PA8650501A1 - Sintesis asimetrica de derivados de dihidrobenzofurano - Google Patents

Sintesis asimetrica de derivados de dihidrobenzofurano

Info

Publication number
PA8650501A1
PA8650501A1 PA20058650501A PA8650501A PA8650501A1 PA 8650501 A1 PA8650501 A1 PA 8650501A1 PA 20058650501 A PA20058650501 A PA 20058650501A PA 8650501 A PA8650501 A PA 8650501A PA 8650501 A1 PA8650501 A1 PA 8650501A1
Authority
PA
Panama
Prior art keywords
asymmetric synthesis
dihydrobenzofuran derivatives
derivatives
dihydrobenzofuran
asymmetric
Prior art date
Application number
PA20058650501A
Other languages
English (en)
Inventor
Gary Paul Stack
Dahui Zhou
Alexander V Gontcharov
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PA8650501A1 publication Critical patent/PA8650501A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

ESTA INVENCION SE REFIERE A UN PROCESO PARA LA PREPARACION DE DERIVADOS DE BENZOFURANO. EN ALGUNOS ASPECTOS, ESTOS COMPUESTOS DE LA FORMULA I: EN DONDE CADA R1, R3 Y R4 ES COMO SE DEFINE AQUI.
PA20058650501A 2004-10-21 2005-10-21 Sintesis asimetrica de derivados de dihidrobenzofurano PA8650501A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62102304P 2004-10-21 2004-10-21

Publications (1)

Publication Number Publication Date
PA8650501A1 true PA8650501A1 (es) 2006-07-03

Family

ID=35965910

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20058650501A PA8650501A1 (es) 2004-10-21 2005-10-21 Sintesis asimetrica de derivados de dihidrobenzofurano

Country Status (14)

Country Link
US (1) US20060089405A1 (es)
EP (1) EP1802598A2 (es)
JP (1) JP2008517929A (es)
CN (1) CN101107238A (es)
AR (1) AR053980A1 (es)
AU (1) AU2005299757A1 (es)
BR (1) BRPI0516236A (es)
CA (1) CA2584775A1 (es)
GT (1) GT200500296A (es)
MX (1) MX2007004637A (es)
PA (1) PA8650501A1 (es)
PE (1) PE20061033A1 (es)
TW (1) TW200619215A (es)
WO (1) WO2006047288A2 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
GT200500297A (es) * 2004-10-21 2006-10-27 Sintesis asimetrica de dehidrobenzofuranos sustituidos
CN101218223A (zh) * 2005-04-22 2008-07-09 惠氏公司 苯并二烷和苯并二氧戊环衍生物及其应用
US20060258713A1 (en) * 2005-04-22 2006-11-16 Wyeth Treatment of pain
PE20061318A1 (es) * 2005-04-22 2006-12-28 Wyeth Corp Nuevas combinaciones terapeuticas para el tratamiento o la prevencion de trastornos psicoticos
JP2008538576A (ja) * 2005-04-22 2008-10-30 ワイス クロマンおよびクロメン誘導体およびその使用
BRPI0610037A2 (pt) * 2005-04-22 2010-05-25 Wyeth Corp derivados de dihidrobenzofurano e uso dos mesmos
AR054347A1 (es) * 2005-04-22 2007-06-20 Wyeth Corp Combinaciones terapeuticas para el tratamiento o la prevencion de la depresion
EP1879875A1 (en) * 2005-04-22 2008-01-23 Wyeth Crystal forms opf {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride
AU2006239910A1 (en) * 2005-04-22 2006-11-02 Wyeth Dihydrobenzofuran derivatives and uses thereof
JP2008538573A (ja) * 2005-04-22 2008-10-30 ワイス ベンゾフラニルアルカナミン誘導体およびその５−ｈｔ２ｃアゴニストとしての使用
AR056980A1 (es) * 2005-04-22 2007-11-07 Wyeth Corp Derivados de dihidrobenzofurano, composiciones farmaceuticas, y uso de los mismos
GT200600162A (es) * 2005-04-24 2007-03-14 Metodos para modular la funcion de la vejiga
AU2007230977A1 (en) * 2006-03-24 2007-10-04 Wyeth Methods for treating cognitive and other disorders
WO2012030953A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
GB2486631A (en) * 2010-12-01 2012-06-27 Univ Sheffield Phenol/quinone boronic acids/esters and method of preparation thereof
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
CN109776465B (zh) * 2019-03-22 2023-06-06 国网湖南省电力有限公司 一种具有c2季碳中心的苯并二氢呋喃衍生物的合成方法
CN110283150A (zh) * 2019-07-12 2019-09-27 南开大学 一类手性二氢苯并呋喃的不对称合成方法
EP3878447A1 (en) 2020-03-11 2021-09-15 InterAx Biotech AG Beta adrenergic receptor antagonists
CN114560754A (zh) * 2022-02-25 2022-05-31 滁州学院 一种烷基醇的制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100327264B1 (ko) * 1993-10-29 2002-07-02 요시히로 미와 인돌유도체,그의염및이를함유하는심질환치료제
US5798382A (en) * 1994-07-07 1998-08-25 Asahi Kasei Kogyo Kabushiki Kaisha 2,3-dihydrobenzofuran derivatives, method for producing the same, and use thereof
JPH09227562A (ja) * 1996-02-23 1997-09-02 Kowa Co インドール誘導体の製造法
JP2000007671A (ja) * 1998-06-25 2000-01-11 Asahi Chem Ind Co Ltd ２，３−ジヒドロベンゾフラン誘導体
JP2000080091A (ja) * 1998-06-26 2000-03-21 Asahi Chem Ind Co Ltd ２，３―ジヒドロベンゾフラン誘導体の製造方法
CN1564818A (zh) * 2001-10-05 2005-01-12 惠氏公司 2－羟甲基－苯并二氢吡喃的立体选择性合成方法
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US7728155B2 (en) * 2003-10-24 2010-06-01 Wyeth Llc Dihydrobenzofuranyl alkanamines and methods for using same as cns agents
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US7516224B2 (en) * 2004-10-21 2009-04-07 Cisco Technology, Inc. Pseudowire termination directly on a router
GT200500297A (es) * 2004-10-21 2006-10-27 Sintesis asimetrica de dehidrobenzofuranos sustituidos
AR054347A1 (es) * 2005-04-22 2007-06-20 Wyeth Corp Combinaciones terapeuticas para el tratamiento o la prevencion de la depresion
WO2006116148A2 (en) * 2005-04-22 2006-11-02 Wyeth (7-arlysubstituted 2, 3-dihydr0-1-benz0furan-2-yl) alkylamines in the treatment' of substance abuse
AU2006239910A1 (en) * 2005-04-22 2006-11-02 Wyeth Dihydrobenzofuran derivatives and uses thereof
CN101218223A (zh) * 2005-04-22 2008-07-09 惠氏公司 苯并二烷和苯并二氧戊环衍生物及其应用
EP1879875A1 (en) * 2005-04-22 2008-01-23 Wyeth Crystal forms opf {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride
US20060258713A1 (en) * 2005-04-22 2006-11-16 Wyeth Treatment of pain
BRPI0610037A2 (pt) * 2005-04-22 2010-05-25 Wyeth Corp derivados de dihidrobenzofurano e uso dos mesmos
PE20061318A1 (es) * 2005-04-22 2006-12-28 Wyeth Corp Nuevas combinaciones terapeuticas para el tratamiento o la prevencion de trastornos psicoticos
JP2008538576A (ja) * 2005-04-22 2008-10-30 ワイス クロマンおよびクロメン誘導体およびその使用
AR056980A1 (es) * 2005-04-22 2007-11-07 Wyeth Corp Derivados de dihidrobenzofurano, composiciones farmaceuticas, y uso de los mismos
JP2008538573A (ja) * 2005-04-22 2008-10-30 ワイス ベンゾフラニルアルカナミン誘導体およびその５−ｈｔ２ｃアゴニストとしての使用
GT200600162A (es) * 2005-04-24 2007-03-14 Metodos para modular la funcion de la vejiga
US7593398B2 (en) * 2005-09-08 2009-09-22 Cisco Technology, Inc. Layer-two interworking applied to L2-L3 pseudowires

Also Published As

Publication number Publication date
WO2006047288A3 (en) 2007-03-15
CA2584775A1 (en) 2006-05-04
AR053980A1 (es) 2007-05-30
PE20061033A1 (es) 2006-11-08
WO2006047288A2 (en) 2006-05-04
MX2007004637A (es) 2007-06-08
EP1802598A2 (en) 2007-07-04
US20060089405A1 (en) 2006-04-27
TW200619215A (en) 2006-06-16
AU2005299757A1 (en) 2006-05-04
CN101107238A (zh) 2008-01-16
BRPI0516236A (pt) 2008-08-26
JP2008517929A (ja) 2008-05-29
GT200500296A (es) 2006-10-02

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