CN107198778A - 用经不可切割接头连接的细胞结合剂美登木素生物碱偶联物 - Google Patents

用经不可切割接头连接的细胞结合剂美登木素生物碱偶联物 Download PDF

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Publication number
CN107198778A
CN107198778A CN201710333830.XA CN201710333830A CN107198778A CN 107198778 A CN107198778 A CN 107198778A CN 201710333830 A CN201710333830 A CN 201710333830A CN 107198778 A CN107198778 A CN 107198778A
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cell
binding agent
cell binding
antibody
maytansinoid
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CN201710333830.XA
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English (en)
Chinese (zh)
Inventor
R·斯蒂夫斯
R·卢茨
R·查里
H·谢
Y·科夫通
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Immunogen Inc
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Immunogen Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34467962&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN107198778(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immunogen Inc filed Critical Immunogen Inc
Priority claimed from CN200480026459.3A external-priority patent/CN101087611B/zh
Publication of CN107198778A publication Critical patent/CN107198778A/zh
Withdrawn legal-status Critical Current

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    • C07ORGANIC CHEMISTRY
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
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    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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CN201710333830.XA 2003-10-10 2004-10-12 用经不可切割接头连接的细胞结合剂美登木素生物碱偶联物 Withdrawn CN107198778A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US50990103P 2003-10-10 2003-10-10
US60/509,901 2003-10-10
US10/960,602 2004-10-08
US10/960,602 US8088387B2 (en) 2003-10-10 2004-10-08 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
CN200480026459.3A CN101087611B (zh) 2003-10-10 2004-10-12 用经不可切割接头连接的细胞结合剂美登木素生物碱偶联物靶向特定细胞群的方法、所述偶联物和制备所述偶联物的方法

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