ATE500321T1 - Verbesserte mevalonatkinase - Google Patents

Verbesserte mevalonatkinase

Info

Publication number
ATE500321T1
ATE500321T1 AT05815027T AT05815027T ATE500321T1 AT E500321 T1 ATE500321 T1 AT E500321T1 AT 05815027 T AT05815027 T AT 05815027T AT 05815027 T AT05815027 T AT 05815027T AT E500321 T1 ATE500321 T1 AT E500321T1
Authority
AT
Austria
Prior art keywords
improved
mevalonate kinase
modified
vectors
producing
Prior art date
Application number
AT05815027T
Other languages
English (en)
Inventor
Renyuan Bai
Markus Wyss
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35907004&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE500321(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Application granted granted Critical
Publication of ATE500321T1 publication Critical patent/ATE500321T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT05815027T 2004-12-14 2005-12-12 Verbesserte mevalonatkinase ATE500321T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04029529 2004-12-14
PCT/EP2005/013282 WO2006063752A1 (en) 2004-12-14 2005-12-12 Improved mevalonate kinase

Publications (1)

Publication Number Publication Date
ATE500321T1 true ATE500321T1 (de) 2011-03-15

Family

ID=35907004

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05815027T ATE500321T1 (de) 2004-12-14 2005-12-12 Verbesserte mevalonatkinase

Country Status (7)

Country Link
US (1) US8338155B2 (de)
EP (1) EP1824969B1 (de)
JP (1) JP4841562B2 (de)
CN (1) CN101080490B (de)
AT (1) ATE500321T1 (de)
DE (1) DE602005026692D1 (de)
WO (1) WO2006063752A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3020799T3 (da) 2006-09-26 2020-09-21 Amyris Biotechnologies Inc Fremstilling af isoprenoider og isoprenoid-prækursorer
JP2009000046A (ja) * 2007-06-21 2009-01-08 Hitachi Zosen Corp トチュウのメバロン酸経路の酵素をコードする遺伝子
DK2235190T3 (en) 2007-12-13 2018-07-23 Danisco Us Inc COMPOSITIONS AND PROCEDURES FOR PRODUCING ISOPRENE
CN102027082B (zh) 2008-04-14 2013-09-18 陶氏康宁公司 硼交联的有机基聚硅氧烷的乳液
JP2011518564A (ja) 2008-04-23 2011-06-30 ダニスコ・ユーエス・インク 改良された微生物によるイソプレン産出用のイソプレンシンターゼ変異体
MY169163A (en) 2008-09-15 2019-02-19 Danisco Us Inc Increased isoprene production using the archaeal lower mevalonate pathway
US8518686B2 (en) 2009-04-23 2013-08-27 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
EP2336310A1 (de) 2009-12-16 2011-06-22 Isobionics B.V. Valencensynthase
EP2575432B1 (de) 2010-06-02 2019-08-14 Evolva, Inc. Rekombinante herstellung von steviol-glycosiden
CN103443271A (zh) 2010-10-27 2013-12-11 丹尼斯科美国公司 用于增加异戊二烯产量的异戊二烯合酶变体
EP2537926A1 (de) 2011-06-21 2012-12-26 Isobionics B.V. Valencensynthase
AU2012294452C1 (en) 2011-08-08 2017-11-30 Danstar Ferment Ag Recombinant production of steviol glycosides
CN102392032A (zh) * 2011-11-28 2012-03-28 山东省农业科学院作物研究所 小麦甲羟戊酸激酶基因TaMVK及其分离克隆、酶活性测定方法
CN103205432B (zh) * 2012-01-11 2015-06-10 安徽医科大学第一附属医院 弥散型浅表性光线性汗孔角化症(dsap)相关基因
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
WO2014122227A2 (en) 2013-02-06 2014-08-14 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
BR112015019160A2 (pt) 2013-02-11 2017-08-22 Dalgaard Mikkelsen Michael Produção de glicosídeos de esteviol em hospedeiros recombinantes
RU2014112066A (ru) 2014-03-28 2015-10-10 Адзиномото Ко., Инк. Способ получения мономерного изопрена
CN114410493A (zh) 2014-08-11 2022-04-29 埃沃尔瓦公司 在重组宿主中生产甜菊醇糖苷
KR20170052647A (ko) 2014-09-09 2017-05-12 에볼바 에스아 재조합 숙주에서 스테비올 글리코시드의 생성
AU2016211124B2 (en) 2015-01-30 2022-04-14 Danstar Ferment Ag Production of steviol glycosides in recombinant hosts
EP3271457B1 (de) 2015-03-16 2021-01-20 DSM IP Assets B.V. Udp-glycosyltransferasen
EP3332018B1 (de) 2015-08-07 2022-07-27 Evolva SA Erzeugung von steviolglycosiden in rekombinanten wirten
KR20180132696A (ko) 2016-04-13 2018-12-12 에볼바 에스아 재조합 숙주에서의 스테비올 글리코사이드의 생산
US10815514B2 (en) 2016-05-16 2020-10-27 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2018083338A1 (en) 2016-11-07 2018-05-11 Evolva Sa Production of steviol glycosides in recombinant hosts
NL2018457B1 (en) 2017-03-02 2018-09-21 Isobionics B V Santalene Synthase
NL2019473B1 (en) 2017-09-01 2019-03-11 Isobionics B V Terpene Synthase producing patchoulol and elemol, and preferably also pogostol
KR20200095534A (ko) 2017-12-07 2020-08-10 지머젠 인코포레이티드 발효에 의한 (6e)-8-히드록시제라니올의 제조를 위해 조작된 생합성 경로
WO2019126778A1 (en) 2017-12-21 2019-06-27 Zymergen Inc. Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone
CN113621631A (zh) * 2021-08-11 2021-11-09 昆明理工大学 一种甲羟戊酸激酶基因rkmk及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI250210B (en) * 1998-05-06 2006-03-01 Dsm Ip Assets Bv An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate
US6410755B1 (en) 1998-07-06 2002-06-25 Dcv, Inc. Method of vitamin production
EP1095034A1 (de) * 1998-07-06 2001-05-02 Eastman Chemical Company Darstellung von tocoferolen
EP1392824B1 (de) 2001-06-06 2008-08-20 DSM IP Assets B.V. Verbesserte isoprenoid herstellung
CA2514694A1 (en) * 2003-02-05 2004-08-19 Basf Aktiengesellschaft Mevalonate kinase as a target for fungicides
CN1806042B (zh) 2003-06-12 2012-07-04 帝斯曼知识产权资产管理有限公司 具有反馈抗性的甲羟戊酸激酶

Also Published As

Publication number Publication date
JP4841562B2 (ja) 2011-12-21
DE602005026692D1 (de) 2011-04-14
US20070286850A1 (en) 2007-12-13
JP2008522635A (ja) 2008-07-03
EP1824969A1 (de) 2007-08-29
CN101080490A (zh) 2007-11-28
EP1824969B1 (de) 2011-03-02
WO2006063752A1 (en) 2006-06-22
US8338155B2 (en) 2012-12-25
CN101080490B (zh) 2012-08-15

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