AR052175A1 - Sulfonamido-macrociclos y sus sales, una composicion farmaceutica que comprende estos compuestos, un metodo de preparacion y el uso de los mismos - Google Patents
Sulfonamido-macrociclos y sus sales, una composicion farmaceutica que comprende estos compuestos, un metodo de preparacion y el uso de los mismosInfo
- Publication number
- AR052175A1 AR052175A1 ARP050105399A ARP050105399A AR052175A1 AR 052175 A1 AR052175 A1 AR 052175A1 AR P050105399 A ARP050105399 A AR P050105399A AR P050105399 A ARP050105399 A AR P050105399A AR 052175 A1 AR052175 A1 AR 052175A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- atoms
- aryl
- halogen
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Sulfonamido-macrociclos y sus sales, una composicion farmacéutica que comprende estos compuestos, un método de preparacion y el uso de los mismos, así como su uso para fabricar una composicion farmacéutica para el tratamiento de enfermedades de crecimiento vascular desregulado o de enfermedades acompanadas por un crecimiento vascular desregulado, donde los compuestos interfieren en forma efectiva con la angiopoyetina y por lo tanto afectan la senalizacion de Tie2. Reivindicacion 1: Un compuesto caracterizado porque responde a la formula general (1) en donde R1 es H y C1-10 alquilo; R2 se selecciona del grupo compuesto preferentemente por H, halogeno, ciano, -NR4COR5, -NR4S(O)2R%, -NR4CONR5R6, -NR4COOR5, - COR4, -S(O)2R4, - (O)2NR4R5 y-CONR4R5; R3 se selecciona del grupo compuesto preferentemente por alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-8, arilo C6-11 y heteroarilo C5-10, donde dichos residuos no están sustituidos o están mono-o polisustituidos independientemente con hidroxi, halogeno,. C1-6 alcoxi, C1-6 alquiltio, amino, C1-6 alquilo, C1-6 hidroxialquilo, C2-6 alquenilo, C2-6 alquinilo, C1-6 alcoxi-C1-6 alquilo, -NH-C1-6 alquilo, -N(C1-6 alquilo)2, -S(O)2(C1-6 alquilo), C1-6 alcanoílo, - CONR4R5, -COR4, C6-11 arilo, C5-10 heteroarilo y/o -NR4R5, donde C6-11 arilo y C5-10 heteroarilo no sustituidos o mono- o polisustituidos independientemente con halogeno, hidroxi, C1-6 alquilo, C1-6 alcoxi, -CF3 o -OCF3 y donde 1 o más átomos de C de la cadena principal de C del -C3-8 cicloalquilo están opcionalmente mono o polisustituidos independientemente por átomos de N, átomos de O, átomos de S y/o residuos C=O; o fenil-(CH2)p-COR4 o fenil-(CH2)p-CONR4R5 opcionalmente sustituido, donde p es un numero entero de 1 a 4, preferentemente 1 a3, más preferentemente 1 o 2; R4, R5 y R6 son iguales o diferentes y se seleccionan independientemente entre sí del grupo compuesto preferentemente por H y residuos seleccionados del grupo compuesto preferentemente por alquilo C1-10, alcoxi C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-8, arilo C6-11 y heteroarilo C5-10, donde dichos residuos no están sustituidos o están mono- o polisustituidos independientemente con hidroxi, halogeno, - C1-6 alcoxi, -C1-6 alquiltio, amino, -C1-6 alquilo, -C3-10 cicloalquilo, C1-6 hidroxialquilo, -C2-6 alquenilo, -C2-6 alquinilo, -C1-6 alcoxi-C1-6 alquilo, -NH-C1-6 alquilo, -N(C1-6 alquilo)2, -S(O)2(C1-6 alquilo), - S(O)2(C1-6 alquilo), -C1-6 alcanoílo, CONR7R8, -COR7, carboxi, C6-11 arilo, C5-10 heteroarilo o -NR7R8; donde C6-11 arilo y C5-10 heteroarilo no sustituidos o mono- o polisustituidos independientemente con halogeno, hidroxi, -C1-6 alquilo, -C1-6 alcoxi, -CF3 o -OCF3 y donde 1 o más átomos de C de la cadena principal de C del -C3-8 cicloalquilo están opcionalmente mono o polisustituidos independientemente por átomos de N, átomos de O, átomos de S y/o residuos C=O; R7 y R8 son iguales o diferentes y se seleccionan independientemente entre sí del grupo compuesto preferentemente por C1-6 alquilo o fenilo, opcionalmente sustituido con halogeno, hidroxi, C1-6 alquilo, C1-6 alcoxi, fenilo, -CF3 y -OCF3; y solvatos, hidratos, N-oxidos, isomeros, diastereomeros, enantiomeros y sales de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04090509A EP1674470A1 (en) | 2004-12-22 | 2004-12-22 | Sulfonamido-macrocycles as Tie2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR052175A1 true AR052175A1 (es) | 2007-03-07 |
Family
ID=34928853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050105399A AR052175A1 (es) | 2004-12-22 | 2005-12-21 | Sulfonamido-macrociclos y sus sales, una composicion farmaceutica que comprende estos compuestos, un metodo de preparacion y el uso de los mismos |
Country Status (15)
| Country | Link |
|---|---|
| EP (2) | EP1674470A1 (es) |
| JP (1) | JP2008524303A (es) |
| KR (1) | KR20070099619A (es) |
| CN (1) | CN101087798A (es) |
| AR (1) | AR052175A1 (es) |
| AU (1) | AU2005318361A1 (es) |
| BR (1) | BRPI0519268A2 (es) |
| CA (1) | CA2590742A1 (es) |
| GT (1) | GT200500383A (es) |
| IL (1) | IL182834A0 (es) |
| NO (1) | NO20073818L (es) |
| PA (1) | PA8658001A1 (es) |
| PE (1) | PE20060881A1 (es) |
| TW (1) | TW200635935A (es) |
| WO (1) | WO2006066957A2 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1870416A1 (en) * | 2006-06-21 | 2007-12-26 | Bayer Schering Pharma Aktiengesellschaft | Sulphonamido-macrocycles as tie2 inhibitors |
| EP1873159A1 (en) * | 2006-06-21 | 2008-01-02 | Bayer Schering Pharma Aktiengesellschaft | Substituted sulphonamido-macrocycles as Tie2 inhibitors and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same |
| US8871753B2 (en) | 2008-04-24 | 2014-10-28 | Incyte Corporation | Macrocyclic compounds and their use as kinase inhibitors |
| AU2009262199B2 (en) | 2008-06-27 | 2012-08-09 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
| WO2017055196A1 (en) | 2015-09-29 | 2017-04-06 | Bayer Pharma Aktiengesellschaft | Novel macrocyclic sulfondiimine compounds |
| JP6888000B2 (ja) * | 2015-10-08 | 2021-06-16 | バイエル ファーマ アクチエンゲゼルシャフト | 新規な修飾された大環状化合物 |
| WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
| US11254690B2 (en) | 2017-03-28 | 2022-02-22 | Bayer Pharma Aktiengesellschaft | PTEFb inhibiting macrocyclic compounds |
| CA3057891A1 (en) | 2017-03-28 | 2018-10-04 | Bayer Aktiengesellschaft | Novel ptefb inhibiting macrocyclic compounds |
| CN115677616A (zh) * | 2021-11-03 | 2023-02-03 | 中国药科大学 | 大环磺酰胺类化合物及其制备方法和医药用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1487824B1 (en) * | 2002-03-01 | 2007-06-20 | SmithKline Beecham Corporation | Diamino-pyrimidines and their use as angiogenesis inhibitors |
| DE10239042A1 (de) * | 2002-08-21 | 2004-03-04 | Schering Ag | Makrozyclische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel |
-
2004
- 2004-12-22 EP EP04090509A patent/EP1674470A1/en not_active Withdrawn
-
2005
- 2005-12-19 EP EP05820679A patent/EP1844056A2/en not_active Withdrawn
- 2005-12-19 CA CA002590742A patent/CA2590742A1/en not_active Abandoned
- 2005-12-19 WO PCT/EP2005/013957 patent/WO2006066957A2/en active Application Filing
- 2005-12-19 CN CNA2005800443140A patent/CN101087798A/zh active Pending
- 2005-12-19 AU AU2005318361A patent/AU2005318361A1/en not_active Abandoned
- 2005-12-19 BR BRPI0519268-4A patent/BRPI0519268A2/pt not_active Application Discontinuation
- 2005-12-19 JP JP2007547386A patent/JP2008524303A/ja active Pending
- 2005-12-19 KR KR1020077016661A patent/KR20070099619A/ko not_active Application Discontinuation
- 2005-12-21 GT GT200500383A patent/GT200500383A/es unknown
- 2005-12-21 TW TW094145438A patent/TW200635935A/zh unknown
- 2005-12-21 AR ARP050105399A patent/AR052175A1/es not_active Application Discontinuation
- 2005-12-22 PA PA20058658001A patent/PA8658001A1/es unknown
-
2006
- 2006-01-03 PE PE2006000007A patent/PE20060881A1/es not_active Application Discontinuation
-
2007
- 2007-04-26 IL IL182834A patent/IL182834A0/en unknown
- 2007-07-20 NO NO20073818A patent/NO20073818L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0519268A2 (pt) | 2009-01-06 |
| PE20060881A1 (es) | 2006-10-01 |
| WO2006066957A3 (en) | 2006-08-31 |
| CA2590742A1 (en) | 2006-06-29 |
| EP1674470A1 (en) | 2006-06-28 |
| EP1844056A2 (en) | 2007-10-17 |
| TW200635935A (en) | 2006-10-16 |
| AU2005318361A1 (en) | 2006-06-29 |
| IL182834A0 (en) | 2007-08-19 |
| KR20070099619A (ko) | 2007-10-09 |
| NO20073818L (no) | 2007-09-21 |
| JP2008524303A (ja) | 2008-07-10 |
| WO2006066957A2 (en) | 2006-06-29 |
| PA8658001A1 (es) | 2006-09-22 |
| CN101087798A (zh) | 2007-12-12 |
| GT200500383A (es) | 2006-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |