AR051141A1 - Sintesis asimetrica de dihidrobenzofuranos sustituidos - Google Patents
Sintesis asimetrica de dihidrobenzofuranos sustituidosInfo
- Publication number
- AR051141A1 AR051141A1 ARP050104385A ARP050104385A AR051141A1 AR 051141 A1 AR051141 A1 AR 051141A1 AR P050104385 A ARP050104385 A AR P050104385A AR P050104385 A ARP050104385 A AR P050104385A AR 051141 A1 AR051141 A1 AR 051141A1
- Authority
- AR
- Argentina
- Prior art keywords
- nitrogen
- sulfur
- oxygen
- membered
- independently selected
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente se refiere a la produccion de un compuesto derivado de dihidrobenzofurano y a sus sales farmacéuticamente aceptables. Reivindicacion 1: Un método para preparar un compuesto de la formula (1), en donde: m es 0-3; R2 es CN, N3 o N(R3)(R4); R3 y R4 son cada uno, de modo independiente, hidrogeno, un grupo protector de amina, alquilo C1-6, haloalquilo inferior, cicloalifático o alquilcicloalifático de 3-6 miembros o R3 y R4 se toman junto con el nitrogeno al que están unidos para formar un grupo protector de amina cíclico o un anillo saturado o parcialmente insaturado de 3-6 miembros con 1-2 heteroátomos seleccionados, de modo independiente, de nitrogeno, oxígeno o azufre; cada Y es, de modo independiente, hidrogeno, cloro, fluor, CN, -OH, alquilo C1-8, perfluoroalquilo C1-6, alcoxi C1-6, perfluoroalcoxi C1-6, arilo de 6-10 miembros, ariloxi de 6-10 miembros, heteroarilo de 5-10 miembros con 1 a 4 heteroátomos seleccionados, de modo independiente, de nitrogeno, oxígeno o azufre, alquenilo C2-8, alcansulfonamido C1-6, dialquilamino C1-6 por resto de alquilo, cicloalifático C3-8 o heterocicloalquilo de 3-8 miembros con 1 a 3 heteroátomos seleccionados, de modo independientes, de nitrogeno, oxígeno o azufre; y Ar es un arilo de 6-10 miembros o heteroarilo de 5-10 miembros opcionalmente sustituido con 1-4 heteroátomos seleccionados, de modo independiente, de nitrogeno, oxígeno o azufre; que comprende las etapas de: proporcionar un compuesto de la formula (2), en donde: m es 0-3; R1 es hidrogeno o un grupo protector de hidroxilo apropiado; ORy es un grupo saliente apropiado; R2 es CN, N3 o N(R3)(R4); R3 y R4 son cada uno, de modo independiente, hidrogeno, un grupo protector de amina, alquilo C1-6, haloalquilo inferior, cicloalifático o alquilcicloalifático de 3-6 miembros o R3 y R4 se toman junto con el nitrogeno al que están unidos para formar un grupo protector de amina cíclico o un anillo saturado o parcialmente insaturado de 3-6 miembros con 1-2 heteroátomos seleccionados, de modo independiente, de nitrogeno, oxígeno o azufre; cada Y es, de modo independiente, hidrogeno, cloro, fluor, CN, -OH, alquilo C1-8, perfluoroalquilo C1-6, alcoxi C1-6, perfluoroalcoxi C1-6, arilo de 6-10 miembros, ariloxi de 6-10 miembros, heteroarilo de 5-10 miembros con 1 a 4 heteroátomos seleccionados, de modo independiente, de nitrogeno, oxígeno o azufre, alquenilo C2-8, alcansulfonamido C1-6, dialquilamino C1-6 por resto de alquilo, cicloalifático C3-8 o heterocicloalquilo de 3-8 miembros con 1 a 3 heteroátomos seleccionados, de modo independiente, de nitrogeno, oxígeno o azufre; y Ar es un arilo de 6-10 miembros o heteroarilo de 5-10 miembros opcionalmente sustituido con 1-4 heteroátomos seleccionados, de modo independiente, de nitrogeno, oxígeno o azufre; y convertir el compuesto de la formula (1) en un compuesto de la formula (2) o una de sus sales farmacéuticamente aceptables.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62102404P | 2004-10-21 | 2004-10-21 | |
US67417705P | 2005-04-22 | 2005-04-22 | |
US72106405P | 2005-09-28 | 2005-09-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR051141A1 true AR051141A1 (es) | 2006-12-20 |
Family
ID=35883812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050104385A AR051141A1 (es) | 2004-10-21 | 2005-10-20 | Sintesis asimetrica de dihidrobenzofuranos sustituidos |
Country Status (13)
Country | Link |
---|---|
US (1) | US20060111438A1 (es) |
EP (1) | EP1802597A1 (es) |
JP (1) | JP2008517919A (es) |
AR (1) | AR051141A1 (es) |
AU (1) | AU2005299884A1 (es) |
BR (1) | BRPI0517456A (es) |
CA (1) | CA2584728A1 (es) |
GT (1) | GT200500297A (es) |
MX (1) | MX2007004698A (es) |
PA (1) | PA8650401A1 (es) |
PE (1) | PE20060988A1 (es) |
TW (1) | TW200621739A (es) |
WO (1) | WO2006047228A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7435837B2 (en) * | 2003-10-24 | 2008-10-14 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
US20050261347A1 (en) * | 2003-10-24 | 2005-11-24 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
GT200500296A (es) * | 2004-10-21 | 2006-10-02 | Sintesis asimetrica de derivados del dehidrobenzofurano | |
BRPI0610037A2 (pt) * | 2005-04-22 | 2010-05-25 | Wyeth Corp | derivados de dihidrobenzofurano e uso dos mesmos |
RU2007139541A (ru) * | 2005-04-22 | 2009-05-27 | Вайет (Us) | Производные хромана и хромена и их применение |
WO2006116150A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Dihydrobenzofuran derivatives and uses thereof |
MX2007013179A (es) * | 2005-04-22 | 2008-01-16 | Wyeth Corp | Formas cristalinas de clorhidrato de {[(2r)-7-(diclorofenil)-5- fluoro-2,3-dihidro-1-benzofurano-2-il]metil}amina. |
MX2007013026A (es) * | 2005-04-22 | 2008-01-11 | Wyeth Corp | Combinaciones terapeuticas para el tratamiento o prevencion de trastornos psicoticos. |
EP1871358A1 (en) * | 2005-04-22 | 2008-01-02 | Wyeth | Benzofuranyl alkanamine derivatives and uses thereof as 5-ht2c agonists |
CN101218223A (zh) * | 2005-04-22 | 2008-07-09 | 惠氏公司 | 苯并二烷和苯并二氧戊环衍生物及其应用 |
WO2006116136A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Dihydrobenzofuran derivatives and uses thereof |
CA2605117A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Treatment of pain |
EP1871355A1 (en) * | 2005-04-22 | 2008-01-02 | Wyeth | New therapeutic combianations for the treatment or prevention of depression |
AU2006239941A1 (en) * | 2005-04-24 | 2006-11-02 | Wyeth | Methods for modulating bladder function |
AR060090A1 (es) * | 2006-03-24 | 2008-05-21 | Wyeth Corp | Metodos para tratar trastornos cognitivos y otros afines |
EP2018863B9 (en) | 2006-05-16 | 2015-02-18 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound and use thereof |
TW200840566A (en) * | 2006-12-22 | 2008-10-16 | Esteve Labor Dr | Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments |
US20100266504A1 (en) | 2007-11-15 | 2010-10-21 | Takahiro Matsumoto | Condensed pyridine derivative and use thereof |
JPWO2019131902A1 (ja) | 2017-12-27 | 2020-12-10 | 武田薬品工業株式会社 | 腹圧性尿失禁および便失禁の治療薬 |
EP3878447A1 (en) | 2020-03-11 | 2021-09-15 | InterAx Biotech AG | Beta adrenergic receptor antagonists |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3153335B2 (ja) * | 1992-06-05 | 2001-04-09 | 興和株式会社 | キノリン誘導体又はその塩 |
US6700001B2 (en) * | 2001-10-05 | 2004-03-02 | Wyeth | Process for stereoselective synthesis of 2-hydroxymethyl chromans |
US20050261347A1 (en) * | 2003-10-24 | 2005-11-24 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
US7728155B2 (en) * | 2003-10-24 | 2010-06-01 | Wyeth Llc | Dihydrobenzofuranyl alkanamines and methods for using same as cns agents |
US7435837B2 (en) * | 2003-10-24 | 2008-10-14 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
GT200500296A (es) * | 2004-10-21 | 2006-10-02 | Sintesis asimetrica de derivados del dehidrobenzofurano | |
BRPI0610037A2 (pt) * | 2005-04-22 | 2010-05-25 | Wyeth Corp | derivados de dihidrobenzofurano e uso dos mesmos |
CN101218223A (zh) * | 2005-04-22 | 2008-07-09 | 惠氏公司 | 苯并二烷和苯并二氧戊环衍生物及其应用 |
MX2007013179A (es) * | 2005-04-22 | 2008-01-16 | Wyeth Corp | Formas cristalinas de clorhidrato de {[(2r)-7-(diclorofenil)-5- fluoro-2,3-dihidro-1-benzofurano-2-il]metil}amina. |
CA2605117A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Treatment of pain |
EP1871355A1 (en) * | 2005-04-22 | 2008-01-02 | Wyeth | New therapeutic combianations for the treatment or prevention of depression |
MX2007013024A (es) * | 2005-04-22 | 2009-02-16 | Wyeth Corp | Tratamiento de abuso de drogas. |
RU2007139541A (ru) * | 2005-04-22 | 2009-05-27 | Вайет (Us) | Производные хромана и хромена и их применение |
WO2006116136A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Dihydrobenzofuran derivatives and uses thereof |
EP1871358A1 (en) * | 2005-04-22 | 2008-01-02 | Wyeth | Benzofuranyl alkanamine derivatives and uses thereof as 5-ht2c agonists |
WO2006116150A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Dihydrobenzofuran derivatives and uses thereof |
MX2007013026A (es) * | 2005-04-22 | 2008-01-11 | Wyeth Corp | Combinaciones terapeuticas para el tratamiento o prevencion de trastornos psicoticos. |
AU2006239941A1 (en) * | 2005-04-24 | 2006-11-02 | Wyeth | Methods for modulating bladder function |
-
2005
- 2005-10-19 GT GT200500297A patent/GT200500297A/es unknown
- 2005-10-20 PE PE2005001233A patent/PE20060988A1/es not_active Application Discontinuation
- 2005-10-20 AR ARP050104385A patent/AR051141A1/es not_active Application Discontinuation
- 2005-10-20 TW TW094136636A patent/TW200621739A/zh unknown
- 2005-10-21 JP JP2007538039A patent/JP2008517919A/ja active Pending
- 2005-10-21 AU AU2005299884A patent/AU2005299884A1/en not_active Abandoned
- 2005-10-21 CA CA002584728A patent/CA2584728A1/en not_active Abandoned
- 2005-10-21 WO PCT/US2005/037772 patent/WO2006047228A1/en active Application Filing
- 2005-10-21 US US11/255,645 patent/US20060111438A1/en not_active Abandoned
- 2005-10-21 PA PA20058650401A patent/PA8650401A1/es unknown
- 2005-10-21 EP EP05812939A patent/EP1802597A1/en not_active Withdrawn
- 2005-10-21 MX MX2007004698A patent/MX2007004698A/es not_active Application Discontinuation
- 2005-10-21 BR BRPI0517456-2A patent/BRPI0517456A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2584728A1 (en) | 2006-05-04 |
US20060111438A1 (en) | 2006-05-25 |
GT200500297A (es) | 2006-10-27 |
MX2007004698A (es) | 2007-06-14 |
JP2008517919A (ja) | 2008-05-29 |
AU2005299884A1 (en) | 2006-05-04 |
EP1802597A1 (en) | 2007-07-04 |
PA8650401A1 (es) | 2006-07-03 |
TW200621739A (en) | 2006-07-01 |
WO2006047228A1 (en) | 2006-05-04 |
BRPI0517456A (pt) | 2008-10-07 |
PE20060988A1 (es) | 2006-11-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |