MX2022004145A - Compuestos heterociclicos de arilmetileno como bloqueadores del canal de potasio tipo shaker kv1.3. - Google Patents
Compuestos heterociclicos de arilmetileno como bloqueadores del canal de potasio tipo shaker kv1.3.Info
- Publication number
- MX2022004145A MX2022004145A MX2022004145A MX2022004145A MX2022004145A MX 2022004145 A MX2022004145 A MX 2022004145A MX 2022004145 A MX2022004145 A MX 2022004145A MX 2022004145 A MX2022004145 A MX 2022004145A MX 2022004145 A MX2022004145 A MX 2022004145A
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- MX
- Mexico
- Prior art keywords
- arylmethylene
- potassium
- heterocyclic compounds
- channel blockers
- shaker channel
- Prior art date
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
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- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
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Abstract
Un compuesto de la fórmula I (ver Fórmula), o una sal farmacéuticamente aceptable del mismo, se describe, en donde los sustituyentes son como se define en la presente. También se describen composiciones farmacéuticas que los comprenden y el método de uso de las mismas.
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US201962911652P | 2019-10-07 | 2019-10-07 | |
PCT/US2020/054360 WO2021071812A1 (en) | 2019-10-07 | 2020-10-06 | Arylmethylene heterocyclic compounds as kv1.3 potassium shaker channel blockers |
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MX2022004145A true MX2022004145A (es) | 2022-06-14 |
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MX2022004145A MX2022004145A (es) | 2019-10-07 | 2020-10-06 | Compuestos heterociclicos de arilmetileno como bloqueadores del canal de potasio tipo shaker kv1.3. |
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US (1) | US20220411367A1 (es) |
EP (1) | EP4041228A4 (es) |
JP (1) | JP2022551198A (es) |
KR (1) | KR20220079881A (es) |
CN (1) | CN114727993A (es) |
AU (1) | AU2020363360A1 (es) |
BR (1) | BR112022006226A2 (es) |
CA (1) | CA3157031A1 (es) |
IL (1) | IL291869A (es) |
MX (1) | MX2022004145A (es) |
WO (1) | WO2021071812A1 (es) |
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SI1381590T1 (sl) * | 2001-04-16 | 2007-10-31 | Schering Corp | 3,4-disubstituirani ciklobuten-1,2-dioni kot ligandi CXC-kemokinskega receptorja |
WO2008115118A1 (en) * | 2007-03-21 | 2008-09-25 | Innate Pharmaceuticals Ab | Method and means for preventing and inhibiting type iii secretion in infections caused by gram-negative bacteria |
JP2020502064A (ja) * | 2016-11-29 | 2020-01-23 | エピザイム,インコーポレイティド | スルホン酸基を含むkat阻害剤としての化合物 |
WO2019040647A1 (en) * | 2017-08-22 | 2019-02-28 | Cedars-Sinai Medical Center | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER |
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2020
- 2020-10-06 MX MX2022004145A patent/MX2022004145A/es unknown
- 2020-10-06 CN CN202080084714.9A patent/CN114727993A/zh active Pending
- 2020-10-06 US US17/766,889 patent/US20220411367A1/en active Pending
- 2020-10-06 EP EP20874457.3A patent/EP4041228A4/en active Pending
- 2020-10-06 IL IL291869A patent/IL291869A/en unknown
- 2020-10-06 CA CA3157031A patent/CA3157031A1/en active Pending
- 2020-10-06 WO PCT/US2020/054360 patent/WO2021071812A1/en active Application Filing
- 2020-10-06 JP JP2022546590A patent/JP2022551198A/ja active Pending
- 2020-10-06 KR KR1020227013512A patent/KR20220079881A/ko not_active Application Discontinuation
- 2020-10-06 AU AU2020363360A patent/AU2020363360A1/en active Pending
- 2020-10-06 BR BR112022006226A patent/BR112022006226A2/pt unknown
Also Published As
Publication number | Publication date |
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CA3157031A1 (en) | 2021-04-15 |
US20220411367A1 (en) | 2022-12-29 |
CN114727993A (zh) | 2022-07-08 |
WO2021071812A8 (en) | 2022-04-14 |
KR20220079881A (ko) | 2022-06-14 |
EP4041228A1 (en) | 2022-08-17 |
BR112022006226A2 (pt) | 2022-06-28 |
AU2020363360A1 (en) | 2022-05-05 |
JP2022551198A (ja) | 2022-12-07 |
IL291869A (en) | 2022-06-01 |
WO2021071812A1 (en) | 2021-04-15 |
EP4041228A4 (en) | 2023-10-18 |
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