BR112015020255A2 - célula de fluxo, fluido envoltório e sistemas de foco automático e métodos para análise de partículas em amostras de urina - Google Patents
célula de fluxo, fluido envoltório e sistemas de foco automático e métodos para análise de partículas em amostras de urinaInfo
- Publication number
- BR112015020255A2 BR112015020255A2 BR112015020255A BR112015020255A BR112015020255A2 BR 112015020255 A2 BR112015020255 A2 BR 112015020255A2 BR 112015020255 A BR112015020255 A BR 112015020255A BR 112015020255 A BR112015020255 A BR 112015020255A BR 112015020255 A2 BR112015020255 A2 BR 112015020255A2
- Authority
- BR
- Brazil
- Prior art keywords
- particle
- flow cell
- sample
- contrast pattern
- methods
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 10
- 238000000034 method Methods 0.000 title abstract 4
- 210000002700 urine Anatomy 0.000 title abstract 4
- 238000004458 analytical method Methods 0.000 title abstract 2
- 239000012530 fluid Substances 0.000 title abstract 2
- 230000003287 optical effect Effects 0.000 abstract 3
- 238000010191 image analysis Methods 0.000 abstract 2
- 238000003384 imaging method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 238000012634 optical imaging Methods 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
- G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
- G01N2015/1452—Adjustment of focus; Alignment
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/85—Investigating moving fluids or granular solids
- G01N2021/8557—Special shaping of flow, e.g. using a by-pass line, jet flow, curtain flow
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physiology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Biophysics (AREA)
- Ecology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Optical Measuring Cells (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
abstract of the disclosure the present disclosure relates to apparatus, systems, compositions, and methods for analyzing a sample containing particles. a particle imaging system or analyzer can include a flowcell through which a urine sample containing particles is caused to flow, and a high optical resolution imaging device which captures images for image analysis. a contrast pattern for autofocusing is provided on the flowcell. the image processor assesses focus accuracy from pixel data contrast. a positioning motor moves the microscope and/or flowcell along the optical axis for autofocusing on the contrast pattern target. the processor then displaces microscope and flowcell by a known distance between the contrast pattern and the sample stream, thus focusing on the sample stream. cell or particle images are collected from that position until autofocus is reinitiated, periodically, by input signal, or when detecting temperature changes or focus inaccuracy in the image data. tradução do resumo resumo patente de invenção "célula de fluxo, fluido envoltório e sistemas de foco automático e métodos para análise de partículas em amostras de urina" a presente revelação se refere a aparelho, sistemas, composições e métodos para analisar uma amostra que contém partículas. um sistema de imageamento ou analisador de partículas pode incluir uma célula de fluxo através da qual uma amostra de urina que contém partículas é induzida a fluir, e um dispositivo de imageamento de alta resolução óptica que captura imagens para a análise de imagem. um padrão de contraste para a focalização automática é fornecido na célula de fluxo. o processador de imagem avalia a exatidão de foco a partir do contraste de dados de pixel. um motor de posicionamento move o microscópio e/ou célula de fluxo ao longo do eixo geométrico óptico para focalização automática no alvo de padrão de contraste. o processador, então, desloca o microscópio e a célula de fluxo por uma distância conhecida entre o padrão de contraste e a corrente de amostra, focalizando, assim, a corrente de amostra. as imagens de célula ou partícula são coletadas a partir daquela posição até que o foco automático seja reiniciado, periodicamente, por sinal de entrada, ou quando se detecta mudanças de temperatura ou inexatidão de foco nos dados de imagem.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361799014P | 2013-03-15 | 2013-03-15 | |
US61/799,014 | 2013-03-15 | ||
US14/217,228 US9857361B2 (en) | 2013-03-15 | 2014-03-17 | Flowcell, sheath fluid, and autofocus systems and methods for particle analysis in urine samples |
US14/217,228 | 2014-03-17 | ||
PCT/US2014/030940 WO2014146062A2 (en) | 2013-03-15 | 2014-03-18 | Flowcell, sheath fluid, and autofocus systems and methods for particle analysis in urine samples |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112015020255A2 true BR112015020255A2 (pt) | 2017-07-18 |
BR112015020255B1 BR112015020255B1 (pt) | 2021-02-23 |
Family
ID=50928246
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015020255-1A BR112015020255B1 (pt) | 2013-03-15 | 2014-03-18 | método para o imageamento de partículas com o uso de um sistema de análise de partículas configurado para a hidro-focalização geométrica, e sistema de análise de partículas que realiza a hidro-focalização geométrica para o imageamento de partículas em uma amostra de fluido corpóreo |
Country Status (7)
Country | Link |
---|---|
US (2) | US9857361B2 (pt) |
EP (1) | EP2972215A2 (pt) |
JP (1) | JP6521940B2 (pt) |
KR (1) | KR102083051B1 (pt) |
CN (1) | CN105122034B (pt) |
BR (1) | BR112015020255B1 (pt) |
WO (1) | WO2014146062A2 (pt) |
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WO2014146062A3 (en) | 2014-12-18 |
US20180143182A1 (en) | 2018-05-24 |
BR112015020255B1 (pt) | 2021-02-23 |
CN105122034A (zh) | 2015-12-02 |
CN105122034B (zh) | 2019-03-29 |
US9857361B2 (en) | 2018-01-02 |
US10794900B2 (en) | 2020-10-06 |
KR20150129707A (ko) | 2015-11-20 |
JP2016519760A (ja) | 2016-07-07 |
EP2972215A2 (en) | 2016-01-20 |
KR102083051B1 (ko) | 2020-02-28 |
US20140329265A1 (en) | 2014-11-06 |
WO2014146062A2 (en) | 2014-09-18 |
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