CN101775017B - 大环化合物的丙型肝炎丝氨酸蛋白酶抑制剂 - Google Patents
大环化合物的丙型肝炎丝氨酸蛋白酶抑制剂 Download PDFInfo
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- CN101775017B CN101775017B CN200910175949.4A CN200910175949A CN101775017B CN 101775017 B CN101775017 B CN 101775017B CN 200910175949 A CN200910175949 A CN 200910175949A CN 101775017 B CN101775017 B CN 101775017B
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- diazacyclo
- pyrrolo
- dioxo
- nitrae
- isosorbide
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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Abstract
Description
Claims (21)
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US61/191725 | 2008-09-11 | ||
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US20968909P | 2009-03-10 | 2009-03-10 | |
US61/209689 | 2009-03-10 | ||
US61/209,689 | 2009-03-10 |
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CN2012100719006A Division CN102641271B (zh) | 2008-09-11 | 2009-09-11 | 大环化合物的丙型肝炎丝氨酸蛋白酶抑制剂 |
CN201410116146.2A Division CN103896950A (zh) | 2008-09-11 | 2009-09-11 | 大环化合物的丙型肝炎丝氨酸蛋白酶抑制剂 |
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CN200910175949.4A Active CN101775017B (zh) | 2008-09-11 | 2009-09-11 | 大环化合物的丙型肝炎丝氨酸蛋白酶抑制剂 |
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CN103896950A (zh) * | 2008-09-11 | 2014-07-02 | 艾博特公司 | 大环化合物的丙型肝炎丝氨酸蛋白酶抑制剂 |
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US8937150B2 (en) * | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
EP2483290A4 (en) * | 2009-09-28 | 2013-05-01 | Intermune Inc | CYCLIC PEPTIC INHIBITORS FOR REPLICATION OF HEPATITIS C VIRUS |
US8785487B2 (en) | 2010-01-25 | 2014-07-22 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8933110B2 (en) | 2010-01-25 | 2015-01-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
ES2613608T3 (es) * | 2010-03-10 | 2017-05-24 | Abbvie Ireland Unlimited Company | Composiciones sólidas |
AU2011352145A1 (en) * | 2010-12-30 | 2013-07-18 | Abbvie Inc. | Phenanthridine macrocyclic hepatitis C serine protease inhibitors |
EP2658859A4 (en) * | 2010-12-30 | 2014-07-30 | Enanta Pharm Inc | MACROCYCLIC HEPATITIS C SERIN PROTEASE INHIBITORS |
US9044480B1 (en) | 2011-03-03 | 2015-06-02 | Abbvie Inc. | Compositions and methods for treating HCV |
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