ZA200606295B - Crystalline polymorphs of a CXC-chemokine receptor ligand - Google Patents

Crystalline polymorphs of a CXC-chemokine receptor ligand Download PDF

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Publication number
ZA200606295B
ZA200606295B ZA200606295A ZA200606295A ZA200606295B ZA 200606295 B ZA200606295 B ZA 200606295B ZA 200606295 A ZA200606295 A ZA 200606295A ZA 200606295 A ZA200606295 A ZA 200606295A ZA 200606295 B ZA200606295 B ZA 200606295B
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ZA
South Africa
Prior art keywords
disease
compound
pain
inhibitors
group
Prior art date
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ZA200606295A
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English (en)
Inventor
Hu Mengwei
Dwyer Michael
Kim-Meade Agnes
Fu Xiaoyong
Zhang Shuyi
Yu Younong
Arthur G Taveras
Yin Jianguo
Mcallister Timothy
Klopper Kevin
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Schering Corp
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Application filed by Schering Corp filed Critical Schering Corp
Publication of ZA200606295B publication Critical patent/ZA200606295B/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • AHUMAN NECESSITIES
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    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
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    • AHUMAN NECESSITIES
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    • A61P9/00Drugs for disorders of the cardiovascular system
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Biotechnology (AREA)
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ZA200606295A 2004-01-30 2006-07-28 Crystalline polymorphs of a CXC-chemokine receptor ligand ZA200606295B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54048704P 2004-01-30 2004-01-30

Publications (1)

Publication Number Publication Date
ZA200606295B true ZA200606295B (en) 2008-02-27

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ID=34837390

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200606295A ZA200606295B (en) 2004-01-30 2006-07-28 Crystalline polymorphs of a CXC-chemokine receptor ligand

Country Status (26)

Country Link
US (2) US20050192345A1 (de)
EP (1) EP1723131B1 (de)
JP (2) JP2007519751A (de)
KR (1) KR100883476B1 (de)
CN (1) CN1914187B (de)
AR (1) AR047739A1 (de)
AT (1) ATE478061T1 (de)
AU (1) AU2005210504B2 (de)
BR (1) BRPI0507329A (de)
CA (1) CA2554709C (de)
CO (1) CO5700731A2 (de)
DE (1) DE602005022986D1 (de)
EC (1) ECSP066733A (de)
ES (1) ES2349788T3 (de)
HK (1) HK1091496A1 (de)
IL (1) IL177033A0 (de)
MX (1) MXPA06008599A (de)
MY (1) MY144657A (de)
NO (1) NO20063841L (de)
NZ (1) NZ548499A (de)
PE (1) PE20051093A1 (de)
PL (1) PL380997A1 (de)
RU (1) RU2388756C2 (de)
TW (1) TW200536848A (de)
WO (1) WO2005075447A1 (de)
ZA (1) ZA200606295B (de)

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US20040106794A1 (en) 2001-04-16 2004-06-03 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US7132445B2 (en) * 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
WO2006051340A1 (en) * 2004-07-22 2006-05-18 Pliva - Istrazivanje I Razvoj D.O.O. Novel form of celecoxib
GB2418427A (en) 2004-09-02 2006-03-29 Univ Cambridge Tech Ligands for G-protein coupled receptors
AR061448A1 (es) 2006-06-12 2008-08-27 Schering Corp Formulaciones y compuestos farmaceuticos de un antagonista selectivo ya sea del receptor cxcr2, y los metodos para utilizar el mismo en el tratamiento de enfermedades inflamatorias
JP5243539B2 (ja) * 2007-07-03 2013-07-24 メルク・シャープ・アンド・ドーム・コーポレーション 1,2−置換3,4−ジオキソ−1−シクロブテン化合物の合成のための方法および中間体
WO2009005802A1 (en) * 2007-07-05 2009-01-08 Schering Corporation Process for controlled crystal size in 1,2-substituted 3,4-dioxo-1-cyclobutene compounds
MX2010006089A (es) * 2007-12-04 2010-09-22 Schering Corp Metodos de tratamiento de enfermedad pulmonar obstructiva cronica.
GB2455539B (en) * 2007-12-12 2012-01-18 Cambridge Entpr Ltd Anti-inflammatory compositions and combinations
UA103198C2 (en) 2008-08-04 2013-09-25 Новартис Аг Squaramide derivatives as cxcr2 antagonists
WO2010063802A1 (en) * 2008-12-05 2010-06-10 Novartis Ag 3, 4-di-substituted cyclobutene- 1, 2 -diones as cxcr2 receptor antagonists
AU2010328186B2 (en) 2009-12-08 2014-12-18 Case Western Reserve University Compounds and methods of treating ocular disorders
ES2655942T3 (es) 2011-09-02 2018-02-22 Novartis Ag Sal de colina de un compuesto anti-inflamatorio de ciclobutenodiona sustituida
US8865723B2 (en) 2012-10-25 2014-10-21 Tetra Discovery Partners Llc Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury
US9763992B2 (en) 2014-02-13 2017-09-19 Father Flanagan's Boys' Home Treatment of noise induced hearing loss
TWI734715B (zh) 2015-11-19 2021-08-01 美商卡默森屈有限公司 趨化因子受體調節劑
TWI724056B (zh) 2015-11-19 2021-04-11 美商卡默森屈有限公司 Cxcr2抑制劑
EP3426253A4 (de) 2016-03-11 2019-11-06 Ardea Biosciences, Inc. Cxcr-2-inhibitoren zur behandlung von kristallarthropathien
BR112020004697A2 (pt) * 2017-09-12 2020-10-27 Ardea Biosciences, Inc. inibidores de cxcr-2 para tratamento de distúrbios
AU2019205786B2 (en) 2018-01-08 2023-12-14 Chemocentryx, Inc. Methods of treating generalized pustular psoriasis with an antagonist of CCR6 or CXCR2

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5125894A (en) * 1990-03-30 1992-06-30 Alza Corporation Method and apparatus for controlled environment electrotransport
US7027859B1 (en) * 1994-09-26 2006-04-11 Alza Corporation Electrotransport delivery device having improved safety and reduced abuse potential
DK1818325T3 (da) * 2001-04-16 2010-05-31 Schering Corp 3,4-di-substituerede cyklobuten-1,2-dioner som CXC-chemokin receptorligander
US7132445B2 (en) * 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
MXPA04009127A (es) * 2002-03-18 2005-01-25 Schering Corp Tratamiento de enfermedades mediadas por quimiocinas.
SG167671A1 (en) * 2003-04-18 2011-01-28 Schering Corp Synthesis of 2-hydroxy-n,n-dimethyl-3-[[2-[1(r)-(5-methyl-2- furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]aminobenzamide

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Publication number Publication date
DE602005022986D1 (de) 2010-09-30
ATE478061T1 (de) 2010-09-15
US20050192345A1 (en) 2005-09-01
IL177033A0 (en) 2006-12-10
MXPA06008599A (es) 2006-08-28
NO20063841L (no) 2006-10-27
RU2006131050A (ru) 2008-03-10
US20080279822A1 (en) 2008-11-13
CN1914187A (zh) 2007-02-14
EP1723131A1 (de) 2006-11-22
CA2554709A1 (en) 2005-08-18
PE20051093A1 (es) 2006-01-16
ES2349788T3 (es) 2011-01-11
KR20060128981A (ko) 2006-12-14
CO5700731A2 (es) 2006-11-30
ECSP066733A (es) 2006-11-24
PL380997A1 (pl) 2007-04-16
BRPI0507329A (pt) 2007-07-03
CN1914187B (zh) 2012-01-25
HK1091496A1 (en) 2007-01-19
RU2388756C2 (ru) 2010-05-10
AU2005210504B2 (en) 2009-01-08
AU2005210504A1 (en) 2005-08-18
JP2011042692A (ja) 2011-03-03
AR047739A1 (es) 2006-02-15
US8207221B2 (en) 2012-06-26
JP2007519751A (ja) 2007-07-19
CA2554709C (en) 2011-11-15
NZ548499A (en) 2010-06-25
EP1723131B1 (de) 2010-08-18
MY144657A (en) 2011-10-31
TW200536848A (en) 2005-11-16
WO2005075447A1 (en) 2005-08-18
KR100883476B1 (ko) 2009-02-16

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