PE20060988A1 - Sintesis asimetrica de dihidrobenzofuranos sustituidos - Google Patents

Sintesis asimetrica de dihidrobenzofuranos sustituidos

Info

Publication number
PE20060988A1
PE20060988A1 PE2005001233A PE2005001233A PE20060988A1 PE 20060988 A1 PE20060988 A1 PE 20060988A1 PE 2005001233 A PE2005001233 A PE 2005001233A PE 2005001233 A PE2005001233 A PE 2005001233A PE 20060988 A1 PE20060988 A1 PE 20060988A1
Authority
PE
Peru
Prior art keywords
compound
formula
contact
dihidrobenzofurans
substituted
Prior art date
Application number
PE2005001233A
Other languages
English (en)
Inventor
Alexander V Gontchrov
Gulnaz Khafizova
Quing Yu
Gary Paul Stack
Dahui Zhou
Chia-Cheng Shaw
John R Potoski
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20060988A1 publication Critical patent/PE20060988A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE UN COMPUESTO DE FORMULA (I-a) DONDE m ES 0 A 3; Y ES H, CLORO, CN, OH, ENTRE OTROS; Z ES Cl, F, CN, ENTRE OTROS; n ES 0 A 5; QUE COMPRENDE LAS ETAPAS: A) PONER EN CONTACTO UN COMPUESTO DE FORMULA E-2 DONDE R1 ES UN GRUPO PROTECTOR HIDROXILO CON RYCl DONDE RY ES ALQUILSULFONILOXI, ALQUENILSULFONILOXI O ARILSULFONILOXI OPCIONALMENTE SUSTITUIDO Y UNA BASE PARA PRODUCIR UN COMPUESTO DE FORMULA F-2; B) PONER EN CONTACTO EL COMPUESTO DE FORMULA F-2 CON UN AGENTE SEPARADOR ETER METILICO TAL COMO BBr3 PARA PRODUCIR UN COMPUESTO DE FORMULA G-2 Y C) PONER EN CONTACTO EL COMPUESTO DE FORMULA G-2 CON HIDRAZINA EN PRESENCIA DE ALCOHOL O SOLVENTE THF PARA OBTENER EL COMPUESTO DE FORMULA (I-a). DICHOS COMPUESTOS SON AGONISTAS DEL RECEPTOR DE SEROTONINA 5HT2C SIENDO UTILES EN EL TRATAMIENTO DE ESQUIZOFRENIA, TRASTORNO DELIRANTE, PSICOSIS
PE2005001233A 2004-10-21 2005-10-20 Sintesis asimetrica de dihidrobenzofuranos sustituidos PE20060988A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62102404P 2004-10-21 2004-10-21
US67417705P 2005-04-22 2005-04-22
US72106405P 2005-09-28 2005-09-28

Publications (1)

Publication Number Publication Date
PE20060988A1 true PE20060988A1 (es) 2006-11-07

Family

ID=35883812

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005001233A PE20060988A1 (es) 2004-10-21 2005-10-20 Sintesis asimetrica de dihidrobenzofuranos sustituidos

Country Status (13)

Country Link
US (1) US20060111438A1 (es)
EP (1) EP1802597A1 (es)
JP (1) JP2008517919A (es)
AR (1) AR051141A1 (es)
AU (1) AU2005299884A1 (es)
BR (1) BRPI0517456A (es)
CA (1) CA2584728A1 (es)
GT (1) GT200500297A (es)
MX (1) MX2007004698A (es)
PA (1) PA8650401A1 (es)
PE (1) PE20060988A1 (es)
TW (1) TW200621739A (es)
WO (1) WO2006047228A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
GT200500296A (es) * 2004-10-21 2006-10-02 Sintesis asimetrica de derivados del dehidrobenzofurano
AR056979A1 (es) * 2005-04-22 2007-11-07 Wyeth Corp Derivados de dihidrobenzofuranos y usos de los mismos
TW200718692A (en) * 2005-04-22 2007-05-16 Wyeth Corp Dihydrobenzofuran derivatives and uses thereof
CA2605117A1 (en) * 2005-04-22 2006-11-02 Wyeth Treatment of pain
TW200722081A (en) * 2005-04-22 2007-06-16 Wyeth Corp New therapeutic combinations for the treatment or prevention of depression
MX2007013021A (es) * 2005-04-22 2008-01-11 Wyeth Corp Derivados de benzofuranil-alcanamina y usos de los mismos como agonistas de 5-ht2c.
TW200716091A (en) * 2005-04-22 2007-05-01 Wyeth Corp New therapeutic combinations for the treatment or prevention of psychotic disorders
TW200716583A (en) * 2005-04-22 2007-05-01 Wyeth Corp Crystal forms of {[(2R)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride
GT200600159A (es) * 2005-04-22 2007-03-14 Derivados benzodioxano y benzodioxolano y usos de los mismos
CN101203505A (zh) * 2005-04-22 2008-06-18 惠氏公司 苯并二氢吡喃和苯并吡喃衍生物及其用途
CA2605435A1 (en) * 2005-04-22 2006-11-02 Wyeth Dihydrobenzofuran derivatives and uses thereof
MX2007013064A (es) * 2005-04-24 2008-01-16 Wyeth Corp Metodo para modular la funcion de la vejiga.
CA2647048A1 (en) * 2006-03-24 2007-10-04 Wyeth Methods for treating cognitive and other disorders
EP2018863B9 (en) 2006-05-16 2015-02-18 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
TW200840566A (en) * 2006-12-22 2008-10-16 Esteve Labor Dr Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments
WO2009063992A1 (ja) 2007-11-15 2009-05-22 Takeda Pharmaceutical Company Limited 縮合ピリジン誘導体およびその用途
US20210052600A1 (en) 2017-12-27 2021-02-25 Takeda Pharmaceutical Company Limited Therapeutic agents for stress urinary incontinence and incotinence of feces
EP3878447A1 (en) 2020-03-11 2021-09-15 InterAx Biotech AG Beta adrenergic receptor antagonists

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3153335B2 (ja) * 1992-06-05 2001-04-09 興和株式会社 キノリン誘導体又はその塩
WO2003031429A1 (en) * 2001-10-05 2003-04-17 Wyeth A process for the stereoselective synthesis of 2-hydroxymethyl-chromans
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US7728155B2 (en) * 2003-10-24 2010-06-01 Wyeth Llc Dihydrobenzofuranyl alkanamines and methods for using same as cns agents
GT200500296A (es) * 2004-10-21 2006-10-02 Sintesis asimetrica de derivados del dehidrobenzofurano
AR056979A1 (es) * 2005-04-22 2007-11-07 Wyeth Corp Derivados de dihidrobenzofuranos y usos de los mismos
TW200716091A (en) * 2005-04-22 2007-05-01 Wyeth Corp New therapeutic combinations for the treatment or prevention of psychotic disorders
GT200600159A (es) * 2005-04-22 2007-03-14 Derivados benzodioxano y benzodioxolano y usos de los mismos
CN101203505A (zh) * 2005-04-22 2008-06-18 惠氏公司 苯并二氢吡喃和苯并吡喃衍生物及其用途
CA2605435A1 (en) * 2005-04-22 2006-11-02 Wyeth Dihydrobenzofuran derivatives and uses thereof
TW200716583A (en) * 2005-04-22 2007-05-01 Wyeth Corp Crystal forms of {[(2R)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride
TW200718692A (en) * 2005-04-22 2007-05-16 Wyeth Corp Dihydrobenzofuran derivatives and uses thereof
CN101389325A (zh) * 2005-04-22 2009-03-18 惠氏公司 药物滥用的治疗
CA2605117A1 (en) * 2005-04-22 2006-11-02 Wyeth Treatment of pain
MX2007013021A (es) * 2005-04-22 2008-01-11 Wyeth Corp Derivados de benzofuranil-alcanamina y usos de los mismos como agonistas de 5-ht2c.
TW200722081A (en) * 2005-04-22 2007-06-16 Wyeth Corp New therapeutic combinations for the treatment or prevention of depression
MX2007013064A (es) * 2005-04-24 2008-01-16 Wyeth Corp Metodo para modular la funcion de la vejiga.

Also Published As

Publication number Publication date
AR051141A1 (es) 2006-12-20
EP1802597A1 (en) 2007-07-04
BRPI0517456A (pt) 2008-10-07
WO2006047228A1 (en) 2006-05-04
MX2007004698A (es) 2007-06-14
CA2584728A1 (en) 2006-05-04
AU2005299884A1 (en) 2006-05-04
TW200621739A (en) 2006-07-01
GT200500297A (es) 2006-10-27
PA8650401A1 (es) 2006-07-03
US20060111438A1 (en) 2006-05-25
JP2008517919A (ja) 2008-05-29

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