CA2350609C - N-substituted 2-cyanopyrrolidines - Google Patents

N-substituted 2-cyanopyrrolidines Download PDF

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Publication number
CA2350609C
CA2350609C CA002350609A CA2350609A CA2350609C CA 2350609 C CA2350609 C CA 2350609C CA 002350609 A CA002350609 A CA 002350609A CA 2350609 A CA2350609 A CA 2350609A CA 2350609 C CA2350609 C CA 2350609C
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CA
Canada
Prior art keywords
salt
amino
compound
mammal
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CA002350609A
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English (en)
French (fr)
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CA2350609A1 (en
Inventor
Edwin Bernard Villhauer
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Individual
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Novartis AG
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22777194&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2350609(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of CA2350609A1 publication Critical patent/CA2350609A1/en
Application granted granted Critical
Publication of CA2350609C publication Critical patent/CA2350609C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CA002350609A 1998-12-10 1999-12-09 N-substituted 2-cyanopyrrolidines Expired - Lifetime CA2350609C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20906898A 1998-12-10 1998-12-10
US09/209,068 1998-12-10
PCT/EP1999/009708 WO2000034241A1 (en) 1998-12-10 1999-12-09 N-substituted 2-cyanopyrrolidines

Publications (2)

Publication Number Publication Date
CA2350609A1 CA2350609A1 (en) 2000-06-15
CA2350609C true CA2350609C (en) 2008-09-02

Family

ID=22777194

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002350609A Expired - Lifetime CA2350609C (en) 1998-12-10 1999-12-09 N-substituted 2-cyanopyrrolidines

Country Status (34)

Country Link
US (1) US6166063A (ref)
EP (1) EP1137635B1 (ref)
JP (2) JP3681110B2 (ref)
KR (2) KR100509311B1 (ref)
CN (1) CN1160330C (ref)
AR (1) AR023719A1 (ref)
AT (1) ATE307112T1 (ref)
BR (1) BRPI9915985B8 (ref)
CA (1) CA2350609C (ref)
CO (1) CO5150173A1 (ref)
CY (3) CY1105355T1 (ref)
CZ (1) CZ299151B6 (ref)
DE (3) DE122008000007I1 (ref)
DK (1) DK1137635T3 (ref)
ES (1) ES2251847T3 (ref)
FR (1) FR08C0005I2 (ref)
HK (1) HK1040394B (ref)
HU (1) HU226769B1 (ref)
ID (1) ID28796A (ref)
IL (2) IL143091A0 (ref)
LU (2) LU91409I2 (ref)
MY (1) MY123244A (ref)
NL (2) NL300333I2 (ref)
NO (3) NO318741B1 (ref)
NZ (1) NZ511935A (ref)
PE (1) PE20001317A1 (ref)
PL (1) PL199443B1 (ref)
RU (1) RU2251544C2 (ref)
SK (1) SK286635B6 (ref)
TR (1) TR200101478T2 (ref)
TW (1) TW509674B (ref)
UY (1) UY25843A1 (ref)
WO (1) WO2000034241A1 (ref)
ZA (1) ZA200104581B (ref)

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