HK1091496A1 - Crystalline polymorphs of a cxc-chemokine receptor ligand - Google Patents

Crystalline polymorphs of a cxc-chemokine receptor ligand

Info

Publication number
HK1091496A1
HK1091496A1 HK06113165.6A HK06113165A HK1091496A1 HK 1091496 A1 HK1091496 A1 HK 1091496A1 HK 06113165 A HK06113165 A HK 06113165A HK 1091496 A1 HK1091496 A1 HK 1091496A1
Authority
HK
Hong Kong
Prior art keywords
cxc
chemokine receptor
receptor ligand
crystalline polymorphs
polymorphs
Prior art date
Application number
HK06113165.6A
Other languages
English (en)
Inventor
Xiaoyong Fu
Arthur G Taveras
Michael Dwyer
Younong Yu
Kevin Klopfer
Jianguo Yin
Shuyi Zhang
Mengwei Hu
Agnes Kim-Meade
Timothy Mcallister
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34837390&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1091496(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of HK1091496A1 publication Critical patent/HK1091496A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/12—Antihypertensives
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Biotechnology (AREA)
  • Nutrition Science (AREA)
HK06113165.6A 2004-01-30 2006-11-30 Crystalline polymorphs of a cxc-chemokine receptor ligand HK1091496A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54048704P 2004-01-30 2004-01-30
PCT/US2005/003414 WO2005075447A1 (en) 2004-01-30 2005-01-28 Crystalline polymorphs of a cxc-chemokine receptor ligand

Publications (1)

Publication Number Publication Date
HK1091496A1 true HK1091496A1 (en) 2007-01-19

Family

ID=34837390

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06113165.6A HK1091496A1 (en) 2004-01-30 2006-11-30 Crystalline polymorphs of a cxc-chemokine receptor ligand

Country Status (26)

Country Link
US (2) US20050192345A1 (de)
EP (1) EP1723131B1 (de)
JP (2) JP2007519751A (de)
KR (1) KR100883476B1 (de)
CN (1) CN1914187B (de)
AR (1) AR047739A1 (de)
AT (1) ATE478061T1 (de)
AU (1) AU2005210504B2 (de)
BR (1) BRPI0507329A (de)
CA (1) CA2554709C (de)
CO (1) CO5700731A2 (de)
DE (1) DE602005022986D1 (de)
EC (1) ECSP066733A (de)
ES (1) ES2349788T3 (de)
HK (1) HK1091496A1 (de)
IL (1) IL177033A0 (de)
MX (1) MXPA06008599A (de)
MY (1) MY144657A (de)
NO (1) NO20063841L (de)
NZ (1) NZ548499A (de)
PE (1) PE20051093A1 (de)
PL (1) PL380997A1 (de)
RU (1) RU2388756C2 (de)
TW (1) TW200536848A (de)
WO (1) WO2005075447A1 (de)
ZA (1) ZA200606295B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040106794A1 (en) 2001-04-16 2004-06-03 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US7132445B2 (en) * 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
WO2006051340A1 (en) * 2004-07-22 2006-05-18 Pliva - Istrazivanje I Razvoj D.O.O. Novel form of celecoxib
GB2418427A (en) 2004-09-02 2006-03-29 Univ Cambridge Tech Ligands for G-protein coupled receptors
AR061448A1 (es) 2006-06-12 2008-08-27 Schering Corp Formulaciones y compuestos farmaceuticos de un antagonista selectivo ya sea del receptor cxcr2, y los metodos para utilizar el mismo en el tratamiento de enfermedades inflamatorias
JP5243539B2 (ja) * 2007-07-03 2013-07-24 メルク・シャープ・アンド・ドーム・コーポレーション １，２−置換３，４−ジオキソ−１−シクロブテン化合物の合成のための方法および中間体
WO2009005802A1 (en) * 2007-07-05 2009-01-08 Schering Corporation Process for controlled crystal size in 1,2-substituted 3,4-dioxo-1-cyclobutene compounds
MX2010006089A (es) * 2007-12-04 2010-09-22 Schering Corp Metodos de tratamiento de enfermedad pulmonar obstructiva cronica.
GB2455539B (en) * 2007-12-12 2012-01-18 Cambridge Entpr Ltd Anti-inflammatory compositions and combinations
UA103198C2 (en) 2008-08-04 2013-09-25 Новартис Аг Squaramide derivatives as cxcr2 antagonists
WO2010063802A1 (en) * 2008-12-05 2010-06-10 Novartis Ag 3, 4-di-substituted cyclobutene- 1, 2 -diones as cxcr2 receptor antagonists
AU2010328186B2 (en) 2009-12-08 2014-12-18 Case Western Reserve University Compounds and methods of treating ocular disorders
ES2655942T3 (es) 2011-09-02 2018-02-22 Novartis Ag Sal de colina de un compuesto anti-inflamatorio de ciclobutenodiona sustituida
US8865723B2 (en) 2012-10-25 2014-10-21 Tetra Discovery Partners Llc Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury
US9763992B2 (en) 2014-02-13 2017-09-19 Father Flanagan's Boys' Home Treatment of noise induced hearing loss
TWI734715B (zh) 2015-11-19 2021-08-01 美商卡默森屈有限公司 趨化因子受體調節劑
TWI724056B (zh) 2015-11-19 2021-04-11 美商卡默森屈有限公司 Ｃｘｃｒ２抑制劑
EP3426253A4 (de) 2016-03-11 2019-11-06 Ardea Biosciences, Inc. Cxcr-2-inhibitoren zur behandlung von kristallarthropathien
BR112020004697A2 (pt) * 2017-09-12 2020-10-27 Ardea Biosciences, Inc. inibidores de cxcr-2 para tratamento de distúrbios
AU2019205786B2 (en) 2018-01-08 2023-12-14 Chemocentryx, Inc. Methods of treating generalized pustular psoriasis with an antagonist of CCR6 or CXCR2

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5125894A (en) * 1990-03-30 1992-06-30 Alza Corporation Method and apparatus for controlled environment electrotransport
US7027859B1 (en) * 1994-09-26 2006-04-11 Alza Corporation Electrotransport delivery device having improved safety and reduced abuse potential
DK1818325T3 (da) * 2001-04-16 2010-05-31 Schering Corp 3,4-di-substituerede cyklobuten-1,2-dioner som CXC-chemokin receptorligander
US7132445B2 (en) * 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
MXPA04009127A (es) * 2002-03-18 2005-01-25 Schering Corp Tratamiento de enfermedades mediadas por quimiocinas.
SG167671A1 (en) * 2003-04-18 2011-01-28 Schering Corp Synthesis of 2-hydroxy-n,n-dimethyl-3-[[2-[1(r)-(5-methyl-2- furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]aminobenzamide

Also Published As

Publication number Publication date
DE602005022986D1 (de) 2010-09-30
ZA200606295B (en) 2008-02-27
ATE478061T1 (de) 2010-09-15
US20050192345A1 (en) 2005-09-01
IL177033A0 (en) 2006-12-10
MXPA06008599A (es) 2006-08-28
NO20063841L (no) 2006-10-27
RU2006131050A (ru) 2008-03-10
US20080279822A1 (en) 2008-11-13
CN1914187A (zh) 2007-02-14
EP1723131A1 (de) 2006-11-22
CA2554709A1 (en) 2005-08-18
PE20051093A1 (es) 2006-01-16
ES2349788T3 (es) 2011-01-11
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CO5700731A2 (es) 2006-11-30
ECSP066733A (es) 2006-11-24
PL380997A1 (pl) 2007-04-16
BRPI0507329A (pt) 2007-07-03
CN1914187B (zh) 2012-01-25
RU2388756C2 (ru) 2010-05-10
AU2005210504B2 (en) 2009-01-08
AU2005210504A1 (en) 2005-08-18
JP2011042692A (ja) 2011-03-03
AR047739A1 (es) 2006-02-15
US8207221B2 (en) 2012-06-26
JP2007519751A (ja) 2007-07-19
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EP1723131B1 (de) 2010-08-18
MY144657A (en) 2011-10-31
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KR100883476B1 (ko) 2009-02-16

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