DE60220778T2 - 3,4-disubstituierte cyclobuten-1,2-dione als cxc-chemokinrezeptorliganden - Google Patents

3,4-disubstituierte cyclobuten-1,2-dione als cxc-chemokinrezeptorliganden Download PDF

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Publication number
DE60220778T2
DE60220778T2 DE60220778T DE60220778T DE60220778T2 DE 60220778 T2 DE60220778 T2 DE 60220778T2 DE 60220778 T DE60220778 T DE 60220778T DE 60220778 T DE60220778 T DE 60220778T DE 60220778 T2 DE60220778 T2 DE 60220778T2
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substituted
group
unsubstituted
alkyl
groups
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English (en)
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DE60220778D1 (en
Inventor
Arthur G. Denville TAVERAS
Cynthia J. Livingston AKI
Richard W. Union BOND
Jianping Summit CHAO
Michael Scotch Plains DWYER
Johan A. Bensalem FERREIRA
Jianhua Pompton Lakes CHAO
Younong Piscataway YU
John J. Gwynedd Valley BALDWIN
Bernd Wallingford KAISER
Ge Li
J. Robert Ewing MERRITT
Kingsley H. Mebane NELSON
Laura L. Union ROKOSZ
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Merck Sharp and Dohme LLC
Pharmacopeia LLC
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Pharmacopeia Drug Discovery Inc
Schering Corp
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
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  • Dermatology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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  • Rheumatology (AREA)
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  • Urology & Nephrology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
DE60220778T 2001-04-16 2002-04-15 3,4-disubstituierte cyclobuten-1,2-dione als cxc-chemokinrezeptorliganden Expired - Lifetime DE60220778T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28402601P 2001-04-16 2001-04-16
US284026P 2001-04-16
PCT/US2002/012681 WO2002083624A1 (en) 2001-04-16 2002-04-15 3,4-di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands

Publications (2)

Publication Number Publication Date
DE60220778D1 DE60220778D1 (en) 2007-08-02
DE60220778T2 true DE60220778T2 (de) 2008-03-06

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Application Number Title Priority Date Filing Date
DE60220778T Expired - Lifetime DE60220778T2 (de) 2001-04-16 2002-04-15 3,4-disubstituierte cyclobuten-1,2-dione als cxc-chemokinrezeptorliganden
DE60235507T Expired - Lifetime DE60235507D1 (de) 2001-04-16 2002-04-15 3,4-DI-substituierte Cyclobuten-1,2-Dione als CXC-Chemokin-Rezeptorliganden

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DE60235507T Expired - Lifetime DE60235507D1 (de) 2001-04-16 2002-04-15 3,4-DI-substituierte Cyclobuten-1,2-Dione als CXC-Chemokin-Rezeptorliganden

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EP (2) EP1381590B1 (enExample)
JP (3) JP4499993B2 (enExample)
KR (2) KR100952531B1 (enExample)
CN (2) CN1289471C (enExample)
AR (1) AR035825A1 (enExample)
AT (2) ATE458715T1 (enExample)
AU (3) AU2002311841B2 (enExample)
BR (1) BRPI0208957B8 (enExample)
CA (1) CA2444031C (enExample)
CY (2) CY1109908T1 (enExample)
CZ (1) CZ20032831A3 (enExample)
DE (2) DE60220778T2 (enExample)
DK (2) DK1381590T3 (enExample)
EC (1) ECSP034809A (enExample)
ES (2) ES2287284T3 (enExample)
HU (1) HUP0401783A3 (enExample)
IL (3) IL158262A0 (enExample)
MX (1) MXPA03009441A (enExample)
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Families Citing this family (75)

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Publication number Priority date Publication date Assignee Title
US7132445B2 (en) 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US20040106794A1 (en) 2001-04-16 2004-06-03 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
JP2005505595A (ja) 2001-10-12 2005-02-24 シェーリング　コーポレイション Ｃｘｃ−ケモカインレセプターアンタゴニストとしての３，４−二置換マレイミド化合物
US8246969B2 (en) 2001-11-16 2012-08-21 Skinmedica, Inc. Compositions containing aromatic aldehydes and their use in treatments
US6878709B2 (en) 2002-01-04 2005-04-12 Schering Corporation 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
CN100444839C (zh) * 2002-03-18 2008-12-24 先灵公司 式(i)化合物在制备治疗化学激活物中介的疾病的药物中的应用
GB0218326D0 (en) * 2002-08-07 2002-09-11 Glaxo Group Ltd Compounds
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