이 릴리 앤드 캄파니 Thermal locking mechanism for a medication delivery device
KR101789687B1 (en) * 2015-06-12 2017-10-25 서울대학교산학협력단 Glucose control system, method for forming the clucose control system, and method for controlling clucose using the clucose control system
WO2016200104A1 (en) * 2015-06-12 2016-12-15 서울대학교산학협력단 Biosensor and method for forming same and glucose control system, method for forming the glucose control system, and method for controlling glucose thereby
USD821572S1 (en) * 2016-06-20 2018-06-26 Medimmune, Llc Drug delivery implement with translucent housing
USD822199S1 (en) * 2016-06-22 2018-07-03 Medimmune, Llc Drug delivery implement
US10332623B2 (en) 2017-01-17 2019-06-25 Kaleo, Inc. Medicament delivery devices with wireless connectivity and event detection

Citations (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3089815A (en) * 1951-10-11 1963-05-14 Lieb Hans Injectable pharmaceutical preparation, and a method of making same
US3608549A (en) * 1970-01-15 1971-09-28 Merrill Edward Wilson Method of administering drugs and capsule therefor
US3858581A (en) * 1973-07-02 1975-01-07 Dean Kamen Medication injection device
US3982537A (en) * 1974-12-30 1976-09-28 Louis Bucalo Dynamic implants and method for implanting the same
US4007742A (en) * 1974-06-03 1977-02-15 Surgical Design Corporation. Surgical system for controlling the infusion of fluid to and the evacuation of fluid and material from an operating field
US4030499A (en) * 1974-12-30 1977-06-21 Louis Bucalo Method and apparatus for providing living beings with absorbable implants
US4054138A (en) * 1974-12-30 1977-10-18 Louis Bucalo Implants for acting on living beings
US4122850A (en) * 1976-06-07 1978-10-31 Louis Bucalo Apparatus for providing living beings with absorbable implants
US4184510A (en) * 1977-03-15 1980-01-22 Fibra-Sonics, Inc. Valued device for controlling vacuum in surgery
US4246932A (en) * 1979-10-18 1981-01-27 Burron Medical, Inc. Multiple additive valve assembly
US4265618A (en) * 1977-09-09 1981-05-05 Solar Energy Technology, Inc. Electrically heated endodontic syringe for injecting thermoplastic material into a root canal cavity
US4357136A (en) * 1977-09-09 1982-11-02 Solar Energy Technology, Inc. Method for filling a root canal
US4392827A (en) * 1981-11-04 1983-07-12 Howard Martin Self-contained root canal heated condenser dental instrument
US4474752A (en) * 1983-05-16 1984-10-02 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4484915A (en) * 1983-03-28 1984-11-27 Tartaglia John A Medical syringe
US4582488A (en) * 1984-04-27 1986-04-15 Newman Martin H Dental materials dispenser and applicator
US4684344A (en) * 1986-04-11 1987-08-04 Nalge Company Electrically powered and heated endodontic syringe
US4704088A (en) * 1984-04-27 1987-11-03 Newman Martin H Dental materials dispenser and applicator
US4713446A (en) * 1985-09-06 1987-12-15 Minnesota Mining And Manufacturing Company Viscoelastic collagen solution for ophthalmic use and method of preparation
US4795423A (en) * 1980-04-14 1989-01-03 Thomas Jefferson University Oxygenated perfluorinated perfusion of the ocular globe to treat ischemic retinopathy
US4830855A (en) * 1987-11-13 1989-05-16 Landec Labs, Inc. Temperature-controlled active agent dispenser
US4992045A (en) * 1987-04-01 1991-02-12 Dentsply Research & Development Corp. Battery powered condenser for root canals
US5066276A (en) * 1988-06-21 1991-11-19 Alcon Laboratories, Inc. Method and apparatus for injecting viscous fluid into the eye to lift pre-retinal and post-retinal membrane with linear pressure control
US5120307A (en) * 1988-06-21 1992-06-09 Alcon Laboratories, Inc. Method for injecting viscous fluid into the eye to life retinal membrane
US5336175A (en) * 1992-10-29 1994-08-09 Mames Robert N Method for the treatment of retinal detachments
US5360413A (en) * 1991-12-06 1994-11-01 Filtertek, Inc. Needleless access device
US5370630A (en) * 1993-11-12 1994-12-06 Smidebush; Michael J. Device for injection of fluidic materials into body tissue
US5476511A (en) * 1992-05-04 1995-12-19 Allergan, Inc. Subconjunctival implants for ocular drug delivery
US5487725A (en) * 1994-05-12 1996-01-30 Syntec, Inc. Pneumatic vitrectomy for retinal attachment
US5582595A (en) * 1995-09-28 1996-12-10 Habley Medical Technology Corporation Aspirating syringe having a plunger guide for a reciprocating plunger assembly
US5620700A (en) * 1990-10-30 1997-04-15 Alza Corporation Injectable drug delivery system and method
US5743886A (en) * 1994-02-15 1998-04-28 Lawrence A. Lynn Sequential medical fluid aspiration and injection system and method
US5773019A (en) * 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US5783205A (en) * 1990-10-30 1998-07-21 Alza Corporation Injectable drug delivery system and method
US5824072A (en) * 1993-11-15 1998-10-20 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5860949A (en) * 1996-12-20 1999-01-19 Chen; Jen-Yie Volume homeostatic fluid-fluid exchanger
US5928663A (en) * 1997-07-30 1999-07-27 Vitrophage, Inc. Intraocular perfluorcarbon compositions and surgical methods of using same
US5984889A (en) * 1996-02-23 1999-11-16 Allergan Sales, Inc. Apparatus and method for delivering viscoelastic material to an eye
US6210357B1 (en) * 1998-07-06 2001-04-03 Robert E Morris Apparatus for performing surgery inside the human retina using fluidic internal limiting membrane (ILM) separation (films)
US6221045B1 (en) * 1995-04-20 2001-04-24 Acist Medical Systems, Inc. Angiographic injector system with automatic high/low pressure switching
US6270343B1 (en) * 2000-01-07 2001-08-07 Howard Martin Endodontic thermal condenser dental instrument
US6290690B1 (en) * 1999-06-21 2001-09-18 Alcon Manufacturing, Ltd. Simultaneous injection and aspiration of viscous fluids in a surgical system
US6372246B1 (en) * 1998-12-16 2002-04-16 Ortho-Mcneil Pharmaceutical, Inc. Polyethylene glycol coating for electrostatic dry deposition of pharmaceuticals
US20020055720A1 (en) * 2000-05-18 2002-05-09 Dentsply Research & Development Corp. Fluid material dispensing syringe
US6413245B1 (en) * 1999-10-21 2002-07-02 Alcon Universal Ltd. Sub-tenon drug delivery
US6419656B1 (en) * 1999-03-19 2002-07-16 Arzneimittel Gmbh Apotheker Vetter & Ravensburg Medical syringe with braked step-advance plunger
US6436143B1 (en) * 1999-02-22 2002-08-20 Anthony C. Ross Method and apparatus for treating intervertebral disks
US6488659B1 (en) * 1999-08-05 2002-12-03 Biocardia, Inc. System and method for delivering thermally sensitive and reverse-thermal gelation materials
US20030055380A1 (en) * 2001-09-19 2003-03-20 Flaherty J. Christopher Plunger for patient infusion device
US6585700B1 (en) * 2000-10-05 2003-07-01 Medrad, Inc. Syringe, syringe plunger and attachment mechanism for front loading medical injector
US6595979B1 (en) * 2001-07-10 2003-07-22 Myocardial Therapeutics, Inc. Methods for sterile aspiration/reinjection of bodily fluid
US6635267B1 (en) * 1998-11-10 2003-10-21 Denki Kagaku Kogyo Kabushiki Kaisha Hyaluronic acid gel, process for the preparation thereof and medical materials containing the same
US6645179B1 (en) * 1999-07-06 2003-11-11 Nihon Chemical Research Co., Ltd. Injection syringe
US20040231667A1 (en) * 2001-06-11 2004-11-25 Horton Andrew Paul Medicament dispenser
US20050065477A1 (en) * 2003-09-19 2005-03-24 Stefan Jost Device for dispensing an injectable product in doses
US20050177137A1 (en) * 2002-08-31 2005-08-11 Urs Kipfer Administering device with temperature sensor
US6940209B2 (en) * 2003-09-08 2005-09-06 New Scale Technologies Ultrasonic lead screw motor
US6991457B2 (en) * 2003-05-06 2006-01-31 Aseptico, Inc. Endodontic obturator with disposable cartridge

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US210200A (en) * 1878-11-26 Improvement in machines for cutting escutcheons
US133155A (en) * 1872-11-19 Improvement in portable cooking apparatus
US176720A (en) * 1876-04-25 Improvement in processes for preserving eggs
US125665A (en) * 1872-04-16 Improvement in brakes for railway cars
US52761A (en) * 1866-02-20 Improvement in telegraph-insulators
US47250A (en) * 1865-04-11 carteb
US177137A (en) * 1876-05-09 Improvement in devices for starting pendulum-clocks
US39253A (en) * 1863-07-14 Improved hinged collar for lamps
US1252614A (en) * 1917-04-24 1918-01-08 Oscar H Pieper Hot-air syringe.
US3466752A (en) * 1967-08-14 1969-09-16 Gilles G Braun Heater stand and cavity injector
GB1175650A (en) * 1968-11-07 1969-12-23 Standard Telephones Cables Ltd Adhesive Applicator
US3892537A (en) * 1973-11-28 1975-07-01 Corning Glass Works Preload means for ceramic substrate in exhaust gas purifiers
US4003493A (en) 1975-05-27 1977-01-18 Wells Robert A Easy-open container with nondetachable opening member
JPH0140621B2 (en) 1981-05-04 1989-08-30 Sooraa Enaajii Tekunorojii Inc
US4648872A (en) * 1983-11-15 1987-03-10 Kamen Dean L Volumetric pump with replaceable reservoir assembly
EP0398394B1 (en) * 1983-11-15 1993-10-06 KAMEN, Dean L. Reservoir assembly for removable engagement with a motor drive
EP0227817A1 (en) 1985-06-26 1987-07-08 JACOB, Ezekiel J. Root canal implant-proximity indicative-delivery means
US5242391A (en) * 1990-04-25 1993-09-07 Alza Corporation Urethral insert for treatment of erectile dysfunction
US5127522A (en) * 1990-08-02 1992-07-07 Sherwood Medical Company Sharps container with notched insert
US5170779A (en) * 1991-01-22 1992-12-15 Ginsberg Irwin A Automated ear cleansing device
US5368582A (en) * 1992-08-10 1994-11-29 The Schepens Eye Research Institute Method and apparatus for introducing fluid material into an eye
DE69324824D1 (en) 1992-12-29 1999-06-10 Insite Vision Inc Softened bioerodible system for the controlled release
US5882338A (en) * 1993-05-04 1999-03-16 Zeneca Limited Syringes and syringe pumps
NZ290896A (en) 1994-08-04 1997-04-24 Quadrant Holdings Cambridge Solid dose delivery composition containing a glassy vehicle and at least one guest substance
FR2734485B1 (en) 1995-05-24 1997-10-10 Biodome pre-filled safety syringe
US5891094A (en) * 1995-09-07 1999-04-06 Innerdyne, Inc. System for direct heating of fluid solution in a hollow body organ and methods
US5868710A (en) * 1996-11-22 1999-02-09 Liebel Flarsheim Company Medical fluid injector
US6139571A (en) * 1997-07-09 2000-10-31 Fuller Research Corporation Heated fluid surgical instrument
US6079765A (en) 1997-10-27 2000-06-27 Lear Automotive Dearborn, Inc. Wire holding clip for trim panel
US6352722B1 (en) 1997-12-23 2002-03-05 Quadrant Holdings Cambridge Limited Derivatized carbohydrates, compositions comprised thereof and methods of use thereof
WO1999049818A1 (en) * 1998-03-30 1999-10-07 Marchosky J Alexander Prosthetic system
EP1087808B1 (en) 1998-06-15 2003-12-03 Medrad Inc. Encoding of syringe information
CA2350706A1 (en) * 1998-11-13 2000-05-25 Elan Pharma International Limited Drug delivery systems and methods
US6375638B2 (en) * 1999-02-12 2002-04-23 Medtronic Minimed, Inc. Incremental motion pump mechanisms powered by shape memory alloy wire or the like
US6520930B2 (en) * 1999-11-24 2003-02-18 Medrad, Inc. Injectors, injector systems and injector control
JP2004505730A (en) * 2000-08-15 2004-02-26 ユニバーシティ オブ ケンタッキー リサーチ ファウンデーション Programmable multi-dose intranasal drug delivery device
JP4471568B2 (en) * 2000-08-30 2010-06-02 ジョンズ・ホプキンス・ユニバーシティ Intraocular drug delivery device
US6691977B2 (en) * 2001-03-16 2004-02-17 Delphi Technologies, Inc. Shape memory alloy fuel injector
US7648496B2 (en) * 2001-09-17 2010-01-19 Durect Corporation Device and method for accurate delivery of an active agent
US7086861B2 (en) * 2002-03-01 2006-08-08 Pitz Richard J System for dispensing viscous materials
US7052251B2 (en) * 2002-04-22 2006-05-30 Medtronic Minimed, Inc. Shape memory alloy wire driven positive displacement micropump with pulsatile output
US6960192B1 (en) * 2002-04-23 2005-11-01 Insulet Corporation Transcutaneous fluid delivery system
US7176030B2 (en) * 2002-06-17 2007-02-13 O.R. Solutions, Inc. Method and apparatus for ensuring sterility of disposable medical items used with medical equipment
WO2004009127A1 (en) * 2002-07-19 2004-01-29 Arizona Board Of Regents, Acting For And On Behalf Of, Arizona State University Localized delivery system for phenstatin using n-isopropylacrylamide
US6929619B2 (en) * 2002-08-02 2005-08-16 Liebel-Flarshiem Company Injector
US7316676B2 (en) * 2002-08-20 2008-01-08 Gholam A. Peyman Treatment of retinal detachment
US20040176720A1 (en) * 2002-08-31 2004-09-09 Urs Kipfer Device for administering a liquid solution of an active substance
US7128727B2 (en) * 2002-09-30 2006-10-31 Flaherty J Christopher Components and methods for patient infusion device
US7186247B2 (en) * 2003-04-04 2007-03-06 Medtronic, Inc. Apparatus and system for delivery of drug therapies
US7364570B2 (en) * 2003-04-16 2008-04-29 Allergan, Inc. Controlled volume injection/aspiration device
AU2004249238A1 (en) 2003-06-20 2004-12-29 Allergan, Inc. Needless injectors
US20040267202A1 (en) * 2003-06-26 2004-12-30 Potter Daniel J. Tearable hemostasis valve and splittable sheath
US20050186531A1 (en) * 2004-02-20 2005-08-25 Joshua Friedman Heated compule
US20060047250A1 (en) 2004-08-30 2006-03-02 Hickingbotham Dyson W Fluid delivery device
US7507221B2 (en) 2004-10-13 2009-03-24 Mallinckrodt Inc. Powerhead of a power injection system
US20070038174A1 (en) * 2005-08-09 2007-02-15 Hopkins Mark A Ophthalmic injector system
US20070060887A1 (en) * 2005-08-22 2007-03-15 Marsh David A Ophthalmic injector
US20070270750A1 (en) * 2006-05-17 2007-11-22 Alcon, Inc. Drug delivery device

Patent Citations (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3089815A (en) * 1951-10-11 1963-05-14 Lieb Hans Injectable pharmaceutical preparation, and a method of making same
US3608549A (en) * 1970-01-15 1971-09-28 Merrill Edward Wilson Method of administering drugs and capsule therefor
US3858581A (en) * 1973-07-02 1975-01-07 Dean Kamen Medication injection device
US4007742A (en) * 1974-06-03 1977-02-15 Surgical Design Corporation. Surgical system for controlling the infusion of fluid to and the evacuation of fluid and material from an operating field
US4054138A (en) * 1974-12-30 1977-10-18 Louis Bucalo Implants for acting on living beings
US3982537A (en) * 1974-12-30 1976-09-28 Louis Bucalo Dynamic implants and method for implanting the same
US4030499A (en) * 1974-12-30 1977-06-21 Louis Bucalo Method and apparatus for providing living beings with absorbable implants
US4122850A (en) * 1976-06-07 1978-10-31 Louis Bucalo Apparatus for providing living beings with absorbable implants
US4184510A (en) * 1977-03-15 1980-01-22 Fibra-Sonics, Inc. Valued device for controlling vacuum in surgery
US4265618A (en) * 1977-09-09 1981-05-05 Solar Energy Technology, Inc. Electrically heated endodontic syringe for injecting thermoplastic material into a root canal cavity
US4357136A (en) * 1977-09-09 1982-11-02 Solar Energy Technology, Inc. Method for filling a root canal
US4246932A (en) * 1979-10-18 1981-01-27 Burron Medical, Inc. Multiple additive valve assembly
US4795423A (en) * 1980-04-14 1989-01-03 Thomas Jefferson University Oxygenated perfluorinated perfusion of the ocular globe to treat ischemic retinopathy
US4392827A (en) * 1981-11-04 1983-07-12 Howard Martin Self-contained root canal heated condenser dental instrument
US4484915A (en) * 1983-03-28 1984-11-27 Tartaglia John A Medical syringe
US4474752A (en) * 1983-05-16 1984-10-02 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4704088A (en) * 1984-04-27 1987-11-03 Newman Martin H Dental materials dispenser and applicator
US4582488A (en) * 1984-04-27 1986-04-15 Newman Martin H Dental materials dispenser and applicator
US4713446A (en) * 1985-09-06 1987-12-15 Minnesota Mining And Manufacturing Company Viscoelastic collagen solution for ophthalmic use and method of preparation
US4684344A (en) * 1986-04-11 1987-08-04 Nalge Company Electrically powered and heated endodontic syringe
US4992045A (en) * 1987-04-01 1991-02-12 Dentsply Research & Development Corp. Battery powered condenser for root canals
US4830855A (en) * 1987-11-13 1989-05-16 Landec Labs, Inc. Temperature-controlled active agent dispenser
US5066276A (en) * 1988-06-21 1991-11-19 Alcon Laboratories, Inc. Method and apparatus for injecting viscous fluid into the eye to lift pre-retinal and post-retinal membrane with linear pressure control
US5120307A (en) * 1988-06-21 1992-06-09 Alcon Laboratories, Inc. Method for injecting viscous fluid into the eye to life retinal membrane
US5328481A (en) * 1988-06-21 1994-07-12 Alcon Laboratories, Inc. Method for injecting viscous fluid into the eye to lift retinal membrane
US5620700A (en) * 1990-10-30 1997-04-15 Alza Corporation Injectable drug delivery system and method
US5783205A (en) * 1990-10-30 1998-07-21 Alza Corporation Injectable drug delivery system and method
US5360413A (en) * 1991-12-06 1994-11-01 Filtertek, Inc. Needleless access device
US5476511A (en) * 1992-05-04 1995-12-19 Allergan, Inc. Subconjunctival implants for ocular drug delivery
US5336175A (en) * 1992-10-29 1994-08-09 Mames Robert N Method for the treatment of retinal detachments
US5370630A (en) * 1993-11-12 1994-12-06 Smidebush; Michael J. Device for injection of fluidic materials into body tissue
US5824072A (en) * 1993-11-15 1998-10-20 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5743886A (en) * 1994-02-15 1998-04-28 Lawrence A. Lynn Sequential medical fluid aspiration and injection system and method
US5487725A (en) * 1994-05-12 1996-01-30 Syntec, Inc. Pneumatic vitrectomy for retinal attachment
US6221045B1 (en) * 1995-04-20 2001-04-24 Acist Medical Systems, Inc. Angiographic injector system with automatic high/low pressure switching
US5773019A (en) * 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US5582595A (en) * 1995-09-28 1996-12-10 Habley Medical Technology Corporation Aspirating syringe having a plunger guide for a reciprocating plunger assembly
US5984889A (en) * 1996-02-23 1999-11-16 Allergan Sales, Inc. Apparatus and method for delivering viscoelastic material to an eye
US5860949A (en) * 1996-12-20 1999-01-19 Chen; Jen-Yie Volume homeostatic fluid-fluid exchanger
US5928663A (en) * 1997-07-30 1999-07-27 Vitrophage, Inc. Intraocular perfluorcarbon compositions and surgical methods of using same
US6210357B1 (en) * 1998-07-06 2001-04-03 Robert E Morris Apparatus for performing surgery inside the human retina using fluidic internal limiting membrane (ILM) separation (films)
US6635267B1 (en) * 1998-11-10 2003-10-21 Denki Kagaku Kogyo Kabushiki Kaisha Hyaluronic acid gel, process for the preparation thereof and medical materials containing the same
US6372246B1 (en) * 1998-12-16 2002-04-16 Ortho-Mcneil Pharmaceutical, Inc. Polyethylene glycol coating for electrostatic dry deposition of pharmaceuticals
US6436143B1 (en) * 1999-02-22 2002-08-20 Anthony C. Ross Method and apparatus for treating intervertebral disks
US6419656B1 (en) * 1999-03-19 2002-07-16 Arzneimittel Gmbh Apotheker Vetter & Ravensburg Medical syringe with braked step-advance plunger
US6290690B1 (en) * 1999-06-21 2001-09-18 Alcon Manufacturing, Ltd. Simultaneous injection and aspiration of viscous fluids in a surgical system
US6645179B1 (en) * 1999-07-06 2003-11-11 Nihon Chemical Research Co., Ltd. Injection syringe
US6488659B1 (en) * 1999-08-05 2002-12-03 Biocardia, Inc. System and method for delivering thermally sensitive and reverse-thermal gelation materials
US6413245B1 (en) * 1999-10-21 2002-07-02 Alcon Universal Ltd. Sub-tenon drug delivery
US6270343B1 (en) * 2000-01-07 2001-08-07 Howard Martin Endodontic thermal condenser dental instrument
US20020055720A1 (en) * 2000-05-18 2002-05-09 Dentsply Research & Development Corp. Fluid material dispensing syringe
US6585700B1 (en) * 2000-10-05 2003-07-01 Medrad, Inc. Syringe, syringe plunger and attachment mechanism for front loading medical injector
US20040231667A1 (en) * 2001-06-11 2004-11-25 Horton Andrew Paul Medicament dispenser
US6595979B1 (en) * 2001-07-10 2003-07-22 Myocardial Therapeutics, Inc. Methods for sterile aspiration/reinjection of bodily fluid
US20030055380A1 (en) * 2001-09-19 2003-03-20 Flaherty J. Christopher Plunger for patient infusion device
US20050177137A1 (en) * 2002-08-31 2005-08-11 Urs Kipfer Administering device with temperature sensor
US6991457B2 (en) * 2003-05-06 2006-01-31 Aseptico, Inc. Endodontic obturator with disposable cartridge
US6940209B2 (en) * 2003-09-08 2005-09-06 New Scale Technologies Ultrasonic lead screw motor
US20050065477A1 (en) * 2003-09-19 2005-03-24 Stefan Jost Device for dispensing an injectable product in doses

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9486581B2 (en) 2002-09-11 2016-11-08 Becton, Dickinson And Company Injector device with force lock-out and injection rate limiting mechanisms
US20060229570A1 (en) * 2002-09-11 2006-10-12 Becton, Dickinson And Company Injector device with force lock-out and injection rate limiting mechanisms
US7871399B2 (en) 2006-05-17 2011-01-18 Alcon Research, Ltd. Disposable ophthalmic injection device
US20070293820A1 (en) * 2006-05-17 2007-12-20 Bruno Dacquay Disposable Ophthalmic Injection Device
US20080015545A1 (en) * 2006-05-17 2008-01-17 Robert Sanchez Dual Thermal Coefficient Dispensing Chamber
US20080021438A1 (en) * 2006-05-17 2008-01-24 Bruno Dacquay Ophthalmic Injection Method
US7887521B2 (en) 2006-05-17 2011-02-15 Alcon Research, Ltd. Ophthalmic injection system
US7815603B2 (en) 2006-05-17 2010-10-19 Alcon Research, Ltd. Ophthalmic injection method
US9022970B2 (en) 2006-10-16 2015-05-05 Alcon Research, Ltd. Ophthalmic injection device including dosage control device
US20100106089A1 (en) * 2006-10-16 2010-04-29 Cesario Dos Santos Temperature control device and thermal sensor assembly for medical device
US9782541B2 (en) 2006-10-16 2017-10-10 Alcon Research, Ltd. Temperature control device and thermal sensor assembly for medical device
US20100030136A1 (en) * 2006-10-16 2010-02-04 Bruno Dacquay Ophthalmic Injection Device Including Dosage Control Device
US20080281292A1 (en) * 2006-10-16 2008-11-13 Hickingbotham Dyson W Retractable Injection Port
US8632511B2 (en) 2009-05-06 2014-01-21 Alcon Research, Ltd. Multiple thermal sensors in a multiple processor environment for temperature control in a drug delivery device
US8372036B2 (en) 2009-05-06 2013-02-12 Alcon Research, Ltd. Multi-layer heat assembly for a drug delivery device
US8177747B2 (en) 2009-12-22 2012-05-15 Alcon Research, Ltd. Method and apparatus for drug delivery
US8403888B2 (en) 2010-04-15 2013-03-26 Teneo Innovations Inc. Device and electronic controller for syringe piston control
US20130053816A1 (en) * 2011-07-25 2013-02-28 Tandem Diabetes Care, Inc. Multi-reservoir infusion pump systems and methods
US9750871B2 (en) 2012-05-17 2017-09-05 Tandem Diabetes Care, Inc. Pump device with multiple medicament reservoirs
US10258736B2 (en) 2012-05-17 2019-04-16 Tandem Diabetes Care, Inc. Systems including vial adapter for fluid transfer
US9962486B2 (en) 2013-03-14 2018-05-08 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US10182939B2 (en) 2015-09-16 2019-01-22 Novartis Ag Hydraulic injector and methods for intra-ocular lens insertion

Also Published As

Publication number Publication date
KR20070111394A (en) 2007-11-21
BRPI0702340A (en) 2008-01-15
MX2007005846A (en) 2008-12-01
US20080021413A1 (en) 2008-01-24
US7762981B2 (en) 2010-07-27
US20080197035A1 (en) 2008-08-21
EP1857130A1 (en) 2007-11-21
US20080021412A1 (en) 2008-01-24
TW200744558A (en) 2007-12-16
US20080015545A1 (en) 2008-01-17
CN101073682A (en) 2007-11-21
IL183295D0 (en) 2007-12-03
CA2588519A1 (en) 2007-11-17
AR061002A1 (en) 2008-07-30
US20080021419A1 (en) 2008-01-24
US8821440B2 (en) 2014-09-02
US20080097311A1 (en) 2008-04-24
US7887517B2 (en) 2011-02-15
JP2007307376A (en) 2007-11-29
AU2007202216A1 (en) 2007-12-06

Similar Documents

Publication Publication Date Title
US7316676B2 (en) Treatment of retinal detachment
US4836201A (en) "Envelope" apparatus for inserting intra-ocular lens into the eye
ES2231257T3 (en) Device for the administration of pharmacos.
CA2674877C (en) Apparatus for intra-ocular injection
JP5542691B2 (en) Devices and methods for delivering therapeutic agents
CN105056369B (en) Method and apparatus for being transported to ocular implants in eyes
US6402734B1 (en) Apparatus and method for cannulating retinal blood vessels
DE60018298T2 (en) Ophthalmological medicament feeding device
US20050101935A1 (en) Anesthetic dental injection apparatus and methods
JP5416048B2 (en) Reservoir device for intraocular drug delivery
US8221353B2 (en) Intravitreal injection device and system
US6168575B1 (en) Method and apparatus for controlling intraocular pressure
US7468065B2 (en) Apparatus for delivery of ocular implants
US5487725A (en) Pneumatic vitrectomy for retinal attachment
JP2012515627A (en) Subretinal access device
US20040102729A1 (en) Devices and methods for glaucoma treatment
EP1077736B1 (en) Angulated phacoemulsification needle whose outer surface converges and inner channel narrows
US20040147870A1 (en) Glaucoma treatment kit
US20070021716A1 (en) Nozzle device with skin stretching means
ES2694079T3 (en) Long-term medical device
JP2018090632A (en) Methods and devices for the treatment of ocular diseases in human subjects
US6936053B1 (en) Ocular implant needle
US7708711B2 (en) Ocular implant with therapeutic agents and methods thereof
CA2451663C (en) Method and device for subretinal drug delivery
US8603051B2 (en) Implantable drug delivery devices

Legal Events

Date Code Title Description
AS Assignment

Owner name: ALCON, INC., SWITZERLAND

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:DACQUAY, BRUNO;ZICA, MICHAEL A.;REEL/FRAME:017898/0874;SIGNING DATES FROM 20060508 TO 20060515

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION