ECSP066733A - Polimorfos cristalinos de un ligando receptor de cxc-quimiocina - Google Patents

Polimorfos cristalinos de un ligando receptor de cxc-quimiocina

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Publication number
ECSP066733A
ECSP066733A EC2006006733A ECSP066733A ECSP066733A EC SP066733 A ECSP066733 A EC SP066733A EC 2006006733 A EC2006006733 A EC 2006006733A EC SP066733 A ECSP066733 A EC SP066733A EC SP066733 A ECSP066733 A EC SP066733A
Authority
EC
Ecuador
Prior art keywords
cxc
chemiokin
polymorphes
crystalline
binding receiver
Prior art date
Application number
EC2006006733A
Other languages
English (en)
Inventor
Arthur G Taveras
Michael Dwyer
Younong Yu
Mengwel Hu
Agnes Kim-Meade
Jianguo Yin
Xiaoyong Fu
Timothy Mcallister
Shuyi Zhang
Kevin Klopfer
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34837390&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP066733(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of ECSP066733A publication Critical patent/ECSP066733A/es

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    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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  • Communicable Diseases (AREA)
  • Diabetes (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
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Abstract

La presente invención se refiere a cuatro polimorfos cristalinos distintos de un monohidrato del Compuesto A que tiene la siguiente estructura química:Compuesto AEstas cuatro formas polimórficas denominadas aquí Forma I, II, III y IV son activas como ligandos receptores CXC-quimiocina. La invención está además dirigida a las formulaciones, métodos de tratamiento y procedimientos de síntesis de estas formas polimórficas.
EC2006006733A 2004-01-30 2006-07-28 Polimorfos cristalinos de un ligando receptor de cxc-quimiocina ECSP066733A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54048704P 2004-01-30 2004-01-30

Publications (1)

Publication Number Publication Date
ECSP066733A true ECSP066733A (es) 2006-11-24

Family

ID=34837390

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006733A ECSP066733A (es) 2004-01-30 2006-07-28 Polimorfos cristalinos de un ligando receptor de cxc-quimiocina

Country Status (26)

Country Link
US (2) US20050192345A1 (es)
EP (1) EP1723131B1 (es)
JP (2) JP2007519751A (es)
KR (1) KR100883476B1 (es)
CN (1) CN1914187B (es)
AR (1) AR047739A1 (es)
AT (1) ATE478061T1 (es)
AU (1) AU2005210504B2 (es)
BR (1) BRPI0507329A (es)
CA (1) CA2554709C (es)
CO (1) CO5700731A2 (es)
DE (1) DE602005022986D1 (es)
EC (1) ECSP066733A (es)
ES (1) ES2349788T3 (es)
HK (1) HK1091496A1 (es)
IL (1) IL177033A0 (es)
MX (1) MXPA06008599A (es)
MY (1) MY144657A (es)
NO (1) NO20063841L (es)
NZ (1) NZ548499A (es)
PE (1) PE20051093A1 (es)
PL (1) PL380997A1 (es)
RU (1) RU2388756C2 (es)
TW (1) TW200536848A (es)
WO (1) WO2005075447A1 (es)
ZA (1) ZA200606295B (es)

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US7132445B2 (en) * 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
WO2006051340A1 (en) * 2004-07-22 2006-05-18 Pliva - Istrazivanje I Razvoj D.O.O. Novel form of celecoxib
GB2418427A (en) 2004-09-02 2006-03-29 Univ Cambridge Tech Ligands for G-protein coupled receptors
TWI351399B (en) * 2006-06-12 2011-11-01 Schering Corp Pharmaceutical formulations and compositions of a
US8519168B2 (en) * 2007-07-03 2013-08-27 Merck Sharp & Dohme Corp. Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds
WO2009005802A1 (en) * 2007-07-05 2009-01-08 Schering Corporation Process for controlled crystal size in 1,2-substituted 3,4-dioxo-1-cyclobutene compounds
EP2252327A2 (en) * 2007-12-04 2010-11-24 Schering Corporation Methods of treating copd
GB2455539B (en) * 2007-12-12 2012-01-18 Cambridge Entpr Ltd Anti-inflammatory compositions and combinations
UA103198C2 (en) 2008-08-04 2013-09-25 Новартис Аг Squaramide derivatives as cxcr2 antagonists
WO2010063802A1 (en) * 2008-12-05 2010-06-10 Novartis Ag 3, 4-di-substituted cyclobutene- 1, 2 -diones as cxcr2 receptor antagonists
WO2011071995A2 (en) 2009-12-08 2011-06-16 Case Western Reserve University Compounds and methods of treating ocular disorders
EP3287438A1 (en) 2011-09-02 2018-02-28 Novartis AG Choline salt of an anti-inflammatory substituted cyclobutenedione compound
US8865723B2 (en) 2012-10-25 2014-10-21 Tetra Discovery Partners Llc Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury
US9763992B2 (en) 2014-02-13 2017-09-19 Father Flanagan's Boys' Home Treatment of noise induced hearing loss
TWI734715B (zh) 2015-11-19 2021-08-01 美商卡默森屈有限公司 趨化因子受體調節劑
TWI724056B (zh) 2015-11-19 2021-04-11 美商卡默森屈有限公司 Ｃｘｃｒ２抑制劑
CA3017345A1 (en) 2016-03-11 2017-09-14 Ardea Biosciences, Inc. Cxcr-2 inhibitors for treating crystal arthropathy disorders
BR112020004697A2 (pt) * 2017-09-12 2020-10-27 Ardea Biosciences, Inc. inibidores de cxcr-2 para tratamento de distúrbios
MA50424A (fr) 2018-01-08 2020-08-26 Chemocentryx Inc Méthodes de traitement du psoriasis pustuleux généralisé avec un antagoniste de ccr6 ou cxcr2

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MXPA03009441A (es) * 2001-04-16 2004-02-12 Schering Corp Ciclobuteno-1,2-dionas 3,4-disustituidas como ligandos del receptor de quimocina cxc.
US7132445B2 (en) * 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
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US7071342B2 (en) * 2003-04-18 2006-07-04 Schering Corporation Synthesis of 2-hydroxy-N,N-dimethyl-3-[ [2-[1 (R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]aminobenzamide

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CA2554709A1 (en) 2005-08-18
AU2005210504A1 (en) 2005-08-18
AR047739A1 (es) 2006-02-15
US20050192345A1 (en) 2005-09-01
CN1914187B (zh) 2012-01-25
BRPI0507329A (pt) 2007-07-03
MXPA06008599A (es) 2006-08-28
KR100883476B1 (ko) 2009-02-16
CO5700731A2 (es) 2006-11-30
JP2011042692A (ja) 2011-03-03
EP1723131A1 (en) 2006-11-22
NZ548499A (en) 2010-06-25
DE602005022986D1 (de) 2010-09-30
RU2388756C2 (ru) 2010-05-10
CA2554709C (en) 2011-11-15
US8207221B2 (en) 2012-06-26
RU2006131050A (ru) 2008-03-10
ES2349788T3 (es) 2011-01-11
AU2005210504B2 (en) 2009-01-08
TW200536848A (en) 2005-11-16
ZA200606295B (en) 2008-02-27
NO20063841L (no) 2006-10-27
HK1091496A1 (en) 2007-01-19
MY144657A (en) 2011-10-31
PE20051093A1 (es) 2006-01-16
PL380997A1 (pl) 2007-04-16
ATE478061T1 (de) 2010-09-15
WO2005075447A1 (en) 2005-08-18
EP1723131B1 (en) 2010-08-18
US20080279822A1 (en) 2008-11-13
JP2007519751A (ja) 2007-07-19
CN1914187A (zh) 2007-02-14
KR20060128981A (ko) 2006-12-14
IL177033A0 (en) 2006-12-10

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