PL208928B1 - 3, 4-di-podstawione cyklobuten-1, 2-diony jako ligandy receptora CXC chemokiny - Google Patents

3, 4-di-podstawione cyklobuten-1, 2-diony jako ligandy receptora CXC chemokiny

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Publication number
PL208928B1
PL208928B1 PL390082A PL39008202A PL208928B1 PL 208928 B1 PL208928 B1 PL 208928B1 PL 390082 A PL390082 A PL 390082A PL 39008202 A PL39008202 A PL 39008202A PL 208928 B1 PL208928 B1 PL 208928B1
Authority
PL
Poland
Prior art keywords
alkyl
product
preparative example
group
mixture
Prior art date
Application number
PL390082A
Other languages
English (en)
Polish (pl)
Inventor
Arthur G. Taveras
Cynthia J. Aki
Richard W. Bond
Jianping Chao
Michael Dwyer
Johan A. Ferreira
Jianhua Chao
Younong Yu
John J. Baldwin
Bernd Kaiser
Ge Li
J. Robert Merritt
Kingsley H. Nelson
Laura L. Rokosz
Original Assignee
Pharmacopeia
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacopeia, Schering Corp filed Critical Pharmacopeia
Publication of PL208928B1 publication Critical patent/PL208928B1/pl

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Health & Medical Sciences (AREA)
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  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
  • Diabetes (AREA)
  • AIDS & HIV (AREA)
  • Toxicology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
PL390082A 2001-04-16 2002-04-15 3, 4-di-podstawione cyklobuten-1, 2-diony jako ligandy receptora CXC chemokiny PL208928B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28402601P 2001-04-16 2001-04-16

Publications (1)

Publication Number Publication Date
PL208928B1 true PL208928B1 (pl) 2011-06-30

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ID=23088576

Family Applications (2)

Application Number Title Priority Date Filing Date
PL390082A PL208928B1 (pl) 2001-04-16 2002-04-15 3, 4-di-podstawione cyklobuten-1, 2-diony jako ligandy receptora CXC chemokiny
PL367129A PL207255B1 (pl) 2001-04-16 2002-04-15 3,4-di-podstawione cyklobuten-1,2-diony i ich zastosowanie oraz zawierająca je kompozycja farmaceutyczna

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PL367129A PL207255B1 (pl) 2001-04-16 2002-04-15 3,4-di-podstawione cyklobuten-1,2-diony i ich zastosowanie oraz zawierająca je kompozycja farmaceutyczna

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Country Link
EP (2) EP1818325B1 (enExample)
JP (3) JP4499993B2 (enExample)
KR (2) KR100952531B1 (enExample)
CN (2) CN1990457A (enExample)
AR (1) AR035825A1 (enExample)
AT (2) ATE458715T1 (enExample)
AU (3) AU2002311841B2 (enExample)
BR (1) BRPI0208957B8 (enExample)
CA (1) CA2444031C (enExample)
CY (2) CY1109908T1 (enExample)
CZ (1) CZ20032831A3 (enExample)
DE (2) DE60220778T2 (enExample)
DK (2) DK1818325T3 (enExample)
EC (1) ECSP034809A (enExample)
ES (2) ES2287284T3 (enExample)
HU (1) HUP0401783A3 (enExample)
IL (3) IL158262A0 (enExample)
MX (1) MXPA03009441A (enExample)
MY (2) MY138202A (enExample)
NO (2) NO330790B1 (enExample)
NZ (3) NZ543869A (enExample)
PE (1) PE20021084A1 (enExample)
PL (2) PL208928B1 (enExample)
PT (2) PT1818325E (enExample)
RU (1) RU2344123C9 (enExample)
SI (2) SI1381590T1 (enExample)
SK (1) SK287598B6 (enExample)
TW (2) TW200736196A (enExample)
WO (1) WO2002083624A1 (enExample)
ZA (1) ZA200307905B (enExample)

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US7132445B2 (en) 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
EP1434775A1 (en) 2001-10-12 2004-07-07 Schering Corporation 3,4-di-substituted maleimide compounds as cxc-chemokine receptor antagonists
US8246969B2 (en) 2001-11-16 2012-08-21 Skinmedica, Inc. Compositions containing aromatic aldehydes and their use in treatments
US6878709B2 (en) 2002-01-04 2005-04-12 Schering Corporation 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
NZ535314A (en) * 2002-03-18 2007-08-31 Schering Corp Combination treatments for chemokine-mediated diseases
GB0218326D0 (en) * 2002-08-07 2002-09-11 Glaxo Group Ltd Compounds
ES2321186T3 (es) 2002-10-09 2009-06-03 Schering Corporation Dioxidos de tiadiazol y monoxidos de tiadiazol como ligandos de los receptores de quimioquinas cxc y cc.
GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
US7893096B2 (en) 2003-03-28 2011-02-22 Novartis Vaccines And Diagnostics, Inc. Use of small molecule compounds for immunopotentiation
JP4705015B2 (ja) 2003-04-03 2011-06-22 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング カルボニル化合物
AR044027A1 (es) * 2003-04-18 2005-08-24 Schering Corp Sintesis de 2-hidroxi-n,n-dimetil-3-[[2-[1(r) - (5-metil-2-furanil)propil]amino]- 3,4-dioxo-1-ciclobuten-1-il]amino]benzamida
NZ544756A (en) 2003-07-22 2009-09-25 Astex Therapeutics Ltd 3,4-Disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators
GB0320983D0 (en) * 2003-09-08 2003-10-08 Biofocus Plc Compound libraries
DE602004024798D1 (de) 2003-09-23 2010-02-04 Fermion Oy Herstellung von quetiapin
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