ATE457307T1 - Synthese von 2-hydroxy-n,n-dimethyl-3-[[2-[1(r)- (5-methyl-2-furanyl)propyl amino -3,4-dioxo-1- cyclobuten-1-yl amino benzamid - Google Patents
Synthese von 2-hydroxy-n,n-dimethyl-3-[[2-[1(r)- (5-methyl-2-furanyl)propyl amino -3,4-dioxo-1- cyclobuten-1-yl amino benzamidInfo
- Publication number
- ATE457307T1 ATE457307T1 AT04759956T AT04759956T ATE457307T1 AT E457307 T1 ATE457307 T1 AT E457307T1 AT 04759956 T AT04759956 T AT 04759956T AT 04759956 T AT04759956 T AT 04759956T AT E457307 T1 ATE457307 T1 AT E457307T1
- Authority
- AT
- Austria
- Prior art keywords
- amino
- cyclobuten
- dioxo
- furanyl
- hydroxy
- Prior art date
Links
- AZEDKKBQQPVYQU-UHFFFAOYSA-N C(C1=CC=CC=C1)(=O)N(C1=C(C(C1=O)=O)N)N Chemical compound C(C1=CC=CC=C1)(=O)N(C1=C(C(C1=O)=O)N)N AZEDKKBQQPVYQU-UHFFFAOYSA-N 0.000 title 1
- OCBFFGCSTGGPSQ-UHFFFAOYSA-N [CH2]CC Chemical compound [CH2]CC OCBFFGCSTGGPSQ-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Furan Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46377303P | 2003-04-18 | 2003-04-18 | |
| PCT/US2004/011882 WO2004094398A2 (en) | 2003-04-18 | 2004-04-16 | Synthesis of 2-hydroxy-n,n-dimethyl-3-[[2-[1(r)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE457307T1 true ATE457307T1 (de) | 2010-02-15 |
Family
ID=33310818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04759956T ATE457307T1 (de) | 2003-04-18 | 2004-04-16 | Synthese von 2-hydroxy-n,n-dimethyl-3-[[2-[1(r)- (5-methyl-2-furanyl)propyl amino -3,4-dioxo-1- cyclobuten-1-yl amino benzamid |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7071342B2 (de) |
| EP (2) | EP2168956B8 (de) |
| JP (2) | JP4440917B2 (de) |
| CN (3) | CN101514168B (de) |
| AR (1) | AR044027A1 (de) |
| AT (1) | ATE457307T1 (de) |
| CA (1) | CA2522748C (de) |
| DE (1) | DE602004025458D1 (de) |
| ES (1) | ES2338657T3 (de) |
| HK (1) | HK1078315A1 (de) |
| MX (1) | MXPA05011183A (de) |
| SG (1) | SG167671A1 (de) |
| WO (1) | WO2004094398A2 (de) |
| ZA (3) | ZA200508129B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040106794A1 (en) * | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| NZ548499A (en) * | 2004-01-30 | 2010-06-25 | Schering Corp | Crystalline polymorphs of a CXC-chemokine receptor ligand |
| CL2007001714A1 (es) | 2006-06-12 | 2008-01-18 | Schering Corp | Composicion farmaceutica que comprende 2-hidroxi-n,n-dimetil-3-[[2-[[1(r)-5-metil-2-furanil)propil]amino]-3,4-dioxi-1-ciclobuteno-1-il]amino]benzamida y al menos un excipiente seleccionado de un agente humectante, un aglutinante, un disolvente y un desintegrante, util para tratar una enfermedad inflamatoria tal como artritis y asma. |
| WO2009005801A1 (en) * | 2007-07-03 | 2009-01-08 | Schering Corporation | Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds |
| JP2010532357A (ja) * | 2007-07-05 | 2010-10-07 | シェーリング コーポレイション | １，２−置換３，４−ジオキソ−１−シクロブテン化合物における制御された結晶サイズのための方法 |
| WO2011158959A1 (ja) | 2010-06-16 | 2011-12-22 | 帝人株式会社 | 環状カルボジイミド化合物の中間体の製造方法 |
| WO2012147897A1 (ja) * | 2011-04-25 | 2012-11-01 | 住友化学株式会社 | アミン化合物の製造方法 |
| TWI724056B (zh) | 2015-11-19 | 2021-04-11 | 美商卡默森屈有限公司 | Ｃｘｃｒ２抑制劑 |
| TWI734715B (zh) | 2015-11-19 | 2021-08-01 | 美商卡默森屈有限公司 | 趨化因子受體調節劑 |
| US11052065B2 (en) | 2017-09-27 | 2021-07-06 | Merck Sharp & Dohme Corp. | Compositions and methods for treating cancer with a combination of programmed death receptor (PD-1) antibodies and a CXCR2 antagonist |
| MA50424A (fr) | 2018-01-08 | 2020-08-26 | Chemocentryx Inc | Méthodes de traitement du psoriasis pustuleux généralisé avec un antagoniste de ccr6 ou cxcr2 |
| TW202128643A (zh) * | 2019-11-11 | 2021-08-01 | 美商富曼西公司 | 用於製備３—溴—１—（３—氯吡啶—２—基）—１ｈ—吡唑—５—羧酸乙酯的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2791613A (en) * | 1953-08-24 | 1957-05-07 | Columbia Southern Chem Corp | Metahaloaniline production using copper oxide-chromic oxide catalysts |
| CH691112A5 (de) | 1995-03-14 | 2001-04-30 | Sumitomo Chemical Co | Verfahren zur Herstellung von Kristallen eines Schwefelsäuresalzes des 3-Amino-2-hydroxyacetophenons mit hoher Schüttdiche und verbesserten Fliesseigenschaften . |
| ZA991105B (en) * | 1998-03-04 | 2000-02-11 | Searle & Co | Synthesis of chiral beta-amino acids. |
| US20030204085A1 (en) * | 2001-02-02 | 2003-10-30 | Taveras Arthur G. | 3, 4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor antagonists |
| US20030097004A1 (en) * | 2001-02-02 | 2003-05-22 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC chemokine receptor antagonists |
| US20040106794A1 (en) * | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| MXPA03009441A (es) * | 2001-04-16 | 2004-02-12 | Schering Corp | Ciclobuteno-1,2-dionas 3,4-disustituidas como ligandos del receptor de quimocina cxc. |
| US20040053953A1 (en) | 2002-03-18 | 2004-03-18 | Schering Corporation | Treatment of chemokine mediated diseases |
-
2004
- 2004-04-16 JP JP2006501278A patent/JP4440917B2/ja not_active Expired - Fee Related
- 2004-04-16 CN CN200810173891.5A patent/CN101514168B/zh not_active Expired - Fee Related
- 2004-04-16 EP EP09014248.0A patent/EP2168956B8/de not_active Expired - Lifetime
- 2004-04-16 CN CN2008101738953A patent/CN101514193B/zh not_active Expired - Fee Related
- 2004-04-16 DE DE602004025458T patent/DE602004025458D1/de not_active Expired - Lifetime
- 2004-04-16 CN CNB2004800165225A patent/CN100448860C/zh not_active Expired - Fee Related
- 2004-04-16 WO PCT/US2004/011882 patent/WO2004094398A2/en active Application Filing
- 2004-04-16 EP EP04759956A patent/EP1615903B1/de not_active Expired - Lifetime
- 2004-04-16 AT AT04759956T patent/ATE457307T1/de not_active IP Right Cessation
- 2004-04-16 MX MXPA05011183A patent/MXPA05011183A/es active IP Right Grant
- 2004-04-16 CA CA2522748A patent/CA2522748C/en not_active Expired - Fee Related
- 2004-04-16 AR ARP040101294A patent/AR044027A1/es not_active Application Discontinuation
- 2004-04-16 ES ES04759956T patent/ES2338657T3/es not_active Expired - Lifetime
- 2004-04-16 SG SG200717017-8A patent/SG167671A1/en unknown
- 2004-04-16 US US10/826,456 patent/US7071342B2/en not_active Expired - Lifetime
-
2005
- 2005-10-07 ZA ZA200508129A patent/ZA200508129B/en unknown
-
2006
- 2006-01-23 HK HK06101053.6A patent/HK1078315A1/xx not_active IP Right Cessation
- 2006-05-09 US US11/430,687 patent/US7462740B2/en active Active
-
2008
- 2008-01-16 ZA ZA200800486A patent/ZA200800486B/en unknown
- 2008-01-16 ZA ZA200800487A patent/ZA200800487B/en unknown
- 2008-10-17 US US12/253,356 patent/US7910775B2/en active Active
-
2009
- 2009-12-01 JP JP2009273993A patent/JP5202503B2/ja not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |