PL1817347T3 - Sposób sieciowania kwasu hialuronowego za pomocą diwinylosulfonu - Google Patents

Sposób sieciowania kwasu hialuronowego za pomocą diwinylosulfonu

Info

Publication number
PL1817347T3
PL1817347T3 PL05804061T PL05804061T PL1817347T3 PL 1817347 T3 PL1817347 T3 PL 1817347T3 PL 05804061 T PL05804061 T PL 05804061T PL 05804061 T PL05804061 T PL 05804061T PL 1817347 T3 PL1817347 T3 PL 1817347T3
Authority
PL
Poland
Prior art keywords
divinylsulfone
cross
hyaluronic acid
linking hyaluronic
linking
Prior art date
Application number
PL05804061T
Other languages
English (en)
Inventor
Fanny Longin
Khadija Schwach-Abdellaoui
Original Assignee
Albumedix As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albumedix As filed Critical Albumedix As
Publication of PL1817347T3 publication Critical patent/PL1817347T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/738Cross-linked polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/042Gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00Preparations for affecting hair growth
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00Processes of treating or compounding macromolecular substances
    • C08J3/02Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075Macromolecular gels

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Materials Engineering (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Materials For Medical Uses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL05804061T 2004-11-24 2005-11-24 Sposób sieciowania kwasu hialuronowego za pomocą diwinylosulfonu PL1817347T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200401824 2004-11-24
PCT/DK2005/000753 WO2006056204A1 (en) 2004-11-24 2005-11-24 Method of cross-linking hyaluronic acid with divinylsulfone
EP05804061.9A EP1817347B1 (en) 2004-11-24 2005-11-24 Method of cross-linking hyaluronic acid with divinylsulfone

Publications (1)

Publication Number Publication Date
PL1817347T3 true PL1817347T3 (pl) 2017-10-31

Family

ID=36051535

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05804061T PL1817347T3 (pl) 2004-11-24 2005-11-24 Sposób sieciowania kwasu hialuronowego za pomocą diwinylosulfonu

Country Status (8)

Country Link
US (3) US8481080B2 (pl)
EP (1) EP1817347B1 (pl)
CN (1) CN101107270B (pl)
DK (1) DK1817347T3 (pl)
ES (1) ES2636998T3 (pl)
PL (1) PL1817347T3 (pl)
PT (1) PT1817347T (pl)
WO (1) WO2006056204A1 (pl)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2861734B1 (fr) 2003-04-10 2006-04-14 Corneal Ind Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus
FR2909560B1 (fr) * 2006-12-06 2012-12-28 Fabre Pierre Dermo Cosmetique Gel d'acide hyaluronique pour injection intradermique
PT2107913E (pt) 2006-12-22 2012-05-10 Croma Pharma Ges M B H Uso de polissacarídeos tiolados para aumento de tecidos
JP2008255061A (ja) * 2007-04-06 2008-10-23 Shiseido Co Ltd 可溶性架橋ヒアルロン酸含有眼用組成物
WO2008147867A2 (en) * 2007-05-23 2008-12-04 Allergan, Inc. Cross-linked collagen and uses thereof
US20110077737A1 (en) * 2007-07-30 2011-03-31 Allergan, Inc. Tunably Crosslinked Polysaccharide Compositions
EP2199308B1 (en) * 2007-09-28 2012-02-08 Shiseido Company, Ltd. Swellable crosslinked hyaluronic acid powder and method for producing the same
US8697044B2 (en) 2007-10-09 2014-04-15 Allergan, Inc. Crossed-linked hyaluronic acid and collagen and uses thereof
WO2009065116A1 (en) 2007-11-16 2009-05-22 Aspect Pharmaceuticals Llc Compositions and methods for treating purpura
US8394782B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
US8394784B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having multi-stage bioactive agent delivery
EP2222715B1 (en) * 2007-12-19 2019-07-24 Evonik Degussa GmbH Crosslinked hyaluronic acid in emulsion
US8357795B2 (en) 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
WO2010028025A1 (en) 2008-09-02 2010-03-11 Gurtner Geoffrey C Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
DK2413894T3 (en) * 2009-04-02 2017-04-03 Allergan Inc HIGHLY FORMED HYDROGLES FOR SOFTWARE STRENGTH
US9371402B2 (en) * 2009-04-09 2016-06-21 Scivision Biotech Inc. Method for producing cross-linked hyaluronic acid
FR2945293B1 (fr) 2009-05-11 2011-06-17 Teoxane Procede de preparation d'un gel reticule.
KR101551681B1 (ko) 2009-07-30 2015-09-09 카르빌란 테라퓨틱스, 인코포레이티드 변형된 히알루론산 폴리머 조성물 및 관련방법
CZ2009835A3 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Zpusob prípravy derivátu kyseliny hyaluronové oxidovaného v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd a zpusob jeho modifikace
CZ302504B6 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Derivát kyseliny hyaluronové oxidovaný v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd, zpusob jeho prípravy a zpusob jeho modifikace
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
CN102905677A (zh) 2010-03-12 2013-01-30 阿勒根工业有限公司 用于改善皮肤状况的包含透明质烷聚合物和甘露糖醇的流体组合物
PT2550027T (pt) 2010-03-22 2016-08-12 Allergan Inc Hidrogéis reticulados à base de polissacáridos e proteínopolissacáridos para aumento dos tecidos moles
CN102905710B (zh) * 2010-03-30 2015-03-18 海斯特赛尔有限公司 来自脐带胶质的新生物材料
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
FR2968305B1 (fr) 2010-12-06 2014-02-28 Teoxane Procede de preparation d'un gel reticule
CZ302994B6 (cs) 2010-12-31 2012-02-08 Cpn S.R.O. Hyaluronová vlákna, zpusob jejich prípravy a použití
JP5998201B2 (ja) 2011-04-20 2016-09-28 カービラン セラピューティクス, インコーポレイテッド In−situゲル形成組成物
CN102757572A (zh) * 2011-04-28 2012-10-31 上海其胜生物制剂有限公司 一种具有双抗特性(抗高温、酶解)的无颗粒化交联透明质酸钠凝胶的制备方法
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
CA2838237C (en) 2011-06-03 2020-05-26 Allergan, Inc. Dermal filler compositions including antioxidants
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
RU2613887C2 (ru) 2011-08-10 2017-03-21 Гликорес 2000 С.Р.Л. Устойчивый к расщеплению сшитый низкомолекулярный гиалуронат
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
CZ2012136A3 (cs) 2012-02-28 2013-06-05 Contipro Biotech S.R.O. Deriváty na bázi kyseliny hyaluronové schopné tvorit hydrogely, zpusob jejich prípravy, hydrogely na bázi techto derivátu, zpusob jejich prípravy a pouzití
CZ304512B6 (cs) 2012-08-08 2014-06-11 Contipro Biotech S.R.O. Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití
FR2997014B1 (fr) 2012-10-24 2015-03-20 Teoxane Composition sterile dermo-injectable
FR2997085B1 (fr) 2012-10-24 2015-05-29 Teoxane Procede de preparation d'un gel reticule
CZ2012842A3 (cs) * 2012-11-27 2014-08-20 Contipro Biotech S.R.O. Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití
WO2014096257A1 (en) * 2012-12-19 2014-06-26 Novozymes Biopharma Dk A/S Freeze-dried cross-linked hyaluronic acid sponge
US20200230033A1 (en) * 2013-01-21 2020-07-23 Paean Aesthetics Inc. Micro-spicule composition to control its shape and method for producing the same
HK1224315A1 (zh) * 2013-06-28 2017-08-18 Galderma S.A. 用於制备交联的透明质酸产物的方法
LT3049055T (lt) * 2013-09-27 2018-07-25 Anteis S.A. Injekcinio hidrogelio, sterilizuoto karščiu, sudaryto iš hialurono rūgšties, turinčio miltelių pavidalo lidokaino ir šarminio agento, gamybos būdas
CZ2014150A3 (cs) 2014-03-11 2015-05-20 Contipro Biotech S.R.O. Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití
CZ2014451A3 (cs) 2014-06-30 2016-01-13 Contipro Pharma A.S. Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití
US10722444B2 (en) 2014-09-30 2020-07-28 Allergan Industrie, Sas Stable hydrogel compositions including additives
FR3029928B1 (fr) 2014-12-15 2018-03-09 Teoxane Gel reticule
WO2016128783A1 (en) 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions and methods for improving skin appearance
EP3653232A1 (en) 2015-02-13 2020-05-20 Allergan Industrie, SAS Implants for sculpting, augmenting or correcting facial features such as the chin
CZ309295B6 (cs) 2015-03-09 2022-08-10 Contipro A.S. Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití
CZ306479B6 (cs) 2015-06-15 2017-02-08 Contipro A.S. Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin
US9737395B2 (en) 2015-06-26 2017-08-22 Phi Nguyen Systems and methods for reducing scarring
CZ306662B6 (cs) 2015-06-26 2017-04-26 Contipro A.S. Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití
US10130578B2 (en) 2015-07-23 2018-11-20 Johnson & Johnson Consumer Inc. Topical delivery of skin compositions having low pH
EP3328351A1 (en) 2015-07-27 2018-06-06 Galderma S.A. A process for efficient cross-linking of hyaluronic acid
CZ308106B6 (cs) 2016-06-27 2020-01-08 Contipro A.S. Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití
TW201832783A (zh) * 2016-12-02 2018-09-16 法商賽諾菲公司 包含glp-1/胰高血糖素雙重激動劑、連接子和透明質酸的接合物
CN106750383B (zh) * 2016-12-20 2019-02-12 大连理工大学 聚乙二醇水凝胶材料及其制备方法
KR101944008B1 (ko) * 2017-09-18 2019-01-30 (주) 제이씨바이오 히알루론산을 포함하는 투명 하이드로겔 막 및 이를 이용한 콘택트렌즈
CN107936272B (zh) * 2017-11-27 2020-11-10 华熙生物科技股份有限公司 一种用于放疗防护的3d交联透明质酸盐凝胶的制备方法及其产品
WO2019130359A1 (en) * 2017-12-29 2019-07-04 Matex Lab S.P.A. Method to prepare a filler with a hyaluronic acid base comprising a neutralization step
MA52575A (fr) * 2018-05-08 2021-03-17 Fidia Farm Spa Pansement pour le traitement de la peau endommagée
CN108774330B (zh) * 2018-08-30 2020-11-10 华熙生物科技股份有限公司 一种交联透明质酸凝胶的制备方法及所得产品和应用
CN112714644B (zh) * 2018-09-20 2024-03-29 香港科技大学 滴眼剂组合物
WO2020057606A1 (en) * 2018-09-20 2020-03-26 The Hong Kong University Of Science And Technology Eyedrop compositions
KR102015857B1 (ko) * 2019-04-08 2019-08-30 (주)우성씨앤티 가교 히알루론산과 프리바이오틱스를 활성 성분으로 포함하는 화장품 조성물
EP3797800A1 (en) * 2019-05-02 2021-03-31 Institut National De La Sante Et De La Recherche Medicale - Inserm Hyaluronic acid hydrogels with prolonged antimicrobial activity
WO2020264392A1 (en) * 2019-06-26 2020-12-30 Lacerta Technologies Inc. Cross-linked hyaluronic acid hydrogels comprising proteins
CN111514364B (zh) * 2020-03-19 2022-06-10 中国人民解放军陆军军医大学第二附属医院 一种用于恶性血液病患者肛周感染的敷料及其制备方法
ES2967629T3 (es) * 2020-04-28 2024-05-03 Nanofaber S R L Partículas de microesponjas nanoporosas (NMP) de polímeros biocompatibles como portadores universales para la administración de biomoléculas
CA3208574A1 (en) * 2021-02-16 2022-08-25 Prollenium Medical Technologies, Inc. Cross-linked ha beads, process for making same and uses
CN114209869A (zh) * 2022-01-14 2022-03-22 北京极暖网络科技有限公司 自发热玻尿酸材料、制备方法及裤式卫生巾
CN118403006A (zh) * 2024-03-29 2024-07-30 上海利康瑞生物工程有限公司 交联玻璃酸钠注射液用于治疗骨关节炎的用途

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
US4716224A (en) 1984-05-04 1987-12-29 Seikagaku Kogyo Co. Ltd. Crosslinked hyaluronic acid and its use
SE442820B (sv) * 1984-06-08 1986-02-03 Pharmacia Ab Gel av tverbunden hyaluronsyra for anvendning som glaskroppssubstitut
US4582865A (en) * 1984-12-06 1986-04-15 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US4713448A (en) 1985-03-12 1987-12-15 Biomatrix, Inc. Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
DE3684887D1 (de) * 1985-11-29 1992-05-21 Biomatrix Inc Arzneistoffabgabesysteme auf basis von hyaluronan, dessen derivaten und salzen sowie verfahren zu deren herstellung.
JPS6345198A (ja) 1986-04-23 1988-02-26 Sumitomo Electric Ind Ltd 多元系結晶の製造方法
IT1198449B (it) 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
US5017229A (en) 1990-06-25 1991-05-21 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US5356883A (en) 1989-08-01 1994-10-18 Research Foundation Of State University Of N.Y. Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
US5767079A (en) * 1992-07-08 1998-06-16 Celtrix Pharmaceuticals, Inc. Method of treating ophthalmic disorders using TGF -β
US5866120A (en) * 1995-11-22 1999-02-02 Advanced Corneal Systems, Inc. Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase
IT1303735B1 (it) 1998-11-11 2001-02-23 Falorni Italia Farmaceutici S Acidi ialuronici reticolati e loro usi medici.
FR2827290B1 (fr) * 2001-07-13 2004-07-09 Pierre Jouan Biotechnologies Sa Procede d'obtention d'une fraction proteique enrichie en tgf-beta sous forme activee, fraction proteique et applications therapeutiques
RU2346049C2 (ru) * 2001-12-21 2009-02-10 Новозимс Биополимер А/С Способ получения гиалуронана в рекомбинантной клетке-хозяине
US20050222081A1 (en) 2002-04-17 2005-10-06 Gianolio Diego A Cross-linked hyaluronate compounds
AU2003303820A1 (en) 2003-01-31 2004-08-23 Biosphere S.P.A. Water soluble and biocompatible gels of hyaluronic acid cross-linked with bi-functional l-aminoacids or l-aminoesters
AU2004312532B2 (en) 2003-12-30 2010-05-20 Genzyme Corporation Cohesive gels form cross-linked hyaluronan and/or hylan, their preparation and use
US20050281880A1 (en) * 2004-05-20 2005-12-22 Wei Wang Methods for making injectable polymer hydrogels

Also Published As

Publication number Publication date
WO2006056204A1 (en) 2006-06-01
CN101107270B (zh) 2011-11-23
US20150190420A1 (en) 2015-07-09
DK1817347T3 (en) 2017-08-14
US20130338100A1 (en) 2013-12-19
ES2636998T3 (es) 2017-10-10
US8481080B2 (en) 2013-07-09
US20090155362A1 (en) 2009-06-18
EP1817347B1 (en) 2017-05-17
WO2006056204A8 (en) 2006-08-24
EP1817347A1 (en) 2007-08-15
CN101107270A (zh) 2008-01-16
PT1817347T (pt) 2017-07-21

Similar Documents

Publication Publication Date Title
PT1817347T (pt) Resumo
EP1818344A4 (en) METHOD FOR SYNTHESIZING RETICULATED HYALURONIC ACID GEL
PL1784375T3 (pl) Sposób wytwarzania kwasu mrówkowego
IL181303A0 (en) Method for the production of dihydropteridinones
IL197498A0 (en) Hyaluronic acid derivatives obtained via click chemistry' crosslinking
GB0401821D0 (en) Method of manufacture of polymer composites
TWI349660B (en) Process for producing acetic acid
IL182940A0 (en) Solid electrolyte and method of producing the same
IL176767A0 (en) Production method
GB0409610D0 (en) Improved method of settling commercial indebtedness
IL180742A0 (en) Method of manufacture
PL1903019T3 (pl) Sposób wytwarzania izoolefin
EP2003735A4 (en) END DEVICE AND METHOD FOR THE PRODUCTION THEREOF
IL171145A (en) Method for the production of telmisartan
TWI365182B (en) Process for producing acetic acid
ZA200609923B (en) 2-butanol production method
PL2597175T3 (pl) Sposób wytwarzania powlekanego polimeru
SI1794111T1 (sl) Postopek za pridobivanje ciklopentanona
ZA200709285B (en) Method for the production of pigs, and pigs
EP1892255A4 (en) ACRYLIC ACID POLYMER AND MANUFACTURING METHOD THEREFOR
IL181339A0 (en) Method for the production of diarylcycloalkyl derivatives
PL2121649T3 (pl) Sposób otrzymywania benzofurano-2-karboksyamidów
TWI372158B (en) Method of producing film from polymer solution
ZA200700282B (en) Method for the production of dihydropteridinones
PL372014A1 (pl) Sposób wytwarzania kwasu 1-metylo-4-nitro-3-n-propylo-pirazolo-5-karboksylowego