DE602005022986D1 - Kristalline polymorphe eines cxc-chemokinrezeptorliganden - Google Patents

Kristalline polymorphe eines cxc-chemokinrezeptorliganden

Info

Publication number
DE602005022986D1
DE602005022986D1 DE602005022986T DE602005022986T DE602005022986D1 DE 602005022986 D1 DE602005022986 D1 DE 602005022986D1 DE 602005022986 T DE602005022986 T DE 602005022986T DE 602005022986 T DE602005022986 T DE 602005022986T DE 602005022986 D1 DE602005022986 D1 DE 602005022986D1
Authority
DE
Germany
Prior art keywords
cxc
receptor ligands
crystalline polymorphic
chemokin receptor
chemokin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005022986T
Other languages
English (en)
Inventor
Mengwei Hu
Younong Yu
Michael Dwyer
Arthur G Taveras
Agnes Kim-Meade
Jianguo Yin
Xiaoyong Fu
Timothy Mcallister
Shuyi Zhang
Kevin Klopfer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34837390&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602005022986(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE602005022986D1 publication Critical patent/DE602005022986D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Biotechnology (AREA)
  • Nutrition Science (AREA)
DE602005022986T 2004-01-30 2005-01-28 Kristalline polymorphe eines cxc-chemokinrezeptorliganden Active DE602005022986D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54048704P 2004-01-30 2004-01-30
PCT/US2005/003414 WO2005075447A1 (en) 2004-01-30 2005-01-28 Crystalline polymorphs of a cxc-chemokine receptor ligand

Publications (1)

Publication Number Publication Date
DE602005022986D1 true DE602005022986D1 (de) 2010-09-30

Family

ID=34837390

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005022986T Active DE602005022986D1 (de) 2004-01-30 2005-01-28 Kristalline polymorphe eines cxc-chemokinrezeptorliganden

Country Status (26)

Country Link
US (2) US20050192345A1 (de)
EP (1) EP1723131B1 (de)
JP (2) JP2007519751A (de)
KR (1) KR100883476B1 (de)
CN (1) CN1914187B (de)
AR (1) AR047739A1 (de)
AT (1) ATE478061T1 (de)
AU (1) AU2005210504B2 (de)
BR (1) BRPI0507329A (de)
CA (1) CA2554709C (de)
CO (1) CO5700731A2 (de)
DE (1) DE602005022986D1 (de)
EC (1) ECSP066733A (de)
ES (1) ES2349788T3 (de)
HK (1) HK1091496A1 (de)
IL (1) IL177033A0 (de)
MX (1) MXPA06008599A (de)
MY (1) MY144657A (de)
NO (1) NO20063841L (de)
NZ (1) NZ548499A (de)
PE (1) PE20051093A1 (de)
PL (1) PL380997A1 (de)
RU (1) RU2388756C2 (de)
TW (1) TW200536848A (de)
WO (1) WO2005075447A1 (de)
ZA (1) ZA200606295B (de)

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US20040106794A1 (en) 2001-04-16 2004-06-03 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US7132445B2 (en) * 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
WO2006051340A1 (en) * 2004-07-22 2006-05-18 Pliva - Istrazivanje I Razvoj D.O.O. Novel form of celecoxib
GB2418427A (en) 2004-09-02 2006-03-29 Univ Cambridge Tech Ligands for G-protein coupled receptors
AR061448A1 (es) 2006-06-12 2008-08-27 Schering Corp Formulaciones y compuestos farmaceuticos de un antagonista selectivo ya sea del receptor cxcr2, y los metodos para utilizar el mismo en el tratamiento de enfermedades inflamatorias
JP5243539B2 (ja) * 2007-07-03 2013-07-24 メルク・シャープ・アンド・ドーム・コーポレーション １，２−置換３，４−ジオキソ−１−シクロブテン化合物の合成のための方法および中間体
WO2009005802A1 (en) * 2007-07-05 2009-01-08 Schering Corporation Process for controlled crystal size in 1,2-substituted 3,4-dioxo-1-cyclobutene compounds
MX2010006089A (es) * 2007-12-04 2010-09-22 Schering Corp Metodos de tratamiento de enfermedad pulmonar obstructiva cronica.
GB2455539B (en) * 2007-12-12 2012-01-18 Cambridge Entpr Ltd Anti-inflammatory compositions and combinations
UA103198C2 (en) 2008-08-04 2013-09-25 Новартис Аг Squaramide derivatives as cxcr2 antagonists
WO2010063802A1 (en) * 2008-12-05 2010-06-10 Novartis Ag 3, 4-di-substituted cyclobutene- 1, 2 -diones as cxcr2 receptor antagonists
AU2010328186B2 (en) 2009-12-08 2014-12-18 Case Western Reserve University Compounds and methods of treating ocular disorders
ES2655942T3 (es) 2011-09-02 2018-02-22 Novartis Ag Sal de colina de un compuesto anti-inflamatorio de ciclobutenodiona sustituida
US8865723B2 (en) 2012-10-25 2014-10-21 Tetra Discovery Partners Llc Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury
US9763992B2 (en) 2014-02-13 2017-09-19 Father Flanagan's Boys' Home Treatment of noise induced hearing loss
TWI734715B (zh) 2015-11-19 2021-08-01 美商卡默森屈有限公司 趨化因子受體調節劑
TWI724056B (zh) 2015-11-19 2021-04-11 美商卡默森屈有限公司 Ｃｘｃｒ２抑制劑
EP3426253A4 (de) 2016-03-11 2019-11-06 Ardea Biosciences, Inc. Cxcr-2-inhibitoren zur behandlung von kristallarthropathien
BR112020004697A2 (pt) * 2017-09-12 2020-10-27 Ardea Biosciences, Inc. inibidores de cxcr-2 para tratamento de distúrbios
AU2019205786B2 (en) 2018-01-08 2023-12-14 Chemocentryx, Inc. Methods of treating generalized pustular psoriasis with an antagonist of CCR6 or CXCR2

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US5125894A (en) * 1990-03-30 1992-06-30 Alza Corporation Method and apparatus for controlled environment electrotransport
US7027859B1 (en) * 1994-09-26 2006-04-11 Alza Corporation Electrotransport delivery device having improved safety and reduced abuse potential
DK1818325T3 (da) * 2001-04-16 2010-05-31 Schering Corp 3,4-di-substituerede cyklobuten-1,2-dioner som CXC-chemokin receptorligander
US7132445B2 (en) * 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
MXPA04009127A (es) * 2002-03-18 2005-01-25 Schering Corp Tratamiento de enfermedades mediadas por quimiocinas.
SG167671A1 (en) * 2003-04-18 2011-01-28 Schering Corp Synthesis of 2-hydroxy-n,n-dimethyl-3-[[2-[1(r)-(5-methyl-2- furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]aminobenzamide

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Publication number Publication date
ZA200606295B (en) 2008-02-27
ATE478061T1 (de) 2010-09-15
US20050192345A1 (en) 2005-09-01
IL177033A0 (en) 2006-12-10
MXPA06008599A (es) 2006-08-28
NO20063841L (no) 2006-10-27
RU2006131050A (ru) 2008-03-10
US20080279822A1 (en) 2008-11-13
CN1914187A (zh) 2007-02-14
EP1723131A1 (de) 2006-11-22
CA2554709A1 (en) 2005-08-18
PE20051093A1 (es) 2006-01-16
ES2349788T3 (es) 2011-01-11
KR20060128981A (ko) 2006-12-14
CO5700731A2 (es) 2006-11-30
ECSP066733A (es) 2006-11-24
PL380997A1 (pl) 2007-04-16
BRPI0507329A (pt) 2007-07-03
CN1914187B (zh) 2012-01-25
HK1091496A1 (en) 2007-01-19
RU2388756C2 (ru) 2010-05-10
AU2005210504B2 (en) 2009-01-08
AU2005210504A1 (en) 2005-08-18
JP2011042692A (ja) 2011-03-03
AR047739A1 (es) 2006-02-15
US8207221B2 (en) 2012-06-26
JP2007519751A (ja) 2007-07-19
CA2554709C (en) 2011-11-15
NZ548499A (en) 2010-06-25
EP1723131B1 (de) 2010-08-18
MY144657A (en) 2011-10-31
TW200536848A (en) 2005-11-16
WO2005075447A1 (en) 2005-08-18
KR100883476B1 (ko) 2009-02-16

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