GT200500297A - Sintesis asimetrica de dehidrobenzofuranos sustituidos - Google Patents

Sintesis asimetrica de dehidrobenzofuranos sustituidos

Info

Publication number
GT200500297A
GT200500297A GT200500297A GT200500297A GT200500297A GT 200500297 A GT200500297 A GT 200500297A GT 200500297 A GT200500297 A GT 200500297A GT 200500297 A GT200500297 A GT 200500297A GT 200500297 A GT200500297 A GT 200500297A
Authority
GT
Guatemala
Prior art keywords
dehydrobenzofurans
replaced
disorders
asymmetric synthesis
psychosis associated
Prior art date
Application number
GT200500297A
Other languages
English (en)
Inventor
Alexander Gontcharov
Gulnaz Khafizova
John R Potoski
Qing Yu
Chia-Cheng Shaw
Gary Paul Stack
Dahui Zhou
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200500297A publication Critical patent/GT200500297A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A MÉTODOS DE PREPARACIÓN DE COMPUESTOS QUE TIENEN ACTIVIDAD COMO 5HT2C TOTALES Y PARCIALES. ESTOS COPUESTOS SON ÚTILES PARA EL TRATAMIENTO DE DESORDENES QUE INCLUYEN ESQUIZOFRENIA, SUSTANCIAS QUE INDUCEN A DESORDENES PSICÓTICOS, PSICOSIS ASOCIADO A LA ENFERMEDAD DE ALZHEIMER'S, PSICOSIS ASOCIADA A LA ENFERMEDAD DE PARKINSON, DESORDEN BIPOLAR, DESÓRDENES DEPRESIVOS, ANSIEDAD, EPILEPSIA, DESÓRDENES DEL SUEÑO, MIGRAÑAS, DISFUNCIÓN SEXUAL, PROBLEMAS GASTROINTESTINALES, OBESIDAD ETC.
GT200500297A 2004-10-21 2005-10-19 Sintesis asimetrica de dehidrobenzofuranos sustituidos GT200500297A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62102404P 2004-10-21 2004-10-21
US67417705P 2005-04-22 2005-04-22
US72106405P 2005-09-28 2005-09-28

Publications (1)

Publication Number Publication Date
GT200500297A true GT200500297A (es) 2006-10-27

Family

ID=35883812

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200500297A GT200500297A (es) 2004-10-21 2005-10-19 Sintesis asimetrica de dehidrobenzofuranos sustituidos

Country Status (13)

Country Link
US (1) US20060111438A1 (es)
EP (1) EP1802597A1 (es)
JP (1) JP2008517919A (es)
AR (1) AR051141A1 (es)
AU (1) AU2005299884A1 (es)
BR (1) BRPI0517456A (es)
CA (1) CA2584728A1 (es)
GT (1) GT200500297A (es)
MX (1) MX2007004698A (es)
PA (1) PA8650401A1 (es)
PE (1) PE20060988A1 (es)
TW (1) TW200621739A (es)
WO (1) WO2006047228A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
GT200500296A (es) * 2004-10-21 2006-10-02 Sintesis asimetrica de derivados del dehidrobenzofurano
EP1874756A1 (en) * 2005-04-22 2008-01-09 Wyeth Chromane and chromene derivatives and uses thereof
PE20061327A1 (es) * 2005-04-22 2007-01-02 Wyeth Corp Combinaciones de derivados de benzofurano y un antidepresivo para el tratamiento o la prevencion de la depresion
GT200600164A (es) * 2005-04-22 2007-03-14 Derivados de dihidrobenzofuranos y usos de los mismos
BRPI0609988A2 (pt) * 2005-04-22 2010-05-18 Wyeth Corp derivados de diidrobenzofurano e usos dos mesmos
BRPI0610046A2 (pt) * 2005-04-22 2010-05-25 Wyeth Corp derivados de benzodioxano e benzodioxolano e usos destes
JP2008538577A (ja) * 2005-04-22 2008-10-30 ワイス ジヒドロベンゾフラン誘導体およびその使用
BRPI0610028A2 (pt) * 2005-04-22 2010-05-18 Wyeth Corp combinações terapêuticas para o tratamento ou a prevenção de distúrbios psicóticos
PE20061319A1 (es) * 2005-04-22 2006-12-28 Wyeth Corp Cristales formados de clorhidrato de {[(2r)-7-(2,6-diclorofenil)-5-fluoro-2-3-dihidro-1-benzofurano-2-il]metil}amina
BRPI0607536A2 (pt) * 2005-04-22 2009-09-15 Wyeth Corp tratamento de dor
MX2007013021A (es) * 2005-04-22 2008-01-11 Wyeth Corp Derivados de benzofuranil-alcanamina y usos de los mismos como agonistas de 5-ht2c.
CA2606064A1 (en) * 2005-04-24 2006-11-02 Wyeth Methods for modulating bladder function
MX2008012212A (es) * 2006-03-24 2008-10-02 Wyeth Corp Metodos para tratar trastornos cognitivos y otros afines.
EP2018863B9 (en) 2006-05-16 2015-02-18 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
TW200840566A (en) * 2006-12-22 2008-10-16 Esteve Labor Dr Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments
US20100266504A1 (en) 2007-11-15 2010-10-21 Takahiro Matsumoto Condensed pyridine derivative and use thereof
US20210052600A1 (en) 2017-12-27 2021-02-25 Takeda Pharmaceutical Company Limited Therapeutic agents for stress urinary incontinence and incotinence of feces
EP3878447A1 (en) 2020-03-11 2021-09-15 InterAx Biotech AG Beta adrenergic receptor antagonists

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3153335B2 (ja) * 1992-06-05 2001-04-09 興和株式会社 キノリン誘導体又はその塩
WO2003031429A1 (en) * 2001-10-05 2003-04-17 Wyeth A process for the stereoselective synthesis of 2-hydroxymethyl-chromans
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US7728155B2 (en) * 2003-10-24 2010-06-01 Wyeth Llc Dihydrobenzofuranyl alkanamines and methods for using same as cns agents
GT200500296A (es) * 2004-10-21 2006-10-02 Sintesis asimetrica de derivados del dehidrobenzofurano
PE20061319A1 (es) * 2005-04-22 2006-12-28 Wyeth Corp Cristales formados de clorhidrato de {[(2r)-7-(2,6-diclorofenil)-5-fluoro-2-3-dihidro-1-benzofurano-2-il]metil}amina
JP2008538577A (ja) * 2005-04-22 2008-10-30 ワイス ジヒドロベンゾフラン誘導体およびその使用
BRPI0610046A2 (pt) * 2005-04-22 2010-05-25 Wyeth Corp derivados de benzodioxano e benzodioxolano e usos destes
PE20061327A1 (es) * 2005-04-22 2007-01-02 Wyeth Corp Combinaciones de derivados de benzofurano y un antidepresivo para el tratamiento o la prevencion de la depresion
BRPI0607536A2 (pt) * 2005-04-22 2009-09-15 Wyeth Corp tratamento de dor
AU2006239917A1 (en) * 2005-04-22 2006-11-02 Wyeth (7-arlysubstituted 2, 3-dihydr0-1-benz0furan-2-yl) alkylamines in the treatment' of substance abuse
GT200600164A (es) * 2005-04-22 2007-03-14 Derivados de dihidrobenzofuranos y usos de los mismos
BRPI0610028A2 (pt) * 2005-04-22 2010-05-18 Wyeth Corp combinações terapêuticas para o tratamento ou a prevenção de distúrbios psicóticos
BRPI0609988A2 (pt) * 2005-04-22 2010-05-18 Wyeth Corp derivados de diidrobenzofurano e usos dos mesmos
EP1874756A1 (en) * 2005-04-22 2008-01-09 Wyeth Chromane and chromene derivatives and uses thereof
MX2007013021A (es) * 2005-04-22 2008-01-11 Wyeth Corp Derivados de benzofuranil-alcanamina y usos de los mismos como agonistas de 5-ht2c.
CA2606064A1 (en) * 2005-04-24 2006-11-02 Wyeth Methods for modulating bladder function

Also Published As

Publication number Publication date
EP1802597A1 (en) 2007-07-04
PA8650401A1 (es) 2006-07-03
TW200621739A (en) 2006-07-01
CA2584728A1 (en) 2006-05-04
AU2005299884A1 (en) 2006-05-04
US20060111438A1 (en) 2006-05-25
AR051141A1 (es) 2006-12-20
MX2007004698A (es) 2007-06-14
PE20060988A1 (es) 2006-11-07
JP2008517919A (ja) 2008-05-29
WO2006047228A1 (en) 2006-05-04
BRPI0517456A (pt) 2008-10-07

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