ATE500321T1 - Verbesserte mevalonatkinase - Google Patents

Verbesserte mevalonatkinase

Info

Publication number
ATE500321T1
ATE500321T1 AT05815027T AT05815027T ATE500321T1 AT E500321 T1 ATE500321 T1 AT E500321T1 AT 05815027 T AT05815027 T AT 05815027T AT 05815027 T AT05815027 T AT 05815027T AT E500321 T1 ATE500321 T1 AT E500321T1
Authority
AT
Austria
Prior art keywords
improved
mevalonate kinase
modified
vectors
producing
Prior art date
Application number
AT05815027T
Other languages
English (en)
Inventor
Renyuan Bai
Markus Wyss
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35907004&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE500321(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Application granted granted Critical
Publication of ATE500321T1 publication Critical patent/ATE500321T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT05815027T 2004-12-14 2005-12-12 Verbesserte mevalonatkinase ATE500321T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04029529 2004-12-14
PCT/EP2005/013282 WO2006063752A1 (en) 2004-12-14 2005-12-12 Improved mevalonate kinase

Publications (1)

Publication Number Publication Date
ATE500321T1 true ATE500321T1 (de) 2011-03-15

Family

ID=35907004

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05815027T ATE500321T1 (de) 2004-12-14 2005-12-12 Verbesserte mevalonatkinase

Country Status (7)

Country Link
US (1) US8338155B2 (de)
EP (1) EP1824969B1 (de)
JP (1) JP4841562B2 (de)
CN (1) CN101080490B (de)
AT (1) ATE500321T1 (de)
DE (1) DE602005026692D1 (de)
WO (1) WO2006063752A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8257957B2 (en) 2006-09-26 2012-09-04 The Regents Of The University Of California Production of isoprenoids and isoprenoid precursors
JP2009000046A (ja) * 2007-06-21 2009-01-08 Hitachi Zosen Corp トチュウのメバロン酸経路の酵素をコードする遺伝子
WO2009076676A2 (en) 2007-12-13 2009-06-18 Danisco Us Inc. Compositions and methods for producing isoprene
WO2009129175A1 (en) 2008-04-14 2009-10-22 Dow Corning Corporation Emulsions of boron crosslinked organopolysiloxanes
EP2279251A2 (de) 2008-04-23 2011-02-02 Danisco US Inc. Isoprensynthasevarianten zur verbesserten mikrobiellen herstellung von isopren
MY169163A (en) 2008-09-15 2019-02-19 Danisco Us Inc Increased isoprene production using the archaeal lower mevalonate pathway
CN102656265A (zh) 2009-04-23 2012-09-05 丹尼斯科美国公司 异戊二烯合酶的三维结构及其用于产生变体的用途
EP2336310A1 (de) 2009-12-16 2011-06-22 Isobionics B.V. Valencensynthase
SG10201709458QA (en) 2010-06-02 2017-12-28 Evolva Inc Recombinant production of steviol glycosides
CN103443271A (zh) 2010-10-27 2013-12-11 丹尼斯科美国公司 用于增加异戊二烯产量的异戊二烯合酶变体
EP2537926A1 (de) 2011-06-21 2012-12-26 Isobionics B.V. Valencensynthase
SG10201606565XA (en) 2011-08-08 2016-10-28 Evolva Sa Recombinant production of steviol glycosides
CN102392032A (zh) * 2011-11-28 2012-03-28 山东省农业科学院作物研究所 小麦甲羟戊酸激酶基因TaMVK及其分离克隆、酶活性测定方法
CN103205432B (zh) * 2012-01-11 2015-06-10 安徽医科大学第一附属医院 弥散型浅表性光线性汗孔角化症(dsap)相关基因
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
US9957540B2 (en) 2013-02-06 2018-05-01 Evolva Sa Methods for improved production of Rebaudioside D and Rebaudioside M
SG10201705993YA (en) 2013-02-11 2017-08-30 Evolva Sa Efficient production of steviol glycosides in recombinant hosts
RU2014112066A (ru) 2014-03-28 2015-10-10 Адзиномото Ко., Инк. Способ получения мономерного изопрена
CA2957331A1 (en) 2014-08-11 2016-02-18 Evolva Sa Production of steviol glycosides in recombinant hosts
CA2960693A1 (en) 2014-09-09 2016-03-17 Evolva Sa Production of steviol glycosides in recombinant hosts
SG11201705606PA (en) 2015-01-30 2017-08-30 Evolva Sa Production of steviol glycosides in recombinant hosts
CA2979931A1 (en) 2015-03-16 2016-09-22 Dsm Ip Assets B.V. Udp-glycosyltransferases
CA2995067A1 (en) 2015-08-07 2017-02-16 Evolva Sa Production of steviol glycosides in recombinant hosts
CN109195457A (zh) 2016-04-13 2019-01-11 埃沃尔瓦公司 在重组宿主中产生甜菊醇糖苷
EP3458599A1 (de) 2016-05-16 2019-03-27 Evolva SA Herstellung von steviolglycosiden in rekombinanten wirten
CN110100006A (zh) 2016-11-07 2019-08-06 埃沃尔瓦公司 重组宿主中甜菊糖苷的生产
NL2018457B1 (en) 2017-03-02 2018-09-21 Isobionics B V Santalene Synthase
NL2019473B1 (en) 2017-09-01 2019-03-11 Isobionics B V Terpene Synthase producing patchoulol and elemol, and preferably also pogostol
EP3720944A1 (de) 2017-12-07 2020-10-14 Zymergen Inc. Manipulierte biosynthesewege zur herstellung von (6e)-8-hydroxygeraniol durch fermentation
WO2019126778A1 (en) 2017-12-21 2019-06-27 Zymergen Inc. Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone
CN113621631A (zh) * 2021-08-11 2021-11-09 昆明理工大学 一种甲羟戊酸激酶基因rkmk及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI250210B (en) * 1998-05-06 2006-03-01 Dsm Ip Assets Bv An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate
US6410755B1 (en) 1998-07-06 2002-06-25 Dcv, Inc. Method of vitamin production
JP2002519417A (ja) * 1998-07-06 2002-07-02 イーストマン ケミカル カンパニー ビタミンｅの製造方法
KR100704072B1 (ko) * 2001-06-06 2007-04-05 디에스엠 아이피 어셋츠 비.브이. 개선된 이소프레노이드 제조 방법
AU2004209042A1 (en) * 2003-02-05 2004-08-19 Basf Aktiengesellschaft Mevalonate kinase as a target for fungicides
ES2323175T3 (es) 2003-06-12 2009-07-08 Dsm Ip Assets B.V. Mevalonato-quinasas resistentes a la retroalimentacion.

Also Published As

Publication number Publication date
CN101080490A (zh) 2007-11-28
DE602005026692D1 (de) 2011-04-14
EP1824969A1 (de) 2007-08-29
CN101080490B (zh) 2012-08-15
EP1824969B1 (de) 2011-03-02
US20070286850A1 (en) 2007-12-13
JP2008522635A (ja) 2008-07-03
JP4841562B2 (ja) 2011-12-21
US8338155B2 (en) 2012-12-25
WO2006063752A1 (en) 2006-06-22

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