PE20061319A1 - Cristales formados de clorhidrato de {[(2r)-7-(2,6-diclorofenil)-5-fluoro-2-3-dihidro-1-benzofurano-2-il]metil}amina - Google Patents

Cristales formados de clorhidrato de {[(2r)-7-(2,6-diclorofenil)-5-fluoro-2-3-dihidro-1-benzofurano-2-il]metil}amina

Info

Publication number
PE20061319A1
PE20061319A1 PE2006000421A PE2006000421A PE20061319A1 PE 20061319 A1 PE20061319 A1 PE 20061319A1 PE 2006000421 A PE2006000421 A PE 2006000421A PE 2006000421 A PE2006000421 A PE 2006000421A PE 20061319 A1 PE20061319 A1 PE 20061319A1
Authority
PE
Peru
Prior art keywords
benzofuran
dichlorophenyl
dihydro
fluoro
methyl
Prior art date
Application number
PE2006000421A
Other languages
English (en)
Inventor
Abdolsamad Tadayon
Qing Yu
Michel Bernatchez
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20061319A1 publication Critical patent/PE20061319A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

SE REFIERE A UN POLIMORFO CRISTALINO DE CLORHIDRATO DE {[(2R)-7-(2,6-DICLOROFENIL)-5-FLUORO-2-3-DIHIDRO-1-BENZOFURANO-2-IL]METIL}AMINA CARACTERIZADO POR UN PATRON DE DIFRACCION DE POLVO DE RAYOS X COMPRENDIENDO UN PICO CARACTERISTICO, EN TERMINOS DE 2 TETHA EN ALREDEDOR 10,2; 25,8; 27,0 Y UN BARRIDO DIFERENCIAL CALORIMETRICO ENDOTERMICO CERCANO A 234 C. REFERIDA TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UTIL EN EL TRATAMIENTO DE LA ESQUIZOFRENIA
PE2006000421A 2005-04-22 2006-04-21 Cristales formados de clorhidrato de {[(2r)-7-(2,6-diclorofenil)-5-fluoro-2-3-dihidro-1-benzofurano-2-il]metil}amina PE20061319A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67431805P 2005-04-22 2005-04-22

Publications (1)

Publication Number Publication Date
PE20061319A1 true PE20061319A1 (es) 2006-12-28

Family

ID=36609610

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000421A PE20061319A1 (es) 2005-04-22 2006-04-21 Cristales formados de clorhidrato de {[(2r)-7-(2,6-diclorofenil)-5-fluoro-2-3-dihidro-1-benzofurano-2-il]metil}amina

Country Status (13)

Country Link
US (1) US20060252825A1 (es)
EP (1) EP1879875A1 (es)
JP (1) JP2008538581A (es)
CN (1) CN101163689A (es)
AR (1) AR055054A1 (es)
AU (1) AU2006239897A1 (es)
BR (1) BRPI0610785A2 (es)
CA (1) CA2603900A1 (es)
GT (1) GT200600158A (es)
MX (1) MX2007013179A (es)
PE (1) PE20061319A1 (es)
TW (1) TW200716583A (es)
WO (1) WO2006116218A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
GT200500296A (es) * 2004-10-21 2006-10-02 Sintesis asimetrica de derivados del dehidrobenzofurano
GT200500297A (es) * 2004-10-21 2006-10-27 Sintesis asimetrica de dehidrobenzofuranos sustituidos
BRPI0610037A2 (pt) * 2005-04-22 2010-05-25 Wyeth Corp derivados de dihidrobenzofurano e uso dos mesmos
CA2604916A1 (en) * 2005-04-22 2006-11-02 Wyeth Dihydrobenzofuran derivatives and uses thereof
PE20061335A1 (es) * 2005-04-22 2006-12-29 Wyeth Corp Compuestos derivados de benzodioxano y benzodioxolano como moduladores del receptor 5-ht2c
GT200600163A (es) * 2005-04-22 2007-03-14 Nuevas combinaciones terapeuticas para el tratamiento o la prevencion de la depresion
PE20071432A1 (es) * 2005-04-22 2007-01-24 Wyeth Corp Derivados de dihidrobenzofurano como agonistas o agonistas parciales de receptores metaloninergicos
MX2007013026A (es) * 2005-04-22 2008-01-11 Wyeth Corp Combinaciones terapeuticas para el tratamiento o prevencion de trastornos psicoticos.
US7365095B2 (en) * 2005-04-22 2008-04-29 Wyeth Chromane and chromene derivatives and uses thereof
US7368477B2 (en) * 2005-04-22 2008-05-06 Wyeth Benzofuranyl alkanamine derivatives and uses thereof
MX2007013023A (es) * 2005-04-22 2007-12-13 Wyeth Corp Tratamiento del dolor.
GT200600162A (es) * 2005-04-24 2007-03-14 Metodos para modular la funcion de la vejiga
EP2404919B1 (en) 2005-11-08 2013-08-21 Vertex Pharmaceuticals Incorporated Heterocyclic compound useful as a modulator of ATP-binding cassette transporters.
CL2007000775A1 (es) * 2006-03-24 2008-01-25 Wyeth Corp Uso de compuestos derivados de benzofurano para el tratamiento de un desorden cognitivo.
WO2007132841A1 (ja) 2006-05-16 2007-11-22 Takeda Pharmaceutical Company Limited 縮合複素環化合物およびその用途
JP5520051B2 (ja) 2007-11-15 2014-06-11 武田薬品工業株式会社 縮合ピリジン誘導体およびその用途
MX367154B (es) * 2007-12-07 2019-08-07 Vertex Pharma Formas solidas de acido 3-(6-(1-(2,2-difluorobenzo[d] [1,3]dioxol-5-il)ciclopropancarboxamido)-3-metilpiridin-2-il)benz oico.
IT1397912B1 (it) * 2010-01-28 2013-02-04 Chemi Spa Nuovo polimorfo dell'estere 6-dietilamminometil-2-naftilico dell'acido 4-idrossicarbamoil-fenil-carbammico cloridrato.
JP2013523833A (ja) 2010-04-07 2013-06-17 バーテックス ファーマシューティカルズ インコーポレイテッド ３−（６−（１−（２，２−ジフルオロベンゾ［ｄ］［１，３］ジオキソール−５−イル）シクロプロパンカルボキサミド）−３−メチルピリジン−２−イル）安息香酸の医薬組成物およびその投与
PL3068392T3 (pl) 2013-11-12 2021-07-19 Vertex Pharmaceuticals Incorporated Proces wytwarzania kompozycji farmaceutycznych do leczenia chorób, w których pośredniczy cftr
US20210052600A1 (en) 2017-12-27 2021-02-25 Takeda Pharmaceutical Company Limited Therapeutic agents for stress urinary incontinence and incotinence of feces

Family Cites Families (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2005A (en) * 1841-03-16 Improvement in the manner of constructing molds for casting butt-hinges
US2003A (en) * 1841-03-12 Improvement in horizontal windivhlls
US2004A (en) * 1841-03-12 Improvement in the manner of constructing and propelling steam-vessels
US2006A (en) * 1841-03-16 Clamp for crimping leather
US2554736A (en) * 1951-05-29 Tertiary aminoalkyl-iminodibenzyls
US3513239A (en) * 1967-03-15 1970-05-19 Smithkline Corp Pharmaceutical compositions containing 2-aminoalkyl coumaran derivatives and methods of treating depression therewith
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
US4314081A (en) * 1974-01-10 1982-02-02 Eli Lilly And Company Arloxyphenylpropylamines
NL7503310A (nl) * 1975-03-20 1976-09-22 Philips Nv Verbindingen met antidepressieve werking.
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
US4210754A (en) * 1977-02-01 1980-07-01 Hoffmann-La Roche Inc. Morpholino containing benzamides
US4205080A (en) * 1977-07-21 1980-05-27 Shell Oil Company 2,3-Dihydro benzofuran carboxamides
NL7906913A (nl) * 1979-09-17 1981-03-19 Tno Werkwijze en inrichting voor het tot stand brengen van een ionenstroom.
US4536518A (en) * 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4436371A (en) * 1981-06-24 1984-03-13 Donnelly Mirrors, Inc. Vehicle mirror assembly
US4535186A (en) * 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
US4992464A (en) * 1987-02-10 1991-02-12 Abbott Laboratories Heteroaryl N-hydroxy amides and ureas with polar substituents as 5-lipoxygenase inhibitors
US5223514A (en) * 1989-12-04 1993-06-29 G. D. Searle & Co. Quinolinyl/quinolinylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5212174A (en) * 1989-12-04 1993-05-18 G. D. Searle & Co. Quinoxalinyl/quinoxalinylakyl-N- terminal cycloalkoxy-C- terminal amino hydroxy β-amino acid derivatives
US5217988A (en) * 1989-12-04 1993-06-08 G. D. Searle & Co. Indolyl indolylakyl-N-terminal cycloalkoxy-C-terminal amino hydroxyβ-amino acid derivatives
US5216013A (en) * 1989-12-04 1993-06-01 G. D. Searle & Co. Aralkyl-N-terminal cycloalkoxy-C terminal amino hydroxy β-amino acid derivatives
US5231111A (en) * 1989-12-04 1993-07-27 G. D. Searle & Co. Imidazolyl/imidazolylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5223512A (en) * 1989-12-04 1993-06-29 G. D. Searle & Co. Quinolonyl/quinolonylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5217989A (en) * 1989-12-04 1993-06-08 G. D. Searle & Co. Benothiophenyl/benzothiophenylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5175170A (en) * 1989-12-04 1992-12-29 G. D. Searle & Co. β-amino acid derivatives
US5179102A (en) * 1989-12-04 1993-01-12 G. D. Searle & Co. Naphthyridinyl/naphthyridinylalkyl-n-terminal anino hydroxy β-amino acid derivatives
ES2067635T3 (es) * 1989-12-04 1995-04-01 Searle & Co Derivados heterociclicos de beta-aminoacidos acilaminodiolicos.
US5212175A (en) * 1989-12-04 1993-05-18 G. D. Searle & Co. Benzothiophenyl benzothiophenylalkyl-N-terminal amino hydroxy β-amino acid derivatives
US5180744A (en) * 1989-12-04 1993-01-19 G. D. Searle & Co. Aralkyl-N-terminal amino hydroxy
US5210095A (en) * 1989-12-04 1993-05-11 G. D. Searle & Co. Chromonyl/chromonylalkyl-N-terminal amino hydroxy
US5215996A (en) * 1989-12-04 1993-06-01 G. D. Searle & Co. Naphthyridinyl/naphthyridinylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5217991A (en) * 1989-12-04 1993-06-08 G. D. Searle & Co. Cycloalkyl/cycloalkylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5223532A (en) * 1989-12-04 1993-06-29 G. D. Searle & Co. Chromonyl/chromonylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino derivatives
US5180725A (en) * 1989-12-04 1993-01-19 G. D. Searle & Co. Quinoxalinyl/quinoxaliy; alkyl-N-terminal amino hydroxy
US5110825A (en) * 1989-12-28 1992-05-05 Shionogi & Co., Ltd. Benzofuran derivative
DE4200259A1 (de) * 1992-01-08 1993-07-15 Asta Medica Ag Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung
CA2116863A1 (en) * 1992-07-03 1994-01-20 Sumio Yokota Condensed heterocyclic derivatives and herbicides
US5436246A (en) * 1992-09-17 1995-07-25 Merrell Dow Pharmaceuticals Inc. Serotonin receptor agents
WO1994008962A1 (en) * 1992-10-14 1994-04-28 Merck & Co., Inc. Fibrinogen receptor antagonists
EP0674641B1 (en) * 1992-12-17 1999-03-03 Pfizer Inc. Pyrrolopyrimidines as crf antagonists
TW370529B (en) * 1992-12-17 1999-09-21 Pfizer Pyrazolopyrimidines
CA2150483C (en) * 1992-12-17 1999-09-14 Pfizer Limited Pyrazoles and pyrazolopyrimidines
US5292900A (en) * 1992-12-18 1994-03-08 Abbott Laboratories O-substituted N-hydroxyurea derivatives
DK0638071T3 (da) * 1992-12-28 1997-10-27 Eisai Co Ltd Heterocykliske carboxylsyrederivater, der bindes til retenoidreceptorer (RAR)
ES2174864T3 (es) * 1993-06-28 2002-11-16 Wyeth Corp Nuevos tratamientos que utilizan derivados de fenetilo.
US5705646A (en) * 1993-09-30 1998-01-06 Pfizer Inc. Substituted pyrazoles as CRF antagonists
GB9408577D0 (en) * 1994-04-29 1994-06-22 Fujisawa Pharmaceutical Co New compound
DK0765314T3 (da) * 1994-06-15 2003-08-25 Otsuka Pharma Co Ltd Benzoheterocykliske derivater, der kan anvendes som vasopressin- eller oxytocinmodulatorer
KR100186661B1 (ko) * 1994-07-07 1999-05-01 유미꾸라 레이이찌 신규 2,3-디히드로벤조푸란 유도체, 그의 제조 방법 및 용도
US6150402A (en) * 1994-08-15 2000-11-21 Loma Linda University Medical Center Natriuretic compounds
US5585492A (en) * 1994-10-11 1996-12-17 G. D. Searle & Co. LTA4 Hydrolase inhibitors
PT707007E (pt) * 1994-10-14 2002-06-28 Merck Patent Gmbh Derivados amino(tio)eter como agentes activos no snc
US6514996B2 (en) * 1995-05-19 2003-02-04 Kyowa Hakko Kogyo Co., Ltd. Derivatives of benzofuran or benzodioxole
CA2227985A1 (en) * 1995-08-21 1997-02-27 Takeda Chemical Industries, Ltd. Quinone compound, its production and use
TW359669B (en) * 1995-12-15 1999-06-01 Otsuka Pharma Co Ltd Benzazepine derivatives
CA2246336A1 (en) * 1996-02-13 1997-08-21 G.D. Searle & Co. Combinations, having immunosuppressive effects, containing a cyclooxygenase-2 inhibitor and a leukotriene a4 hydrolase inhibitor
US6274171B1 (en) * 1996-03-25 2001-08-14 American Home Products Corporation Extended release formulation of venlafaxine hydrochloride
HU225960B1 (en) * 1997-02-27 2008-01-28 Takeda Pharmaceutical Amine compounds, their production and use
US6194407B1 (en) * 1997-07-30 2001-02-27 American Home Products Corporation Tricyclic pyrido vasopressin agonists
US6262044B1 (en) * 1998-03-12 2001-07-17 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (PTPASES)
US6251936B1 (en) * 1998-05-12 2001-06-26 American Home Products Corporation Benzothiophenes, benzofurans, and indoles useful in the treatment of insulin resistance and hyperglycemia
CN1302293A (zh) * 1998-06-18 2001-07-04 诺瓦提斯公司 吲哚类化合物及其用途
US6090803A (en) * 1998-07-24 2000-07-18 American Home Products Corporation Tricyclic vasopressin agonists
GB9819035D0 (en) * 1998-09-01 1998-10-28 Cerebrus Res Ltd Chemical compounds VII
US6255324B1 (en) * 1998-11-25 2001-07-03 Ned D. Heindel Amino-and mercurio-substituted 4′,5'-dihydropsoralens and therapeutical uses thereof
US6048891A (en) * 1998-12-17 2000-04-11 Loma Linda University Medical Center Use of γ-tocopherol and its oxidative metabolite LLU-α in the treatment of natriuretic disease
US6410562B1 (en) * 1998-12-18 2002-06-25 Eli Lilly And Company Hypoglycemic imidazoline compounds
US7045545B1 (en) * 1999-01-27 2006-05-16 Eli Lilly And Company Aminoalkylbenzofurans as serotonin (5-HT(2c)) agonists
WO2000044737A1 (en) * 1999-01-27 2000-08-03 Eli Lilly And Company Aminoalkylbenzofurans as serotonin (5-ht(2c)) agonists
US7214540B2 (en) * 1999-04-06 2007-05-08 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
US6630006B2 (en) * 1999-06-18 2003-10-07 The Regents Of The University Of California Method for screening microcrystallizations for crystal formation
US7195670B2 (en) * 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
US7052545B2 (en) * 2001-04-06 2006-05-30 California Institute Of Technology High throughput screening of crystallization of materials
US7217321B2 (en) * 2001-04-06 2007-05-15 California Institute Of Technology Microfluidic protein crystallography techniques
AU2002228598A1 (en) * 2000-11-20 2002-06-03 Parallel Synthesis Technologies, Inc. Methods and devices for high throughput crystallization
AU2002338333A1 (en) * 2001-04-04 2002-10-21 Wyeth Methods for treating hyperactive gastric motility
WO2003016276A2 (en) * 2001-08-14 2003-02-27 Eli Lilly And Company 3-substituted oxindole beta-3 agonists
US6569894B1 (en) * 2001-10-04 2003-05-27 Bristol-Myers Squibb Company Arylalkylbenzofuran derivatives as melatonergic agents
JP2005505586A (ja) * 2001-10-04 2005-02-24 ワイス ５−ヒドロキシトリプタミン−６リガンドとしてのクロマン誘導体
US20030105830A1 (en) * 2001-12-03 2003-06-05 Duc Pham Scalable network media access controller and methods
US20030134835A1 (en) * 2002-01-11 2003-07-17 Arthur Hancock Histamine-3 receptor ligands for diabetes conditions
US7078541B2 (en) * 2002-02-07 2006-07-18 Galileo Pharmaceuticals, Inc. Benzofuran derivatives
US6860940B2 (en) * 2002-02-11 2005-03-01 The Regents Of The University Of California Automated macromolecular crystallization screening
US20040009976A1 (en) * 2002-04-30 2004-01-15 Kumiko Takeuchi Hypoglycemic imidazoline compounds
US20040097433A1 (en) * 2002-11-15 2004-05-20 Sekhar Boddupalli Chroman derivatives for the reduction of inflammation symptoms
DE10341533A1 (de) * 2003-09-09 2005-03-31 Bayer Chemicals Ag Verfahren zur Herstellung von halogenhaltigen 4-Aminophenolen
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US7728155B2 (en) * 2003-10-24 2010-06-01 Wyeth Llc Dihydrobenzofuranyl alkanamines and methods for using same as cns agents
GT200500296A (es) * 2004-10-21 2006-10-02 Sintesis asimetrica de derivados del dehidrobenzofurano
US7516224B2 (en) * 2004-10-21 2009-04-07 Cisco Technology, Inc. Pseudowire termination directly on a router
GT200500297A (es) * 2004-10-21 2006-10-27 Sintesis asimetrica de dehidrobenzofuranos sustituidos
US7593398B2 (en) * 2005-09-08 2009-09-22 Cisco Technology, Inc. Layer-two interworking applied to L2-L3 pseudowires
TW200815388A (en) * 2006-04-18 2008-04-01 Wyeth Corp Chromane and chromene derivatives and uses thereof

Also Published As

Publication number Publication date
US20060252825A1 (en) 2006-11-09
AR055054A1 (es) 2007-08-01
CA2603900A1 (en) 2006-11-02
BRPI0610785A2 (pt) 2016-09-13
TW200716583A (en) 2007-05-01
WO2006116218A1 (en) 2006-11-02
GT200600158A (es) 2006-11-28
AU2006239897A1 (en) 2006-11-02
EP1879875A1 (en) 2008-01-23
WO2006116218A8 (en) 2007-02-22
MX2007013179A (es) 2008-01-16
CN101163689A (zh) 2008-04-16
JP2008538581A (ja) 2008-10-30

Similar Documents

Publication Publication Date Title
PE20061319A1 (es) Cristales formados de clorhidrato de {[(2r)-7-(2,6-diclorofenil)-5-fluoro-2-3-dihidro-1-benzofurano-2-il]metil}amina
MX2009004900A (es) Arilamidas sustituidas por tiazol u oxazol.
ATE397605T1 (de) Nebivolol und dessen pharmazeutisch unbedenkliche salze, herstellungsverfahren und pharmazeutische zusammensetzungen von nebivolol
GEP20094723B (en) Tetraazabenzo [e] azulene derivatives and analogs thereof
EA201101672A1 (ru) Замещенные производные аминомасляной кислоты в качестве ингибиторов неприлизина
TW200621249A (en) Substituted amide beta secretase inhibitors
BRPI0507329A (pt) polimorfos cristalinos de um ligante do receptor de cxc-quimiocina
WO2005051946A3 (en) Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
MY139296A (en) CRYSTALLINE ß2 ADRENERGIC RECEPTOR AGONIST
MXPA05009367A (es) Antagonistas del receptor opioide.
TR201903556T4 (tr) Muskarinik reseptör antagonisti ve beta 2 adrenerjik reseptör agonisti aktivitesine sahip diamid bileşikleri.
CY1111275T1 (el) Κρυσταλλικη μορφη μιας ενωσης κινολινονης-καρβοξαμιδιου
GEP20104964B (en) 3-aminocarbazole compounds, pharmaceutical composition containing the same and method for the preparation thereof
TW200531694A (en) Acetylinic piperazine compounds and their use as metabotropic glutamate receptor antagonists
ATE475640T1 (de) Antagonisten des opioidrezeptors
PL1831152T3 (pl) Pochodne tetraliny i indanu oraz ich zastosowanie jako antagonistów 5-HT
HUP0302553A2 (hu) Egy izotiazol-4-karbonsavamid sói és eljárás az előállításukra és ezek alkalmazására a túlzott mértékű sejtburjánzás visszaszorítására alkalmas gyógyszerkészítmények előállítására
MY169274A (en) Fused, tricyclic sulfonamide inhibitors of gamma secretase
WO2007002764A3 (en) Di-substituted oxadiazoles as cxc-chemokine receptor ligands
WO2007125398A3 (en) : sulfonamide compounds as antagonists of the n-type calcium channel
NO20074622L (no) Metabolitter for NK-1 antagonister for brekninger
WO2007070865A3 (en) Piperazine compounds as agonists of trpv4 channel receptors
ATE399164T1 (de) Antagonisten des opioidrezeptors
WO2004014906A3 (en) Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents
NO20080671L (no) Bisykliske piperaziner som metabotrofiske glutamatreseptorantagonister

Legal Events

Date Code Title Description
FC Refusal