PE20061033A1 - Sintesis asimetrica de derivados de dihidrobenzofurano - Google Patents

Sintesis asimetrica de derivados de dihidrobenzofurano

Info

Publication number
PE20061033A1
PE20061033A1 PE2005001234A PE2005001234A PE20061033A1 PE 20061033 A1 PE20061033 A1 PE 20061033A1 PE 2005001234 A PE2005001234 A PE 2005001234A PE 2005001234 A PE2005001234 A PE 2005001234A PE 20061033 A1 PE20061033 A1 PE 20061033A1
Authority
PE
Peru
Prior art keywords
formula
compound
dihidrobenzofuran
derivatives
asymmetric synthesis
Prior art date
Application number
PE2005001234A
Other languages
English (en)
Inventor
Dahui Zhou
Gary Paul Stack
Alexander V Gontcharov
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20061033A1 publication Critical patent/PE20061033A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE UN COMPUESTO DE FORMULA (E) DONDE R1 Y R2 SON H, CLORO, CN, OH, ENTRE OTROS; Y ES Br, Cl, I. DICHO PROCEDIMIENTO COMPRENDE LAS ETAPAS: A) ELIMINAR EL GRUPO PROTECTOR DEL COMPUESTO DE FORMULA D DONDE R8 ES H O UN GRUPO PROTECTOR OH APROPIADO,PARA PRODUCIR UN COMPUESTO DE FORMULA D-1 Y B) CICLAR EL COMPUESTO DE FORMULA D-1 CUMPLIENDO LAS CONDICIONES DE LA REACCION DE MITSUNOBU, PARA PRODUCIR UN COMPUESTO DE FORMULA E. DICHOS COMPUESTOS SON AGONISTAS DEL RECEPTOR DE SEROTONINA 5HT2C SIENDO UTILES EN EL TRATAMIENTO DE ESQUIZOFRENIA, DEMENCIA
PE2005001234A 2004-10-21 2005-10-20 Sintesis asimetrica de derivados de dihidrobenzofurano PE20061033A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62102304P 2004-10-21 2004-10-21

Publications (1)

Publication Number Publication Date
PE20061033A1 true PE20061033A1 (es) 2006-11-08

Family

ID=35965910

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005001234A PE20061033A1 (es) 2004-10-21 2005-10-20 Sintesis asimetrica de derivados de dihidrobenzofurano

Country Status (14)

Country Link
US (1) US20060089405A1 (es)
EP (1) EP1802598A2 (es)
JP (1) JP2008517929A (es)
CN (1) CN101107238A (es)
AR (1) AR053980A1 (es)
AU (1) AU2005299757A1 (es)
BR (1) BRPI0516236A (es)
CA (1) CA2584775A1 (es)
GT (1) GT200500296A (es)
MX (1) MX2007004637A (es)
PA (1) PA8650501A1 (es)
PE (1) PE20061033A1 (es)
TW (1) TW200619215A (es)
WO (1) WO2006047288A2 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
GT200500297A (es) * 2004-10-21 2006-10-27 Sintesis asimetrica de dehidrobenzofuranos sustituidos
AU2006239930A1 (en) * 2005-04-22 2006-11-02 Wyeth Benzodioxane and benzodioxolane derivatives and uses thereof
TW200722081A (en) * 2005-04-22 2007-06-16 Wyeth Corp New therapeutic combinations for the treatment or prevention of depression
WO2006116151A1 (en) * 2005-04-22 2006-11-02 Wyeth Benzofuranyl alkanamine derivatives and uses thereof as 5-ht2c agonists
CA2605587A1 (en) * 2005-04-22 2006-11-02 Wyeth Chromane and chromene derivatives and uses thereof
AR055916A1 (es) * 2005-04-22 2007-09-12 Wyeth Corp Derivados de dihidrobenzofurano, usos de los mismos en la preparacion de un medicamento y composicion farmaceutica
AR056980A1 (es) * 2005-04-22 2007-11-07 Wyeth Corp Derivados de dihidrobenzofurano, composiciones farmaceuticas, y uso de los mismos
CN101189004A (zh) * 2005-04-22 2008-05-28 惠氏公司 疼痛的治疗
AU2006239942A1 (en) * 2005-04-22 2006-11-02 Wyeth Dihydrobenzofuran derivatives and uses thereof
BRPI0610028A2 (pt) * 2005-04-22 2010-05-18 Wyeth Corp combinações terapêuticas para o tratamento ou a prevenção de distúrbios psicóticos
TW200716583A (en) * 2005-04-22 2007-05-01 Wyeth Corp Crystal forms of {[(2R)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride
EP1874292A2 (en) * 2005-04-24 2008-01-09 Wyeth Methods for modulating bladder function
WO2007112065A2 (en) * 2006-03-24 2007-10-04 Wyeth Methods for treating cognitive and other disorders
US20130267500A1 (en) 2010-09-01 2013-10-10 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
GB2486631A (en) * 2010-12-01 2012-06-27 Univ Sheffield Phenol/quinone boronic acids/esters and method of preparation thereof
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
CN109776465B (zh) * 2019-03-22 2023-06-06 国网湖南省电力有限公司 一种具有c2季碳中心的苯并二氢呋喃衍生物的合成方法
CN110283150A (zh) * 2019-07-12 2019-09-27 南开大学 一类手性二氢苯并呋喃的不对称合成方法
EP3878447A1 (en) 2020-03-11 2021-09-15 InterAx Biotech AG Beta adrenergic receptor antagonists
CN114560754A (zh) * 2022-02-25 2022-05-31 滁州学院 一种烷基醇的制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100327264B1 (ko) * 1993-10-29 2002-07-02 요시히로 미와 인돌유도체,그의염및이를함유하는심질환치료제
EP0769496A4 (en) * 1994-07-07 2001-10-17 Asahi Chemical Ind 2,3-DIHYDROBENZOFURAN DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF
JPH09227562A (ja) * 1996-02-23 1997-09-02 Kowa Co インドール誘導体の製造法
JP2000007671A (ja) * 1998-06-25 2000-01-11 Asahi Chem Ind Co Ltd ２，３−ジヒドロベンゾフラン誘導体
JP2000080091A (ja) * 1998-06-26 2000-03-21 Asahi Chem Ind Co Ltd ２，３―ジヒドロベンゾフラン誘導体の製造方法
CA2462156A1 (en) * 2001-10-05 2003-04-17 Wyeth A process for the stereoselective synthesis of 2-hydroxymethyl-chromans
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US7728155B2 (en) * 2003-10-24 2010-06-01 Wyeth Llc Dihydrobenzofuranyl alkanamines and methods for using same as cns agents
GT200500297A (es) * 2004-10-21 2006-10-27 Sintesis asimetrica de dehidrobenzofuranos sustituidos
US7516224B2 (en) * 2004-10-21 2009-04-07 Cisco Technology, Inc. Pseudowire termination directly on a router
BRPI0610028A2 (pt) * 2005-04-22 2010-05-18 Wyeth Corp combinações terapêuticas para o tratamento ou a prevenção de distúrbios psicóticos
CA2605587A1 (en) * 2005-04-22 2006-11-02 Wyeth Chromane and chromene derivatives and uses thereof
AU2006239942A1 (en) * 2005-04-22 2006-11-02 Wyeth Dihydrobenzofuran derivatives and uses thereof
CN101189004A (zh) * 2005-04-22 2008-05-28 惠氏公司 疼痛的治疗
TW200716583A (en) * 2005-04-22 2007-05-01 Wyeth Corp Crystal forms of {[(2R)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride
AU2006239930A1 (en) * 2005-04-22 2006-11-02 Wyeth Benzodioxane and benzodioxolane derivatives and uses thereof
EP1898895A2 (en) * 2005-04-22 2008-03-19 Wyeth Treatment of drug abuse
AR056980A1 (es) * 2005-04-22 2007-11-07 Wyeth Corp Derivados de dihidrobenzofurano, composiciones farmaceuticas, y uso de los mismos
WO2006116151A1 (en) * 2005-04-22 2006-11-02 Wyeth Benzofuranyl alkanamine derivatives and uses thereof as 5-ht2c agonists
TW200722081A (en) * 2005-04-22 2007-06-16 Wyeth Corp New therapeutic combinations for the treatment or prevention of depression
AR055916A1 (es) * 2005-04-22 2007-09-12 Wyeth Corp Derivados de dihidrobenzofurano, usos de los mismos en la preparacion de un medicamento y composicion farmaceutica
EP1874292A2 (en) * 2005-04-24 2008-01-09 Wyeth Methods for modulating bladder function
US7593398B2 (en) * 2005-09-08 2009-09-22 Cisco Technology, Inc. Layer-two interworking applied to L2-L3 pseudowires

Also Published As

Publication number Publication date
EP1802598A2 (en) 2007-07-04
TW200619215A (en) 2006-06-16
WO2006047288A3 (en) 2007-03-15
AR053980A1 (es) 2007-05-30
GT200500296A (es) 2006-10-02
PA8650501A1 (es) 2006-07-03
CN101107238A (zh) 2008-01-16
US20060089405A1 (en) 2006-04-27
AU2005299757A1 (en) 2006-05-04
WO2006047288A2 (en) 2006-05-04
MX2007004637A (es) 2007-06-08
CA2584775A1 (en) 2006-05-04
BRPI0516236A (pt) 2008-08-26
JP2008517929A (ja) 2008-05-29

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