BR112015021593A2 - sistemas de focalização automática e métodos para análise de partícula em amostras de sangue - Google Patents
sistemas de focalização automática e métodos para análise de partícula em amostras de sangueInfo
- Publication number
- BR112015021593A2 BR112015021593A2 BR112015021593A BR112015021593A BR112015021593A2 BR 112015021593 A2 BR112015021593 A2 BR 112015021593A2 BR 112015021593 A BR112015021593 A BR 112015021593A BR 112015021593 A BR112015021593 A BR 112015021593A BR 112015021593 A2 BR112015021593 A2 BR 112015021593A2
- Authority
- BR
- Brazil
- Prior art keywords
- flow cell
- microscope
- flow
- contrast
- methods
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 3
- 210000004369 blood Anatomy 0.000 title abstract 2
- 239000008280 blood Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 4
- 210000000601 blood cell Anatomy 0.000 abstract 2
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/06—Investigating concentration of particle suspensions
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1429—Signal processing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1429—Signal processing
- G01N15/1433—Signal processing using image recognition
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
- G01N15/1436—Optical arrangements the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
- G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/53—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4915—Blood using flow cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B7/00—Mountings, adjusting means, or light-tight connections, for optical elements
- G02B7/28—Systems for automatic generation of focusing signals
- G02B7/36—Systems for automatic generation of focusing signals using image sharpness techniques, e.g. image processing techniques for generating autofocus signals
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1019—Associating Coulter-counter and optical flow cytometer [OFC]
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
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- G01N2015/1411—Features of sheath fluids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
- G01N2015/1452—Adjustment of focus; Alignment
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1481—Optical analysis of particles within droplets
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- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1486—Counting the particles
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
- G01N2021/058—Flat flow cell
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- G—PHYSICS
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- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/24—Base structure
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- G02B21/244—Devices for focusing using image analysis techniques
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B7/00—Mountings, adjusting means, or light-tight connections, for optical elements
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/10—Image acquisition modality
- G06T2207/10141—Special mode during image acquisition
- G06T2207/10148—Varying focus
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/0002—Inspection of images, e.g. flaw detection
- G06T7/0012—Biomedical image inspection
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Ecology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Signal Processing (AREA)
- Tropical Medicine & Parasitology (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Physiology (AREA)
- Optics & Photonics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Optical Measuring Cells (AREA)
Abstract
resumo patente de invenção "sistemas de focalização automática e métodos para análise de partícula em amostras de sangue". a presente invenção refere-se a partículas que, tais como as células do sangue, podem ser categorizadas e contadas por um processador de imagem digital. uma câmera de microscópio digital pode ser direcionada em uma célula de fluxo definindo uma trajetória de fluxo que se estreita simetricamente na qual a corrente da amostra flui em uma fita achatada pelos parâmetros de fluxo e viscosidade entre as camadas do fluido de revestimento. um padrão contrastante para a focalização automática é fornecido na célula de fluxo, por exemplo, em uma borda de uma abertura de iluminação traseira. o processador de imagem avalia a exatidão do foco a partir do contraste dos dados de pixel. um mecanismo de posicionamento move o microscópio e/ou a célula de fluxo ao longo de um eixo óptico para focalização automática no alvo do padrão de contraste. o processador então desloca o microscópio e a célula de fluxo por uma distância conhecida entre o padrão de contraste e a corrente da amostra, focalizando assim na corrente da amostra. as imagens da célula do sangue são coletadas a partir daquela posição até a focalização automática ser reiniciada, periodicamente, pelo sinal de entrada, ou quando mudanças de temperatura ou inexatidão do foco nos dados da imagem são detectadas.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361799152P | 2013-03-15 | 2013-03-15 | |
US61/799,152 | 2013-03-15 | ||
US14/216,811 | 2014-03-17 | ||
PCT/US2014/030928 WO2014146051A1 (en) | 2013-03-15 | 2014-03-17 | Autofocus systems and methods for particle analysis in blood samples |
US14/216,811 US10705008B2 (en) | 2013-03-15 | 2014-03-17 | Autofocus systems and methods for particle analysis in blood samples |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112015021593A2 true BR112015021593A2 (pt) | 2017-07-18 |
BR112015021593B1 BR112015021593B1 (pt) | 2020-12-29 |
Family
ID=50631094
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015019969-0A BR112015019969B1 (pt) | 2013-03-15 | 2014-03-17 | método para a obtenção de imagens de partículas usando um sistema de análise de partículas configurado para focalização hidrodinâmica combinada da viscosidade e da geometria, e sistema de análise de partículas que realiza focalização hidrodinâmica combinada da viscosidade e da geometria para partículas de imagem em uma amostra de sangue |
BR112015021593-9A BR112015021593B1 (pt) | 2013-03-15 | 2014-03-17 | método para imageamento de partículas em uma amostra de fluido sanguíneo usando um sistema de análise de partícula configurado para a hidrofocalização geométrica, e sistema de análise de partícula que realiza a hidrofocalização geométrica para o imageamento de partículas em uma amostra de fluido sanguíneo |
BR112015020098-2A BR112015020098B1 (pt) | 2013-03-15 | 2014-03-17 | composição de agente de contraste de partículas para colorir uma amostra de fluido sanguíneo e método para tratar partículas de uma amostra de fluido sanguíneo |
BR112015021800-8A BR112015021800B1 (pt) | 2013-03-15 | 2014-03-18 | sistema e método para medir uma quantidade de um primeiro tipo de células em uma amostra de fluido de sangue |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015019969-0A BR112015019969B1 (pt) | 2013-03-15 | 2014-03-17 | método para a obtenção de imagens de partículas usando um sistema de análise de partículas configurado para focalização hidrodinâmica combinada da viscosidade e da geometria, e sistema de análise de partículas que realiza focalização hidrodinâmica combinada da viscosidade e da geometria para partículas de imagem em uma amostra de sangue |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015020098-2A BR112015020098B1 (pt) | 2013-03-15 | 2014-03-17 | composição de agente de contraste de partículas para colorir uma amostra de fluido sanguíneo e método para tratar partículas de uma amostra de fluido sanguíneo |
BR112015021800-8A BR112015021800B1 (pt) | 2013-03-15 | 2014-03-18 | sistema e método para medir uma quantidade de um primeiro tipo de células em uma amostra de fluido de sangue |
Country Status (10)
Country | Link |
---|---|
US (14) | US10705008B2 (pt) |
EP (8) | EP3489656B1 (pt) |
JP (4) | JP6404317B2 (pt) |
KR (4) | KR102055474B1 (pt) |
CN (7) | CN109142195B (pt) |
BR (4) | BR112015019969B1 (pt) |
ES (2) | ES2711364T3 (pt) |
HR (1) | HRP20181125T1 (pt) |
TR (2) | TR201809959T4 (pt) |
WO (4) | WO2014146051A1 (pt) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11525766B2 (en) | 2013-03-15 | 2022-12-13 | Iris International, Inc. | Dynamic range extension systems and methods for particle analysis in blood samples |
Families Citing this family (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4027130B1 (en) | 2007-02-01 | 2022-11-02 | Sysmex Corporation | Sample analyzer |
US9057676B2 (en) | 2010-02-05 | 2015-06-16 | Cytonome/St, Llc | Multiple flow channel particle analysis system |
KR101957923B1 (ko) | 2011-02-28 | 2019-03-14 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 세포 배양 시스템 |
US9977188B2 (en) | 2011-08-30 | 2018-05-22 | Skorpios Technologies, Inc. | Integrated photonics mode expander |
CN105008159B (zh) | 2013-03-14 | 2017-10-10 | 伊利诺斯工具制品有限公司 | 压力释放阀 |
US9316635B2 (en) * | 2013-03-15 | 2016-04-19 | Iris International, Inc. | Sheath fluid systems and methods for particle analysis in blood samples |
US9857361B2 (en) | 2013-03-15 | 2018-01-02 | Iris International, Inc. | Flowcell, sheath fluid, and autofocus systems and methods for particle analysis in urine samples |
US20150030215A1 (en) * | 2013-07-26 | 2015-01-29 | Abbott Point Of Care, Inc. | Method and apparatus for producing an image of undiluted whole blood sample having wright stain coloration |
WO2015183992A1 (en) | 2014-05-27 | 2015-12-03 | Skorpios Technologies, Inc. | Waveguide mode expander using amorphous silicon |
EP3176563B1 (en) * | 2014-07-29 | 2021-06-30 | National University Corporation Hamamatsu University School of Medicine | Identification device and identification method |
AU2015307593B2 (en) * | 2014-08-28 | 2017-04-13 | Sysmex Corporation | Particle imaging apparatus and particle imaging method |
JP6616407B2 (ja) * | 2014-09-29 | 2019-12-04 | バイオサーフィット、 ソシエダッド アノニマ | フォーカシング方法 |
JP6704390B2 (ja) * | 2014-09-29 | 2020-06-03 | バイオサーフィット、 ソシエダッド アノニマ | 血球計数 |
WO2016050837A1 (en) * | 2014-09-30 | 2016-04-07 | Foss Analytical A/S | Method, device and system for hydrodynamic flow focusing |
BR112017007654B1 (pt) * | 2014-10-17 | 2020-12-01 | Iris International, Inc | método para imageamento de uma pluralidade de porções de fluido sanguíneo, e sistema para imageamento de uma pluralidade de porções de fluido sanguíneo |
JP6282969B2 (ja) * | 2014-10-31 | 2018-02-21 | 日本光電工業株式会社 | フロー解析装置、フローサイトメータ、及びフロー解析方法 |
JP6953678B2 (ja) * | 2014-11-12 | 2021-10-27 | 東洋紡株式会社 | 有形成分分析装置及び有形成分分析方法 |
JP6512593B2 (ja) * | 2015-02-23 | 2019-05-15 | 大日本印刷株式会社 | 培養液の培養状態解析システム及び培養状態解析方法、並びに、プログラム |
EP3957991A1 (en) * | 2015-03-31 | 2022-02-23 | Sysmex Corporation | Urine analysis system, image capturing apparatus, cell image capturing apparatus, urine analysis method, management apparatus, and information processing apparatus |
JP6713730B2 (ja) | 2015-05-20 | 2020-06-24 | シスメックス株式会社 | 細胞検出装置および細胞検出方法 |
CN105177978A (zh) * | 2015-07-10 | 2015-12-23 | 郎溪远华纺织有限公司 | 一种纺织布印染过程中的退浆方法 |
CN107850527A (zh) * | 2015-07-30 | 2018-03-27 | 皇家飞利浦有限公司 | 用于颗粒密度检测的激光传感器 |
CN105067488A (zh) * | 2015-08-11 | 2015-11-18 | 长春瑞克医疗科技有限公司 | 一种粒子成像室 |
WO2017057966A1 (ko) * | 2015-09-30 | 2017-04-06 | 주식회사 싸이토젠 | 세포 이미징 장치 및 그 방법 |
KR101873318B1 (ko) | 2015-09-30 | 2018-07-03 | 주식회사 싸이토젠 | 세포 이미징 장치 및 그 방법 |
EP3390963B1 (en) * | 2015-12-18 | 2021-02-17 | Abbott Laboratories | Method for determining the identity of histological stains |
WO2017108129A1 (de) | 2015-12-23 | 2017-06-29 | Siemens Healthcare Gmbh | Fliesszelle zur analyse von partikeln in einer zu untersuchenden flüssigkeit |
KR101807256B1 (ko) * | 2016-01-26 | 2017-12-08 | 한양대학교 에리카산학협력단 | 입자 분리 장치 및 입자 분리 방법 |
CN108780031A (zh) * | 2016-03-30 | 2018-11-09 | 西门子保健有限责任公司 | 使用环境粘弹性流体流对准样本流中的非球形生物实体 |
EP3440830A1 (en) | 2016-04-06 | 2019-02-13 | Biosurfit, S.A. | Method and system for capturing images of a liquid sample |
DE102016005974B4 (de) | 2016-05-13 | 2018-06-14 | Hochschule für Technik und Wirtschaft Dresden | Verfahren und Vorrichtung zur Einstellung des Laserfokus eines Anregungslasers in Blut durchflossenen Gefäßen für optische Messungen zur Bestimmung des Geschlechtes von Vogeleiern |
JP2017219479A (ja) * | 2016-06-09 | 2017-12-14 | 住友電気工業株式会社 | 微小粒子計測装置及び分析方法 |
CN109416313A (zh) * | 2016-06-24 | 2019-03-01 | 拜克门寇尔特公司 | 图像地图集系统和方法 |
EP3512935B1 (en) | 2016-09-13 | 2022-02-23 | President and Fellows of Harvard College | Methods relating to intestinal organ-on-a-chip |
CN109844494B (zh) * | 2016-10-06 | 2022-05-24 | 艾瑞斯国际有限公司 | 动态聚焦系统和方法 |
JP6783153B2 (ja) * | 2017-01-13 | 2020-11-11 | アークレイ株式会社 | フローセル及び測定装置 |
SG11201908847TA (en) | 2017-03-31 | 2019-10-30 | Life Technologies Corp | Apparatuses, systems and methods for imaging flow cytometry |
CN117054316A (zh) | 2017-05-19 | 2023-11-14 | 兴盛生物科技股份有限公司 | 用于计数细胞的系统和方法 |
CN107144521B (zh) * | 2017-06-06 | 2020-05-05 | 深圳小孚医疗科技有限公司 | 成像室姿态调节机构和调节方法 |
CN107144520B (zh) * | 2017-06-06 | 2020-05-05 | 深圳小孚医疗科技有限公司 | 用于显微成像粒子分析的粒子成像室和聚焦系统 |
CN107091800A (zh) * | 2017-06-06 | 2017-08-25 | 深圳小孚医疗科技有限公司 | 用于显微成像粒子分析的聚焦系统和聚焦方法 |
CN107643238A (zh) * | 2017-09-19 | 2018-01-30 | 中山大学附属第医院 | 一种定量检测血液循环微粒浓度的方法 |
US10466173B2 (en) * | 2017-10-06 | 2019-11-05 | Wyatt Technology Corporation | Optical flow cell assembly incorporating a replaceable transparent flow cell |
EP3697294B1 (en) * | 2017-10-16 | 2023-12-06 | Massachusetts Institute Of Technology | System and method for non-invasive hematological measurements |
US11609224B2 (en) | 2017-10-26 | 2023-03-21 | Essenlix Corporation | Devices and methods for white blood cell analyses |
CN108073547B (zh) * | 2017-12-06 | 2021-05-18 | 苏州大学 | 一种基于能量耗散的溶血经验预测方法及装置 |
US10274410B1 (en) * | 2018-01-23 | 2019-04-30 | Cbrn International, Ltd. | Bioaerosol particle detector |
CN108489872B (zh) * | 2018-03-23 | 2022-03-04 | 奥星制药设备(石家庄)有限公司 | 在线粒度监测方法和系统 |
CN108801740B (zh) * | 2018-03-28 | 2021-08-06 | 迈克生物股份有限公司 | 铁染色试剂 |
KR102026983B1 (ko) * | 2018-03-29 | 2019-09-30 | 두산중공업 주식회사 | 가스터빈 내 파이프를 통과하는 유체의 오염물을 모니터링 하는 시스템 및 그 방법 |
JP7109229B2 (ja) * | 2018-03-30 | 2022-07-29 | シスメックス株式会社 | フローサイトメーター及び粒子検出方法 |
SE542402C2 (en) * | 2018-07-02 | 2020-04-21 | Cellavision Ab | Method and apparatus for training a neural network classifier to classify an image depicting one or more objects of a biological sample |
EP3837543A4 (en) * | 2018-08-16 | 2022-11-16 | Essenlix Corporation | CELLULAR ANALYSIS IN BODY FLUIDS, ESPECIALLY BLOOD |
KR102100197B1 (ko) * | 2018-08-17 | 2020-04-14 | (주)엠큐빅 | 플로우 셀을 이용한 미세조류 연속 모니터링 장치 |
WO2020091720A1 (en) * | 2018-10-29 | 2020-05-07 | University Of Wyoming | Enhancement of fountain flow cytometry by reducing background light intensity |
US11802826B2 (en) * | 2018-10-29 | 2023-10-31 | Kyocera Corporation | Measurement apparatus |
CN109100286A (zh) * | 2018-10-31 | 2018-12-28 | 江苏卓微生物科技有限公司 | 细胞计数仪 |
WO2020133285A1 (zh) * | 2018-12-28 | 2020-07-02 | 深圳迈瑞生物医疗电子股份有限公司 | 一种血液细胞参数修正方法、血液样本检测仪和存储介质 |
CN109919946B (zh) * | 2019-02-19 | 2021-04-20 | 温州医科大学 | 一种基于光学相干层析成像技术预测巩膜透氧型接触镜镜后泪液形态变化止点的方法 |
CN113498362B (zh) * | 2019-02-27 | 2023-01-20 | 京瓷株式会社 | 粒子分离测量设备以及粒子分离测量装置 |
JP7274605B2 (ja) * | 2019-04-18 | 2023-05-16 | フンダシオ インスティテュート デ サイエンセズ フォトニクス | 個々の微生物の光学的調査のための流体装置 |
CN111760795B (zh) * | 2019-07-16 | 2022-02-01 | 北京京东乾石科技有限公司 | 用于分拣货物的方法和装置 |
CN116211296A (zh) | 2019-07-24 | 2023-06-06 | 麻省理工学院 | 用于甲襞成像装置的手指插入件 |
EP4042134A1 (en) | 2019-10-11 | 2022-08-17 | Beckman Coulter, Inc. | Method and composition for staining and sample processing |
US11125675B2 (en) * | 2019-10-18 | 2021-09-21 | Roger Lawrence Deran | Fluid suspended particle classifier |
WO2021118882A1 (en) * | 2019-12-10 | 2021-06-17 | Siemens Healthcare Diagnostics Inc. | Device for visualization of components in a blood sample |
US11877731B2 (en) * | 2020-03-07 | 2024-01-23 | Hall Labs Llc | Toilet with integral microscope slide |
CN111624065B (zh) * | 2020-05-22 | 2023-10-27 | 嘉兴优瑞生物科技有限公司 | 一种动物专用Diff-Quik染液及制备方法 |
US11860154B2 (en) | 2020-05-28 | 2024-01-02 | Leuko Labs, Inc | Method to detect white blood cells and/or white blood cell subtypes from non-invasive capillary videos |
CN111721950A (zh) * | 2020-05-29 | 2020-09-29 | 迪瑞医疗科技股份有限公司 | 一种稳定的有形成分分析聚焦液及其制备方法 |
JP2023550929A (ja) | 2020-11-19 | 2023-12-06 | ソニーグループ株式会社 | フレキシブルな画像ベースの粒子ソーティングのための分類ワークフロー |
CN112881246A (zh) * | 2021-01-26 | 2021-06-01 | 苏州胤煌精密仪器科技有限公司 | 一种可连续变倍的图像法粒度仪 |
US20240133779A1 (en) * | 2021-04-02 | 2024-04-25 | Noul Co., Ltd. | Hydrogel-based stamping for solution-free blood cell staining |
CN113326743B (zh) * | 2021-05-10 | 2023-10-13 | 大连海洋大学 | 一种养殖背景条件下鱼群运动行为参数提取和分析方法 |
WO2023010059A1 (en) * | 2021-07-27 | 2023-02-02 | Gateway Genomics, Llc | Methods, compositions, and kits for the preservation of nucleic acids |
US20230046207A1 (en) * | 2021-08-10 | 2023-02-16 | Becton, Dickinson And Company | Outlet fittings for reducing bubbles at the interface with a flow cell, and flow cytometers and methods using the same |
KR102572517B1 (ko) * | 2021-08-18 | 2023-08-31 | 주식회사 아폴론 | 인공지능 기반 호산구의 라만 데이터 처리 방법 및 장치 |
CN118159890A (zh) * | 2021-09-27 | 2024-06-07 | 贝克曼库尔特有限公司 | 可调节式安装设备 |
AU2022394321A1 (en) * | 2021-11-17 | 2024-03-21 | Becton, Dickinson And Company | Methods for dynamic real-time adjustment of a data acquisition parameter in a flow cytometer |
WO2023114204A1 (en) | 2021-12-17 | 2023-06-22 | Beckman Coulter, Inc. | Focus quality determination through multi-layer processing |
CN114441271B (zh) * | 2021-12-27 | 2023-06-27 | 桂林优利特医疗电子有限公司 | 一种新型染色液的配置及染色方法 |
WO2023129647A1 (en) | 2021-12-29 | 2023-07-06 | Beckman Coulter, Inc. | Biological sample driving system and method |
WO2023123466A1 (zh) * | 2021-12-31 | 2023-07-06 | 深圳迈瑞动物医疗科技股份有限公司 | 一种样本分析装置和样本分析方法 |
WO2023140235A1 (ja) * | 2022-01-20 | 2023-07-27 | 株式会社堀場製作所 | 粒子径分布測定装置、粒子径分布測定方法、及び粒子径分布測定用プログラム |
WO2023150064A1 (en) | 2022-02-02 | 2023-08-10 | Beckman Coulter, Inc. | Measure image quality of blood cell images |
WO2023172763A1 (en) | 2022-03-11 | 2023-09-14 | Beckman Coulter, Inc. | Controls and their use in analyzers |
WO2024020215A1 (en) | 2022-07-22 | 2024-01-25 | Beckman Coulter, Inc. | Biological sample staining module and biological analysis systems and methods |
FR3138211A1 (fr) * | 2022-07-25 | 2024-01-26 | Horiba Abx Sas | Dispositif pour le comptage et la différenciation de particules d’un flux d’échantillon |
WO2024030620A1 (en) * | 2022-08-05 | 2024-02-08 | Beckman Coulter, Inc. | Identification of immature cell types utilizing imaging |
WO2024123780A1 (en) | 2022-12-05 | 2024-06-13 | Beckman Coulter, Inc. | Hematology flow system |
Family Cites Families (147)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3888782A (en) | 1972-05-08 | 1975-06-10 | Allergan Pharma | Soft contact lens preserving solution |
US3822095A (en) * | 1972-08-14 | 1974-07-02 | Block Engineering | System for differentiating particles |
US3819270A (en) * | 1972-10-02 | 1974-06-25 | Block Engineering | Blood cell analyzer |
GB1471976A (en) | 1974-09-20 | 1977-04-27 | Coulter Electronics | Particle sensing apparatus including a device for orienting generally flat particles |
DE2543310C2 (de) * | 1975-09-27 | 1982-04-29 | Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München | Einrichtung zum Zählen und Klassifizieren von in einer Flüssigkeit suspendierten Teilchen |
US4338024A (en) | 1980-05-02 | 1982-07-06 | International Remote Imaging Systems, Inc. | Flow analyzer and system for analysis of fluids with particles |
FR2484077B1 (fr) | 1980-06-06 | 1984-07-06 | Inst Nat Sante Rech Med | Procede et dispositif de mesure de la deformabilite de cellules vivantes, notamment des globules rouges du sang |
US4393466A (en) | 1980-09-12 | 1983-07-12 | International Remote Imaging Systems | Method of analyzing particles in a dilute fluid sample |
JPS5774372A (en) | 1980-10-27 | 1982-05-10 | Seiko Epson Corp | Fluid ink for printer |
DE3315195A1 (de) | 1982-04-29 | 1983-11-03 | International Remote Imaging Systems Inc., 91311 Chatsworth, Calif. | Verfahren zum ausrichten von teilchen in einer fluidprobe |
EP0125857B1 (en) * | 1983-05-12 | 1989-04-26 | Kabushiki Kaisha Toshiba | Grain counter |
US4647531A (en) * | 1984-02-06 | 1987-03-03 | Ortho Diagnostic Systems, Inc. | Generalized cytometry instrument and methods of use |
AU563260B2 (en) | 1984-11-29 | 1987-07-02 | International Remote Imaging Systems Inc. | Method of operating a microscopic instrument |
US4732479A (en) * | 1985-10-18 | 1988-03-22 | Canon Kabushiki Kaisha | Particle analyzing apparatus |
DE3851458T2 (de) | 1987-04-08 | 1995-02-09 | Hitachi Ltd | Vorrichtung mit einer scheideförmigen Durchflusszelle. |
JPS63262565A (ja) * | 1987-04-20 | 1988-10-28 | Hitachi Ltd | フロ−セル |
DE3902079A1 (de) | 1988-04-15 | 1989-10-26 | Bayer Ag | I.m. injektionsformen von gyrase-inhibitoren |
US5123055A (en) | 1989-08-10 | 1992-06-16 | International Remote Imaging Systems, Inc. | Method and an apparatus for differentiating a sample of biological cells |
JP2939647B2 (ja) * | 1990-07-24 | 1999-08-25 | シスメックス株式会社 | フローイメージングサイトメータにおける自動焦点調整方法 |
JP2874746B2 (ja) * | 1990-11-22 | 1999-03-24 | シスメックス株式会社 | フローイメージングサイトメータにおけるフローセル機構 |
JP3075370B2 (ja) * | 1991-07-26 | 2000-08-14 | シスメックス株式会社 | 粒子分析用のサンプル扁平流形成装置 |
US5412466A (en) * | 1991-07-26 | 1995-05-02 | Toa Medical Electronics Co., Ltd. | Apparatus for forming flattened sample flow for analyzing particles |
EP0556971B1 (en) | 1992-02-18 | 1999-12-08 | Hitachi, Ltd. | An apparatus for investigating particles in a fluid, and a method of operation thereof |
JP3111706B2 (ja) * | 1992-02-18 | 2000-11-27 | 株式会社日立製作所 | 粒子分析装置及び粒子分析方法 |
US5308526A (en) | 1992-07-07 | 1994-05-03 | The Procter & Gamble Company | Liquid personal cleanser with moisturizer |
JP3215175B2 (ja) | 1992-08-10 | 2001-10-02 | シスメックス株式会社 | 粒子分析装置 |
US5889881A (en) * | 1992-10-14 | 1999-03-30 | Oncometrics Imaging Corp. | Method and apparatus for automatically detecting malignancy-associated changes |
CN1040888C (zh) * | 1993-01-14 | 1998-11-25 | 方奉谁 | 快速细胞染色剂 |
JP3052665B2 (ja) * | 1993-01-26 | 2000-06-19 | 株式会社日立製作所 | フローセル装置 |
US5585246A (en) | 1993-02-17 | 1996-12-17 | Biometric Imaging, Inc. | Method for preparing a sample in a scan capillary for immunofluorescent interrogation |
JP2826448B2 (ja) * | 1993-09-17 | 1998-11-18 | 株式会社日立製作所 | フロー式粒子画像解析方法およびフロー式粒子画像解析装置 |
JP3039594B2 (ja) | 1993-10-08 | 2000-05-08 | 株式会社日立製作所 | 染色試薬およびその使用方法 |
JP3290786B2 (ja) | 1993-11-26 | 2002-06-10 | シスメックス株式会社 | 粒子分析装置 |
US5812419A (en) * | 1994-08-01 | 1998-09-22 | Abbott Laboratories | Fully automated analysis method with optical system for blood cell analyzer |
ES2278566T3 (es) | 1994-10-20 | 2007-08-16 | Sysmex Corporation | Reactivo y metodo para analizar componentes solidos en la orina. |
AU4741796A (en) | 1994-12-23 | 1996-07-19 | International Remote Imaging Systems Inc. | Method and apparatus of analyzing particles in a fluid sample and displaying same |
US5619032A (en) | 1995-01-18 | 1997-04-08 | International Remote Imaging Systems, Inc. | Method and apparatus for automatically selecting the best focal position from a plurality of focal positions for a focusing apparatus |
JPH0989753A (ja) * | 1995-09-25 | 1997-04-04 | Hitachi Ltd | 粒子分析装置 |
US5808737A (en) | 1996-02-29 | 1998-09-15 | Sienna Biotech, Inc. | Pre-analysis chamber for a flow particle analyzer |
WO1997043620A1 (en) | 1996-05-15 | 1997-11-20 | International Remote Imaging Systems, Inc. | Selectively emphasizing particles of interest from a fluid sample for analysis |
US6184978B1 (en) | 1996-05-15 | 2001-02-06 | International Remote Imaging Systems, Inc. | Method and apparatus for verifying uniform flow of a fluid sample through a flow cell and distribution on a slide |
US5872627A (en) * | 1996-07-30 | 1999-02-16 | Bayer Corporation | Method and apparatus for detecting scattered light in an analytical instrument |
KR100200734B1 (ko) | 1996-10-10 | 1999-06-15 | 윤종용 | 에어리얼 이미지 측정 장치 및 방법 |
US5985216A (en) | 1997-07-24 | 1999-11-16 | The United States Of America, As Represented By The Secretary Of Agriculture | Flow cytometry nozzle for high efficiency cell sorting |
US5935857A (en) * | 1997-08-01 | 1999-08-10 | Coulter International Corp. | Blood diluent |
US20020028471A1 (en) * | 1998-02-20 | 2002-03-07 | Oberhardt Bruce J. | Cell analysis methods and apparatus |
JP3867880B2 (ja) | 1998-04-08 | 2007-01-17 | シスメックス株式会社 | 尿中赤血球の鑑別装置および方法 |
DE69937353T2 (de) * | 1998-08-21 | 2008-07-17 | Union Biometrica, Inc., Somerville | Instrument zur analyse und selektiven verteilung von objektproben |
US20030059440A1 (en) | 1998-09-01 | 2003-03-27 | Tim Clarot | Composition and method for moisturizing nasal tissue |
US6130745A (en) * | 1999-01-07 | 2000-10-10 | Biometric Imaging, Inc. | Optical autofocus for use with microtiter plates |
JP2000214070A (ja) | 1999-01-21 | 2000-08-04 | Sysmex Corp | シ―スフロ―セルとそれを用いた血液分析装置 |
US6575930B1 (en) * | 1999-03-12 | 2003-06-10 | Medrad, Inc. | Agitation devices and dispensing systems incorporating such agitation devices |
JP4824157B2 (ja) | 1999-08-06 | 2011-11-30 | インベンテイオ・アクテイエンゲゼルシヤフト | 長いエスカレータと動く歩道の支持構造体 |
US6632676B1 (en) | 1999-09-24 | 2003-10-14 | Clinical Diagnostic Solutions | Multi-purpose reagent system and method for enumeration of red blood cells, white blood cells and thrombocytes and differential determination of white blood cells |
AU2730801A (en) | 1999-12-21 | 2001-07-03 | Yale University | Survivin promotion of angiogenesis |
JP2004500562A (ja) * | 1999-12-29 | 2004-01-08 | ユニオン バイオメトリカ インコーポレイテッド | フローサイトメトリーのための高粘度シース試薬 |
US6974938B1 (en) | 2000-03-08 | 2005-12-13 | Tibotec Bvba | Microscope having a stable autofocusing apparatus |
JP2001290161A (ja) | 2000-04-04 | 2001-10-19 | Advanced Display Inc | 液晶表示装置およびその製法 |
KR100347760B1 (ko) * | 2000-04-19 | 2002-08-09 | 엘지전자주식회사 | 기울어진 세탁조가 구비된 세탁기 |
CN1214340C (zh) | 2000-04-24 | 2005-08-10 | 国际遥距成象系统公司 | 多个神经网络的成像设备和方法 |
US7236623B2 (en) | 2000-04-24 | 2007-06-26 | International Remote Imaging Systems, Inc. | Analyte recognition for urinalysis diagnostic system |
US7283223B2 (en) * | 2002-08-21 | 2007-10-16 | Honeywell International Inc. | Cytometer having telecentric optics |
CA2349995A1 (en) | 2000-06-14 | 2001-12-14 | Lianne Ing | Viewing particles in a relatively translucent medium |
US7061595B2 (en) * | 2000-08-02 | 2006-06-13 | Honeywell International Inc. | Miniaturized flow controller with closed loop regulation |
US6875973B2 (en) * | 2000-08-25 | 2005-04-05 | Amnis Corporation | Auto focus for a flow imaging system |
AU2001290879A1 (en) * | 2000-09-15 | 2002-03-26 | California Institute Of Technology | Microfabricated crossflow devices and methods |
US20040070757A1 (en) * | 2000-12-29 | 2004-04-15 | Moore Richard Channing | High viscosity sheath reagent for flow cytometry |
FR2821428B1 (fr) * | 2001-02-23 | 2004-08-06 | Abx Sa | Reactif et procede pour l'identification et le comptage de cellules biologiques |
US7907765B2 (en) * | 2001-03-28 | 2011-03-15 | University Of Washington | Focal plane tracking for optical microtomography |
EP1395374B1 (en) * | 2001-05-17 | 2013-04-17 | Beckman Coulter, Inc. | Flow cytometer with active automated optical alignment system |
JP4838446B2 (ja) | 2001-06-20 | 2011-12-14 | オリンパス株式会社 | 顕微鏡装置 |
JP2003005088A (ja) | 2001-06-22 | 2003-01-08 | Nikon Corp | 顕微鏡用焦点合わせ装置およびそれを備えた顕微鏡 |
AU2002335715A1 (en) * | 2001-09-07 | 2003-03-24 | Burstein Technologies, Inc. | Optical bio-disc systems for nuclear morphology based identification |
JP4021183B2 (ja) | 2001-11-29 | 2007-12-12 | オリンパス株式会社 | 合焦状態信号出力装置 |
US20060050946A1 (en) * | 2002-05-10 | 2006-03-09 | Mitchison Timothy J | Computer-assisted cell analysis |
JP4370554B2 (ja) | 2002-06-14 | 2009-11-25 | 株式会社ニコン | オートフォーカス装置およびオートフォーカス付き顕微鏡 |
WO2004022774A1 (ja) * | 2002-09-05 | 2004-03-18 | Fuji Electric Systems Co.,Ltd. | 微生物または細胞の検出方法 |
US7319907B2 (en) | 2002-11-18 | 2008-01-15 | International Remote Imaging Systems, Inc. | Multi-level controller system |
US6825926B2 (en) | 2002-11-19 | 2004-11-30 | International Remote Imaging Systems, Inc. | Flow cell for urinalysis diagnostic system and method of making same |
JP2004188042A (ja) | 2002-12-13 | 2004-07-08 | Hitachi Hometec Ltd | 炊飯器 |
EP1447454A1 (en) * | 2003-02-14 | 2004-08-18 | DR. Chip Biotechnology Incorporation | Method and apparatus for detecting pathogens |
GB0304515D0 (en) * | 2003-02-27 | 2003-04-02 | Dakocytomation Denmark As | Standard |
WO2004077057A1 (en) * | 2003-02-27 | 2004-09-10 | Dakocytomation Denmark A/S | Standard for immunohistochemistry, immunocytochemistry and molecular cytogenetics |
DE10308171A1 (de) | 2003-02-27 | 2004-09-09 | Leica Microsystems Jena Gmbh | Verfahren zur automatischen Fokussierung |
US6900058B2 (en) * | 2003-03-11 | 2005-05-31 | Bionostics, Inc. | Control solution for photometric analysis |
US7324694B2 (en) | 2003-05-23 | 2008-01-29 | International Remote Imaging Systems, Inc. | Fluid sample analysis using class weights |
US20040241677A1 (en) | 2003-05-29 | 2004-12-02 | Lin Jeffrey S | Techniques for automated diagnosis of cell-borne anomalies with digital optical microscope |
JP4057539B2 (ja) * | 2004-01-09 | 2008-03-05 | 浜松ホトニクス株式会社 | シースフローセルキュベット及びその製造方法 |
US9176121B2 (en) | 2004-02-13 | 2015-11-03 | Roche Diagnostics Hematology, Inc. | Identification of blood elements using inverted microscopy |
US7394943B2 (en) | 2004-06-30 | 2008-07-01 | Applera Corporation | Methods, software, and apparatus for focusing an optical system using computer image analysis |
JP2006039315A (ja) | 2004-07-28 | 2006-02-09 | Hamamatsu Photonics Kk | 自動焦点装置及びそれを用いた顕微鏡装置 |
US7340957B2 (en) * | 2004-07-29 | 2008-03-11 | Los Alamos National Security, Llc | Ultrasonic analyte concentration and application in flow cytometry |
US7822276B2 (en) | 2005-02-17 | 2010-10-26 | Iris International, Inc. | Method and apparatus for analyzing body fluids |
CN101253401B (zh) | 2005-07-01 | 2013-01-02 | 霍尼韦尔国际公司 | 带三维流体动力学集中的模制标本盒 |
JP2007024844A (ja) * | 2005-07-21 | 2007-02-01 | Sysmex Corp | 血液分析方法及び血液分析装置 |
DE102005034441A1 (de) | 2005-07-22 | 2007-02-22 | Carl Zeiss Microimaging Gmbh | Mikroskopobjektiv |
EP1930717B1 (en) | 2005-09-29 | 2019-06-19 | Olympus Corporation | Focal position determining method and apparatus |
JP4896534B2 (ja) * | 2006-01-31 | 2012-03-14 | シスメックス株式会社 | 粒子分析装置用シース液 |
US20070209938A1 (en) * | 2006-03-13 | 2007-09-13 | Jianzhong Zhang | Method and apparatus for biopolymer analysis |
WO2007123744A2 (en) * | 2006-03-31 | 2007-11-01 | Solexa, Inc. | Systems and devices for sequence by synthesis analysis |
CN1834612A (zh) * | 2006-04-29 | 2006-09-20 | 北京索通医疗技术有限公司 | 一种用于血细胞分析仪的多功能稀释液及其制备方法 |
EP2487248A1 (en) * | 2006-05-10 | 2012-08-15 | The Board of Regents of the University of Texas System | Detecting tumor biomarker in oral cancer |
EP2028264A4 (en) | 2006-06-15 | 2012-10-24 | Nikon Corp | CELL INCUBATOR |
DE102006027836B4 (de) | 2006-06-16 | 2020-02-20 | Carl Zeiss Microscopy Gmbh | Mikroskop mit Autofokuseinrichtung |
SE530750C2 (sv) | 2006-07-19 | 2008-09-02 | Hemocue Ab | En mätapparat, en metod och ett datorprogram |
CN1945326A (zh) | 2006-10-13 | 2007-04-11 | 江西特康科技有限公司 | 基于视觉形态的五分类全血细胞分析方法 |
US7835000B2 (en) * | 2006-11-03 | 2010-11-16 | Los Alamos National Security, Llc | System and method for measuring particles in a sample stream of a flow cytometer or the like |
US7799575B2 (en) * | 2006-11-07 | 2010-09-21 | Genetix Limited | Flow cytometers |
JP2008276070A (ja) | 2007-05-02 | 2008-11-13 | Olympus Corp | 拡大撮像装置 |
WO2009014792A2 (en) | 2007-05-11 | 2009-01-29 | The Government Of The United States Of America, As Represented By The Secretary Of The Navy | Electrical detection using confined fluids |
WO2008149365A2 (en) | 2007-06-07 | 2008-12-11 | Technion Research & Development Foundation Ltd. | Systems and methods for focusing particles |
US8941826B2 (en) * | 2007-09-10 | 2015-01-27 | The Penn State Research Foundation | Three-dimensional (3D) hydrodynamic focusing using a microfluidic device |
JP5393013B2 (ja) | 2007-10-04 | 2014-01-22 | 株式会社タイトー | 制御プログラム、Webサーバ及びゲーム配信システム |
JP2009089753A (ja) | 2007-10-04 | 2009-04-30 | Olympia:Kk | 遊技機、遊技機用プログラム、及び、遊技機用プログラムを記録したコンピュータ読み取り可能な記録媒体 |
US8266951B2 (en) * | 2007-12-19 | 2012-09-18 | Los Alamos National Security, Llc | Particle analysis in an acoustic cytometer |
US8714014B2 (en) * | 2008-01-16 | 2014-05-06 | Life Technologies Corporation | System and method for acoustic focusing hardware and implementations |
US9017610B2 (en) | 2008-04-25 | 2015-04-28 | Roche Diagnostics Hematology, Inc. | Method of determining a complete blood count and a white blood cell differential count |
US9602777B2 (en) | 2008-04-25 | 2017-03-21 | Roche Diagnostics Hematology, Inc. | Systems and methods for analyzing body fluids |
EP2290350B1 (en) * | 2008-06-04 | 2018-11-21 | Hitachi High-Technologies Corporation | Particle image analysis method and device |
CA2727478A1 (en) | 2008-06-13 | 2009-12-17 | Xy, Llc | Lubricious microfluidic flow path system |
RU2520848C2 (ru) * | 2008-06-30 | 2014-06-27 | Микробикс Байосистемз Инк. | Способ и прибор для сортировки клеток |
US8343978B2 (en) | 2008-08-04 | 2013-01-01 | Adds Pharmaceuticals Llc | Fast onset orodispersable tablets |
US8603773B2 (en) * | 2008-09-19 | 2013-12-10 | Beckman Coulter | Method and system for analyzing a blood sample |
EP2331992A4 (en) | 2008-10-02 | 2014-12-17 | Pixcell Medical Technologies Ltd | VISCOELASTIC FOCUSING BASED OPTICAL IMAGING |
US20100221752A2 (en) * | 2008-10-06 | 2010-09-02 | Somalogic, Inc. | Ovarian Cancer Biomarkers and Uses Thereof |
FR2940976B1 (fr) | 2009-01-13 | 2017-11-03 | Oreal | Utilisation a des fins de criblage d'actifs anti-ages de formes solubles de la proteine de type desmogleine i |
JP5337912B2 (ja) | 2009-06-10 | 2013-11-06 | シンベニオ・バイオシステムズ・インコーポレーテッド | シース流装置及び方法 |
EP2288056A3 (en) * | 2009-07-22 | 2012-07-11 | Yamaha Corporation | Audio signal processing system comprising a plurality of devices connected by an audio network |
JP5586889B2 (ja) * | 2009-07-29 | 2014-09-10 | 株式会社日立ハイテクノロジーズ | 粒子画像解析装置 |
WO2011026136A1 (en) * | 2009-08-31 | 2011-03-03 | Life Technologies Corporation | Low-volume sequencing system and method of use |
US8362409B2 (en) | 2009-10-29 | 2013-01-29 | Applied Precision, Inc. | System and method for continuous, asynchronous autofocus of optical instruments |
US9068916B2 (en) * | 2010-03-15 | 2015-06-30 | Bio-Rad Laboratories, Inc. | Microassembled imaging flow cytometer |
CN102272574B (zh) * | 2010-03-31 | 2014-04-09 | 古河电气工业株式会社 | 光信息解析装置及光信息解析方法 |
US9090865B2 (en) * | 2010-10-29 | 2015-07-28 | The Regents Of The University Of California | Systems and methods for particle classification and sorting |
US8528427B2 (en) | 2010-10-29 | 2013-09-10 | Becton, Dickinson And Company | Dual feedback vacuum fluidics for a flow-type particle analyzer |
JP6121409B2 (ja) * | 2011-06-17 | 2017-04-26 | ロッシュ ダイアグノスティクス ヘマトロジー インコーポレイテッド | 生体試料の組織処理のための溶液 |
EP2568288A1 (en) | 2011-09-08 | 2013-03-13 | Koninklijke Philips Electronics N.V. | Means and methods for staining acid-fast cells |
KR101849974B1 (ko) | 2011-09-16 | 2018-04-19 | 삼성전자주식회사 | 개구수 제어 유닛, 이를 채용한 가변형 광 프로브 및 깊이 스캐닝 방법 |
US9810704B2 (en) | 2013-02-18 | 2017-11-07 | Theranos, Inc. | Systems and methods for multi-analysis |
US20140193892A1 (en) * | 2012-07-25 | 2014-07-10 | Theranos, Inc. | Image analysis and measurement of biological samples |
CA2920132C (en) * | 2012-10-24 | 2021-03-02 | The Regents Of The University Of California | System and method for deforming and analyzing particles |
CN102998437A (zh) | 2012-11-26 | 2013-03-27 | 江苏美诚生物科技有限公司 | 尿沉渣分析用鞘液及其制备方法 |
US9316635B2 (en) | 2013-03-15 | 2016-04-19 | Iris International, Inc. | Sheath fluid systems and methods for particle analysis in blood samples |
CN109142195B (zh) | 2013-03-15 | 2021-10-01 | 艾瑞思国际股份有限公司 | 用于体液样品中的粒子分析的自聚焦系统和方法 |
KR101772782B1 (ko) | 2013-03-15 | 2017-08-29 | 아이리스 인터내셔널 인크. | 소변 샘플을 염색 및 처리하기 위한 방법 및 조성물 |
US9857361B2 (en) | 2013-03-15 | 2018-01-02 | Iris International, Inc. | Flowcell, sheath fluid, and autofocus systems and methods for particle analysis in urine samples |
JP6112066B2 (ja) | 2014-05-27 | 2017-04-12 | 横河電機株式会社 | モジュール式電子機器連結用収納部材 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11525766B2 (en) | 2013-03-15 | 2022-12-13 | Iris International, Inc. | Dynamic range extension systems and methods for particle analysis in blood samples |
US11543340B2 (en) | 2013-03-15 | 2023-01-03 | Iris International, Inc. | Autofocus systems and methods for particle analysis in blood samples |
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