MX2009013276A - Compuestos anti-inflamatorios de ciclobutenodiona sustituida. - Google Patents

Compuestos anti-inflamatorios de ciclobutenodiona sustituida.

Info

Publication number
MX2009013276A
MX2009013276A MX2009013276A MX2009013276A MX2009013276A MX 2009013276 A MX2009013276 A MX 2009013276A MX 2009013276 A MX2009013276 A MX 2009013276A MX 2009013276 A MX2009013276 A MX 2009013276A MX 2009013276 A MX2009013276 A MX 2009013276A
Authority
MX
Mexico
Prior art keywords
compounds
inflammatory
substituted cyclobutenedione
cyclobutenedione compounds
inflammatory substituted
Prior art date
Application number
MX2009013276A
Other languages
English (en)
Inventor
Neil John Press
Simon James Watson
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2009013276A publication Critical patent/MX2009013276A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Abstract

La presente invención se refiere a los compuestos de la fórmula (I): (ver fórmula (I)) con los sustituyentes como se definen en la presente, y al uso de los mismos.
MX2009013276A 2007-06-06 2008-06-04 Compuestos anti-inflamatorios de ciclobutenodiona sustituida. MX2009013276A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07109704 2007-06-06
PCT/EP2008/056902 WO2008148790A1 (en) 2007-06-06 2008-06-04 Anti -inflammatory substituted cyclobutenedione compounds

Publications (1)

Publication Number Publication Date
MX2009013276A true MX2009013276A (es) 2010-01-25

Family

ID=38626949

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009013276A MX2009013276A (es) 2007-06-06 2008-06-04 Compuestos anti-inflamatorios de ciclobutenodiona sustituida.

Country Status (13)

Country Link
US (1) US8183281B2 (es)
EP (1) EP2155670B1 (es)
JP (1) JP2010529079A (es)
KR (1) KR20100031718A (es)
CN (1) CN101772485A (es)
AT (1) ATE554066T1 (es)
AU (1) AU2008258588B2 (es)
BR (1) BRPI0812222A2 (es)
CA (1) CA2689581A1 (es)
EA (1) EA200901612A1 (es)
ES (1) ES2386489T3 (es)
MX (1) MX2009013276A (es)
WO (1) WO2008148790A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA103198C2 (en) 2008-08-04 2013-09-25 Новартис Аг Squaramide derivatives as cxcr2 antagonists
US8648070B2 (en) * 2010-12-17 2014-02-11 Boehringer Ingelheim International Gmbh Bicyclic ring system substituted sulfonamide functionalised phenols as medicaments
US8648118B2 (en) 2010-12-17 2014-02-11 Boehringer Ingelheim International Gmbh Bicyclic ring system substituted amide functionalised phenols as medicaments
BR112014004963A2 (pt) 2011-09-02 2017-03-21 Novartis Ag sal de colina do composto anti-inflamatório ciclobutanodiona substituído
FR2981934B1 (fr) * 2011-10-28 2013-12-20 Galderma Res & Dev Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines.
FR2981935B1 (fr) * 2011-10-28 2015-08-07 Galderma Res & Dev Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines.
CZ305626B6 (cs) * 2014-05-09 2016-01-13 Vysoká škola chemicko- technologická v Praze Dioxocyklobutenylhydrazony a jejich protirakovinné účinky
FR3030515B1 (fr) 2014-12-23 2017-01-20 Galderma Res & Dev Nouveaux composes antagonistes des recepteurs cxcr1 et cxcr2 aux chimiokines, et leur utilisation dans le traitement de pathologies mediees par des chimiokines
TWI734715B (zh) 2015-11-19 2021-08-01 美商卡默森屈有限公司 趨化因子受體調節劑
TWI724056B (zh) 2015-11-19 2021-04-11 美商卡默森屈有限公司 Ｃｘｃｒ２抑制劑
KR20200037857A (ko) * 2017-08-14 2020-04-09 알러간, 인코포레이티드 3,4-이치환된 3-시클로부텐-1,2-디온 및 그의 용도
IL275839B2 (en) 2018-01-08 2024-02-01 Chemocentryx Inc Methods for the treatment of generalized abscess psoriasis using a CCR6 or CXCR2 antagonist
GEP20237476B (en) 2018-09-21 2023-03-27 Pfizer N-substituted-dioxocyclobutenylamino-3-hydroxypicolinamides useful as ccr6 inhibitors
CN109824629B (zh) * 2019-02-27 2022-12-09 南京工业大学 一种利用N-乙酰氨基葡萄糖制备3-氨基-5-(α-氨基乙基)四氢呋喃的方法
EP4021572A1 (en) 2019-08-28 2022-07-06 Novartis AG Substituted 1,3-phenyl heteroaryl derivatives and their use in the treatment of disease
CN112759549B (zh) * 2019-11-05 2023-07-28 中国医学科学院药物研究所 3-取代氨基-4-((取代吡啶基)氨基)环丁-3-烯-1,2-二酮类化合物
CN112851635B (zh) * 2019-11-28 2022-09-16 中国医学科学院药物研究所 环状砜类化合物及其制备方法、用途和药物组合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6166050A (en) * 1998-12-14 2000-12-26 American Home Products Corporation 3,4-diamino-3-cyclobutene-1,2-dione derivatives which inhibit leukocyte adhesion mediated by VLA-4
DE60216229T2 (de) 2001-01-16 2007-10-04 Smithkline Beecham Corp. Il-8-rezeptorantagonisten
US20040106794A1 (en) 2001-04-16 2004-06-03 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
ATE365154T1 (de) * 2001-04-16 2007-07-15 Schering Corp 3,4-disubstituierte cyclobuten-1,2-dione als cxc- chemokinrezeptorliganden
US7132445B2 (en) * 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
BR0308739A (pt) 2002-03-18 2005-01-11 Schering Corp Tratamentos em combinação para doenças mediadas por quimiocina

Also Published As

Publication number Publication date
ATE554066T1 (de) 2012-05-15
EP2155670A1 (en) 2010-02-24
CN101772485A (zh) 2010-07-07
CA2689581A1 (en) 2008-12-11
BRPI0812222A2 (pt) 2014-12-16
ES2386489T3 (es) 2012-08-21
KR20100031718A (ko) 2010-03-24
AU2008258588A1 (en) 2008-12-11
US8183281B2 (en) 2012-05-22
AU2008258588B2 (en) 2011-11-10
US20100125071A1 (en) 2010-05-20
EA200901612A1 (ru) 2010-06-30
JP2010529079A (ja) 2010-08-26
EP2155670B1 (en) 2012-04-18
AU2008258588A8 (en) 2010-05-13
WO2008148790A8 (en) 2010-01-07
WO2008148790A1 (en) 2008-12-11

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