CN102641271B - 大环化合物的丙型肝炎丝氨酸蛋白酶抑制剂 - Google Patents
大环化合物的丙型肝炎丝氨酸蛋白酶抑制剂 Download PDFInfo
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- CN102641271B CN102641271B CN2012100719006A CN201210071900A CN102641271B CN 102641271 B CN102641271 B CN 102641271B CN 2012100719006 A CN2012100719006 A CN 2012100719006A CN 201210071900 A CN201210071900 A CN 201210071900A CN 102641271 B CN102641271 B CN 102641271B
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
Description
Claims (7)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
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US19172508P | 2008-09-11 | 2008-09-11 | |
US61/191,725 | 2008-09-11 | ||
US61/191725 | 2008-09-11 | ||
US20968909P | 2009-03-10 | 2009-03-10 | |
US61/209689 | 2009-03-10 | ||
US61/209,689 | 2009-03-10 |
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CN102641271A CN102641271A (zh) | 2012-08-22 |
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CN200910175949.4A Active CN101775017B (zh) | 2008-09-11 | 2009-09-11 | 大环化合物的丙型肝炎丝氨酸蛋白酶抑制剂 |
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CN200910175949.4A Active CN101775017B (zh) | 2008-09-11 | 2009-09-11 | 大环化合物的丙型肝炎丝氨酸蛋白酶抑制剂 |
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Cited By (1)
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CN103896950A (zh) * | 2008-09-11 | 2014-07-02 | 艾博特公司 | 大环化合物的丙型肝炎丝氨酸蛋白酶抑制剂 |
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US8937150B2 (en) * | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
AU2010298028A1 (en) * | 2009-09-28 | 2012-04-19 | Intermune, Inc. | Cyclic peptide inhibitors of hepatitis C virus replication |
CA2787309A1 (en) | 2010-01-25 | 2011-07-28 | Enanta Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
US8933110B2 (en) | 2010-01-25 | 2015-01-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
BR112012022774A2 (pt) * | 2010-03-10 | 2017-09-12 | Abbott Lab | Composição sólida compreendendo primeira e segunda dispersões sólidas amorfas |
WO2012092409A2 (en) * | 2010-12-30 | 2012-07-05 | Enanta Phararmaceuticals, Inc | Macrocyclic hepatitis c serine protease inhibitors |
US8951964B2 (en) * | 2010-12-30 | 2015-02-10 | Abbvie Inc. | Phenanthridine macrocyclic hepatitis C serine protease inhibitors |
US9044480B1 (en) * | 2011-03-03 | 2015-06-02 | Abbvie Inc. | Compositions and methods for treating HCV |
US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
JP2014530195A (ja) * | 2011-09-16 | 2014-11-17 | アッヴィ・インコーポレイテッド | Hcvを治療するための方法 |
AU2015200715A1 (en) * | 2011-10-21 | 2015-03-05 | Abbvie Ireland Unlimited Company | Methods for treating HCV |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN103896950A (zh) * | 2008-09-11 | 2014-07-02 | 艾博特公司 | 大环化合物的丙型肝炎丝氨酸蛋白酶抑制剂 |
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