PE20021084A1 - Ciclobuten-1,2-dionas 3,4-di-substituidas como ligandos del receptor de cxc-quimiocina - Google Patents

Ciclobuten-1,2-dionas 3,4-di-substituidas como ligandos del receptor de cxc-quimiocina

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Publication number
PE20021084A1
PE20021084A1 PE2002000318A PE2002000318A PE20021084A1 PE 20021084 A1 PE20021084 A1 PE 20021084A1 PE 2002000318 A PE2002000318 A PE 2002000318A PE 2002000318 A PE2002000318 A PE 2002000318A PE 20021084 A1 PE20021084 A1 PE 20021084A1
Authority
PE
Peru
Prior art keywords
cyclobuten
cxc
substituted
dionas
ligands
Prior art date
Application number
PE2002000318A
Other languages
English (en)
Inventor
Richard W Bond
Michael Dwyer
Johan A Ferreira
Jianhua Chao
Cynthia J Aki
Younong Yu
Ge Li
Nelson
J Robert Merrit
Bernd Kaiser
Laura Rokosz
Arthur G Taveras
John J Baldwin
Jianping Chao
Original Assignee
Schering Corp
Pharmacopeia Drug Discovery
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp, Pharmacopeia Drug Discovery filed Critical Schering Corp
Publication of PE20021084A1 publication Critical patent/PE20021084A1/es

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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

SE FERIERE A CICLOBUTEN-1,2-DIONAS 3,4-DI-SUBSTITUIDAS DE FORMULA I DONDE A ES EL GRUPO a, b, ENTRE OTROS; R7 Y R8 SON H, ALQUILO, ARILO, HETEROARILO, HETEROARILALQUILO, ENTRE OTROS; R9 ES R7, R8, HALOGENO, CF3, -COR7, -OR7, ENTRE OTROS; B ES EL GRUPO a, ENTRE OTROS; R2 ES H, OH, C(O)OH, SH, ENTRE OTROS; R3 Y R4 SON H, HALOGENO, ALQUILO, ALCOXI, ENTRE OTROS; R5 Y R6 SON H, HALOGENO, ALQUILO, ALCOXI, ENTRE OTROS. LOS COMPUESTOS DE FORMULA I SON LIGANDOS DEL RECEPTOR DE CXC-QUIMIOCINA Y SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS
PE2002000318A 2001-04-16 2002-04-16 Ciclobuten-1,2-dionas 3,4-di-substituidas como ligandos del receptor de cxc-quimiocina PE20021084A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28402601P 2001-04-16 2001-04-16

Publications (1)

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PE20021084A1 true PE20021084A1 (es) 2002-12-20

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PE2002000318A PE20021084A1 (es) 2001-04-16 2002-04-16 Ciclobuten-1,2-dionas 3,4-di-substituidas como ligandos del receptor de cxc-quimiocina

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EP (2) EP1381590B1 (es)
JP (3) JP4499993B2 (es)
KR (2) KR100952531B1 (es)
CN (2) CN1289471C (es)
AR (1) AR035825A1 (es)
AT (2) ATE365154T1 (es)
AU (3) AU2002311841B2 (es)
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EC (1) ECSP034809A (es)
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HK (2) HK1057538A1 (es)
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MY (2) MY138202A (es)
NO (2) NO330790B1 (es)
NZ (3) NZ560453A (es)
PE (1) PE20021084A1 (es)
PL (2) PL207255B1 (es)
PT (2) PT1818325E (es)
RU (1) RU2344123C9 (es)
SI (2) SI1818325T1 (es)
SK (1) SK287598B6 (es)
TW (2) TWI316930B (es)
WO (1) WO2002083624A1 (es)
ZA (1) ZA200307905B (es)

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