CA3112106C - Hyaluronic acid-based gels including anesthetic agents - Google Patents
Hyaluronic acid-based gels including anesthetic agents Download PDFInfo
- Publication number
- CA3112106C CA3112106C CA3112106A CA3112106A CA3112106C CA 3112106 C CA3112106 C CA 3112106C CA 3112106 A CA3112106 A CA 3112106A CA 3112106 A CA3112106 A CA 3112106A CA 3112106 C CA3112106 C CA 3112106C
- Authority
- CA
- Canada
- Prior art keywords
- lidocaine
- gel
- composition
- crosslinked
- dermal filler
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 229920002674 hyaluronan Polymers 0.000 title claims abstract description 246
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 245
- 229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 245
- 239000003193 general anesthetic agent Substances 0.000 title abstract description 21
- 239000000499 gel Substances 0.000 title description 118
- 239000000203 mixture Substances 0.000 claims abstract description 151
- 229960004194 lidocaine Drugs 0.000 claims abstract description 71
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims abstract description 70
- 239000000945 filler Substances 0.000 claims abstract description 54
- 238000000034 method Methods 0.000 claims abstract description 47
- 230000001954 sterilising effect Effects 0.000 claims abstract description 20
- 230000002500 effect on skin Effects 0.000 claims abstract description 19
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- SHKUUQIDMUMQQK-UHFFFAOYSA-N 2-[4-(oxiran-2-ylmethoxy)butoxymethyl]oxirane Chemical compound C1OC1COCCCCOCC1CO1 SHKUUQIDMUMQQK-UHFFFAOYSA-N 0.000 claims description 12
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
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- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 6
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
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- PGMKGZOHRBZSSQ-UHFFFAOYSA-N 2-[2-(oxiran-2-ylmethoxy)ethenoxymethyl]oxirane Chemical group C1OC1COC=COCC1CO1 PGMKGZOHRBZSSQ-UHFFFAOYSA-N 0.000 description 2
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- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
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- 239000001273 butane Substances 0.000 description 2
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- GYZLOYUZLJXAJU-UHFFFAOYSA-N diglycidyl ether Chemical compound C1OC1COCC1CO1 GYZLOYUZLJXAJU-UHFFFAOYSA-N 0.000 description 2
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- 239000004615 ingredient Substances 0.000 description 2
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- 239000003589 local anesthetic agent Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 2
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- 229940010747 sodium hyaluronate Drugs 0.000 description 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 2
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- GCJXHLAUPMDQPQ-UHFFFAOYSA-N (2,5-dimethyl-1-prop-2-enylpiperidin-4-yl) benzoate Chemical compound CC1CN(CC=C)C(C)CC1OC(=O)C1=CC=CC=C1 GCJXHLAUPMDQPQ-UHFFFAOYSA-N 0.000 description 1
- HGKAMARNFGKMLC-MOPGFXCFSA-N (2r)-2-[(4r)-2,2-diphenyl-1,3-dioxolan-4-yl]piperidine Chemical compound C([C@@H]1[C@H]2OC(OC2)(C=2C=CC=CC=2)C=2C=CC=CC=2)CCCN1 HGKAMARNFGKMLC-MOPGFXCFSA-N 0.000 description 1
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 description 1
- CAFOIGUDKPQBIO-BYIOMEFUSA-N (r)-[(2s,4s,5r)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-[6-(3-methylbutoxy)quinolin-4-yl]methanol Chemical compound C1=C(OCCC(C)C)C=C2C([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4CC)=CC=NC2=C1 CAFOIGUDKPQBIO-BYIOMEFUSA-N 0.000 description 1
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- ZLMQPGUWYWFPEG-UHFFFAOYSA-N 2-(diethylamino)ethyl 4-amino-2-butoxybenzoate Chemical compound CCCCOC1=CC(N)=CC=C1C(=O)OCCN(CC)CC ZLMQPGUWYWFPEG-UHFFFAOYSA-N 0.000 description 1
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Landscapes
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA3209175A CA3209175A1 (en) | 2008-08-04 | 2009-03-02 | Hyaluronic acid-based gels including anesthetic agents |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8595608P | 2008-08-04 | 2008-08-04 | |
| US61/085,956 | 2008-08-04 | ||
| US8793408P | 2008-08-11 | 2008-08-11 | |
| US61/087,934 | 2008-08-11 | ||
| US9627808P | 2008-09-11 | 2008-09-11 | |
| US61/096,278 | 2008-09-11 | ||
| US12/393,768 US8450475B2 (en) | 2008-08-04 | 2009-02-26 | Hyaluronic acid-based gels including lidocaine |
| US12/393,884 US8357795B2 (en) | 2008-08-04 | 2009-02-26 | Hyaluronic acid-based gels including lidocaine |
| US12/393,884 | 2009-02-26 | ||
| US12/393,768 | 2009-02-26 | ||
| CA3023168A CA3023168C (en) | 2008-08-04 | 2009-03-02 | Hyaluronic acid-based gels including lidocaine |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3023168A Division CA3023168C (en) | 2008-08-04 | 2009-03-02 | Hyaluronic acid-based gels including lidocaine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3209175A Division CA3209175A1 (en) | 2008-08-04 | 2009-03-02 | Hyaluronic acid-based gels including anesthetic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA3112106A1 CA3112106A1 (en) | 2010-02-11 |
| CA3112106C true CA3112106C (en) | 2023-10-17 |
Family
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Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3112106A Active CA3112106C (en) | 2008-08-04 | 2009-03-02 | Hyaluronic acid-based gels including anesthetic agents |
| CA2944734A Active CA2944734C (en) | 2008-08-04 | 2009-03-02 | Hyaluronic acid-based gels including lidocaine |
| CA2732928A Abandoned CA2732928A1 (en) | 2008-08-04 | 2009-03-02 | Hyaluronic acid-based gels including anesthetic agents |
| CA3209175A Pending CA3209175A1 (en) | 2008-08-04 | 2009-03-02 | Hyaluronic acid-based gels including anesthetic agents |
| CA3023168A Active CA3023168C (en) | 2008-08-04 | 2009-03-02 | Hyaluronic acid-based gels including lidocaine |
| CA2732788A Active CA2732788C (en) | 2008-08-04 | 2009-03-02 | Hyaluronic acid-based gels including lidocaine |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2944734A Active CA2944734C (en) | 2008-08-04 | 2009-03-02 | Hyaluronic acid-based gels including lidocaine |
| CA2732928A Abandoned CA2732928A1 (en) | 2008-08-04 | 2009-03-02 | Hyaluronic acid-based gels including anesthetic agents |
| CA3209175A Pending CA3209175A1 (en) | 2008-08-04 | 2009-03-02 | Hyaluronic acid-based gels including anesthetic agents |
| CA3023168A Active CA3023168C (en) | 2008-08-04 | 2009-03-02 | Hyaluronic acid-based gels including lidocaine |
| CA2732788A Active CA2732788C (en) | 2008-08-04 | 2009-03-02 | Hyaluronic acid-based gels including lidocaine |
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