CO5721000A2 - (tiazol-2-il)-amida o sulfonamida substituida como activado- res de glicocinasa utiles en el tratamiento de diabetes de tipo 2 - Google Patents
(tiazol-2-il)-amida o sulfonamida substituida como activado- res de glicocinasa utiles en el tratamiento de diabetes de tipo 2Info
- Publication number
- CO5721000A2 CO5721000A2 CO05027999A CO05027999A CO5721000A2 CO 5721000 A2 CO5721000 A2 CO 5721000A2 CO 05027999 A CO05027999 A CO 05027999A CO 05027999 A CO05027999 A CO 05027999A CO 5721000 A2 CO5721000 A2 CO 5721000A2
- Authority
- CO
- Colombia
- Prior art keywords
- hydrogen
- alkyl
- glicocinase
- tiazol
- amida
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/50—Nitrogen atoms bound to hetero atoms
- C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
1.- Un compuesto de la formula:R-NH-Q (I)en donde:(i) Q es un radical: en donde R1 y R2 son independientemente hidrogeno o halogeno; oQ es un radical en donde R3 es hidrogeno, halogeno, alquilo, cicloalquilo, arilo, alcoxi, cicloalcoxi, ariloxi, alquiltio, cicloalquiltio, ariltio, acilo, sulfonilo, alquilamino, cicloalquilamino, arilamino, acilamino, sulfonamido o alcoxicarbonilo; Y es CH o nitrogeno; y R es un radical de la formula:en donde:R4 es alquilo de 2 a 4 atomos de carbono, cicloalquilo de 3 a 7 atomos de carbono o heterocicloalquilo de 5 a 7 atomos de carbono;R5 y R6 son independientemente hidrogeno, halogeno, ciano, R7, -C(O)R7 o -S(O)2R7, en dondeR7 es -(CR8R9)m-W-R10, en dondeR8 y R9 son independientemente hidrogeno o alquilo inferior;W es un enlace, O, S o -NR11, en donde R11 es hidrogeno o alquilo inferior;R10 es hidrogeno, alquilo, cicloalquilo, arilo o heterociclilo, o R10 y R11, combinados, son alquileno que junto con el atomo de nitrogeno al cual estan unidos forman un anillo de 5 a 7 miembros;m es cero o un entero de 1 a 5;n es cero o un entero de 1 o 2;o un isomero optico del mismo; o una sal farmacéuticamente aceptable del mismo; o ...
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41586002P | 2002-10-03 | 2002-10-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5721000A2 true CO5721000A2 (es) | 2007-01-31 |
Family
ID=32469191
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO05027999A CO5721000A2 (es) | 2002-10-03 | 2005-03-30 | (tiazol-2-il)-amida o sulfonamida substituida como activado- res de glicocinasa utiles en el tratamiento de diabetes de tipo 2 |
Country Status (18)
Country | Link |
---|---|
US (2) | US7812167B2 (es) |
EP (1) | EP1549626A1 (es) |
JP (1) | JP2006509774A (es) |
KR (1) | KR20050074959A (es) |
CN (2) | CN1703408A (es) |
AU (1) | AU2003302279B2 (es) |
BR (1) | BR0314864A (es) |
CA (1) | CA2498089A1 (es) |
CO (1) | CO5721000A2 (es) |
EC (1) | ECSP055705A (es) |
HK (1) | HK1079788A1 (es) |
MX (1) | MXPA05003559A (es) |
NO (1) | NO20052159L (es) |
NZ (1) | NZ539013A (es) |
PL (1) | PL375021A1 (es) |
RU (1) | RU2005113713A (es) |
WO (1) | WO2004050645A1 (es) |
ZA (1) | ZA200501532B (es) |
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SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
KR20050074959A (ko) | 2002-10-03 | 2005-07-19 | 노파르티스 아게 | 제ii형 당뇨병 치료에 유용한 글루코키나아제 활성인자로서의 치환된 (티아졸-2-일)-아미드 또는 술폰아미드 |
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WO2006016194A1 (en) | 2004-08-12 | 2006-02-16 | Prosidion Limited | Substituted phenylacetamides and their use as glucokinase activators |
EP1824835A1 (en) | 2004-12-03 | 2007-08-29 | Novo Nordisk A/S | Heteroaromatic glucokinase activators |
GT200600428A (es) | 2005-09-30 | 2007-05-21 | Compuestos organicos | |
GT200600429A (es) | 2005-09-30 | 2007-04-30 | Compuestos organicos |
-
2003
- 2003-10-02 KR KR1020057005672A patent/KR20050074959A/ko not_active Application Discontinuation
- 2003-10-02 BR BR0314864-5A patent/BR0314864A/pt not_active Application Discontinuation
- 2003-10-02 MX MXPA05003559A patent/MXPA05003559A/es active IP Right Grant
- 2003-10-02 EP EP03810838A patent/EP1549626A1/en not_active Withdrawn
- 2003-10-02 CN CNA2003801008797A patent/CN1703408A/zh active Pending
- 2003-10-02 US US10/529,670 patent/US7812167B2/en not_active Expired - Fee Related
- 2003-10-02 PL PL03375021A patent/PL375021A1/xx not_active Application Discontinuation
- 2003-10-02 WO PCT/EP2003/010977 patent/WO2004050645A1/en active Application Filing
- 2003-10-02 NZ NZ539013A patent/NZ539013A/en unknown
- 2003-10-02 AU AU2003302279A patent/AU2003302279B2/en not_active Ceased
- 2003-10-02 CN CN201010145133A patent/CN101805358A/zh active Pending
- 2003-10-02 RU RU2005113713/04A patent/RU2005113713A/ru not_active Application Discontinuation
- 2003-10-02 CA CA002498089A patent/CA2498089A1/en not_active Abandoned
- 2003-10-02 JP JP2004556081A patent/JP2006509774A/ja active Pending
-
2005
- 2005-02-22 ZA ZA200501532A patent/ZA200501532B/xx unknown
- 2005-03-28 EC EC2005005705A patent/ECSP055705A/es unknown
- 2005-03-30 CO CO05027999A patent/CO5721000A2/es not_active Application Discontinuation
- 2005-05-02 NO NO20052159A patent/NO20052159L/no not_active Application Discontinuation
- 2005-12-29 HK HK05112147.2A patent/HK1079788A1/zh unknown
-
2010
- 2010-09-03 US US12/875,215 patent/US20100330021A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2003302279A1 (en) | 2004-06-23 |
WO2004050645A1 (en) | 2004-06-17 |
ECSP055705A (es) | 2005-05-30 |
BR0314864A (pt) | 2005-08-02 |
NZ539013A (en) | 2007-05-31 |
EP1549626A1 (en) | 2005-07-06 |
PL375021A1 (en) | 2005-11-14 |
US7812167B2 (en) | 2010-10-12 |
ZA200501532B (en) | 2006-11-29 |
US20050282851A1 (en) | 2005-12-22 |
CA2498089A1 (en) | 2004-06-17 |
JP2006509774A (ja) | 2006-03-23 |
MXPA05003559A (es) | 2005-06-03 |
HK1079788A1 (zh) | 2006-04-13 |
CN1703408A (zh) | 2005-11-30 |
AU2003302279B2 (en) | 2008-06-12 |
WO2004050645A8 (en) | 2005-05-19 |
NO20052159L (no) | 2005-05-02 |
CN101805358A (zh) | 2010-08-18 |
US20100330021A1 (en) | 2010-12-30 |
KR20050074959A (ko) | 2005-07-19 |
RU2005113713A (ru) | 2006-01-20 |
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