BR112014003037A2 - produção recombinante de glicosídeos de esteviol - Google Patents

produção recombinante de glicosídeos de esteviol

Info

Publication number
BR112014003037A2
BR112014003037A2 BR112014003037-5A BR112014003037A BR112014003037A2 BR 112014003037 A2 BR112014003037 A2 BR 112014003037A2 BR 112014003037 A BR112014003037 A BR 112014003037A BR 112014003037 A2 BR112014003037 A2 BR 112014003037A2
Authority
BR
Brazil
Prior art keywords
recombinant production
steviol glycosides
steviol
glycosides
recombinant
Prior art date
Application number
BR112014003037-5A
Other languages
English (en)
Other versions
BR112014003037B1 (pt
Inventor
Houghton-Larsen Jens
M. Hicks Paula
Naesby Michael
Thomas Ostergaard Tange
Hansen Jorgen
Dalgaard Mikkelsen Michael
Esben Halkjaer Hansen
Simon Ernesto
De Andrade Pereira Tavares Sabrina
Original Assignee
Evolva Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46724642&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014003037(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Evolva Sa filed Critical Evolva Sa
Priority to BR122021015509-7A priority Critical patent/BR122021015509B1/pt
Priority to BR122021015508-9A priority patent/BR122021015508B1/pt
Priority to BR122020019161-9A priority patent/BR122020019161B1/pt
Publication of BR112014003037A2 publication Critical patent/BR112014003037A2/pt
Publication of BR112014003037B1 publication Critical patent/BR112014003037B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0032—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with oxygen as acceptor (1.5.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Seasonings (AREA)
BR112014003037-5A 2011-08-08 2012-08-08 Hospedeiro recombinante e método para produzir um glicosídeo de esteviol BR112014003037B1 (pt)

Priority Applications (3)

Application Number Priority Date Filing Date Title
BR122021015509-7A BR122021015509B1 (pt) 2011-08-08 2012-08-08 Método para produzir um glicosídeo de esteviol alvo
BR122021015508-9A BR122021015508B1 (pt) 2011-08-08 2012-08-08 Método para produzir um glicosídeo de esteviol alvo
BR122020019161-9A BR122020019161B1 (pt) 2011-08-08 2012-08-08 Hospedeiro recombinante

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201161521203P 2011-08-08 2011-08-08
US201161521084P 2011-08-08 2011-08-08
US201161521051P 2011-08-08 2011-08-08
US61/521,084 2011-08-08
US61/521,203 2011-08-08
US61/521.051 2011-08-08
US61/521.203 2011-08-08
US61/521,051 2011-08-08
US201161523487P 2011-08-15 2011-08-15
US61/523,487 2011-08-15
US201161567929P 2011-12-07 2011-12-07
US61/567,929 2011-12-07
US201261603639P 2012-02-27 2012-02-27
US61/603,639 2012-02-27
PCT/US2012/050021 WO2013022989A2 (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides

Publications (2)

Publication Number Publication Date
BR112014003037A2 true BR112014003037A2 (pt) 2018-09-04
BR112014003037B1 BR112014003037B1 (pt) 2022-04-05

Family

ID=46724642

Family Applications (4)

Application Number Title Priority Date Filing Date
BR122021015508-9A BR122021015508B1 (pt) 2011-08-08 2012-08-08 Método para produzir um glicosídeo de esteviol alvo
BR112014003037-5A BR112014003037B1 (pt) 2011-08-08 2012-08-08 Hospedeiro recombinante e método para produzir um glicosídeo de esteviol
BR122020019161-9A BR122020019161B1 (pt) 2011-08-08 2012-08-08 Hospedeiro recombinante
BR122021015509-7A BR122021015509B1 (pt) 2011-08-08 2012-08-08 Método para produzir um glicosídeo de esteviol alvo

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR122021015508-9A BR122021015508B1 (pt) 2011-08-08 2012-08-08 Método para produzir um glicosídeo de esteviol alvo

Family Applications After (2)

Application Number Title Priority Date Filing Date
BR122020019161-9A BR122020019161B1 (pt) 2011-08-08 2012-08-08 Hospedeiro recombinante
BR122021015509-7A BR122021015509B1 (pt) 2011-08-08 2012-08-08 Método para produzir um glicosídeo de esteviol alvo

Country Status (11)

Country Link
US (5) US9631215B2 (pt)
EP (3) EP3009508B1 (pt)
JP (4) JP6262653B2 (pt)
KR (2) KR102114493B1 (pt)
CN (2) CN103732753B (pt)
AU (4) AU2012294452C1 (pt)
BR (4) BR122021015508B1 (pt)
CA (2) CA3128532A1 (pt)
MY (1) MY173212A (pt)
SG (4) SG10201606565XA (pt)
WO (1) WO2013022989A2 (pt)

Families Citing this family (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9107436B2 (en) 2011-02-17 2015-08-18 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US8790730B2 (en) 2005-10-11 2014-07-29 Purecircle Usa Process for manufacturing a sweetener and use thereof
US8318459B2 (en) 2011-02-17 2012-11-27 Purecircle Usa Glucosyl stevia composition
US8257948B1 (en) 2011-02-17 2012-09-04 Purecircle Usa Method of preparing alpha-glucosyl Stevia composition
US9392799B2 (en) 2011-02-17 2016-07-19 Purecircle Sdn Bhd Glucosyl stevia composition
US9386797B2 (en) 2011-02-17 2016-07-12 Purecircle Sdn Bhd Glucosyl stevia composition
WO2011059954A1 (en) 2009-11-12 2011-05-19 Purecircle Usa Granulation of a stevia sweetener
EP2544538B1 (en) 2010-03-12 2022-06-15 PureCircle USA Inc. High-purity steviol glycosides
US10696706B2 (en) 2010-03-12 2020-06-30 Purecircle Usa Inc. Methods of preparing steviol glycosides and uses of the same
BR122021005283B1 (pt) 2010-06-02 2022-02-22 Evolva, Inc Hospedeiro recombinante que compreende genes recombinantes para produção deesteviol ou glicosídeo de esteviol, método para produzir esteviol, glicosídeo de esteviol ou composição de glicosídeo de esteviol e método para sintetizar esteviol ou glicosídeo de esteviol
US9510611B2 (en) 2010-12-13 2016-12-06 Purecircle Sdn Bhd Stevia composition to improve sweetness and flavor profile
WO2012082587A2 (en) 2010-12-13 2012-06-21 Purecircle Usa Highly soluble rebaudioside d
BR112013020511B1 (pt) 2011-02-10 2018-05-22 Purecircle Usa Inc. Composição de rebaudiosida b e seu processo de produção, bem como composições de adoçante e de sabor, ingrediente alimentício, bebida e produto cosmético ou farmacêutico compreendendo a dita composição de rebaudiosida b
US11690391B2 (en) 2011-02-17 2023-07-04 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US9603373B2 (en) 2011-02-17 2017-03-28 Purecircle Sdn Bhd Glucosyl stevia composition
US9474296B2 (en) 2011-02-17 2016-10-25 Purecircle Sdn Bhd Glucosyl stevia composition
US9894922B2 (en) 2011-05-18 2018-02-20 Purecircle Sdn Bhd Glucosyl rebaudioside C
ES2727031T3 (es) 2011-05-31 2019-10-11 Purecircle Usa Inc Composición de Estevia
EP3101024A1 (en) 2011-06-03 2016-12-07 Purecircle USA Stevia compostion comprising rebaudioside a or d with rebaudioside b
US9771434B2 (en) 2011-06-23 2017-09-26 Purecircle Sdn Bhd Products from stevia rebaudiana
KR102114493B1 (ko) * 2011-08-08 2020-05-26 에볼바 에스아 스테비올 글리코시드의 재조합 생산
US10480019B2 (en) 2011-08-10 2019-11-19 Purecircle Sdn Bhd Process for producing high-purity rubusoside
EP2753189B1 (en) 2011-09-07 2020-12-16 Purecircle Usa Inc. Highly soluble stevia sweetener
FR2984743B1 (fr) * 2011-12-23 2014-08-22 Oreal Utilisation cosmetique du steviol, d'un derive glycoside du steviol, ou un de leurs isomeres pour stimuler, restaurer ou reguler le metabolisme des cellules de la peau et des semi-muqueuses.
DK2806754T3 (en) * 2012-01-23 2019-02-18 Dsm Ip Assets Bv Diterpene PREPARATION
CA2867112C (en) 2012-03-16 2021-04-20 Suntory Holdings Limited Steviol glucosyltransferases and genes encoding the same
US10113154B2 (en) 2012-03-27 2018-10-30 Suntory Holdings Limited Method for producing steviol glycoside
WO2013148257A1 (en) * 2012-03-30 2013-10-03 J.R. Simplot Company Steviol and steviol glycoside formation in plants
US9752174B2 (en) * 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
JP6346174B2 (ja) 2012-05-22 2018-06-20 ピュアサークル スンディリアン ブルハド 高純度ステビオールグリコシド
US20150342234A1 (en) * 2012-12-05 2015-12-03 Evolva Sa Steviol Glycoside Compositions Sensory Properties
SG11201505597SA (en) 2013-02-06 2015-08-28 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
KR20150128705A (ko) 2013-02-11 2015-11-18 에볼바 에스아 재조합 숙주에서 스테비올 글리코시드의 효율적인 생성
KR101404728B1 (ko) * 2013-02-28 2014-06-09 씨제이제일제당 (주) 스테비오사이드로부터 리바우디오사이드 a를 제조하는 방법
PE20151544A1 (es) * 2013-03-15 2015-11-04 Cargill Inc Plantas de stevia con un contenido de rebaudiosido d incrementado
ES2779252T3 (es) * 2013-05-15 2020-08-14 Purecircle Usa Inc Procedimiento para obtener una composición de estevia
US10689681B2 (en) 2013-05-31 2020-06-23 Dsm Ip Assets B.V. Microorganisms for diterpene production
AU2014273054A1 (en) * 2013-05-31 2015-12-03 Dsm Ip Assets B.V. Extracellular diterpene production
US10952458B2 (en) 2013-06-07 2021-03-23 Purecircle Usa Inc Stevia extract containing selected steviol glycosides as flavor, salty and sweetness profile modifier
MX2015016791A (es) 2013-06-07 2016-09-09 Purecircle Usa Inc Extracto de estevia que contiene glicosidos de esteviol seleccionados como modificador del perfil de sabor, salado y de dulzura.
US10039834B2 (en) 2013-07-12 2018-08-07 The Coca-Cola Company Compositions and methods using rebaudioside X to provide sweetness enhancement
WO2015007748A1 (en) * 2013-07-15 2015-01-22 Dsm Ip Assets B.V. Diterpene production
EP3024941B1 (en) 2013-07-23 2019-07-03 DSM IP Assets B.V. Diterpene production in yarrowia
WO2015014969A1 (en) * 2013-07-31 2015-02-05 Dsm Ip Assets B.V. Steviol glycosides
CN103397064B (zh) 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙m的方法
US20160251635A1 (en) * 2013-11-01 2016-09-01 Conagen Inc. Recombinant production of steviol glycosides
KR102115640B1 (ko) * 2014-01-28 2020-05-26 페푸시코인코포레이팃드 효소 방법을 사용하여 레바우디오사이드 m을 제조하기 위한 방법
WO2015162305A1 (en) * 2014-04-25 2015-10-29 Dsm Ip Assets B.V. Stabilization of cytochrome p450 reductase
US9522929B2 (en) * 2014-05-05 2016-12-20 Conagen Inc. Non-caloric sweetener
JP2017528125A (ja) 2014-08-11 2017-09-28 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． 組み換え宿主におけるステビオールグリコシドの産生
CN114052237A (zh) * 2014-08-19 2022-02-18 谱赛科有限责任公司 制备莱鲍迪苷i的方法以及用途
EP3189065B1 (en) 2014-09-02 2021-07-07 PureCircle USA Inc. Stevia extracts enriched in rebaudioside d, e, n and/or o and process for the preparation thereof.
CA2960693A1 (en) * 2014-09-09 2016-03-17 Evolva Sa Production of steviol glycosides in recombinant hosts
CN104232496B (zh) * 2014-09-18 2017-06-06 广州康琳奈生物科技有限公司 一种重组毕赤酵母工程菌及其在合成莱鲍迪苷a中的应用
MX2017003666A (es) * 2014-09-19 2018-02-01 Purecircle Sdn Bhd Esteviol glicosidos de alta pureza.
MX2017004248A (es) * 2014-10-03 2017-05-19 Conagen Inc Edulcorantes no caloricos y metodos para sintetizar.
MY182396A (en) 2014-11-05 2021-01-23 Manus Biosynthesis Inc Microbial production of steviol glycosides
CN107249356B (zh) 2014-12-17 2021-08-06 嘉吉公司 用于口服摄入或使用的甜菊醇糖苷化合物、组合物以及用于增强甜菊醇糖苷溶解度的方法
CN108522291B (zh) * 2015-01-23 2022-01-04 谱赛科美国公司 利用甜叶菊新品种814011谱星3号制备高rm含量甜菊糖苷的方法
CA2973674A1 (en) * 2015-01-30 2016-08-04 Evolva Sa Production of steviol glycosides in recombinant hosts
BR112017017207B1 (pt) * 2015-02-10 2022-10-18 Purecircle Usa Inc. Processo para produzir um glicosídeo terpenoide, composição de sabor, ingrediente alimentício, alimento, bebida ou outro produto consumível, cosmético e produto farmacêutico que compreende o dito glicosídeo terpenoide
WO2016141207A1 (en) 2015-03-03 2016-09-09 The Regents Of The University Of California Protecting group chemistry for clean, reductant-free dyeing
EP3271457B1 (en) 2015-03-16 2021-01-20 DSM IP Assets B.V. Udp-glycosyltransferases
BR112017020308A2 (pt) * 2015-03-23 2018-07-10 Dsm Ip Assets Bv udp-glicosiltransferases
WO2016156616A1 (en) 2015-04-03 2016-10-06 Dsm Ip Assets B.V. Steviol glycosides
HUE051977T2 (hu) 2015-04-14 2021-04-28 Conagen Inc Kalóriamentes édesítõk elõállítása mesterséges egész sejtes katalizátorok használatával
BR112017022298A2 (pt) * 2015-04-21 2018-07-10 Dsm Ip Assets Bv geranilgeranil pirofosfato sintase
JP2018516081A (ja) 2015-05-29 2018-06-21 カーギル・インコーポレイテッド 配糖体を産生するための熱処理
CA2987630A1 (en) * 2015-05-29 2016-12-08 Cargill, Incorporated Fermentation methods for producing steviol glycosides with multi-phase feeding
US10815513B2 (en) 2015-05-29 2020-10-27 Cargill, Incorporated Fermentation methods for producing steviol glycosides using high pH and compositions obtained therefrom
CN105200098A (zh) * 2015-06-30 2015-12-30 苏州汉酶生物技术有限公司 一种利用酿酒酵母酶法制备瑞鲍迪甙m的方法
JP2018521680A (ja) 2015-08-06 2018-08-09 カーギル・インコーポレイテッド ステビオール配糖体を生成するための発酵法
AU2016307066A1 (en) 2015-08-07 2018-02-08 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3943504A1 (en) 2015-08-13 2022-01-26 DSM IP Assets B.V. Steviol glycoside transport
US9765117B2 (en) 2015-08-24 2017-09-19 Romek Figa Peptides for treating cancer
CN108138152B (zh) 2015-10-05 2023-01-06 帝斯曼知识产权资产管理有限公司 贝壳杉烯酸羟化酶
ES2970118T3 (es) 2015-10-26 2024-05-27 Purecircle Usa Inc Composiciones de glicósido de esteviol
WO2017093895A1 (en) * 2015-11-30 2017-06-08 Purecircle Sdn Bhd Process for producing high purity steviol glycosides
AU2016367317A1 (en) * 2015-12-10 2018-05-24 Evolva Sa Production of steviol glycosides in recombinant hosts
US11653686B2 (en) 2015-12-15 2023-05-23 Purecircle Usa Inc. Steviol glycoside compositions
RU2733441C2 (ru) * 2016-03-01 2020-10-01 Вм. Ригли Джр. Компани Составы подсластителя с длительным подслащивающим эффектом
EP3426791A1 (en) * 2016-03-11 2019-01-16 Evolva SA Production of steviol glycosides in recombinant hosts
WO2017178632A1 (en) 2016-04-13 2017-10-19 Evolva Sa Production of steviol glycosides in recombinant hosts
US10815514B2 (en) 2016-05-16 2020-10-27 Evolva Sa Production of steviol glycosides in recombinant hosts
CN109477128A (zh) * 2016-05-16 2019-03-15 埃沃尔瓦公司 在重组宿主中甜菊醇糖苷的生产
SG11201811144WA (en) * 2016-06-17 2019-01-30 Cargill Inc Steviol glycoside compositions for oral ingestion or use
BR112018074999A2 (pt) * 2016-08-12 2019-03-12 Amyris, Inc. glicosiltransferase dependente de udp para a produção de alta eficiência de rebaudiosídeo
RU2019114181A (ru) 2016-10-14 2020-11-16 Конаджен Инк. Биосинтетическое получение стевиоловых гликозидов и связанные с этим способы
EP3530745A4 (en) 2016-10-21 2020-07-22 Pepsico, Inc. PROCESS FOR PREPARING REBAUDIOSIDE N USING AN ENZYMATIC PROCESS
CN110177881B (zh) * 2016-10-21 2023-06-02 百事可乐公司 一种酶法制备瑞鲍迪甙j的方法
RU2736155C1 (ru) * 2016-10-21 2020-11-12 Пепсико, Инк. Способ получения ребаудиозида c с применением ферментативного способа
JP2019532655A (ja) * 2016-10-27 2019-11-14 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． ゲラニルゲラニルピロリン酸シンターゼ
CN110100006A (zh) 2016-11-07 2019-08-06 埃沃尔瓦公司 重组宿主中甜菊糖苷的生产
WO2018111194A1 (en) * 2016-12-16 2018-06-21 Temasek Life Sciences Laboratory Limited Targets for improving terpene production in rhodosporidium toruloides
CN110121556A (zh) * 2016-12-27 2019-08-13 三得利控股株式会社 甜菊醇糖苷己糖转移酶及编码该物质的基因
IL268121B2 (en) * 2017-02-03 2024-01-01 Codexis Inc Transgenic glycosyltransferases and steviol glycoside glucosylation methods
KR102554790B1 (ko) * 2017-03-06 2023-07-13 코나겐 인크. 레바우디오시드 e로부터 스테비올 글리코시드 레바우디오시드 d4의 생합성 제조
US11284577B2 (en) 2017-03-08 2022-03-29 Purecircle Usa Inc. High rebaudioside M stevia plant cultivars and methods of producing the same
CN110494564B (zh) * 2017-04-12 2024-03-15 三得利控股株式会社 来自甜菊的鼠李糖合成酶及基因
WO2018211032A1 (en) 2017-05-17 2018-11-22 Evolva Sa Production of steviol glycosides in recombinant hosts
CA3068440A1 (en) * 2017-06-30 2019-01-03 Conagen Inc. Hydrolysis of steviol glycosides by beta-glucosidase
AU2018314249A1 (en) 2017-08-11 2020-03-05 Amyris, Inc. Pisum sativum kaurene oxidase for high efficiency production of rebaudiosides
US11365417B2 (en) 2017-09-12 2022-06-21 Bio Capital Holdings, LLC Biological devices and methods of use thereof to produce steviol glycosides
CN107446874B (zh) * 2017-09-25 2020-07-28 四川盈嘉合生科技有限公司 重组大肠杆菌及其在合成莱鲍迪苷d中的用途
US20200291442A1 (en) 2017-12-05 2020-09-17 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3765627A4 (en) 2018-03-12 2021-10-13 Conagen Inc. BIOSYNTHETIC PRODUCTION OF STEVIOL GLYCOSIDES REBAUDIOSIDE J AND REBAUDIOSIDE N
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
BR112021000876A2 (pt) * 2018-07-16 2021-04-13 Manus Bio, Inc. Produção de glicosídeos de esteviol através da biotransformação com células inteiras
CN109393426A (zh) * 2018-09-29 2019-03-01 四川盈嘉合生科技有限公司 一种复合甜味剂
CN113260699A (zh) 2018-10-15 2021-08-13 阿迈瑞斯公司 用于高效生成瑞鲍迪苷的甜叶菊异贝壳杉烯酸羟化酶变体
WO2020117792A2 (en) * 2018-12-04 2020-06-11 The Regents Of The University Of California Scalable biosynthesis of the seaweed neurochemical kainic acid
CN113474464A (zh) * 2018-12-12 2021-10-01 科纳根公司 变体甜菊醇糖苷的生物合成生产
KR102618015B1 (ko) * 2018-12-21 2023-12-26 주식회사 삼양사 스테비올 또는 이의 전구체의 생산
AU2020211408A1 (en) 2019-01-24 2021-08-12 Amyris, Inc. ABC transporters for the high efficiency production of rebaudiosides
CN109913380B (zh) * 2019-03-25 2021-12-10 南京工业大学 生产(-)-α-红没药醇的重组解脂耶氏酵母菌及其构建方法和应用
US20220282228A1 (en) * 2019-05-03 2022-09-08 Amyris, Inc. Kaurenoic acid 13-hydroxylase (kah) variants and uses thereof
CA3144658A1 (en) 2019-06-25 2020-12-30 Manus Bio, Inc. Uridine diphosphate-dependent glycosyltransferase enzyme
KR102379608B1 (ko) * 2019-10-29 2022-03-29 주식회사 삼양사 개선된 스테비올 배당체 화합물 또는 이의 전구체의 생산
CN111088176B (zh) * 2019-12-30 2022-03-25 北京化工大学 产β-胡萝卜素的基因工程菌及其应用
CN112006035B (zh) * 2020-07-24 2021-07-30 江西新龙生物科技股份有限公司 用于防治植物病害的微生物源杀菌剂及其制备方法
WO2023006179A1 (en) 2020-07-27 2023-02-02 Dsm Ip Assets B.V. Method to produce retinyl acetate
WO2022084482A1 (en) 2020-10-22 2022-04-28 Dsm Ip Assets B.V. Microorganisms for diterpene production
JP7210626B2 (ja) * 2021-02-18 2023-01-23 ペプシコ・インク 酵素的方法を使用してレバウディオサイドｊを調製するための方法
US11299700B1 (en) 2021-02-19 2022-04-12 Acequia Biotechnology, Llc Bioreactor containers and methods of growing hairy roots using the same
CA3209929A1 (en) 2021-03-01 2022-09-09 Erin EVANS Xylosylated steviol glycosides and enzymatic methods for production
CN115478060B (zh) * 2021-06-16 2023-11-28 弈柯莱生物科技(集团)股份有限公司 一种糖基转移酶及其应用
WO2023006851A1 (en) 2021-07-27 2023-02-02 Dsm Ip Assets B.V. Fermentative production of retinyl acetate in the presence of ethanol
KR102564619B1 (ko) 2021-08-10 2023-08-07 이재준 사각육면 밀폐형 접이식 스퀘어박스
WO2023044368A1 (en) * 2021-09-17 2023-03-23 Doublerainbow Biosciences Inc. Method for producing glycosylated therapeutics by using an immobilized enzyme preparation
CN113930377B (zh) * 2021-10-14 2023-12-26 广西大学 一株全细胞催化提高莱鲍迪苷a含量的工程菌
CN114196696B (zh) * 2021-12-06 2023-10-20 天津大学 一种与特定短肽标签融合能高效催化Reb M生成的重组酶
WO2023122649A1 (en) * 2021-12-21 2023-06-29 Mozhdehi Davoud Temperature-responsive nano-biomaterials from genetically encoded farnesylated proteins
CN114561310B (zh) * 2022-03-17 2022-12-02 江南大学 一种生产甜茶苷的酿酒酵母及其应用
WO2024010442A1 (en) * 2022-07-07 2024-01-11 Purecircle Sdn Bhd High-purity steviol glycosides
WO2024011263A2 (en) * 2022-07-08 2024-01-11 Cibus Us Llc Producing sesquiterpenes and other terpenes using plant-based biomasses
WO2024042405A1 (en) 2022-08-26 2024-02-29 Amyris Bio Products Portugal, Unipessoal, Ltda. Compositions and methods for the synthesis of bio-based polymers
WO2024042486A1 (en) 2022-08-26 2024-02-29 Amyris Bio Products Portugal, Unipessoal, Ltda. Compositions and methods for the production of polyurethanes
WO2024118831A1 (en) * 2022-11-30 2024-06-06 Velozbio Company Compositions and methods for protein production
WO2024116153A1 (en) 2022-12-02 2024-06-06 Amyris Bio Products Portugal, Unipessoal, Ltda. Compositions and methods for using previously cultured cells

Family Cites Families (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58149697A (ja) * 1982-02-27 1983-09-06 Dainippon Ink & Chem Inc β−１，３グリコシルステビオシドの製造方法
JPS59101408A (ja) 1982-12-02 1984-06-12 Junichi Iwamura 植物生長調整剤
US6946587B1 (en) 1990-01-22 2005-09-20 Dekalb Genetics Corporation Method for preparing fertile transgenic corn plants
US5484956A (en) 1990-01-22 1996-01-16 Dekalb Genetics Corporation Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin
JPH03277275A (ja) 1990-03-28 1991-12-09 Dainippon Ink & Chem Inc 新規酵素及びその酵素を用いた配糖体の製造方法
US5204253A (en) 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
US5306862A (en) 1990-10-12 1994-04-26 Amoco Corporation Method and composition for increasing sterol accumulation in higher plants
US5460949A (en) 1990-11-15 1995-10-24 Amoco Corporation Method and composition for increasing the accumulation of squalene and specific sterols in yeast
US5712112A (en) 1992-11-04 1998-01-27 National Science Council Of R.O.C. Gene expression system comprising the promoter region of the alpha-amylase genes
JPH09503905A (ja) 1993-07-15 1997-04-22 ネオゼ ファーマシューティカルス 糖組成物の合成方法
US7186891B1 (en) 1996-04-12 2007-03-06 University Of Kentucky, Research Foundation Plant cells and plants expressing chimeric isoprenoid synthases
JPH10117776A (ja) 1996-10-22 1998-05-12 Japan Tobacco Inc インディカイネの形質転換方法
EP1021551A1 (en) 1997-10-06 2000-07-26 Centre National De La Recherche Scientifique Plant fatty acid hydroxylase genes
US6255557B1 (en) 1998-03-31 2001-07-03 Her Majesty The Queen In Right Of Canada As Represented By The Ministerof Agriculture And Agri-Food Canada Stevia rebaudiana with altered steviol glycoside composition
KR100724004B1 (ko) 1998-04-14 2007-06-04 교와 학꼬 고교 가부시키가이샤 항균 또는 제초 활성을 갖는 물질의 탐색 방법
TWI250210B (en) 1998-05-06 2006-03-01 Dsm Ip Assets Bv An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate
EP0955363A3 (en) 1998-05-06 2004-01-28 F. Hoffmann-La Roche Ag Dna sequences encoding enzymes involved in production of isoprenoids
US6531303B1 (en) 1998-07-06 2003-03-11 Arkion Life Sciences Llc Method of producing geranylgeraniol
ES2534937T3 (es) 1998-07-06 2015-04-30 Dcv Inc. Doing Business As Bio-Technical Resourses Procedimiento de producción de vitaminas
JP3277275B2 (ja) 1998-07-28 2002-04-22 有限会社シャトウバッグ バッグ等に用いる模様付き表地材及びその製造方法
AR021636A1 (es) 1998-12-17 2002-07-31 Rubicon Forests Holdings Ltd Materiales y metodos para la modificacion del contenido, la composicion y el metabolismo de los isoprenoides
EP1141356A2 (en) 1998-12-23 2001-10-10 The Samuel Roberts Noble Foundation, Inc. Plant transformation process
CA2369844C (en) 1999-04-15 2013-02-26 Calgene Llc Nucleic acid sequences to proteins involved in tocopherol synthesis
NZ513993A (en) 1999-04-21 2001-09-28 Samuel Roberts Noble Found Inc Plant transformation process
AU6280300A (en) 1999-08-04 2001-03-05 Adelbert Bacher Isoprenoid biosynthesis
WO2001012828A1 (en) 1999-08-18 2001-02-22 Paradigm Genetics, Inc. Methods and apparatus for transformation of monocotyledenous plants using agrobacterium in combination with vacuum filtration
AU2001269685A1 (en) 2000-05-03 2001-11-12 The Salk Institute For Biological Studies Crystallization of 4-diphosphocytidyl-2-c-methylerythritol synthesis
DE10027821A1 (de) 2000-06-05 2001-12-06 Adelbert Bacher Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg
WO2002010398A2 (en) 2000-07-31 2002-02-07 Hahn Frederick M Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
AU2001286811B2 (en) 2000-08-24 2007-03-01 Syngenta Participations Ag Stress-regulated genes of plants, transgenic plants containing same, and methods of use
US6818424B2 (en) 2000-09-01 2004-11-16 E. I. Du Pont De Nemours And Company Production of cyclic terpenoids
US6660507B2 (en) 2000-09-01 2003-12-09 E. I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
US6689601B2 (en) 2000-09-01 2004-02-10 E. I. Du Pont De Nemours And Company High growth methanotropic bacterial strain
EP1409530A2 (en) 2000-09-19 2004-04-21 Microbia, Inc. Modulation of secondary metabolite production by zinc binuclear cluster proteins
AU9635901A (en) 2000-09-29 2002-04-08 Cargill Inc Isoprenoid production
US6949362B2 (en) 2000-12-12 2005-09-27 E. I. Du Pont De Nemours And Company Rhodococcus cloning and expression vectors
AU2002227883A1 (en) 2001-01-25 2002-08-06 Evolva Biotech A/S A library of a collection of cells
US20050003474A1 (en) 2001-01-26 2005-01-06 Desouza Mervyn L. Carotenoid biosynthesis
US20040078846A1 (en) 2002-01-25 2004-04-22 Desouza Mervyn L. Carotenoid biosynthesis
DE10201458A1 (de) 2001-04-11 2002-10-17 Adelbert Bacher Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
US7034140B2 (en) 2001-04-24 2006-04-25 E.I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
CN1630718A (zh) 2001-06-06 2005-06-22 Dsmip资产公司 改进的类异戊二烯生产
WO2003008540A2 (en) 2001-06-22 2003-01-30 Syngenta Participations Ag Abiotic stress responsive polynucleotides and polypeptides
US20040072311A1 (en) 2001-08-28 2004-04-15 Dicosimo Deana J. Production of cyclic terpenoids
US20040010815A1 (en) 2001-09-26 2004-01-15 Lange B. Markus Identification and characterization of plant genes
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
JP2005185101A (ja) * 2002-05-30 2005-07-14 National Institute Of Agrobiological Sciences 植物の全長ｃＤＮＡおよびその利用
EP1544300B1 (en) 2002-08-20 2009-09-30 Suntory Holdings Limited Novel glycosyltransferase genes
JP2006500054A (ja) * 2002-09-27 2006-01-05 ディーエスエム アイピー アセッツ ビー．ブイ． Ｓｑｓ遺伝子
US7098000B2 (en) 2003-06-04 2006-08-29 E. I. Du Pont De Nemoure And Company Method for production of C30-aldehyde carotenoids
CN1806042B (zh) 2003-06-12 2012-07-04 帝斯曼知识产权资产管理有限公司 具有反馈抗性的甲羟戊酸激酶
US20060150283A1 (en) 2004-02-13 2006-07-06 Nickolai Alexandrov Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
US7569389B2 (en) 2004-09-30 2009-08-04 Ceres, Inc. Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics
AU2005327292B2 (en) 2004-05-21 2010-11-04 The Regents Of The University Of California Method for enhancing production of isoprenoid compounds
US20060014264A1 (en) 2004-07-13 2006-01-19 Stowers Institute For Medical Research Cre/lox system with lox sites having an extended spacer region
JPWO2006016395A1 (ja) 2004-08-09 2008-05-01 国立大学法人東北大学 Ｕｄｐ−グルクロニル基転移酵素およびその遺伝子
CN101044243B (zh) 2004-08-19 2011-12-28 帝斯曼知识产权资产管理有限公司 类异戊二烯的生产方法
US7923552B2 (en) 2004-10-18 2011-04-12 SGF Holdings, LLC High yield method of producing pure rebaudioside A
ATE500321T1 (de) 2004-12-14 2011-03-15 Dsm Ip Assets Bv Verbesserte mevalonatkinase
WO2006096392A2 (en) 2005-03-04 2006-09-14 Diversa Corporation Enzymes involved in astaxanthin, carotenoid and isoprenoid biosynthetic pathways, genes encoding them and methods of making and using them
WO2006093289A1 (ja) 2005-03-04 2006-09-08 National Institute Of Advanced Industrial Science And Technology Udp-キシロースの製造方法
WO2007022318A2 (en) 2005-08-17 2007-02-22 Cornell Research Foundation Nucleic acids and proteins associated with sucrose accumulation in coffee
US8293307B2 (en) 2005-10-11 2012-10-23 Purecircle Sdn Bhd Process for manufacturing a sweetener and use thereof
EP3199033B1 (en) 2005-11-23 2020-10-07 The Coca-Cola Company Natural high-potency sweetener compositions with improved temporal profile and/or flavor profile, methods for their formulation, and uses
US7927851B2 (en) 2006-03-21 2011-04-19 Vineland Research And Innovation Centre Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same
WO2008034648A1 (en) 2006-04-05 2008-03-27 Metanomics Gmbh Process for the production of a fine chemical
WO2007136847A2 (en) 2006-05-19 2007-11-29 The Regents Of The University Of California Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels
US7964376B2 (en) 2006-06-19 2011-06-21 Givaudan Sa Chimeric proteins and their use in methods to screen for sweet taste modulators
WO2008008256A2 (en) 2006-07-07 2008-01-17 The Regents Of The University Of California Methods for enhancing production of isoprenoid compounds by host cells
BRPI0716954B1 (pt) 2006-09-26 2024-04-30 The Regents Of The University Of California Microrganismos geneticamente modificados capazes de produzir um isoprenóide
US7741119B2 (en) 2006-09-28 2010-06-22 E. I. Du Pont De Nemours And Company Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production
US7629156B2 (en) 2006-09-28 2009-12-08 E.I. Du Pont De Nemours And Company Ethanol production in fermentation of mixed sugars containing xylose
CN101200480B (zh) 2006-12-15 2011-03-30 成都华高药业有限公司 莱鲍迪甙a的提取方法
JP4915917B2 (ja) * 2006-12-22 2012-04-11 独立行政法人農業・食品産業技術総合研究機構 ラクト−ｎ−ビオースｉ及びガラクト−ｎ−ビオースの製造方法
ES2381892T3 (es) 2007-01-22 2012-06-01 Cargill, Incorporated Procedimiento para producir composiciones de rebaudiósido A purificado que utiliza la cristalización disolvente/antidisolvente
JP2008237110A (ja) 2007-03-27 2008-10-09 Institute Of Physical & Chemical Research ステビオール合成酵素遺伝子及びステビオールの製造方法
AU2008254423C1 (en) 2007-05-17 2016-06-02 Eastman Renewable Materials, Llc Methods and compositions for producing solvents
US20080292775A1 (en) 2007-05-22 2008-11-27 The Coca-Cola Company Delivery Systems for Natural High-Potency Sweetener Compositions, Methods for Their Formulation, and Uses
WO2009005704A1 (en) 2007-07-03 2009-01-08 The Regents Of The University Of California Methods of increasing isoprenoid or isoprenoid precursor production
JP2009034080A (ja) 2007-08-03 2009-02-19 Sanei Gen Ffi Inc 新規糖転移酵素、及びそれを利用した配糖体の製造
US7964232B2 (en) 2007-09-17 2011-06-21 Pepsico, Inc. Steviol glycoside isomers
RU2519718C2 (ru) 2007-12-03 2014-06-20 ДСМ АйПи АССЕТС Б.В. Новые нутрицевтические композиции, содержащие экстракт stevia или компоненты экстракта stevia, и их применения
CA2710629C (en) 2007-12-27 2016-06-21 Mcneil Nutritionals, Llc Synergistic sweetening compositions
US20110061124A1 (en) 2008-02-20 2011-03-10 Ceres, Inc Nucleotide sequences and corresponding polypeptides conferring improved nitrogen use efficiency characteristics in plants
TWI475963B (zh) 2008-02-25 2015-03-11 Coca Cola Co 甜菊糖苷ａ衍生性產物以及製造彼的方法
US9005444B2 (en) 2008-05-13 2015-04-14 Cargill, Incorporated Separation of rebaudioside A from stevia glycosides using chromatography
CN101314776B (zh) * 2008-07-11 2010-11-03 南京农业大学 二磷酸尿核甘葡萄糖基转移酶基因及其所编码的蛋白质
WO2010021001A2 (en) 2008-08-19 2010-02-25 Kaushik Ramakrishnan S Process for preparing sweetener from stevia rebaudiana
KR102061165B1 (ko) 2008-10-03 2019-12-31 모리타 가가쿠 고교 가부시키가이샤 신규 스테비올 배당체
CN101720910B (zh) 2008-10-23 2012-07-25 大闽食品（漳州）有限公司 一种甜菊糖甙的制备方法
US8614085B2 (en) 2009-02-27 2013-12-24 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving a multidrug efflux pump gene
US20100297722A1 (en) * 2009-05-20 2010-11-25 Board Of Trustees Of Southern Illinois University Transgenic moss producing terpenoids
ES2660698T3 (es) 2009-06-08 2018-03-23 Jennewein Biotechnologie Gmbh Síntesis de HMO
ES2523997T3 (es) 2009-06-16 2014-12-03 Epc (Beijing) Natural Products Co., Ltd. Reducción o eliminación del sabor residual en un edulcorante utilizando rebaudiósido D
CN102573521B (zh) * 2009-09-04 2014-04-09 红点生物公司 包括莱鲍迪苷a或d的甜度增强剂
AU2010298437B2 (en) 2009-09-22 2014-06-19 Redpoint Bio Corporation Novel polymorphs of rebaudioside C and methods for making and using the same
KR101733515B1 (ko) * 2009-10-15 2017-05-08 퓨어 써클 에스디엔 비에이치디 고순도 레바우디오사이드 ｄ 및 적용
US8299224B2 (en) 2009-10-15 2012-10-30 Purecircle Sdn Bhd High-purity Rebaudioside D
US8703224B2 (en) 2009-11-04 2014-04-22 Pepsico, Inc. Method to improve water solubility of Rebaudioside D
EP2504441B1 (en) 2009-11-23 2020-07-22 E. I. du Pont de Nemours and Company Sucrose transporter genes for increasing plant seed lipids
KR102110725B1 (ko) 2009-12-10 2020-05-13 리전츠 오브 더 유니버스티 오브 미네소타 Ｔａｌ 이펙터-매개된 ｄｎａ 변형
AU2010343073A1 (en) 2009-12-28 2012-08-02 The Coca-Cola Company Sweetness enhancers, compositions thereof, and methods for use
WO2011140329A1 (en) 2010-05-06 2011-11-10 Ceres, Inc. Transgenic plants having increased biomass
US9476082B2 (en) 2010-05-20 2016-10-25 Evolva Sa Method of producing isoprenoid compounds in yeast
WO2011151326A2 (en) 2010-05-31 2011-12-08 Vib Vzw The use of transporters to modulate flavor production by yeast
BR122021005283B1 (pt) * 2010-06-02 2022-02-22 Evolva, Inc Hospedeiro recombinante que compreende genes recombinantes para produção deesteviol ou glicosídeo de esteviol, método para produzir esteviol, glicosídeo de esteviol ou composição de glicosídeo de esteviol e método para sintetizar esteviol ou glicosídeo de esteviol
US20120021111A1 (en) 2010-07-23 2012-01-26 Aexelon Therapeutics, Inc. Natural Low Caloric Sweetener Compositions for Use in Beverages, Foods and Pharmaceuticals, and Their Methods of Manufacture
US20120083593A1 (en) 2010-10-01 2012-04-05 Shanghai Yongyou Bioscience Inc. Separation and Purification of Stevioside and Rebaudioside A
CA2819253A1 (en) * 2010-11-30 2012-06-07 Massachusetts Institute Of Technology Microbial production of natural sweeteners, diterpenoid steviol glycosides
KR20130014227A (ko) 2011-07-29 2013-02-07 한국생명공학연구원 신규한 α-글루코실 스테비오사이드 및 이의 제조 방법
KR102114493B1 (ko) * 2011-08-08 2020-05-26 에볼바 에스아 스테비올 글리코시드의 재조합 생산
IN2014CN03557A (pt) 2011-11-23 2015-10-09 Evolva Sa
CN103159808B (zh) 2011-12-09 2017-03-29 上海泓博智源医药股份有限公司 一种制备天然甜味剂的工艺方法
TR201802109T4 (tr) 2011-12-19 2018-03-21 Coca Cola Co Steviol glikositlerini içeren içecek.
DK2806754T3 (en) 2012-01-23 2019-02-18 Dsm Ip Assets Bv Diterpene PREPARATION
CN102559528B (zh) * 2012-02-09 2013-08-21 南京工业大学 一种产甜叶菊糖基转移酶ugt76g1的基因工程菌及其应用
CA2867112C (en) 2012-03-16 2021-04-20 Suntory Holdings Limited Steviol glucosyltransferases and genes encoding the same
JP6346174B2 (ja) 2012-05-22 2018-06-20 ピュアサークル スンディリアン ブルハド 高純度ステビオールグリコシド
CA2886893C (en) 2012-09-29 2019-05-07 Yong Wang Method for producing stevioside compounds by microorganism
US20150342234A1 (en) 2012-12-05 2015-12-03 Evolva Sa Steviol Glycoside Compositions Sensory Properties
SG11201505597SA (en) 2013-02-06 2015-08-28 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
KR20150128705A (ko) 2013-02-11 2015-11-18 에볼바 에스아 재조합 숙주에서 스테비올 글리코시드의 효율적인 생성
KR101559478B1 (ko) 2013-06-24 2015-10-13 한국생명공학연구원 효소전환법을 이용한 천연 고감미료의 제조방법
EP3024941B1 (en) 2013-07-23 2019-07-03 DSM IP Assets B.V. Diterpene production in yarrowia
WO2015014969A1 (en) 2013-07-31 2015-02-05 Dsm Ip Assets B.V. Steviol glycosides
AU2014298420B2 (en) 2013-07-31 2018-10-04 Dsm Ip Assets B.V. Recovery of steviol glycosides
WO2015016393A1 (ja) 2013-08-02 2015-02-05 サントリーホールディングス株式会社 ヘキセノール配糖体化酵素の利用方法
CN103397064B (zh) 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙m的方法
WO2015028324A2 (en) 2013-08-30 2015-03-05 Evolva Sa A method for producing modified resveratrol
SG10201807693YA (en) 2014-03-07 2018-10-30 Evolva Sa Methods for recombinant production of saffron compounds
JP2017528125A (ja) 2014-08-11 2017-09-28 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． 組み換え宿主におけるステビオールグリコシドの産生
CA2960693A1 (en) 2014-09-09 2016-03-17 Evolva Sa Production of steviol glycosides in recombinant hosts
CA2973674A1 (en) 2015-01-30 2016-08-04 Evolva Sa Production of steviol glycosides in recombinant hosts
AU2016307066A1 (en) 2015-08-07 2018-02-08 Evolva Sa Production of steviol glycosides in recombinant hosts

Also Published As

Publication number Publication date
JP2022101592A (ja) 2022-07-06
JP6262653B2 (ja) 2018-01-17
AU2022203048A1 (en) 2022-05-26
SG10201606563PA (en) 2016-10-28
KR20200057799A (ko) 2020-05-26
US9631215B2 (en) 2017-04-25
US20140329281A1 (en) 2014-11-06
CN108396044A (zh) 2018-08-14
CA3128532A1 (en) 2013-02-14
US10435730B2 (en) 2019-10-08
US20220228185A1 (en) 2022-07-21
BR122020019161B1 (pt) 2022-04-05
CA2843606A1 (en) 2013-02-14
AU2012294452A1 (en) 2014-02-06
AU2012294452C1 (en) 2017-11-30
US20200123583A1 (en) 2020-04-23
EP2742142A2 (en) 2014-06-18
SG10201606569VA (en) 2016-09-29
AU2012294452A8 (en) 2014-03-06
JP7057765B2 (ja) 2022-04-20
BR112014003037B1 (pt) 2022-04-05
WO2013022989A3 (en) 2013-07-04
EP3009508B1 (en) 2020-11-25
EP3792350A1 (en) 2021-03-17
AU2012294452B2 (en) 2017-08-10
JP6554518B2 (ja) 2019-07-31
CN103732753B (zh) 2018-03-30
AU2020200157B2 (en) 2022-02-10
SG10201606567TA (en) 2016-10-28
BR122021015508B1 (pt) 2022-03-29
CN103732753A (zh) 2014-04-16
BR122021015509B1 (pt) 2022-03-29
EP2742142B1 (en) 2016-06-01
AU2020200157A1 (en) 2020-01-30
AU2022203048B2 (en) 2024-03-28
WO2013022989A2 (en) 2013-02-14
EP2742142B2 (en) 2020-03-25
CA2843606C (en) 2021-10-05
JP2014524247A (ja) 2014-09-22
JP2019205445A (ja) 2019-12-05
KR20140057322A (ko) 2014-05-12
EP3009508A1 (en) 2016-04-20
AU2017258907A1 (en) 2017-11-30
MY173212A (en) 2020-01-06
SG10201606565XA (en) 2016-10-28
JP2018019715A (ja) 2018-02-08
KR102114493B1 (ko) 2020-05-26
US20170321238A1 (en) 2017-11-09
US20230407360A1 (en) 2023-12-21

Similar Documents

Publication Publication Date Title
BR112014003037A2 (pt) produção recombinante de glicosídeos de esteviol
SG10201709458QA (en) Recombinant production of steviol glycosides
EP3063286A4 (en) Recombinant production of steviol glycosides
CO6852047A2 (es) Ensamble desgastable
SG11201506127WA (en) Efficient production of steviol glycosides in recombinant hosts
BR112013014614A2 (pt) misturas de glicosídeo
DK2726510T3 (da) Dobbelt målretning
EP2720561A4 (en) Stevia-COMPOSITION
EP2675909A4 (en) GLUCOSYLSTEVIA COMPOSITION
BR112013017183A2 (pt) composições de bepostatina
EP2713762A4 (en) COMPOSITION OF STÉVIA
PL2713763T3 (pl) Kompozycja stewiowa
CO6960555A2 (es) Procedimiento de preparación de 5-fluoro-1h-pirazolopiridinas sustituidas
UY4115Q (es) Reloj
PL2486806T3 (pl) Kompozycja stewii
EP2672840A4 (en) COMPOSITION BASED ON STÉVIA
BR112014003878A2 (pt) síntese de r-bifenilalaninol
GB2493627B (en) Improvements relating to chiroptical switches
DK2814329T3 (da) Ph-indstillet sødemiddel
BR112014020677A2 (pt) composições de farinha de milho e métodos de produção
BR112016006155A2 (pt) glicosídeo de esteviol glicosilado como um modificador de sabor
DE112012000803A5 (de) Aktuatoreinrichtung
BR112013030248A2 (pt) aeronave
BR112014000533A2 (pt) composição comestível
FI20115288L (fi) Murskain

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/08/2012, OBSERVADAS AS CONDICOES LEGAIS.