AR053980A1 - Sintesis asimetrica de derivados de dihidrobenzofurano - Google Patents
Sintesis asimetrica de derivados de dihidrobenzofuranoInfo
- Publication number
- AR053980A1 AR053980A1 ARP050104386A ARP050104386A AR053980A1 AR 053980 A1 AR053980 A1 AR 053980A1 AR P050104386 A ARP050104386 A AR P050104386A AR P050104386 A ARP050104386 A AR P050104386A AR 053980 A1 AR053980 A1 AR 053980A1
- Authority
- AR
- Argentina
- Prior art keywords
- membered
- sulfur
- nitrogen
- oxygen
- formula
- Prior art date
Links
- HBEDSQVIWPRPAY-UHFFFAOYSA-N 2,3-dihydrobenzofuran Chemical class C1=CC=C2OCCC2=C1 HBEDSQVIWPRPAY-UHFFFAOYSA-N 0.000 title 1
- 238000011914 asymmetric synthesis Methods 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 7
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 125000005842 heteroatom Chemical group 0.000 abstract 5
- 229910052757 nitrogen Inorganic materials 0.000 abstract 5
- 239000001301 oxygen Chemical group 0.000 abstract 5
- 229910052760 oxygen Inorganic materials 0.000 abstract 5
- 239000011593 sulfur Chemical group 0.000 abstract 5
- 229910052717 sulfur Inorganic materials 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000000460 chlorine Substances 0.000 abstract 3
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 3
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000002950 monocyclic group Chemical group 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 229920001774 Perfluoroether Polymers 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 230000001351 cycling effect Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Abstract
Reivindicacion 1: Un método para preparar un compuesto de la formula E en donde: R1 y R2 son cada uno, de modo independiente, hidrogeno, cloro, fluor, CH, -OH, alquilo C1-8, perfluoroalquilo C1-6, alcoxi C1-6, perfluoroalcoxi C1-6, arilo de 6-10 mimebros ariloxi de 6-10 miembros, heteroarilo de 5-10 miembros con 1 a 4 heteroátomos seleccionados, de modo independiente, de nitrogeno, oxígeno o azufre, alquenilo C2-8, alcansulfonamido C1-6, dialquilamino de 1 a 6 átomos de carbono por resto de alquilo, cicloalifático C3-8 o heterocicloalquilo de 3-8 miembros de 1 a 3 heteroátomos seleccionados, de modo independiente, de nitrogeno, oxígeno o azufre; o R1 y R2, cuando son adyacentes entre sí, pueden tomarse junto con los átomos de carbono a los que están unidos para formar un resto cíclico seleccionado de un cicloalifático monocíclico de 3 a 8 átomos de carbono, un cicloalifático en puente de 5 a 10 átomos de carbono, un heterocicloalifático de 3 a 8 miembros con 1 a 3 heteroátomos seleccionados, de modo independiente, de nitrogeno, oxígeno o azufre, arilo de 6-10 miembros o heteroarilo de 5-10 miembros con 1 a 3 heteroátomos seleccionados, de modo independiente, de nitrogeno, oxígeno o azufre, en donde el cicloalifático monocíclico o el heterocicloalifático pueden estar opcionalmente sustituidos en un átomo de carbono individual con un anillo cicloalquilo, de 3-5 miembros o un anillo heterocicloalquilo de 3-5 miembros con 1-2 heteroátomos seleccionados de modo independiente, de nitrogeno, oxígeno o azufre, para formar un grupo espirocíclico; e Y es Br, Cl o I, que comprende las etapas de (a) proporcionar un compuesto no racémico quiral de la formula D: en donde Y es Br, Cl o I; y R8 es hidrogeno o un grupo protector de hidroxilo apropiado y (b) ciclar dicho compuesto de la formula D para formar un compuesto de la formula E.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62102304P | 2004-10-21 | 2004-10-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR053980A1 true AR053980A1 (es) | 2007-05-30 |
Family
ID=35965910
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050104386A AR053980A1 (es) | 2004-10-21 | 2005-10-20 | Sintesis asimetrica de derivados de dihidrobenzofurano |
Country Status (14)
Country | Link |
---|---|
US (1) | US20060089405A1 (es) |
EP (1) | EP1802598A2 (es) |
JP (1) | JP2008517929A (es) |
CN (1) | CN101107238A (es) |
AR (1) | AR053980A1 (es) |
AU (1) | AU2005299757A1 (es) |
BR (1) | BRPI0516236A (es) |
CA (1) | CA2584775A1 (es) |
GT (1) | GT200500296A (es) |
MX (1) | MX2007004637A (es) |
PA (1) | PA8650501A1 (es) |
PE (1) | PE20061033A1 (es) |
TW (1) | TW200619215A (es) |
WO (1) | WO2006047288A2 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050261347A1 (en) * | 2003-10-24 | 2005-11-24 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
US7435837B2 (en) * | 2003-10-24 | 2008-10-14 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
GT200500297A (es) * | 2004-10-21 | 2006-10-27 | Sintesis asimetrica de dehidrobenzofuranos sustituidos | |
JP2008538573A (ja) * | 2005-04-22 | 2008-10-30 | ワイス | ベンゾフラニルアルカナミン誘導体およびその5−ht2cアゴニストとしての使用 |
MX2007013163A (es) * | 2005-04-22 | 2008-01-21 | Wyeth Corp | Derivados de cromano y cromeno y usos de los mismos. |
WO2006116149A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | New therapeutic combianations for the treatment or prevention of depression |
US20060258713A1 (en) * | 2005-04-22 | 2006-11-16 | Wyeth | Treatment of pain |
WO2006116221A2 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Therapeutic combinations for the treatment or prevention of psychotic disorders |
MX2007013151A (es) * | 2005-04-22 | 2008-01-16 | Wyeth Corp | Derivados de benzodioxano y benzodioxolano y usos de los mismos. |
MX2007013179A (es) * | 2005-04-22 | 2008-01-16 | Wyeth Corp | Formas cristalinas de clorhidrato de {[(2r)-7-(diclorofenil)-5- fluoro-2,3-dihidro-1-benzofurano-2-il]metil}amina. |
EP1871356A1 (en) * | 2005-04-22 | 2008-01-02 | Wyeth a Corporation of the State of Delaware | Dihydrobenzofuran derivatives and uses thereof |
GT200600164A (es) * | 2005-04-22 | 2007-03-14 | Derivados de dihidrobenzofuranos y usos de los mismos | |
AU2006239910A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Dihydrobenzofuran derivatives and uses thereof |
EP1874292A2 (en) * | 2005-04-24 | 2008-01-09 | Wyeth | Methods for modulating bladder function |
WO2007112065A2 (en) * | 2006-03-24 | 2007-10-04 | Wyeth | Methods for treating cognitive and other disorders |
WO2012030953A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level |
GB2486631A (en) * | 2010-12-01 | 2012-06-27 | Univ Sheffield | Phenol/quinone boronic acids/esters and method of preparation thereof |
WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
CN109776465B (zh) * | 2019-03-22 | 2023-06-06 | 国网湖南省电力有限公司 | 一种具有c2季碳中心的苯并二氢呋喃衍生物的合成方法 |
CN110283150A (zh) * | 2019-07-12 | 2019-09-27 | 南开大学 | 一类手性二氢苯并呋喃的不对称合成方法 |
EP3878447A1 (en) | 2020-03-11 | 2021-09-15 | InterAx Biotech AG | Beta adrenergic receptor antagonists |
CN114560754A (zh) * | 2022-02-25 | 2022-05-31 | 滁州学院 | 一种烷基醇的制备方法 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100327264B1 (ko) * | 1993-10-29 | 2002-07-02 | 요시히로 미와 | 인돌유도체,그의염및이를함유하는심질환치료제 |
US5798382A (en) * | 1994-07-07 | 1998-08-25 | Asahi Kasei Kogyo Kabushiki Kaisha | 2,3-dihydrobenzofuran derivatives, method for producing the same, and use thereof |
JPH09227562A (ja) * | 1996-02-23 | 1997-09-02 | Kowa Co | インドール誘導体の製造法 |
JP2000007671A (ja) * | 1998-06-25 | 2000-01-11 | Asahi Chem Ind Co Ltd | 2,3−ジヒドロベンゾフラン誘導体 |
JP2000080091A (ja) * | 1998-06-26 | 2000-03-21 | Asahi Chem Ind Co Ltd | 2,3―ジヒドロベンゾフラン誘導体の製造方法 |
MXPA04003086A (es) * | 2001-10-05 | 2004-09-06 | Wyeth Corp | Proceso para sintesis estereoselectiva de 2-hidroximetil-cromanos. |
US20050261347A1 (en) * | 2003-10-24 | 2005-11-24 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
US7728155B2 (en) * | 2003-10-24 | 2010-06-01 | Wyeth Llc | Dihydrobenzofuranyl alkanamines and methods for using same as cns agents |
US7435837B2 (en) * | 2003-10-24 | 2008-10-14 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
GT200500297A (es) * | 2004-10-21 | 2006-10-27 | Sintesis asimetrica de dehidrobenzofuranos sustituidos | |
US7516224B2 (en) * | 2004-10-21 | 2009-04-07 | Cisco Technology, Inc. | Pseudowire termination directly on a router |
WO2006116221A2 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Therapeutic combinations for the treatment or prevention of psychotic disorders |
EP1871356A1 (en) * | 2005-04-22 | 2008-01-02 | Wyeth a Corporation of the State of Delaware | Dihydrobenzofuran derivatives and uses thereof |
MX2007013179A (es) * | 2005-04-22 | 2008-01-16 | Wyeth Corp | Formas cristalinas de clorhidrato de {[(2r)-7-(diclorofenil)-5- fluoro-2,3-dihidro-1-benzofurano-2-il]metil}amina. |
AU2006239910A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Dihydrobenzofuran derivatives and uses thereof |
MX2007013163A (es) * | 2005-04-22 | 2008-01-21 | Wyeth Corp | Derivados de cromano y cromeno y usos de los mismos. |
JP2008538573A (ja) * | 2005-04-22 | 2008-10-30 | ワイス | ベンゾフラニルアルカナミン誘導体およびその5−ht2cアゴニストとしての使用 |
US20060258713A1 (en) * | 2005-04-22 | 2006-11-16 | Wyeth | Treatment of pain |
WO2006116149A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | New therapeutic combianations for the treatment or prevention of depression |
AU2006239917A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | (7-arlysubstituted 2, 3-dihydr0-1-benz0furan-2-yl) alkylamines in the treatment' of substance abuse |
MX2007013151A (es) * | 2005-04-22 | 2008-01-16 | Wyeth Corp | Derivados de benzodioxano y benzodioxolano y usos de los mismos. |
GT200600164A (es) * | 2005-04-22 | 2007-03-14 | Derivados de dihidrobenzofuranos y usos de los mismos | |
EP1874292A2 (en) * | 2005-04-24 | 2008-01-09 | Wyeth | Methods for modulating bladder function |
US7593398B2 (en) * | 2005-09-08 | 2009-09-22 | Cisco Technology, Inc. | Layer-two interworking applied to L2-L3 pseudowires |
-
2005
- 2005-10-19 GT GT200500296A patent/GT200500296A/es unknown
- 2005-10-20 AR ARP050104386A patent/AR053980A1/es not_active Application Discontinuation
- 2005-10-20 PE PE2005001234A patent/PE20061033A1/es not_active Application Discontinuation
- 2005-10-20 TW TW094136637A patent/TW200619215A/zh unknown
- 2005-10-21 WO PCT/US2005/037894 patent/WO2006047288A2/en active Application Filing
- 2005-10-21 BR BRPI0516236-0A patent/BRPI0516236A/pt not_active Application Discontinuation
- 2005-10-21 MX MX2007004637A patent/MX2007004637A/es not_active Application Discontinuation
- 2005-10-21 AU AU2005299757A patent/AU2005299757A1/en not_active Abandoned
- 2005-10-21 PA PA20058650501A patent/PA8650501A1/es unknown
- 2005-10-21 CA CA002584775A patent/CA2584775A1/en not_active Abandoned
- 2005-10-21 CN CNA2005800429783A patent/CN101107238A/zh active Pending
- 2005-10-21 US US11/255,562 patent/US20060089405A1/en not_active Abandoned
- 2005-10-21 EP EP05817270A patent/EP1802598A2/en not_active Withdrawn
- 2005-10-21 JP JP2007538064A patent/JP2008517929A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2006047288A3 (en) | 2007-03-15 |
AU2005299757A1 (en) | 2006-05-04 |
CA2584775A1 (en) | 2006-05-04 |
US20060089405A1 (en) | 2006-04-27 |
GT200500296A (es) | 2006-10-02 |
JP2008517929A (ja) | 2008-05-29 |
BRPI0516236A (pt) | 2008-08-26 |
TW200619215A (en) | 2006-06-16 |
CN101107238A (zh) | 2008-01-16 |
PA8650501A1 (es) | 2006-07-03 |
WO2006047288A2 (en) | 2006-05-04 |
PE20061033A1 (es) | 2006-11-08 |
MX2007004637A (es) | 2007-06-08 |
EP1802598A2 (en) | 2007-07-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |