ATE429256T1 - Poröse beta-tricalciumphosphat-körnchen und ein herstellungsverfahren - Google Patents

Poröse beta-tricalciumphosphat-körnchen und ein herstellungsverfahren

Info

Publication number
ATE429256T1
ATE429256T1 AT02748362T AT02748362T ATE429256T1 AT E429256 T1 ATE429256 T1 AT E429256T1 AT 02748362 T AT02748362 T AT 02748362T AT 02748362 T AT02748362 T AT 02748362T AT E429256 T1 ATE429256 T1 AT E429256T1
Authority
AT
Austria
Prior art keywords
porous
tcp
binder
tricalcium phosphate
provides
Prior art date
Application number
AT02748362T
Other languages
English (en)
Inventor
Paresh S Dalal
Godofredo R Dimaano
Carol Ann Toth
Shailesh C Kulkarni
Original Assignee
Stryker Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27121998&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE429256(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US09/798,518 external-priority patent/US20030049328A1/en
Application filed by Stryker Corp filed Critical Stryker Corp
Application granted granted Critical
Publication of ATE429256T1 publication Critical patent/ATE429256T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/811—Peptides or proteins is immobilized on, or in, an inorganic carrier

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Compositions Of Oxide Ceramics (AREA)
AT02748362T 2001-03-02 2002-02-26 Poröse beta-tricalciumphosphat-körnchen und ein herstellungsverfahren ATE429256T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/798,518 US20030049328A1 (en) 2001-03-02 2001-03-02 Porous beta-tricalcium phosphate granules and methods for producing same
US09/960,789 US6949251B2 (en) 2001-03-02 2001-09-21 Porous β-tricalcium phosphate granules for regeneration of bone tissue
PCT/US2002/005827 WO2002070029A2 (en) 2001-03-02 2002-02-26 Porous beta-tricalcium phosphate granules and methods for producing same

Publications (1)

Publication Number Publication Date
ATE429256T1 true ATE429256T1 (de) 2009-05-15

Family

ID=27121998

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02748362T ATE429256T1 (de) 2001-03-02 2002-02-26 Poröse beta-tricalciumphosphat-körnchen und ein herstellungsverfahren

Country Status (8)

Country Link
US (4) US6949251B2 (de)
EP (1) EP1372748B1 (de)
JP (3) JP2005505311A (de)
AT (1) ATE429256T1 (de)
CA (2) CA2439813C (de)
DE (1) DE60232061D1 (de)
ES (1) ES2325573T3 (de)
WO (1) WO2002070029A2 (de)

Families Citing this family (236)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6013591A (en) 1997-01-16 2000-01-11 Massachusetts Institute Of Technology Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production
US7041641B2 (en) * 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US20010016646A1 (en) * 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
US6458162B1 (en) 1999-08-13 2002-10-01 Vita Special Purpose Corporation Composite shaped bodies and methods for their production and use
US20060078847A1 (en) * 2000-09-29 2006-04-13 Kwan Norman H Dental implant system and additional methods of attachment
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
DE60219607T2 (de) * 2001-01-09 2007-12-27 Microchips, Inc., Bedford Flexible mikrochip-vorrichtungen zur ophthalmologischen und anderen applikation
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
US7709029B2 (en) * 2001-01-24 2010-05-04 Ada Foundation Calcium-containing restoration materials
ATE303169T1 (de) * 2001-11-19 2005-09-15 Scil Technology Gmbh Homogen beschichtete vorrichtung mit osteoinduktiven und osteokonduktiven eigenschaften
US7247609B2 (en) * 2001-12-18 2007-07-24 Universitat Zurich Growth factor modified protein matrices for tissue engineering
TW200400062A (en) * 2002-04-03 2004-01-01 Mathys Medizinaltechnik Ag Kneadable, pliable bone replacement material
JP2005528144A (ja) 2002-04-29 2005-09-22 バイオメット ドイチュラント ゲゼルシャフト ミット ベシュレンクテル ハフトング 骨の組織工学用マトリックス（足場）としての構造複合体
US8876532B2 (en) 2002-07-31 2014-11-04 Dentsply International Inc. Bone repair putty
US7842300B2 (en) * 2002-07-31 2010-11-30 Dentsply International, Inc. Bone repair putty
US7820638B2 (en) * 2002-08-09 2010-10-26 Arthrex, Inc. Method of applying hyaluronic acid to implant or graft to enhance lubricity and cellular density
US8227411B2 (en) * 2002-08-20 2012-07-24 BioSurface Engineering Technologies, Incle FGF growth factor analogs
US7166574B2 (en) * 2002-08-20 2007-01-23 Biosurface Engineering Technologies, Inc. Synthetic heparin-binding growth factor analogs
US7598224B2 (en) 2002-08-20 2009-10-06 Biosurface Engineering Technologies, Inc. Dual chain synthetic heparin-binding growth factor analogs
CN100522241C (zh) 2002-09-10 2009-08-05 Scil技术股份有限公司 在低氧气浓度下用骨诱导蛋白包被的金属植入物
FR2850282B1 (fr) 2003-01-27 2007-04-06 Jerome Asius Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation
US20070065652A1 (en) * 2003-03-13 2007-03-22 Willaim Marsh Rice University Composite injectable and pre-fabricated bone replacement material and method for the production of such bone replacement material
WO2004098457A1 (en) * 2003-04-30 2004-11-18 Therics, Inc. Bone void filler and method of manufacture
US8029755B2 (en) * 2003-08-06 2011-10-04 Angstrom Medica Tricalcium phosphates, their composites, implants incorporating them, and method for their production
US7955616B2 (en) * 2003-09-23 2011-06-07 Orthocon, Inc. Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects
WO2005046746A2 (en) * 2003-11-10 2005-05-26 Angiotech International Ag Medical implants and fibrosis-inducing agents
US20080227696A1 (en) * 2005-02-22 2008-09-18 Biosurface Engineering Technologies, Inc. Single branch heparin-binding growth factor analogs
JP4895826B2 (ja) 2004-02-20 2012-03-14 バイオサーフェス エンジニアリング テクノロジーズ，インク． 骨形成蛋白−２の正のモジュレーター
US20070190101A1 (en) * 2004-03-31 2007-08-16 Chunlin Yang Flowable bone grafts
WO2005102281A2 (en) 2004-04-16 2005-11-03 University Of Massachusetts Porous calcium phosphate networks for synthetic bone material
US20070009606A1 (en) 2004-05-12 2007-01-11 Serdy James G Manufacturing process, such as three dimensional printing, including binding of water-soluble material followed by softening and flowing and forming films of organic-solvent-soluble material
EP1604693A1 (de) 2004-06-09 2005-12-14 Scil Technology GmbH In-situ hergestelltes Gerüst, dessen Herstellungsverfahren und dessen Verwendung
TWI374036B (en) * 2004-06-10 2012-10-11 Sean Kerr Flexible bone composite
US9220595B2 (en) 2004-06-23 2015-12-29 Orthovita, Inc. Shapeable bone graft substitute and instruments for delivery thereof
US20060069436A1 (en) * 2004-09-30 2006-03-30 Depuy Spine, Inc. Trial disk implant
US20090088846A1 (en) 2007-04-17 2009-04-02 David Myung Hydrogel arthroplasty device
US7473678B2 (en) * 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US7799754B2 (en) 2004-10-14 2010-09-21 Biomimetic Therapeutics, Inc. Compositions and methods for treating bone
JP2008517660A (ja) * 2004-10-22 2008-05-29 ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ 生物剤を送達する中空かつ多孔質の整形外科用または歯科用のインプラント
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US9107850B2 (en) 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
ATE503465T1 (de) 2004-10-25 2011-04-15 Celonova Biosciences Germany Gmbh Beladbare polyphosphazenhaltige teilchen für therapeutische und/oder diagnostische anwendungen sowie herstellungs- und verwendungsverfahren dafür
US20060110357A1 (en) * 2004-11-22 2006-05-25 Materna Peter A Bone putty composition that maintains granule suspension at reduced temperatures
WO2006070699A1 (ja) * 2004-12-27 2006-07-06 Olympus Corporation 医療機器の洗浄評価用汚物、及び洗浄評価用汚染方法
US8575101B2 (en) 2005-01-06 2013-11-05 Kuros Biosurgery Ag Supplemented matrices for the repair of bone fractures
WO2006072622A2 (en) * 2005-01-06 2006-07-13 Kuros Biosurgery Ag Supplemented matrices for the repair of bone fractures
WO2006073711A2 (en) * 2005-01-06 2006-07-13 Kuros Biosurgery Ag Use of a matrix comprising a contrast agent in soft tissues
WO2007027794A1 (en) 2005-08-30 2007-03-08 Zimmer Dental, Inc. Dental implant with improved osseointegration features
CA2609390A1 (en) * 2005-05-26 2006-11-30 Zimmer Dental, Inc. Prosthetic dental device
US8814567B2 (en) 2005-05-26 2014-08-26 Zimmer Dental, Inc. Dental implant prosthetic device with improved osseointegration and esthetic features
US7901650B2 (en) * 2005-06-22 2011-03-08 Skeletal Kinectics, LLC Porous beta-tricalcium phosphate and methods for producing the same
ES2691646T3 (es) * 2005-07-15 2018-11-28 Micell Technologies, Inc. Revestimientos poliméricos que contienen polvo de fármaco de morfología controlada
WO2007011708A2 (en) 2005-07-15 2007-01-25 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
KR100807108B1 (ko) * 2005-07-20 2008-02-26 주식회사 오스코텍 다공성의 β-인산삼칼슘 과립의 제조 방법
ITTO20050549A1 (it) 2005-08-03 2007-02-04 Consiglio Nazionale Ricerche Materiale composito iniettabile atto ad essere utilizzato come sostituto osseo
US8562346B2 (en) 2005-08-30 2013-10-22 Zimmer Dental, Inc. Dental implant for a jaw with reduced bone volume and improved osseointegration features
US8025903B2 (en) 2005-09-09 2011-09-27 Wright Medical Technology, Inc. Composite bone graft substitute cement and articles produced therefrom
ES2402651T3 (es) 2005-09-09 2013-05-07 Agnovos Healthcare, Llc Cemento sustituto de injerto óseo de material compuesto y artículos producidos del mismo
EP2431060B1 (de) 2005-11-17 2020-04-08 BioMimetic Therapeutics, LLC Kiefer- und Gesichtsknochenerweiterung mithilfe von RHPDGF-BB und einer biokompatiblen Matrix
WO2007068489A2 (en) * 2005-12-14 2007-06-21 Scil Technology Gmbh A moldable biomaterial for bone regeneration
TWI316860B (en) 2005-12-29 2009-11-11 Ind Tech Res Inst Multi-layered matrix, method of tissue repair using the same and multi-layered implant prepared thereof
US10524916B2 (en) 2006-01-11 2020-01-07 Novabone Products, Llc Resorbable macroporous bioactive glass scaffold and method of manufacture
US7758803B2 (en) * 2006-01-11 2010-07-20 Jiang Chang Resorbable macroporous bioactive glass scaffold and method of manufacture
KR100739528B1 (ko) * 2006-02-03 2007-07-13 재단법인서울대학교산학협력재단 제1형 교원질 부착 유도 펩타이드가 고정된 골이식재 및 조직공학용 지지체
US20070255422A1 (en) * 2006-04-25 2007-11-01 Mei Wei Calcium phosphate polymer composite and method
CA2996768C (en) 2006-04-26 2020-12-08 Micell Technologies, Inc. Coatings containing multiple drugs
US20090311303A1 (en) * 2006-04-27 2009-12-17 Queensland University Of Technology Biodegradable implants for bone fusion and compositions therefor
DE102006026000B4 (de) * 2006-06-01 2015-01-15 Curasan Ag Patientenindividuelles Knochenaufbaumittel und Verfahren zu seiner Herstellung
US7820172B1 (en) 2006-06-01 2010-10-26 Biosurface Engineering Technologies, Inc. Laminin-derived multi-domain peptides
CA2692240C (en) 2006-06-22 2018-03-13 Biosurface Engineering Technologies, Inc. Composition and method for delivery of bmp-2 amplifier/co-activator for enhancement of osteogenesis
EP2040765A2 (de) 2006-06-29 2009-04-01 Orthovita, INC. Bioaktiver knochentransplantatersatz
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
ES2664229T3 (es) 2006-06-30 2018-04-18 Biomimetic Therapeutics, Llc Composiciones y métodos de biomatriz-PDGF para el tratamiento de lesiones del manguito rotador
EP3009477B1 (de) 2006-07-20 2024-01-24 Orbusneich Medical Pte. Ltd Bioresorbierbare polymerzusammensetzung für eine medizinische vorrichtung
US7723291B2 (en) * 2006-07-27 2010-05-25 Warsaw Orthopedic, Inc. Release of BMP, bioactive agents and/or cells via a pump into a carrier matrix
US20080033322A1 (en) * 2006-07-31 2008-02-07 Femsuite, Llc Systems and methods for measuring cervical dilation
US20080051796A1 (en) * 2006-08-01 2008-02-28 Warsaw Orthopedic, Inc. Graft retention tack
US20080031914A1 (en) * 2006-08-02 2008-02-07 Drapeau Susan J Flowable biomaterial composition
US20060287654A1 (en) * 2006-08-11 2006-12-21 Jeffrey Posnick Implant securing device and method
GB0618963D0 (en) * 2006-09-26 2006-11-08 Ucl Business Plc Formulations and composites with reactive fillers
WO2008042909A2 (en) 2006-10-02 2008-04-10 Micell Technologies Inc. Surgical sutures having increased strength
DE102006048833A1 (de) * 2006-10-16 2008-04-17 Universität Rostock Behandlung von Osteoporose
US20080097618A1 (en) * 2006-10-18 2008-04-24 Kevin Charles Baker Deposition of calcium-phosphate (CaP) and calcium-phosphate with bone morphogenic protein (CaP+BMP) coatings on metallic and polymeric surfaces
CN101631513B (zh) 2006-10-20 2013-06-05 奥巴斯尼茨医学公司 可生物吸收的聚合物组合物和医疗设备
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
JP5336382B2 (ja) 2006-10-23 2013-11-06 ミセル テクノロジーズ、インコーポレイテッド コーティングの間に基板を荷電するためのホルダー
JP5552315B2 (ja) 2006-11-03 2014-07-16 バイオミメティック セラピューティクス， エルエルシー アースロデティック術のための組成物および方法
WO2008066106A1 (en) * 2006-11-30 2008-06-05 Nihon University Layered gradient material for biological use and method for producing the same
SI3345607T1 (sl) 2006-12-29 2023-03-31 Ossifi-Mab Llc Postopki spreminjanja rasti kosti z dajanjem antagonista ali agonista SOST ali WISE
CN101711137B (zh) 2007-01-08 2014-10-22 米歇尔技术公司 具有可生物降解层的支架
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
FR2911508B1 (fr) * 2007-01-19 2012-11-09 Kasios Substitut osseux a base de ciment phosphocalcique
US20080195476A1 (en) * 2007-02-09 2008-08-14 Marchese Michael A Abandonment remarketing system
WO2008131131A1 (en) * 2007-04-17 2008-10-30 Micell Technologies, Inc. Stents having biodegradable layers
CN101815540B (zh) 2007-05-25 2015-08-19 米歇尔技术公司 用于医疗器材涂层的聚合物膜
WO2009110917A1 (en) * 2007-06-07 2009-09-11 Osteotherapeutics, L.L.C. Bone cement compositions for use as growth factor carriers and methods of making same
US20090010990A1 (en) * 2007-06-20 2009-01-08 Little Marisa A Process for depositing calcium phosphate therapeutic coatings with controlled release rates and a prosthesis coated via the process
WO2009032071A2 (en) * 2007-08-29 2009-03-12 Spinemedica Corporation Orthopaedic cement mixtures with low weight percent polyvinyl alcohol (pva) solution
US20090061389A1 (en) 2007-08-30 2009-03-05 Matthew Lomicka Dental implant prosthetic device with improved osseointegration and shape for resisting rotation
US20090061002A1 (en) * 2007-09-05 2009-03-05 Venbrocks Rudolf A Calcium phospate based delivery of growth and differentiation factors to compromised bone
US7883511B2 (en) * 2007-09-12 2011-02-08 Fernyhough Jeffrey C Method and composition for use in reinforcing bone
US8052787B2 (en) * 2007-09-28 2011-11-08 National Taiwan University Bio-material and method of preparation thereof
WO2009100454A1 (en) * 2008-02-07 2009-08-13 Biomimetic Therapeutics, Inc. Compositions and methods for distraction osteogenesis
US20090226668A1 (en) * 2008-03-10 2009-09-10 Ebi, L.P. Optimized surface for cellular proliferation and differentiation
US8685432B2 (en) * 2008-03-25 2014-04-01 University Of Utah Research Foundation Controlled release tissue graft combination biomaterials
CA2721832C (en) 2008-04-17 2018-08-07 Micell Technologies, Inc. Stents having bioabsorbable layers
US20110059149A1 (en) * 2008-06-16 2011-03-10 Little Marisa A Process for depositing calcium phosphate therapeutic coatings with different release rates and a prosthesis coated via the process
FR2932687B1 (fr) * 2008-06-23 2010-09-17 Centre Nat Rech Scient Biomateriaux a base de phosphates de calcium.
FR2932686B1 (fr) * 2008-06-23 2010-08-27 Centre Nat Rech Scient Combinaison de sang et de particules de ceramique de phosphates de calcium biphases.
US9095396B2 (en) 2008-07-02 2015-08-04 Zimmer Dental, Inc. Porous implant with non-porous threads
US8231387B2 (en) 2008-07-02 2012-07-31 Zimmer, Inc. Porous implant with non-porous threads
US8899982B2 (en) 2008-07-02 2014-12-02 Zimmer Dental, Inc. Implant with structure for securing a porous portion
US8562348B2 (en) 2008-07-02 2013-10-22 Zimmer Dental, Inc. Modular implant with secured porous portion
US20120209396A1 (en) 2008-07-07 2012-08-16 David Myung Orthopedic implants having gradient polymer alloys
WO2010009335A1 (en) 2008-07-17 2010-01-21 Micell Technologies, Inc. Drug delivery medical device
GB0813659D0 (en) 2008-07-25 2008-09-03 Smith & Nephew Fracture putty
WO2010017282A1 (en) 2008-08-05 2010-02-11 Biomimedica, Inc. Polyurethane-grafted hydrogels
WO2010019928A2 (en) * 2008-08-14 2010-02-18 Doerr Timothy E Tack for spine fixation
US20110106170A1 (en) * 2008-08-14 2011-05-05 Doerr Timothy E Tack for spine fixation
NZ602861A (en) 2008-09-09 2014-03-28 Biomimetic Therapeutics Llc Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
US20100114314A1 (en) 2008-11-06 2010-05-06 Matthew Lomicka Expandable bone implant
JP4392460B1 (ja) * 2008-11-13 2010-01-06 株式会社カタリメディック 芳香族炭化水素の残留量が低いリン酸カルシウム多孔体
US9320761B2 (en) 2008-12-18 2016-04-26 Vivex Biomedical, Inc. Bone induction system and methods
US8834913B2 (en) 2008-12-26 2014-09-16 Battelle Memorial Institute Medical implants and methods of making medical implants
JP2012519556A (ja) * 2009-03-05 2012-08-30 バイオミメティック セラピューティクス， インコーポレイテッド 骨軟骨欠損を治療するための血小板由来増殖因子組成物および方法
CN102481195B (zh) 2009-04-01 2015-03-25 米歇尔技术公司 涂覆支架
US20100266691A1 (en) * 2009-04-15 2010-10-21 Battelle Memorial Institute Agents and Methods to Stimulate Bone Healing
EP3366326A1 (de) 2009-04-17 2018-08-29 Micell Technologies, Inc. Stents mit gesteuerter elution
US9707058B2 (en) 2009-07-10 2017-07-18 Zimmer Dental, Inc. Patient-specific implants with improved osseointegration
EP2453834A4 (de) 2009-07-16 2014-04-16 Micell Technologies Inc Medizinische wirkstofffreisetzungsvorrichtung
AU2010275697B2 (en) * 2009-07-23 2014-01-30 Progentix Orthobiology B.V. Injectable and moldable osteoinductive ceramic materials
US8529933B2 (en) * 2009-07-27 2013-09-10 Warsaw Orthopedic, Inc. Biphasic calcium phosphate cement for drug delivery
US8653029B2 (en) * 2009-07-30 2014-02-18 Warsaw Orthopedic, Inc. Flowable paste and putty bone void filler
TWI457146B (zh) * 2009-08-28 2014-10-21 Univ Kaohsiung Medical 藥物緩釋系統及其製備方法
EP2352750B1 (de) 2009-09-17 2012-06-13 Stryker Corporation Puffer zur steuerung des ph-wertes knochenmorphogenetischer proteine
US20110117171A1 (en) * 2009-11-18 2011-05-19 Affinergy, Inc. Implantable bone graft materials
US8602782B2 (en) 2009-11-24 2013-12-10 Zimmer Dental, Inc. Porous implant device with improved core
CA2781518C (en) * 2009-11-25 2016-08-23 Healionics Corporation Granules of porous biocompatible materials
CA2785038A1 (en) 2009-12-22 2011-07-21 Stryker Corporation Bmp-7 variants with reduced immunogenicity
US9163212B2 (en) * 2010-01-25 2015-10-20 Warsaw Orthopedic, Inc. Osteogenic cell delivery matrix
EP2531140B1 (de) 2010-02-02 2017-11-01 Micell Technologies, Inc. Stent und stenteinsatzsystem mit verbesserter einsetzbarkeit
US8338498B2 (en) * 2010-02-18 2012-12-25 Doctors Research Group, Inc. Polymeric bone defect filler
US20110201704A1 (en) * 2010-02-18 2011-08-18 Doctors Research Group, Inc. Polymeric bone defect filler
CA2790403C (en) 2010-02-22 2019-08-27 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of tendinopathies
US9199032B2 (en) 2010-03-03 2015-12-01 Novabone Products, Llc System and kit for delivering collagen bioglass composite bone grafting materials for regenerating hard tissues
AU2011223652B2 (en) * 2010-03-03 2015-01-29 Novabone Products, Llc Devices and methods for the regeneration of bony defects
US9144629B2 (en) 2010-03-03 2015-09-29 Novabone Products, Llc Ionically crosslinked materials and methods for production
US8795762B2 (en) 2010-03-26 2014-08-05 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
WO2011133655A1 (en) 2010-04-22 2011-10-27 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
US9358323B2 (en) 2010-04-29 2016-06-07 Warsaw Orthopedic, Inc. Flowable ceramic putty
US9265857B2 (en) 2010-05-11 2016-02-23 Howmedica Osteonics Corp. Organophosphorous, multivalent metal compounds, and polymer adhesive interpenetrating network compositions and methods
TWI579007B (zh) 2010-07-02 2017-04-21 艾格諾福斯保健公司 骨再生材料之用途
WO2012009684A2 (en) 2010-07-16 2012-01-19 Micell Technologies, Inc. Drug delivery medical device
US20130217829A1 (en) 2010-08-27 2013-08-22 David Myung "hydrophobic and hydrophilic interpenetrating polymer networks derived from hydrophobic polymers and methods of preparing the same"
US8877221B2 (en) * 2010-10-27 2014-11-04 Warsaw Orthopedic, Inc. Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same
CN101991880A (zh) * 2010-11-08 2011-03-30 中国人民解放军军事医学科学院基础医学研究所 由复合msc的plga/tcp和msc组成的制剂及其应用
US10329327B2 (en) * 2010-12-06 2019-06-25 Massachusetts Institute Of Technology Tricalcium phosphate binding peptides and uses thereof
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
MY169686A (en) * 2011-01-27 2019-05-13 Sirim Berhad A method of converting limestone into tri-calcium phosphate and tetra-calcium phosphate powder simultaneously
JP6082901B2 (ja) * 2011-01-31 2017-02-22 オリンパス株式会社 ワクチン・アジュバント
EP2680892A1 (de) 2011-03-03 2014-01-08 Spineart SA Produkt
ES2882852T3 (es) 2011-03-16 2021-12-02 Kuros Biosurgery Ag Formulación farmacéutica para la utilización en la fusión espinal
US9675670B2 (en) 2011-04-11 2017-06-13 Induce Biologics Inc. System and method for multiphasic release of growth factors
WO2012158527A2 (en) 2011-05-13 2012-11-22 Howmedica Osteonics Organophosphorous & multivalent metal compound compositions & methods
WO2012166819A1 (en) 2011-05-31 2012-12-06 Micell Technologies, Inc. System and process for formation of a time-released, drug-eluting transferable coating
EP2529764A1 (de) 2011-05-31 2012-12-05 Curasan AG Biologisch degradierbares kompositmaterial
US10117972B2 (en) 2011-07-15 2018-11-06 Micell Technologies, Inc. Drug delivery medical device
TWI449546B (zh) * 2011-09-07 2014-08-21 財團法人工業技術研究院 應用於軟硬組織修復與再生之生醫材料
US20130103157A1 (en) 2011-10-03 2013-04-25 Lampros Kourtis Polymeric adhesive for anchoring compliant materials to another surface
US9381112B1 (en) 2011-10-06 2016-07-05 William Eric Sponsell Bleb drainage device, ophthalmological product and methods
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
AU2012340699A1 (en) 2011-11-21 2014-06-19 Biomimedica, Inc. Systems, devices, and methods for anchoring orthopaedic implants to bone
US8632489B1 (en) 2011-12-22 2014-01-21 A. Mateen Ahmed Implantable medical assembly and methods
WO2013096831A1 (en) * 2011-12-23 2013-06-27 Skeletal Kinetics, Llc Porous calcium phosphate granules and methods of making and using the same
CN102552986B (zh) * 2012-02-28 2013-12-18 河南科技大学 一种用金属致孔剂制备多孔骨水泥的方法
US10207027B2 (en) 2012-06-11 2019-02-19 Globus Medical, Inc. Bioactive bone graft substitutes
KR101345805B1 (ko) * 2012-09-04 2014-01-03 주식회사 바이오알파 인산칼슘계 주입 및 자기경화형의 다공성 골이식재 및 거대기공을 생성시키기 위한 첨가제 적용방법
WO2014123978A2 (en) 2013-02-05 2014-08-14 University Of Utah Research Foundation Implantable devices for bone or joint defects
CN110269959A (zh) 2013-03-12 2019-09-24 脉胜医疗技术公司 可生物吸收的生物医学植入物
SI2968284T1 (sl) 2013-03-14 2021-08-31 Osteoqc Inc. Alkil-amin harmin derivati za pospeševanje rasti kosti
KR101443814B1 (ko) * 2013-03-28 2014-09-30 주식회사 바이오알파 골 이식재 조성물 및 이의 제조방법
WO2014186532A1 (en) 2013-05-15 2014-11-20 Micell Technologies, Inc. Bioabsorbable biomedical implants
EP3441109A1 (de) 2013-05-30 2019-02-13 Graham H. Creasey Flexibles hautpflaster für ein stimulatorsystem für topische nerven
US11229789B2 (en) 2013-05-30 2022-01-25 Neurostim Oab, Inc. Neuro activator with controller
US9168114B2 (en) 2013-10-17 2015-10-27 B & D Dental Corp. Method of making a dental prosthesis
US9539286B2 (en) 2013-10-18 2017-01-10 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
US9486483B2 (en) 2013-10-18 2016-11-08 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
WO2015081087A1 (en) 2013-11-26 2015-06-04 The Trustees Of Columbia University In The City Of New York Core-centered granule composed of micro-structure body
TWI651103B (zh) 2013-12-13 2019-02-21 萊特醫技股份有限公司 多相骨移植替代材料
CN104771782A (zh) * 2014-01-10 2015-07-15 东莞博捷生物科技有限公司 一种骨修复用材料β-磷酸三钙及其制备方法
US9579421B2 (en) 2014-02-07 2017-02-28 Globus Medical Inc. Bone grafts and methods of making and using bone grafts
US9463264B2 (en) 2014-02-11 2016-10-11 Globus Medical, Inc. Bone grafts and methods of making and using bone grafts
US10632231B2 (en) 2014-04-24 2020-04-28 Ossdsign Ab Methods of forming a porous ceramic shaped article and porous ceramic products
DK3148517T3 (da) * 2014-05-30 2021-07-26 The Resaerch Foundation For The State Univ Of New York Sammensætninger og fremgangsmåder til fremme af knogledannelse
CA2954399C (en) * 2014-07-18 2024-02-06 Mt Ortho S.R.L. Biocompatible material in granules made of metal material or metal alloys and use of said granules for vertebroplasty
WO2016057462A1 (en) * 2014-10-06 2016-04-14 Proxy Biomedical Inc. Tissue integration devices and methods of making the same
KR20170100634A (ko) 2014-12-29 2017-09-04 바이오벤터스 엘엘씨 골 복구에서의 골유도 분자의 전달 향상을 위한 시스템 및 방법
CN104644455B (zh) * 2015-01-26 2017-10-27 华南理工大学 一种生物玻璃‑海藻酸钠复合生物材料及试剂盒和应用
US11077301B2 (en) 2015-02-21 2021-08-03 NeurostimOAB, Inc. Topical nerve stimulator and sensor for bladder control
US11426489B2 (en) 2015-06-10 2022-08-30 Globus Medical, Inc. Biomaterial compositions, implants, and methods of making the same
US10016529B2 (en) 2015-06-10 2018-07-10 Globus Medical, Inc. Biomaterial compositions, implants, and methods of making the same
US11077228B2 (en) 2015-08-10 2021-08-03 Hyalex Orthopaedics, Inc. Interpenetrating polymer networks
JP2018019944A (ja) * 2016-08-04 2018-02-08 国立大学法人 名古屋工業大学 生分解性繊維からなる骨再生用材料、及び骨再生用材料を製造するための方法
WO2017203331A1 (en) 2016-05-27 2017-11-30 Universität Bern Composition and methods for bone tissue engineering
CN106620859A (zh) * 2016-11-19 2017-05-10 华南理工大学 一种生物活性玻璃复合支架及其制备方法
WO2018190687A1 (ko) 2017-04-14 2018-10-18 한국기계연구원 구형 세라믹 과립의 제조방법
WO2018190688A1 (ko) * 2017-04-14 2018-10-18 한국기계연구원 유무기 복합 과립 및 이의 제조방법
CA3074834C (en) 2017-09-08 2025-09-16 Xtant Medical Holdings, Inc. INTERVERTEBRAL IMPLANTS, INSTRUMENTS AND PROCESSES
USD907771S1 (en) 2017-10-09 2021-01-12 Pioneer Surgical Technology, Inc. Intervertebral implant
EP3706856A4 (de) 2017-11-07 2021-08-18 Neurostim Oab, Inc. Nicht-invasiver nervenaktivator mit adaptiver schaltung
CN108144113A (zh) * 2018-02-12 2018-06-12 华南理工大学 一种生物活性玻璃多孔骨修复体材料及其制备方法
US11103618B2 (en) 2018-02-22 2021-08-31 Warsaw Orthopedic, Inc. Demineralized bone matrix having improved handling characteristics
EP3773770B1 (de) * 2018-04-13 2023-11-29 University of Virginia Patent Foundation Zusammensetzungen und verfahren zur herstellung und verwendung von nichtimmunogenen, schnell glühenden, mikroporösen, geglühten partikelhydrogelen
US10869950B2 (en) 2018-07-17 2020-12-22 Hyalex Orthopaedics, Inc. Ionic polymer compositions
JP7695496B2 (ja) 2018-08-14 2025-06-19 オシフィ セラピューティクス リミティド ライアビリティ カンパニー フルオロβ－カルボリン化合物
EP3836923B1 (de) 2018-08-14 2024-10-16 OssiFi Therapeutics LLC Pyrrolo-dipyridinverbindungen zur behandlung von knochenschwund
CA3115298A1 (en) 2018-10-12 2020-04-16 Theradaptive, Inc. Polypeptides including a beta-tricalcium phosphate-binding sequence and uses thereof
US12428484B2 (en) 2018-12-06 2025-09-30 Alexion Pharmaceuticals, Inc. Anti-ALK2 antibodies and uses thereof
RU2705084C1 (ru) * 2019-03-29 2019-11-01 Федеральное государственное бюджетное учреждение науки Институт металлургии и материаловедения им. А.А. Байкова Российской академии наук (ИМЕТ РАН) Способ получения пористых материалов из альгината натрия и поливинилпирролидона, содержащих фосфаты кальция
US11458311B2 (en) 2019-06-26 2022-10-04 Neurostim Technologies Llc Non-invasive nerve activator patch with adaptive circuit
US11311647B2 (en) * 2019-07-26 2022-04-26 Warsaw Orthopedic, Inc. Implantable calcium phosphate compositions and methods
US12599696B2 (en) 2019-07-26 2026-04-14 Warsaw Orthopedic, Inc. Hydratable and flowable implantable compositions and methods of making and using them
KR102196242B1 (ko) 2020-03-31 2020-12-30 (주)메드파크 골 이식재 조성물 및 이의 제조방법
TWI739485B (zh) * 2019-08-19 2021-09-11 喜樂醫療器材股份有限公司 止血方法
US20220323641A1 (en) * 2019-08-20 2022-10-13 Theradaptive, Inc. Materials for delivery of tetherable proteins in bone implants
US11793452B2 (en) 2019-10-03 2023-10-24 Johnson & Johnson Consumer Inc. Method of visualizing and quantifying remineralization
EP4017580A4 (de) 2019-12-16 2023-09-06 Neurostim Technologies LLC Nicht-invasiver nervenaktivator mit verstärkter ladungsabgabe
US10786597B1 (en) 2020-03-24 2020-09-29 Secada Medical Llc Methods of producing an osteoinductive calcium phosphate material for bone grafting
BR112022020809A2 (pt) 2020-04-15 2023-02-23 Theradaptive Inc Composições e métodos para entrega terapêutica direcionada ao osso
US11083557B1 (en) 2020-05-01 2021-08-10 Secada Medical Llc Bone graft containment system
US11896736B2 (en) 2020-07-13 2024-02-13 Globus Medical, Inc Biomaterial implants and methods of making the same
US12383246B2 (en) 2020-10-12 2025-08-12 Abbott Cardiovascular Systems, Inc. Vessel closure device with improved safety and tract hemostasis
AU2022378270B2 (en) * 2021-11-01 2025-01-02 Lg Chem, Ltd. Composite filler, and product using the same
CN116806160A (zh) * 2021-11-01 2023-09-26 株式会社Lg化学 复合填料和使用其的产品
CN116492450B (zh) * 2023-06-25 2023-10-10 朗肽生物制药股份有限公司 重组人碱性成纤维细胞生长因子口腔凝胶及其制备方法

Family Cites Families (188)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306297B1 (en) 1968-07-08 2001-10-23 Asahi Kogaku Kogyo Kabushiki Kaisha Packing material for liquid chromatography and process for producing the same
DE2242867C3 (de) 1972-08-31 1975-09-25 Battelle-Institut E.V., 6000 Frankfurt Verfahren zur Herstellung implantierbarer, keramischer Knochenersatz-, Knochenverbund- oder Prothesenverankerung swerkstoffe
DE2620890C3 (de) 1976-05-12 1987-09-10 Battelle-Institut eV, 6000 Frankfurt Plastische Masse auf der Basis von gesinterten Calciumphosphaten für implantierbare Knochenersatz-, Knochenverbund- oder Prothesenverankerungswerkstoffe
DE2905878A1 (de) 1979-02-16 1980-08-28 Merck Patent Gmbh Implantationsmaterialien und verfahren zu ihrer herstellung
JPS56166843A (en) 1980-05-28 1981-12-22 Mitsubishi Mining & Cement Co Filler for bone broken section and void section
DK154260C (da) 1981-02-20 1989-05-22 Mundipharma Gmbh Fremgangsmaade til fremstilling af et knogleimplantat af braendt tricalciumphosphat, specielt til udfyldning af hulrum eller til sammensaetning af knogledele efter fraktur.
DE3106917C2 (de) 1981-02-25 1984-04-05 Schuett Und Grundei Gmbh Medizintechnische Fabrikation, 2400 Luebeck Verfahren zur Herstellung eines Implantates als Knochenersatz
DE3224265C2 (de) 1982-06-28 1987-01-08 S + G Implants GmbH, 2400 Lübeck Verfahren zur Herstellung eines Implantates als Knochenersatz
DE3239033A1 (de) * 1982-10-21 1984-04-26 Dr. C. Otto & Co Gmbh, 4630 Bochum Porosiertes, insbesonder feuerfestes keramisches erzeugnis sowie verfahren zu seiner herstellung
JPS59101145A (ja) 1982-11-30 1984-06-11 日本特殊陶業株式会社 薬液含浸多孔質セラミツクス
JPS59131346A (ja) 1983-01-17 1984-07-28 日本特殊陶業株式会社 薬液含浸多孔質セラミツクスの製造法
JPS59135053A (ja) 1983-01-20 1984-08-03 日本特殊陶業株式会社 薬液含浸繊維質セラミツクス
US4911720A (en) 1983-03-10 1990-03-27 Collier John P Particular surface replacement prosthesis
JPS59171546A (ja) 1983-03-18 1984-09-28 日本特殊陶業株式会社 代替骨用充填材
DE3325111A1 (de) 1983-07-12 1985-01-24 Merck Patent Gmbh, 6100 Darmstadt Implantationsmaterialien
NL8402158A (nl) 1983-07-09 1985-02-01 Sumitomo Cement Co Poreus keramisch materiaal en werkwijze voor de bereiding daarvan.
JPS6021763A (ja) 1983-07-15 1985-02-04 ティーディーケイ株式会社 人工骨材料
JPS6090880A (ja) 1983-10-25 1985-05-22 住友セメント株式会社 リン酸カルシウム多孔体およびその製造方法
JPS60142857A (ja) * 1983-12-29 1985-07-29 住友セメント株式会社 骨セメント組成物
US4563489A (en) 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
JPS60142857U (ja) 1984-02-29 1985-09-21 日本電気株式会社 デイスク収納容器応動型デイスク取り出し装置
DE3414924A1 (de) 1984-04-19 1985-10-31 Klaus Dr.med. Dr.med.habil. 8000 München Draenert Beschichtetes verankerungsteil fuer implantate
US4596574A (en) 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
JPS6131163A (ja) 1984-07-23 1986-02-13 京セラ株式会社 セラミツク製生体補綴材とその製造方法
NL8402534A (nl) 1984-08-17 1986-03-17 Gerrit Johannes Brinks Materiaal, geschikt voor toepassing als implantatiemateriaal bij mens en dier ter vervanging van afwezig botweefsel, alsmede werkwijze ter bereiding van het materiaal.
JPS6179462A (ja) * 1984-09-25 1986-04-23 ティーディーケイ株式会社 多孔質人工骨材料
US4629464A (en) 1984-09-25 1986-12-16 Tdk Corporation Porous hydroxyapatite material for artificial bone substitute
JPS61127658A (ja) 1984-11-26 1986-06-14 セントラル硝子株式会社 多孔体リン酸カルシウム系セラミツクの製造法
US5522894A (en) 1984-12-14 1996-06-04 Draenert; Klaus Bone replacement material made of absorbable beads
US4636526A (en) 1985-02-19 1987-01-13 The Dow Chemical Company Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics
US4693986A (en) 1985-06-25 1987-09-15 Orthomatrix, Inc. Ceramic process and products
US5034352A (en) 1985-06-25 1991-07-23 Lifecore Biomedical, Inc. Calcium phosphate materials
US4645503A (en) 1985-08-27 1987-02-24 Orthomatrix Inc. Moldable bone-implant material
CA1279175C (en) 1985-12-31 1991-01-22 Ronald L. Salsbury Ceramic processing and products
JPS62158175A (ja) 1986-01-07 1987-07-14 住友大阪セメント株式会社 代替骨用多孔質セラミツク成形体およびその製造方法
JPH0655219B2 (ja) 1986-03-04 1994-07-27 住友セメント株式会社 義肢取付具
US4830994A (en) 1986-03-31 1989-05-16 The Dow Chemical Company Greenware binder
DE3613213A1 (de) * 1986-04-18 1987-10-22 Merck Patent Gmbh Tricalciumphosphat fuer implantationsmaterialien
US4777153A (en) 1986-05-06 1988-10-11 Washington Research Foundation Process for the production of porous ceramics using decomposable polymeric microspheres and the resultant product
JPS62281953A (ja) 1986-05-28 1987-12-07 旭光学工業株式会社 骨補填材
JPS6346171A (ja) 1986-06-06 1988-02-27 旭光学工業株式会社 生体内留置医療用具の支持体
US4839215A (en) 1986-06-09 1989-06-13 Ceramed Corporation Biocompatible particles and cloth-like article made therefrom
US5939388A (en) 1986-07-01 1999-08-17 Rosen; Vicki A. Methods of administering BMP-5 compositions
US6432919B1 (en) 1986-07-01 2002-08-13 Genetics Institute, Inc. Bone morphogenetic protein-3 and compositions
JPS6346167A (ja) 1986-08-14 1988-02-27 株式会社明電舎 多孔質体の製造方法
JP2508654B2 (ja) 1986-08-14 1996-06-19 富士ゼロックス株式会社 電子写真用感光体
JPS63125259A (ja) 1986-11-14 1988-05-28 旭光学工業株式会社 リン酸カルシウム系多孔質骨補填材
US4737411A (en) 1986-11-25 1988-04-12 University Of Dayton Controlled pore size ceramics particularly for orthopaedic and dental applications
JPS63159313A (ja) 1986-12-24 1988-07-02 Olympus Optical Co Ltd 治療用薬剤
CA1325327C (en) 1987-01-20 1993-12-21 Kenji Saita Process for production of porous ceramic article
US4861733A (en) 1987-02-13 1989-08-29 Interpore International Calcium phosphate bone substitute materials
JP2608721B2 (ja) 1987-05-12 1997-05-14 旭光学工業株式会社 リン酸カルシウム系材料の製造方法
JP2572606B2 (ja) 1987-09-14 1997-01-16 旭光学工業株式会社 表面多孔質なリン酸カルシウム系セラミックスの製造法
JP2702953B2 (ja) 1988-01-30 1998-01-26 オリンパス光学工業株式会社 薬液含浸セラミックス
JP3058174B2 (ja) * 1988-09-20 2000-07-04 旭光学工業株式会社 多孔質セラミックス及びその製造用乾燥体並びにそれらの製造方法
DE68911811T2 (de) * 1988-09-20 1994-06-09 Asahi Optical Co Ltd Poröser keramischer Sinter und Verfahren zu dessen Herstellung.
US5207710A (en) 1988-09-29 1993-05-04 Collagen Corporation Method for improving implant fixation
US5258029A (en) 1988-09-29 1993-11-02 Collagen Corporation Method for improving implant fixation
US5059388A (en) 1988-10-06 1991-10-22 Sumitomo Cement Co., Ltd. Process for manufacturing sintered bodies
US5106626A (en) 1988-10-11 1992-04-21 International Genetic Engineering, Inc. Osteogenic factors
EP0376331A3 (de) 1988-12-29 1991-03-13 Asahi Kogaku Kogyo Kabushiki Kaisha Granula zur langsamen Wirkstoffabgabe sowie Verfahren zu deren Herstellung
US5135394A (en) 1989-01-06 1992-08-04 Olympus Optical Co., Ltd. Extraction cavity filling member and a manufacturing method thereof
JPH02182261A (ja) * 1989-01-06 1990-07-16 Olympus Optical Co Ltd 生体用セラミクス部材の製造方法
SE9000650L (sv) 1989-02-28 1990-08-29 Asahi Optical Co Ltd Separation av celler eller virus
US5422340A (en) 1989-09-01 1995-06-06 Ammann; Arthur J. TGF-βformulation for inducing bone growth
US5152791A (en) 1989-12-07 1992-10-06 Olympus Optical Co., Ltd. Prosthetic artificial bone having ceramic layers of different porosity
US5011495A (en) 1990-02-16 1991-04-30 The United States Of America As Represented By The Secretary Of The Army Unique bone regeneration tricalcium phosphate
US5492697A (en) 1990-03-05 1996-02-20 Board Of Regents, Univ. Of Texas System Biodegradable implant for fracture nonunions
US5164187A (en) 1990-04-05 1992-11-17 Norian Corporation Hydroxyapatite prosthesis coatings
US5263985A (en) 1990-08-14 1993-11-23 Pfizer Hospital Products Group, Inc. Bone growth stimulator
US6080801A (en) 1990-09-13 2000-06-27 Klaus Draenert Multi-component material and process for its preparation
DE4033343A1 (de) 1990-10-19 1992-04-23 Draenert Klaus Werkstoff als ausgangsmaterial zur herstellung von knochenzement und verfahren zu seiner herstellung
US6350462B1 (en) 1990-12-26 2002-02-26 Olympus Optical Co., Ltd. Hollow porous ceramic carrier for embedding in patient for sustained medicament release and method of preparation thereof
JP2922667B2 (ja) * 1991-04-26 1999-07-26 京セラ株式会社 徐放性薬剤含有セラミックス多孔体
DE4120325A1 (de) 1991-06-20 1992-12-24 Merck Patent Gmbh Implantatwerkstoff
DK0591392T3 (da) 1991-06-21 1996-09-30 Genetics Inst Farmaceutiske formuleringer af osteogene proteiner
DE4121043A1 (de) 1991-06-26 1993-01-07 Merck Patent Gmbh Knochenersatzmaterial mit fgf
DE4133877C1 (de) 1991-10-12 1993-05-19 S + G Implants Gmbh, 2400 Luebeck, De
US5338356A (en) 1991-10-29 1994-08-16 Mitsubishi Materials Corporation Calcium phosphate granular cement and method for producing same
US5306303A (en) 1991-11-19 1994-04-26 The Medical College Of Wisconsin, Inc. Bone induction method
ES2040626B1 (es) * 1991-11-22 1994-05-16 Boltong Maria G Procedimiento para la obtencion de cementos de fosfatos de calcio y su empleo como biomteriales.
JP3191963B2 (ja) 1991-12-26 2001-07-23 株式会社日立製作所 変圧器鉄心の組立方法及び組立装置並びに変圧器鉄心
SE469653B (sv) 1992-01-13 1993-08-16 Lucocer Ab Poroest implantat
US6537574B1 (en) 1992-02-11 2003-03-25 Bioform, Inc. Soft tissue augmentation material
ZA93506B (en) 1992-02-11 1994-05-11 Bristol Myers Squibb Co Soft tissue augmentation material
US7060287B1 (en) 1992-02-11 2006-06-13 Bioform Inc. Tissue augmentation material and method
WO1993020859A1 (en) 1992-04-20 1993-10-28 Board Of Regents Of The University Of Washington Sustained release compositions for delivery of growth factors
DE4216496C2 (de) 1992-05-19 1994-09-22 Werner Prof Dr Med Sattel Verwendung eines Plombenkörpers zum Einsetzen in eine Knochenhöhle, insbesondere in den Markraum eines Röhrenknochens
US6303297B1 (en) 1992-07-17 2001-10-16 Incyte Pharmaceuticals, Inc. Database for storage and analysis of full-length sequences
JP3347144B2 (ja) 1993-01-12 2002-11-20 ジェネンテク，インコーポレイテッド 骨成長を誘発させるためのＴＧＦ−β製剤
GB9300746D0 (en) 1993-01-15 1993-03-03 Univ Southampton Prosthesis
JP3231135B2 (ja) 1993-04-16 2001-11-19 日本特殊陶業株式会社 生体インプラント材料及びその製造方法
US5492440A (en) * 1993-05-18 1996-02-20 U.S. Philips Corporation Apparatus for movement of an object
US5581176A (en) * 1993-05-24 1996-12-03 North American Philips Corporation Analog autonomous test bus framework for testing integrated circuits on a printed circuit board
US5964745A (en) * 1993-07-02 1999-10-12 Med Usa Implantable system for cell growth control
US5385887A (en) 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US5531794A (en) 1993-09-13 1996-07-02 Asahi Kogaku Kogyo Kabushiki Kaisha Ceramic device providing an environment for the promotion and formation of new bone
CH686518A5 (de) 1993-10-05 1996-04-15 Asahi Optical Co Ltd Granulares Polymerkomposit, Herstellungsverfahren fur dieses und diagnostische Mittel.
WO1995013089A1 (en) * 1993-11-10 1995-05-18 Henry M. Jackson Foundation For The Advancement Of Military Medicine Compositions and method for stimulating antibody release by b lymphocytes
FR2715853B1 (fr) 1994-02-08 1996-04-26 Centre Nat Rech Scient Composition pour bio-matériau; procédé de préparation.
US5962427A (en) 1994-02-18 1999-10-05 The Regent Of The University Of Michigan In vivo gene transfer methods for wound healing
JP3933716B2 (ja) * 1994-03-02 2007-06-20 株式会社アドバンス α−リン酸三カルシウムセラミックの製造方法
US5626861A (en) * 1994-04-01 1997-05-06 Massachusetts Institute Of Technology Polymeric-hydroxyapatite bone composite
JPH07291759A (ja) 1994-04-27 1995-11-07 Ngk Spark Plug Co Ltd 多孔質セラミックスの製造方法
US5707968A (en) * 1994-05-26 1998-01-13 Abbott Laboratories Inhibition of attachment of H.influenzae to human cells
US5639402A (en) * 1994-08-08 1997-06-17 Barlow; Joel W. Method for fabricating artificial bone implant green parts
US5520923A (en) 1994-09-19 1996-05-28 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US6180606B1 (en) 1994-09-28 2001-01-30 Gensci Orthobiologics, Inc. Compositions with enhanced osteogenic potential, methods for making the same and uses thereof
US5707962A (en) 1994-09-28 1998-01-13 Gensci Regeneration Sciences Inc. Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof
DE4435680A1 (de) 1994-10-06 1996-04-11 Merck Patent Gmbh Poröse Knochenersatzmaterialien
US6376573B1 (en) 1994-12-21 2002-04-23 Interpore International Porous biomaterials and methods for their manufacture
US5741329A (en) 1994-12-21 1998-04-21 Board Of Regents, The University Of Texas System Method of controlling the pH in the vicinity of biodegradable implants
US6599515B1 (en) * 1995-01-16 2003-07-29 Baxter International Inc. Fibrin porous structure
US5641502A (en) 1995-06-07 1997-06-24 United States Surgical Corporation Biodegradable moldable surgical material
WO1997005185A2 (en) 1995-07-28 1997-02-13 Focal, Inc. Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatment agents
US5776193A (en) 1995-10-16 1998-07-07 Orquest, Inc. Bone grafting matrix
US6048964A (en) * 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
JP3600676B2 (ja) 1996-01-29 2004-12-15 ペンタックス株式会社 生体内可溶性複合体粒子
EP0883410B1 (de) 1996-02-29 2004-08-18 Bioactive Bone Substitute OY, AB Osteogene vorrichtungen und methode zur herstellung derselben
DE69739540D1 (de) * 1996-04-19 2009-10-01 Osiris Therapeutics Inc Die wiederherstellung und verstärkung von knochen mittels mesenchymalen stammzellen
US5792477A (en) 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
CA2252860C (en) * 1996-05-28 2011-03-22 1218122 Ontario Inc. Resorbable implant biomaterial made of condensed calcium phosphate particles
US6051247A (en) 1996-05-30 2000-04-18 University Of Florida Research Foundation, Inc. Moldable bioactive compositions
FR2749756B1 (fr) 1996-06-14 1998-09-11 Bioland Procede de preparation d'un materiau composite implantable, materiau obtenu, implant comprenant ce materiau et kit de mise en oeuvre
GB2317887A (en) 1996-10-04 1998-04-08 Dytech Corp Ltd Porous ceramic articles; bone cell growth and drug carriers
US6037519A (en) * 1997-10-20 2000-03-14 Sdgi Holdings, Inc. Ceramic fusion implants and compositions
FI105159B (fi) 1996-10-25 2000-06-30 Biocon Ltd Kirurginen implantaatti, väline tai sen osa
US5866155A (en) 1996-11-20 1999-02-02 Allegheny Health, Education And Research Foundation Methods for using microsphere polymers in bone replacement matrices and composition produced thereby
JP3635316B2 (ja) * 1996-11-25 2005-04-06 株式会社アドバンス 球状セラミックス多孔体の製造方法
FR2758988B1 (fr) 1997-02-05 2000-01-21 S H Ind Procede d'elaboration de substituts osseux synthetiques d'architecture poreuse parfaitement maitrisee
US5914121A (en) * 1997-02-12 1999-06-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Formation of human bone in vivo using ceramic powder and human marrow stromal fibroblasts
EP0914072B1 (de) 1997-03-04 2004-05-19 Technology Finance Corporation (Proprietary) Limited Als knochenimplantat geeignetes erzeugnis
JP3679570B2 (ja) * 1997-03-14 2005-08-03 ペンタックス株式会社 骨補填材及びその製造方法
US7041641B2 (en) * 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US6210612B1 (en) 1997-03-31 2001-04-03 Pouvair Corporation Method for the manufacture of porous ceramic articles
US6210715B1 (en) 1997-04-01 2001-04-03 Cap Biotechnology, Inc. Calcium phosphate microcarriers and microspheres
DE69821510T2 (de) 1997-04-24 2004-06-24 Takeda Chemical Industries, Ltd. Mit apatit beschichtete feste zusammensetzung
JP3490864B2 (ja) 1997-06-02 2004-01-26 ペンタックス株式会社 セラミックス球状顆粒の製造方法
US6296667B1 (en) 1997-10-01 2001-10-02 Phillips-Origen Ceramic Technology, Llc Bone substitutes
US6136029A (en) 1997-10-01 2000-10-24 Phillips-Origen Ceramic Technology, Llc Bone substitute materials
DE59805647D1 (de) 1997-10-21 2002-10-24 Augmentec Ag Implantat aus resorbierbaren phosphatglas
US20010014667A1 (en) * 1998-01-05 2001-08-16 Chen Charles C. Compositions with enhanced osteogenic potential, methods for making the same and therapeutic uses thereof
US6063117A (en) 1998-01-22 2000-05-16 Perry; Arthur C. Porous orbital implant structure
US6030635A (en) 1998-02-27 2000-02-29 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
JPH11276468A (ja) 1998-03-27 1999-10-12 Sumitomo Osaka Cement Co Ltd 骨塩定量用ファントム
JP3360810B2 (ja) 1998-04-14 2003-01-07 ペンタックス株式会社 骨補填材の製造方法
US6027744A (en) 1998-04-24 2000-02-22 University Of Massachusetts Medical Center Guided development and support of hydrogel-cell compositions
US6281257B1 (en) 1998-04-27 2001-08-28 The Regents Of The University Of Michigan Porous composite materials
US6261322B1 (en) 1998-05-14 2001-07-17 Hayes Medical, Inc. Implant with composite coating
AU766735B2 (en) * 1998-09-15 2003-10-23 Isotis N.V. Osteoinduction
GB9820874D0 (en) 1998-09-26 1998-11-18 Smith & Nephew Melt-mouldable composites
US6165486A (en) 1998-11-19 2000-12-26 Carnegie Mellon University Biocompatible compositions and methods of using same
WO2000035511A1 (en) 1998-12-17 2000-06-22 Cambridge Scientific, Inc. Sequenced incorporation of cortical bone allografts
US6194006B1 (en) 1998-12-30 2001-02-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of microparticles having a selected release profile
JP3324075B2 (ja) * 1999-01-20 2002-09-17 瑞安大薬廠股▲ふん▼有限公司 骨充填剤材料とその製造方法
US6383519B1 (en) 1999-01-26 2002-05-07 Vita Special Purpose Corporation Inorganic shaped bodies and methods for their production and use
DE60020526T2 (de) * 1999-02-04 2006-05-11 SDGI Holdings, Inc., Wilmington Osteogene pastenzusammensetzungen und ihre verwendung
CA2362049A1 (en) * 1999-02-04 2000-08-10 Sdgi Holdings, Inc. Highly-mineralized osteogenic sponge compositions, and uses thereof
EP1027897B1 (de) 1999-02-10 2005-04-13 IsoTis N.V. Verfahren zur Knorpelgeweberegeneration
US6656489B1 (en) * 1999-02-10 2003-12-02 Isotis N.V. Scaffold for tissue engineering cartilage having outer surface layers of copolymer and ceramic material
AU2531400A (en) 1999-02-25 2000-09-14 Degradable Solutions Ag Biodegradable, porous shaped bodies
JP2000262608A (ja) 1999-03-12 2000-09-26 Mitsubishi Materials Corp 複合型骨充填材
JP3400740B2 (ja) 1999-04-13 2003-04-28 東芝セラミックス株式会社 リン酸カルシウム系多孔質焼結体およびその製造方法
US6667049B2 (en) * 1999-06-14 2003-12-23 Ethicon, Inc. Relic process for producing bioresorbable ceramic tissue scaffolds
EP1210092B1 (de) 1999-07-08 2009-04-08 CAP Biotechnology, Inc. Calcium-enthaltende strukture und verfahren zur herstellung und verwendung davon
JP4358374B2 (ja) 1999-08-10 2009-11-04 日本特殊陶業株式会社 生体インプラント材の製造方法
JP4365485B2 (ja) 1999-08-19 2009-11-18 株式会社アドバンス 多孔質リン酸カルシウムセラミックスの製造方法
DE19940717A1 (de) 1999-08-26 2001-03-01 Gerontocare Gmbh Resorblerbares Knochenersatz- und Knochenaufbaumaterial
EP1220693B1 (de) 1999-10-15 2004-12-08 Genetics Institute, LLC Zusammensetzungen zur abgabe osteogener proteine
EP1226232A2 (de) 1999-10-15 2002-07-31 Mount Sinai Hospital Synthetisches substrat zur gewebebildung
US6451059B1 (en) 1999-11-12 2002-09-17 Ethicon, Inc. Viscous suspension spinning process for producing resorbable ceramic fibers and scaffolds
AU778651B2 (en) 1999-12-16 2004-12-16 Isotis N.V. Porous ceramic body
AU3242201A (en) 1999-12-16 2001-06-25 Isotis N.V. Porous ceramic body
DE29922585U1 (de) 1999-12-22 2000-07-20 Biovision GmbH, 98693 Ilmenau Temporärer Knochendefektfüller
AU4234901A (en) * 2000-01-28 2001-08-07 Dot Dunnschicht Und Oberflache Inorganic resorbable bone substitute material and production method
US7758882B2 (en) * 2000-01-31 2010-07-20 Indiana University Research And Technology Corporation Composite biomaterial including anisometric calcium phosphate reinforcement particles and related methods
GB2366738B (en) 2000-03-10 2004-03-03 Technology Finance Corp Implant including a body of non-resorbable bioactive material
US20020022885A1 (en) * 2000-05-19 2002-02-21 Takahiro Ochi Biomaterial
US9387094B2 (en) * 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
EP1305056B1 (de) 2000-08-04 2005-12-21 Orthogem Limited Poröse synthetische knochenimplantate und verfahren zu deren herstellung
GB0020610D0 (en) 2000-08-21 2000-10-11 Dytech Corp Ltd Uses of porous carriers
US7045125B2 (en) 2000-10-24 2006-05-16 Vita Special Purpose Corporation Biologically active composites and methods for their production and use
US20020114795A1 (en) * 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US20020193883A1 (en) 2001-01-25 2002-12-19 Wironen John F. Injectable porous bone graft materials
US20020115742A1 (en) * 2001-02-22 2002-08-22 Trieu Hai H. Bioactive nanocomposites and methods for their use
US7122057B2 (en) * 2001-04-12 2006-10-17 Therics, Llc Method and apparatus for engineered regenerative biostructures such as hydroxyapatite substrates for bone healing applications
ATE419810T1 (de) 2001-05-01 2009-01-15 Amedica Corp Röntgendurchlässiges knochentransplantat
WO2010063119A1 (en) 2008-12-04 2010-06-10 Tajinder Manku Multi-transport mode devices having improved data throughput

Also Published As

Publication number Publication date
CA2659188A1 (en) 2002-09-12
US20060292198A1 (en) 2006-12-28
AU2002306592C1 (en) 2002-09-19
DE60232061D1 (de) 2009-06-04
WO2002070029A2 (en) 2002-09-12
EP1372748A2 (de) 2004-01-02
JP2004262758A (ja) 2004-09-24
US20030180376A1 (en) 2003-09-25
US7390498B2 (en) 2008-06-24
US20050170012A1 (en) 2005-08-04
JP2005505311A (ja) 2005-02-24
JP2009101174A (ja) 2009-05-14
US20090110743A1 (en) 2009-04-30
WO2002070029A3 (en) 2003-02-06
US8173149B2 (en) 2012-05-08
US7357941B2 (en) 2008-04-15
ES2325573T3 (es) 2009-09-09
CA2439813A1 (en) 2002-09-12
EP1372748B1 (de) 2009-04-22
CA2439813C (en) 2009-06-16
US6949251B2 (en) 2005-09-27

Similar Documents

Publication Publication Date Title
DE60232061D1 (de) Poröse beta-tricalciumphosphat-körnchen und ein herstellungsverfahren
ATE328549T1 (de) Chirurgisches implantat
DE60045103D1 (de) Verbundformkörper sowie verfahren zur herstellung und zum gebrauch
ATE419810T1 (de) Röntgendurchlässiges knochentransplantat
ATE464073T1 (de) Metallimplantate mit einer aufgerauhten oberfläche und verfahren zu ihrer herstellung
FI834150A0 (fi) Polymera akrylproteser
CA2370724A1 (en) Body for providing ingrowth and growth of bone tissue and/or connective tissue and method of making such a body
WO2003024316A3 (en) Pore-forming agents for orthopedic cements
BR9913579A (pt) Implante, método de fabricação do mesmo e uso do mesmo
SE0102389L (sv) Förfarande för behandling av implantat genom beläggning med kalciumfosfat och bentillväxtstimulerande medel
DE59914332D1 (de) Verfahren zur Herstellung von Zahnersatz und dentalen Hilfsteilen
DE60206023D1 (de) Vorrichtung zur knochenvorbereitung
ES2173817A1 (es) Metodo para la fabricacion de implantes endo-oseos o protesis medicas mediante la tecnica de implantacion ionica.
ATE224213T1 (de) Implantat aus resorbierbaren phosphatglas
EP1508311A3 (de) Verfahren zur Befestigung eines Implantats sowie ein Befestigungselement für das Implantat und ein Verbundimplantat
DE69923290D1 (de) Biokompatible struktur welche ein einwachsen fibrovaskulärer strukturen verstärkt
JP2543605B2 (ja) 移植物およびその作成方法
TW200509872A (en) Methods for preparing medical implants from calcium phosphate cement and medical implants
AU2003279406A8 (en) Method of producing endosseous implants or medical prostheses by means of ionic implantation, and endosseous implant or medical prosthesis thus produced
JP2006513753A5 (de)
WO2002083176A8 (en) Biomaterials comprising a melanocyte stimulating hormone (msh), and method of forming
DE60017933D1 (de) Element zur implantation in körpergewebe und gerät zu dessen herstellung
SE0202316D0 (sv) Anordning för att medelst bioaktivt eller beninduktivt material bygga upp benbaserat sidostöd för implantat i käkben
SE9700514D0 (sv) Bone tissue regeneration device
TR199900038A2 (xx) Gözenekli kalsiyum hidroksiapatit (HA) ve tri-kalsiyum fosfat (TCP) biyoseramiklerinin üretimi.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties