DE69901024D1 - Asymmetrischen synthese von 2-aryl-1-substituierten butan-2,3-diolen - Google Patents

Asymmetrischen synthese von 2-aryl-1-substituierten butan-2,3-diolen

Info

Publication number
DE69901024D1
DE69901024D1 DE69901024T DE69901024T DE69901024D1 DE 69901024 D1 DE69901024 D1 DE 69901024D1 DE 69901024 T DE69901024 T DE 69901024T DE 69901024 T DE69901024 T DE 69901024T DE 69901024 D1 DE69901024 D1 DE 69901024D1
Authority
DE
Germany
Prior art keywords
dioles
aryl
substituted butane
asymmetrical synthesis
asymmetrical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69901024T
Other languages
English (en)
Inventor
Pal Singh
Inderjit Sidhu
Bhupinder Palak
G Micetich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Naeja Pharmaceutical Inc
Taiho Pharmaceutical Co Ltd
Original Assignee
Naeja Pharmaceutical Inc
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Naeja Pharmaceutical Inc, Taiho Pharmaceutical Co Ltd filed Critical Naeja Pharmaceutical Inc
Application granted granted Critical
Publication of DE69901024D1 publication Critical patent/DE69901024D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
    • C07C29/10—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes
    • C07C29/103—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes of cyclic ethers
    • C07C29/106—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes of cyclic ethers of oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/483—Monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69901024T 1998-04-15 1999-04-15 Asymmetrischen synthese von 2-aryl-1-substituierten butan-2,3-diolen Expired - Lifetime DE69901024D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/060,138 US6133485A (en) 1998-04-15 1998-04-15 Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl butan-2,3-diols
PCT/IB1999/000679 WO1999052840A1 (en) 1998-04-15 1999-04-15 Asymmetric synthesis of 2-aryl-1-substituted butan-2,3-diols

Publications (1)

Publication Number Publication Date
DE69901024D1 true DE69901024D1 (de) 2002-04-18

Family

ID=22027614

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69901024T Expired - Lifetime DE69901024D1 (de) 1998-04-15 1999-04-15 Asymmetrischen synthese von 2-aryl-1-substituierten butan-2,3-diolen

Country Status (6)

Country Link
US (1) US6133485A (de)
EP (1) EP1071640B1 (de)
JP (1) JP2002511434A (de)
CA (1) CA2328727A1 (de)
DE (1) DE69901024D1 (de)
WO (1) WO1999052840A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN192526B (de) * 2001-09-25 2004-04-24 Ranbaxy Lab
WO2004018485A1 (en) * 2002-08-26 2004-03-04 Ranbaxy Laboratories Limited Azole derivatives as antifungal agents
JP4627413B2 (ja) * 2003-05-06 2011-02-09 三井化学株式会社 １−アゾール−２−フェニル−２、３−プロパンジオール誘導体の製造法
SI1954264T1 (sl) * 2005-12-01 2010-01-29 Basilea Pharmaceutica Ag Postopek priprave intermediatov epoksibutanola
US8207352B2 (en) * 2009-10-08 2012-06-26 Drug Process Licensing Associates LLC Process for the manufacture of enantiomerically pure antifungal azoles as ravuconazole and isavuconazole
CN101798290B (zh) * 2010-04-02 2012-03-07 北京欧凯纳斯科技有限公司 一种手性环唑醇的合成方法
CN105367528A (zh) * 2015-11-10 2016-03-02 南通诺泰生物医药技术有限公司 一种三唑类药物中间体(d)-1-(1-环烷仲胺基)-2-(2-四氢吡喃基)氧-1-丙酮类化合物及合成方法
WO2019031240A1 (ja) 2017-08-10 2019-02-14 住友化学株式会社 エポキシアルコール化合物の製造方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227543A (en) * 1988-01-11 1993-07-13 Massachusetts Institute Of Technology Facilitation of turnover in the ADH by additives which catalyze the hydrolysis of the OS(VI) glycolate esters
US5516929A (en) * 1988-01-11 1996-05-14 Massachusetts Institute Of Technology Method for catalytic asymmetric dihydroxylation of olefins using heterocyclic chiral ligands
US5126494A (en) * 1988-01-11 1992-06-30 Massachusetts Institute Of Technology Methods for catalytic asymmetric dihydroxylation of olefins
US5260461A (en) * 1988-01-11 1993-11-09 Massachusetts Institute Of Technology Ligands for ADH: cinchona alkaloids and moderately sized organic substituents linked through a planar aromatic spacer group
NO171272C (no) * 1988-03-04 1993-02-17 Sankyo Co Analogifremgangsmaate til fremstilling av terapeutisk aktive 1,2,4-triazolforbindelser
US5204333A (en) * 1989-01-24 1993-04-20 Larkin John P Pesticidal compounds
JPH03128338A (ja) * 1989-07-17 1991-05-31 Sankyo Co Ltd 光学活性なジオール化合物の製造法
IL95540A0 (en) * 1989-09-01 1991-06-30 Schering Corp Asymetric chemical synthesis of antifungal mercapto alkanol derivatives and intermediates for making them
IE903395A1 (en) * 1989-09-26 1991-04-10 Takeda Chemical Industries Ltd Triazole compounds, their production and use
CA2039857A1 (en) * 1990-04-26 1991-10-27 Wilfred Po-Sum Shum Process for producing epoxyalcohols of high optical purity
GB9115054D0 (en) * 1991-07-12 1991-08-28 Ciba Geigy Aqueous compositions
EP0548553A1 (de) * 1991-11-25 1993-06-30 Takeda Chemical Industries, Ltd. Optisch aktive Azolverbindungen, ihre Herstellung und Anwendung
DE4143139A1 (de) * 1991-12-28 1993-07-01 Hoechst Ag Chirale oxiranylmethyl-ether und ihre verwendung als dotierstoffe in fluessigkristallmischungen
DE4211562A1 (de) * 1992-04-07 1993-10-14 Hoechst Ag Chirale Oxiranderivate und ihre Verwendung als Dotierstoffe in Flüssigkristallmischungen
DE4211563A1 (de) * 1992-04-07 1993-10-14 Hoechst Ag Chirale Oxiranderivate und ihre Verwendung als Dotierstoffe in Flüssigkristallmischungen
TW218017B (de) * 1992-04-28 1993-12-21 Takeda Pharm Industry Co Ltd
DE59310130D1 (de) * 1992-06-09 2001-01-25 Aventis Res & Tech Gmbh & Co 3-Fluorpyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Flüssigkristallmischungen
ES2099004B1 (es) * 1993-02-11 1998-01-16 Uriach & Cia Sa J Nuevos antifungicos activos por via oral.
DE4315867A1 (de) * 1993-05-12 1994-11-17 Hoechst Ag 3-Chlorpyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Flüssigkristallmischungen
CA2182698A1 (en) * 1994-02-25 1995-08-31 Jun Sato Injectable emulsions containing antifungal triazole derivatives
US5645652A (en) * 1994-12-13 1997-07-08 Toda Kogyo Corporation Spindle-shaped magnetic iron-based alloy particles containing cobalt and iron as the main ingredients and process for producing the same
AU4675596A (en) * 1995-02-17 1996-09-04 Takeda Chemical Industries Ltd. Azole compounds, their production and use

Also Published As

Publication number Publication date
EP1071640A1 (de) 2001-01-31
WO1999052840A1 (en) 1999-10-21
EP1071640B1 (de) 2002-03-13
JP2002511434A (ja) 2002-04-16
US6133485A (en) 2000-10-17
CA2328727A1 (en) 1999-10-21

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