MY149050A - 3,4 di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands - Google Patents

3,4 di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands

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Publication number
MY149050A
MY149050A MYPI20070922A MYPI20070922A MY149050A MY 149050 A MY149050 A MY 149050A MY PI20070922 A MYPI20070922 A MY PI20070922A MY PI20070922 A MYPI20070922 A MY PI20070922A MY 149050 A MY149050 A MY 149050A
Authority
MY
Malaysia
Prior art keywords
cxc
diones
chemokine receptor
receptor ligands
substituted cyclobutene
Prior art date
Application number
MYPI20070922A
Other languages
English (en)
Inventor
Arthur G Taveras
Kaiser Bernd
Li Ge
Merritt J Robert
Kingsley H Nelson Jr
Laura L Rokosz
Cynthia J Aki
Richard W Bond
Chao Jianping
Dwyer Michael
Ferreira Johan
Chao Jianhua
Yu Younong
John J Baldwin
Original Assignee
Merck Sharp & Dohme
Pharmacopeia Drug Discovery
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme, Pharmacopeia Drug Discovery filed Critical Merck Sharp & Dohme
Publication of MY149050A publication Critical patent/MY149050A/en

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
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    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
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  • Communicable Diseases (AREA)
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  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • AIDS & HIV (AREA)
  • Otolaryngology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
MYPI20070922A 2001-04-16 2002-04-15 3,4 di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands MY149050A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28402601P 2001-04-16 2001-04-16

Publications (1)

Publication Number Publication Date
MY149050A true MY149050A (en) 2013-07-15

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ID=23088576

Family Applications (2)

Application Number Title Priority Date Filing Date
MYPI20021372A MY138202A (en) 2001-04-16 2002-04-15 3,4 di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands
MYPI20070922A MY149050A (en) 2001-04-16 2002-04-15 3,4 di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands

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MYPI20021372A MY138202A (en) 2001-04-16 2002-04-15 3,4 di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands

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JP (3) JP4499993B2 (enExample)
KR (2) KR20100008794A (enExample)
CN (2) CN1289471C (enExample)
AR (1) AR035825A1 (enExample)
AT (2) ATE458715T1 (enExample)
AU (3) AU2002311841B2 (enExample)
BR (1) BRPI0208957B8 (enExample)
CA (1) CA2444031C (enExample)
CY (2) CY1109908T1 (enExample)
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DK (2) DK1381590T3 (enExample)
EC (1) ECSP034809A (enExample)
ES (2) ES2340207T3 (enExample)
HU (1) HUP0401783A3 (enExample)
IL (3) IL158262A0 (enExample)
MX (1) MXPA03009441A (enExample)
MY (2) MY138202A (enExample)
NO (2) NO330790B1 (enExample)
NZ (3) NZ529551A (enExample)
PE (1) PE20021084A1 (enExample)
PL (2) PL207255B1 (enExample)
PT (2) PT1818325E (enExample)
RU (1) RU2344123C9 (enExample)
SI (2) SI1381590T1 (enExample)
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TW (2) TWI316930B (enExample)
WO (1) WO2002083624A1 (enExample)
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MXPA04003439A (es) 2001-10-12 2004-07-08 Schering Corp Compuestos de maleimida 3,4 disustituidos como antagonistas de receptor de quimiocina cxc.
US8246969B2 (en) 2001-11-16 2012-08-21 Skinmedica, Inc. Compositions containing aromatic aldehydes and their use in treatments
US6878709B2 (en) 2002-01-04 2005-04-12 Schering Corporation 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
BR0308739A (pt) * 2002-03-18 2005-01-11 Schering Corp Tratamentos em combinação para doenças mediadas por quimiocina
GB0218326D0 (en) * 2002-08-07 2002-09-11 Glaxo Group Ltd Compounds
ATE422203T1 (de) 2002-10-09 2009-02-15 Schering Corp Thiadiazoldioxide und thiadiazoloxide als cxc- und cc-chemokinrezeptor liganden
GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
WO2004087153A2 (en) * 2003-03-28 2004-10-14 Chiron Corporation Use of organic compounds for immunopotentiation
BRPI0408420A (pt) * 2003-04-03 2006-03-21 Merck Patent Gmbh compostos de carbonila
ES2338657T3 (es) * 2003-04-18 2010-05-11 Schering Corporation Sintesis de 2-hydroxi-n,n-dimetil-3-((2-((1(r)-(5-metil-2-furanil)propil)amino)-3,4-dioxo-1-ciclobuten-1-il)amino)benzamida.
BRPI0412259B1 (pt) 2003-07-22 2019-08-20 Astex Therapeutics Limited Compostos de 1H-pirazol 3,4-dissubstituídos como moduladores de quinases dependentes de ciclina (CDK), seus usos, processo para a preparação dos mesmos e composição farmacêutica
GB0320983D0 (en) * 2003-09-08 2003-10-08 Biofocus Plc Compound libraries
JP2007505864A (ja) 2003-09-23 2007-03-15 フェルミオン オサケ ユキチュア クエチアピンの製造
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