CN1289471C - 作为cxc－趋化因子受体配体的3,4－二取代的环丁烯－1,2－二酮 - Google Patents

作为cxc－趋化因子受体配体的3,4－二取代的环丁烯－1,2－二酮 Download PDF

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Publication number
CN1289471C
CN1289471C CNB028119797A CN02811979A CN1289471C CN 1289471 C CN1289471 C CN 1289471C CN B028119797 A CNB028119797 A CN B028119797A CN 02811979 A CN02811979 A CN 02811979A CN 1289471 C CN1289471 C CN 1289471C
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substituted
formula
compound
unsubstituted
preparation
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Expired - Fee Related
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CNB028119797A
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Chinese (zh)
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CN1516687A (zh
Inventor
A·G·塔维拉斯
C·J·阿基
R·W·邦德
巢健萍
M·德怀尔
J·A·费雷拉
曹建华
郁友农
J·J·巴尔德温
B·凯泽
李革
J·R·默里特
K·H·内尔森
L·L·罗科斯兹
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Merck Sharp and Dohme LLC
Pharmacopeia LLC
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French Copia Co
Pharmacopeia Drug Discovery Inc
Schering Corp
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Publication of CN1516687A publication Critical patent/CN1516687A/zh
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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CNB028119797A 2001-04-16 2002-04-15 作为cxc－趋化因子受体配体的3,4－二取代的环丁烯－1,2－二酮 Expired - Fee Related CN1289471C (zh)

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US28402601P 2001-04-16 2001-04-16
US60/284,026 2001-04-16

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CNA2006101374093A Division CN1990457A (zh) 2001-04-16 2002-04-15 作为cxc－趋化因子受体配体的3,4－二取代的环丁烯－1,2－二酮

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CN1516687A CN1516687A (zh) 2004-07-28
CN1289471C true CN1289471C (zh) 2006-12-13

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CNA2006101374093A Pending CN1990457A (zh) 2001-04-16 2002-04-15 作为cxc－趋化因子受体配体的3,4－二取代的环丁烯－1,2－二酮

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US7132445B2 (en) 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US20040106794A1 (en) 2001-04-16 2004-06-03 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
JP2005505595A (ja) 2001-10-12 2005-02-24 シェーリング　コーポレイション Ｃｘｃ−ケモカインレセプターアンタゴニストとしての３，４−二置換マレイミド化合物
US8246969B2 (en) 2001-11-16 2012-08-21 Skinmedica, Inc. Compositions containing aromatic aldehydes and their use in treatments
US6878709B2 (en) 2002-01-04 2005-04-12 Schering Corporation 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
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