US10464100B2 - System and process for formation of a time-released, drug-eluting transferable coating - Google Patents
System and process for formation of a time-released, drug-eluting transferable coating Download PDFInfo
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- US10464100B2 US10464100B2 US14/122,862 US201214122862A US10464100B2 US 10464100 B2 US10464100 B2 US 10464100B2 US 201214122862 A US201214122862 A US 201214122862A US 10464100 B2 US10464100 B2 US 10464100B2
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- delivery device
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- expandable delivery
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D1/00—Processes for applying liquids or other fluent materials
- B05D1/02—Processes for applying liquids or other fluent materials performed by spraying
- B05D1/04—Processes for applying liquids or other fluent materials performed by spraying involving the use of an electrostatic field
- B05D1/06—Applying particulate materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D1/00—Processes for applying liquids or other fluent materials
- B05D1/02—Processes for applying liquids or other fluent materials performed by spraying
- B05D1/04—Processes for applying liquids or other fluent materials performed by spraying involving the use of an electrostatic field
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1027—Making of balloon catheters
- A61M25/1029—Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
- A61M2025/1031—Surface processing of balloon members, e.g. coating or deposition; Mounting additional parts onto the balloon member's surface
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
Definitions
- the present invention relates generally to preparation of composite coatings. More particularly, the invention relates to a system and process for forming transferable coatings on expandable medical devices that upon deployment within a patient or host yield time-released, drug-eluting coatings for treatment of medical conditions.
- Expandable medical balloons have conventionally been used in the medical arts to open up plaque-restricted vessels by compressing the plaque that has accumulated within the vessel.
- these vessels can be damaged at the point of deployment of the medical balloons.
- conventional balloon technologies have been unable to provide any delivery of drugs over time to tissues damaged by the balloon expansion or the resulting distension of vessel walls.
- stents have been used to deliver drugs within a patient over a period of time, the stents must remain in the patient for the period over which the drug delivery occurs, which can be problematic as the body responds to the presence of the stent. Accordingly, new devices and methods are needed that can deliver drugs over time in a patient that provide medical intervention without the need for the delivery device to remain in the patient.
- FIG. 1 shows a system for formation of transferable coatings on the surface of expandable medical devices, according to an embodiment of the invention.
- FIG. 2 shows two expandable balloons of an “over-the-wire” catheter type used in accordance with the invention.
- FIG. 3 shows a test configuration of system 100 for preparing e-RESS and e-STAT transferable coatings in accordance with the present invention
- FIG. 4 presents exemplary process steps for delivering e-RESS coating layers as a component of transferable coatings formed in accordance with an embodiment of the invention.
- FIG. 5 presents exemplary process steps for delivering e-STAT coating layers as a component of transferable coatings formed in accordance with an embodiment of the invention.
- FIG. 6 presents exemplary process steps for delivering combined e-RESS/e-STAT coating layers as a component of transferable coatings formed in accordance with an embodiment of the invention.
- FIG. 7 shows a transferable, time-released drug-eluting coating delivered in accordance with an embodiment of the process of the invention.
- the present invention includes a system and process for forming composite coatings on expandable medical devices that, upon deployment within a patient or host, transfer time-released, drug-eluting deposits at selected sites within the patient that deliver treatments for various medical conditions.
- preparation of drug-eluting coatings on balloon surfaces is detailed including modifications that allow transfer of the drug-eluting coatings within target vessels where medical intervention is needed for treatment, that results in the formation of the time-released, drug-eluting coatings therein.
- particles that yield the coating layers include various materials including polymers, drugs, and polymer/drug combinations detailed herein.
- the present invention also includes a process for modifying the surface of the composite coating that contains, e.g., time-released drugs that allows delivery of the material within the coating from the surface of the medical balloon to a target location within the patient, which forms a time-released, drug-eluting deposit of material at the target location. Formation of these drug-eluting deposits and deployment from expandable medical balloons to the actual host vessels (e.g., heart) has been demonstrated.
- time-released drugs that allows delivery of the material within the coating from the surface of the medical balloon to a target location within the patient, which forms a time-released, drug-eluting deposit of material at the target location.
- a method for forming an implantable, drug-eluting coating on the surface of an expandable medical device characterized by the steps of: mounting an expandable delivery device with an internally disposed conducting member that maximizes conduction of charge on the surface of the device; delivering preselected potentials with the conducting member to the surface of the expandable delivery device to maximize collection of coating particles on the surface thereof; and coating the expandable delivery device with coating particles delivered via an e-RESS process, and e-STAT process, or a combined e-RESS process and e-STAT process to form one or more coating layers on the surface thereof.
- the expandable delivery device is a medical balloon.
- at least one coating layer of the expandable delivery device includes a drug-eluting component and at least one coating layer includes a biosorbable polymer forming the implantable drug eluting coating on the surface of the device.
- the medical balloon comprises nylon.
- the coating provides transfer of at least a portion of the one or more coating layers upon contact with a host vessel.
- the expandable delivery device is at least a portion of a medical implant device.
- the expandable delivery device is an interventional device.
- the expandable delivery device is a diagnostic device.
- the expandable delivery device is mounted to a delivery device prior to insertion into a host vessel.
- the delivery device is a catheter.
- the conduction of charge on the surface is via gas-phase conduction or surface conduction of charge.
- the delivering of preselected potentials includes delivering an active potential with the conducting component. In some embodiments, the delivering of preselected potentials does not include applying an active potential to the conducting component. In some embodiments, the delivering includes applying an electrostatic field potential on the surface of the expandable delivery device of at least about 15 kV prior to the coating step with the e-STAT process.
- the biosorbable polymer and drug eluting component are located within the same coating layer.
- the coating includes coating the surface simultaneously with the e-RESS process and the e-STAT process to encapsulate a drug and a biosorbable polymer in a single layer of the drug-eluting coating.
- the drug-eluting component includes a drug dispersed within a biosorbable polymer disposed in a single coating layer.
- the biosorbable polymer and drug-eluting component are located in different coating layers.
- at least one coating layer includes a binding component comprising polylactoglycolic acid (PLGA).
- the expandable delivery device is at least partially expanded during coating of same.
- the biosorbable polymer has a preselected molecular weight that enhances transferability of the drug-eluting coating to the receiving surface within the host vessel.
- the drug is a time-released drug that provides time-selectivity for treatment of a host or patient.
- the drug has a crystalline form.
- the drug comprises sirolimus.
- the coating includes masking one or more preselected portions of the expandable delivery device.
- the masking includes forming preselected shapes selected from: oval, square, rectangle, triangular, or cylindrical within the coating layers on the surface of the expandable delivery device that contain an active drug delivered in the drug-eluting coating when in contact with the receiving surface.
- At least one coating layer includes a releasing agent selected from the group consisting of hydrophilic or hydrophobic chemicals or polymers that lower the interfacial energy between the surface of the medical device and the coating layers, water soluble chemicals or polymers that dissolve to eliminate adhesion between coatings layers and the medical device surface, brittle or friable coatings that lose mechanical cohesion upon, polyethylene glycols (PEG), hydrogels, polyesters, polyacrylates, polysaccharides, silicones, silanes, tocopherol, glycerin, sucrose, cellulose, shellac, and combinations thereof providing release of the coating to the receiving surface upon contact with same.
- the releasing agent is located within a coating layer disposed between the surface of the expandable delivery device and a first layer comprising a biosorbable polymer.
- At least one coating layer on the surface of the expandable delivery device comprises a low-energy releasing agent selected from the group consisting of a releasing agent with surface energy of less than 35 dynes/cm or agents onto which a drop of water would experience a contact angle of greater than 90 degrees, polyvinyl alcohols (PVA), ethylene vinyl acetates (EVA), folyolefins, fluorosilanes, fluoroacrylates, fluorohydrocarbons, paraffin, long chain hydrocarbons, and combinations thereof.
- the low-energy releasing agent is located within a coating layer disposed between the surface of the expandable delivery device and a first layer comprising a biosorbable polymer.
- At least one coating layer on the surface of the expandable delivery device comprises an adhesive agent selected from the group consisting of agents with cationic moieties that assist in cellular adhesion/uptake, shattering agents that penetrate tissue surface and promote adhesion through mechanical entanglement, viscous polymeric agents, and cationic polyamino acids such as polyarginine, polylysine, polyhistidine, and polyethyleneimine (PEI), 3,4-dihydroxy-L-phenylalanine (dopa), (as in active component in mussel adhesive), laminins, cationic surfactant molecules such as didodecyldimethylammonium bromide (DMAB), ethylhexadecyldimethylammonium bromide, dodecyltrimethyl ammonium bromide, tetradodecylammonium bromide, dimethylditetradecylammonium bromide, detrabutylammonium iod
- At least one coating layer includes both the biosorbable polymer and a drug or therapeutic agent to provide timed-release delivery of the drug or therapeutic agent by dissolution of the biosorbable polymer layer within the coating material transferred to the host vessel.
- the leading layer of the transferable coating on the surface of the expandable delivery device contains therapeutic drug particles modified with a surface charge prior.
- the coating particles are of a size between about 0.01 micrometers and about 10 micrometers.
- the sintering includes sintering the transferable coating material in the presence of a solvent gas to form a dense, thermally stable film on the surface of the expandable delivery device.
- the method further includes the step of transferring at least a portion of the coating from the expandable delivery device to a receiving surface of a host vessel to form a drug-eluting deposit therein.
- the transferring includes expanding the expandable delivery device to transfer and implant at least a portion of the drug-eluting coating to the receiving surface of the host vessel.
- the step of expanding includes expanding the expandable delivery device using a fluid that maintains rigidity and integrity of along the external surface of same.
- the expanding includes at least partially deflating the expandable delivery device to reduce the physical dimensions of the expandable delivery device when inserting same into the host vessel prior to transferring the coating to the receiving surface of the host vessel.
- devices comprising the elements noted herein, which may be produced according to methods described herein.
- a system and process are detailed for forming composite coatings of transferable material on the surface of expandable medical devices. While various embodiments of the invention will be described in reference to coating of expandable medical balloons, the invention is not intended to be limited thereto. For example, the invention is applicable to any of a variety of expandable medical devices. Thus, no limitations are intended.
- the invention finds application in medical intervention technologies wherein medical catheters and stents are routinely deployed including, e.g., medical angioplasty and treatment of vascular conditions. For example, these composite coatings of transferable material are deployed at various target locations within the vascular system of a patient or host by activation (i.e., expansion) of the expandable device.
- coating means at least one layer containing a selected material or materials (e.g., preselected drugs and polymers) of a selected thickness that extends over at least a portion of the surface of the expandable medical device.
- the present invention provides benefits for delivery of drugs not achieved with prior art devices including, but not limited to, e.g., preparation of composite coatings of transferable materials onto the surface of expandable medical delivery devices, transfer of the composite material from the surface of the medical balloon to the target location within the host vessel, implantation of the transferable material that forms the time-released drug-eluting deposite within the patient or host, and removal of the expandable medical device once the material is transferred into the patient or host. At least some portion of the drug-eluting deposit remains at the target site providing delivery of the time-released drug for the term of treatment without the medical delivery device remaining in the patient or host.
- Composite coatings comprising one or more layers of selected materials are formed on the surface of individual medical balloons by electrostatic collection of coating particles.
- FIG. 1 is a schematic showing a coating system 100 for coating expandable medical balloon devices 4 , according to one embodiment of the invention.
- System 100 includes a coating chamber 50 that mounts to a coating delivery stage 2 .
- Coating delivery stage 2 is configured to deliver respective e-STAT and e-RESS coating particles generated in processes e-RESS plumes 22 and e-STAT plumes 4 , described herein.
- e-RESS is a process by which electrostatically charged coating particles of a selected size (between about 5 ⁇ m to about 100 nm) are delivered by Rapid Expansion of Supercritical Solution (RESS) and electrostatically collected to form one or more coating layers on the surface of medical balloon 4 .
- the e-RESS process is detailed in U.S. Pat. Nos.
- e-STAT is a process by which dry coating particles of a selected size (between about 0.1 ⁇ m to about 10 ⁇ m) are delivered by abrupt entrainment of the solid particles in a carrier gas without use of an expansion fluid or delivery solvent. The particles are electrostatically collected to form one or more coating layers on the surface on the medical balloon devices 4 .
- the e-STAT process is detailed in patent publication number WO 2007/011707 A2 (assigned to Battelle Memorial Institute, Richland, Wash., USA, and MiCell Technologies, Inc., Raleigh, N.C., USA), which reference is incorporated herein in its entirety.
- the e-RESS and e-STAT processes can be performed either sequentially (i.e., first one and then the other), or concurrently (i.e., simultaneously) to form any number of individual coating layers or to provide unique combinations and concentrations of materials in a single coating layer. Any combination or sequence of e-RESS and e-STAT steps may be used to produce a coating.
- the e-RESS process for forming coating particles is preferred for delivery of materials that are soluble in a supercritical fluid or other solvent and where micrometer-scale (or smaller diameter) particles are desirable or where other particle types are generated. For example, rapid nucleation occurs during the RESS process and typically leads to formation of amorphous or non-crystalline nanoparticles.
- the e-STAT process is preferred when delivery of particles is desired which are insoluble in a supercritical fluid solvent, or when a solution or solvent may alter the desirable physical or chemical properties of the particles, as when, e.g., highly crystalline particles are desired or need to be collected.
- Coating layers composed of these various e-RESS and/or e-STAT coating particles are generated and deposited on the surface of the medical balloons forming coating layers, as detailed hereafter.
- an e-STAT delivery nozzle 20 is positioned adjacent to, and apart from, the e-RESS delivery nozzle 18 , but positioning of delivery nozzles 18 and 20 nozzles is not limited.
- chamber 50 includes a balloon mounting assembly 16 of a dual ring type that circumvolves the e-RESS delivery nozzle 18 .
- Balloon mounting assembly 16 includes an upper staging ring 12 and a lower (base) staging ring 14 that provide an equal separation distance between delivery nozzle 18 and balloons 4 mounted in upper staging ring 12 of stage 16 .
- Ring 12 also provides a suitable separation distance between adjacent medical balloons 4 for coating.
- Medical balloons 4 are preferably of an “over-the-wire” catheter type that include an inner guide wire (not shown) covered by a sleeve (not shown) internal to balloon 4 , forming a tube-within-a-balloon or a sleeve-within-a-balloon arrangement, described further herein.
- e-RESS nozzle 18 couples to a cylinder 36 filled with a preselected solvent (e.g., R236ea).
- e-RESS nozzle 18 sprays a coating material in a supercritical solvent that expands as a plume 24 of electrostatically charged coating particles that collect on the surface of the medical balloons 4 mounted in mounting assembly 16 .
- solvent is delivered via syringe pump 32 and mixed in a high pressure cell 34 (e.g., 50 cm 3 cell volume) with a 2 nd material (e.g. PLGA polymer) and the resulting mixed coating solution is delivered via syringe pump 30 through a heated block 28 configured with temperature control feedback at a high pressure (e.g., 5500 psi), forming the supercritical solution containing the mixed materials.
- Pressure is maintained within the delivery system by passing solution through the small diameter (e.g., 50 ⁇ m to 200 ⁇ m) e-RESS nozzle 18 .
- the e-RESS nozzle 18 consists of a length of capillary tubing (exemplary dimensions: 100 ⁇ m I.D. ⁇ 1/16 th inch O.D. ⁇ 10 cm) constructed of, e.g., a thermoplastic polymer [e.g., polyether ether ketone also known as PEEK® (Victrex USA, Inc., West Conshohocken, Pa., USA], but is not limited thereto.
- a thermoplastic polymer e.g., polyether ether ketone also known as PEEK® (Victrex USA, Inc., West Conshohocken, Pa., USA
- other capillary materials may be used including, but not limited to, e.g., stainless steel.
- the nozzle materials may also be preformed, e.g., of sapphire. Thus, no limitations are intended.
- RESS nozzle 18 (comprising, e.g., PEEK® tubing) is encased in stainless steel (e.g., 1 ⁇ 4′′ OD stainless steel tubing) that is grounded to establish a uniform electric field over each balloon 4 mounted to mounting assembly 16 . Pressure drops continuously over the length of the nozzle (capillary) 18 .
- the supercritical coating solution is delivered through e-RESS nozzle 18 as a plume 22 of coating particles in conjunction with a timed pneumatic valve 40 at a preselected pressure (e.g., 5500 psi) and a preselected temperature (e.g., 150° C.).
- the expanded e-RESS solution produces dry coating particles (e.g., of a solute polymer) of a preselected size in a plume 22 of solvent gas.
- the solute particles then are electrostatically collected on the surface of the medical balloons, forming a coating layer.
- coating particles were generated by expansion of a near-critical or a supercritical solution prepared using a hydrofluorocarbon solvent, (e.g., fluoropropane R-236ea, Dyneon, Oakdale, Minn., USA) that further contained a dissolved biosorbable polymer [e.g., a 50:50 poly(DL-lactide-co-glycolide) (PLGA)] available commercially (Catalog No.
- e-STAT orifice 20 delivers dry coating particles in a plume 24 in the absence of a supercritical solvent to the surfaces of medical balloons 4 in mounting assembly 16 .
- e-STAT orifice 20 is constructed from a modified bulkhead union (e.g., 1 ⁇ 2-inch SWAGELOK®) composed of a plastic material (e.g., nylon), but is not limited thereto. e-STAT orifice 20 is not charged.
- e-STAT orifice 20 couples to a reservoir 46 filled with a preselected drug (e.g., Sirolimus) or other coating material in a crystalline or dry powder form with particles preferably of a size in the range from about 10 ⁇ m to about 10 nm, but is not limited thereto.
- a preselected drug e.g., Sirolimus
- the drug or coating material in dry form is provided to e-STAT nozzle 20 through tubing 44 (e.g., 1 ⁇ 2 inch polypropylene or another polymeric tubing).
- Drug reservoir 46 containing the dry coating powder couples to a pneumatic valve 42 that delivers the dry coating particles as a plume 24 through the connecting tubing 44 and the e-STAT orifice 20 into the containment vessel 50 at a preselected pressure (e.g., 500 psi nitrogen) and temperature where particles are electrostatically collected on the surface of the medical balloons 4 mounted in mounting assembly 16 . Pressures at which dry coating particles are delivered are not limited.
- Pneumatic valve 42 further couples to a gas reservoir 48 containing an inert gas (e.g., N 2 ) via tubing 49 that provides a discharging gas to pneumatic valve 42 .
- an inert gas e.g., N 2
- metal-containing guide wires 8 encased within the inner sleeve of the balloon 4 are charged with voltages that range preferably from about 5 kV to about 25 kV. More particularly, voltages range from about 10 kV to about 20 kV.
- e-RESS and e-STAT coating processes delivery conditions are those described previously herein for the individual RESS and STAT processes, but the processes are performed simultaneously. Thus, the disclosure is not intended to be limited by the descriptions to the individual e-RESS and e-STAT processes.
- FIG. 2 shows two medical balloons 4 of an “over-the-wire” catheter type coated in conjunction with one embodiment of the invention.
- medical balloons 4 each include a catheter guide 6 through which a metal guide (conducting) wire 8 passes.
- Guide wire 8 passes through the center of each balloon 4 in a sleeve 10 that runs the length of balloon 4 .
- the sleeve-within-the balloon configuration separates sleeve 10 from the expansion volume of each balloon 4 .
- Sleeve 10 and balloon 4 are fused at either end of the balloon 4 , forming a seal that allows for inflation of balloon 4 by introducing expansion gas through catheter guide 6 .
- balloons 4 were expanded by means of, e.g., a syringe coupled to a luer connection described hereafter positioned at the end of each catheter guide 6 distal to the expandable balloon 4 , but the mechanism for expansion of balloons is not limited thereto.
- a pneumatic pressure system may also be used, e.g., for production scale processing.
- metal guide wire 8 in balloon 4 was inserted to the tip of balloon 4 without protruding from the upper end (i.e., the normal coating condition).
- balloon 4 guide wire 8 was retracted to below the mid section of balloon 4 prior to coating. Results in each image demonstrate that the coating on balloon 4 covers an area equal to the terminal position of guide wire 8 in sleeve 10 , illustrating the effect the guide wire 8 has on collection efficiency of the coating materials.
- FIG. 3 shows a test configuration of system 100 for preparing e-RESS and e-STAT transferable coatings in accordance with the present invention.
- System 100 includes a balloon mounting assembly 16 for mounting and coating expandable medical devices including medical balloons 4 .
- lower (base) staging ring 14 In the e-RESS coating process used in conjunction with the present invention, lower (base) staging ring 14 , metal sheath (post) 19 surrounding e-RESS nozzle 18 , and guide wires 8 are grounded.
- medical balloons 4 are shown vertically mounted on upper staging ring 12 of mounting assembly 16 . The upper ends of balloon catheters 6 are inserted in slots machined in the upper stage ring 12 , providing vertical staging of balloons 4 for coating.
- Guide wires 8 are enclosed within the balloons 4 within the internal catheter guide sleeves 6 (e.g., in a tube-within-a-balloon arrangement). At the top end of balloons 4 , one end of guide wires 8 extends through sleeve 10 from inside the inner balloon 4 , with the tip of the metal guide wire 8 retracted immediately ( ⁇ 1 mm) below the tip of balloon 4 .
- Metal guide wires 8 extend a non-limiting distance of ⁇ 12 inches from the end of balloon 4 within catheter guide 6 .
- Guide wires 8 protrude from the catheter guide 6 , e.g., below base staging ring 14 , which are then coupled to an electrical source 22 (e.g., a high voltage power supply).
- This arrangement allows preselected potentials or electrical grounding to be applied to each guide wire 8 that delivers an electric field through surfaces of each balloon 4 individually or collectively during deposition of coating particles. Retraction of the guide wire 8 into the balloon 4 prevents disruptive fields (i.e. coronal discharge) from forming at the exposed tip of wire 8 that can lead to poor quality depositions on the balloon 4 surface.
- Guide wires 8 in the instant embodiment provide a convenient way to electrically connect the interior of the balloons 4 to the surface of the balloons 4 , but the process is not intended to be limited to the use of catheter guide wires 8 as active electrodes.
- base staging ring 14 is composed of a molded or machined engineering plastic (e.g., DELRIN®) to which a conductive metal (e.g., copper) grounding wire or ring (not shown) is positioned along the perimeter of lower staging ring 14 , providing a common potential to each metal guide wire 8 during e-RESS coating of medical balloons 4 with e-RESS coating particles.
- base ring 14 includes a loop for attaching guide wires 8 to grounding screws mounted next, or adjacent, to the conductive ring on base staging ring 14 .
- the grounding ring further couples to a power source 22 , e.g., using a clip mechanism or other attaching means, which permits guide wires 8 to be charged or grounded (when not charged) as required for preparation of specific coatings on the surface of medical balloons 4 described further herein. When charged, guide wires 8 provide a uniform field over the surface of balloon 4 .
- balloons 4 were inflated by connecting a 1 cm 3 (cc) syringe to a luer coupling (shown at left) located at the catheter 6 end of balloons 4 and fully depressing the syringe plunger, allowing the plunger to come back to an equilibrium position determined by the plunger friction in the syringe body, thereby providing a source of air that inflated each balloon 4 .
- a manifold of luer connections may be attached at the terminal ends of the catheters 6 and pumped to a pre-determined pressure such that each balloon 4 is pressurized equally for purposes of coating.
- a separate gas supply and pneumatics can be coupled for inflation of individual balloons 4 or simultaneous inflation of multiple balloons 4 during production. No limitations are intended.
- Composite coatings deposited to surfaces of expandable medical devices in conjunction with the invention using modified e-RESS and e-STAT processes can include various combinations of polymers and drugs in one or more coating layers that define the composite coating.
- Transferable deposits of the present invention prepared on the surfaces of expandable medical devices are preferably, but not exclusively, drug-eluting materials.
- the components of these composite coatings are subsequently transferred from the medical device to a specific location in a vessel (e.g., an artery) or other vascular location within a patient or host by activation or inflation of the balloons. Drugs and other therapeutic agents present in the various layers of the composite coating transferred are needed, thereby effecting treatment.
- a time-released drug or drugs in the transferred coating provides medical intervention or treatment at the delivery site over time (e.g., in a time-released fashion).
- the present invention further provides target delivery of a drug or drugs without need for long-term retention of the delivery device (i.e., the medical balloon or a stent) within the patient or host.
- the drug-eluting coating of transferrable material includes a drug that is dispersed in a matrix consisting of a biosorbable polymer that allows the drug to be deployed in a time-released fashion to a target location within the vascular system of the patient or host.
- the coating on the balloon that is completely or partially transferred to the vessel wall when deployed in the host vessel includes at least one layer that includes at least one drug.
- the coating may also include at least one biosorbable polymer (e.g., PLGA) in a single layer or in different layers.
- coating particles can include various materials selected from, e.g., polymers, drugs, biosorbable materials, bioactive proteins and peptides, as well as combinations of these materials. These materials find use in coatings that are applied to, e.g., medical devices (e.g., medical balloons) and medical implant devices (e.g., drug-eluting stents), but are not limited thereto. Choice for near-critical or supercritical fluid is based on the solubility of the selected solute(s) of interest, which is not limited.
- Polymers used in conjunction with various embodiments include, but are not limited to, e.g., polylactoglycolic acid (PLGA); polyethylene vinyl acetate (PEVA); poly(butyl methacrylate) (PBMA); perfluorooctanoic acid (PFOA); tetrafluoroethylene (TFE); hexafluoropropylene (HFP); polylactic acid (PLA); polyglycolic acid (PGA); including combinations of these polymers.
- Other polymers include various mixtures of tetrafluoroethylene; hexafluoropropylene; and vinylidene fluoride (e.g., THV) at varying molecular ratios (e.g., 1:1:1).
- Biosorbable polymers used in conjunction in some embodiments include, but are not limited to, e.g., polylactic acid (PLA); poly(DL-lactide-co-glycolide) (PLGA); poly(lactic-co-glycolic acid); polycaprolactone (poly(e-caprolactone)) (PCL); polyglycolide (PG) or (PGA); poly-3-hydroxybutyrate; LPLA poly(L-lactide); DLPLA poly(DL-lactide); PDO poly(dioxolane); PGA-TMC; 85/15 DLPLG poly(DL-lactide-co-glycolide); 75/25 DLPL; 65/35 DLPLG; 50/50 DLPLG; TMC poly(trimethylcarbonate); poly(CPP:SA); poly(1,3-bis-p-(carboxyphenoxy)propane-co-sebacic acid); and blends; combinations; homopolymers; condensation polymers; alternating; block; dendritic;
- Durable (biostable) polymers used in some embodiments include, but are not limited to, e.g., polyester; aliphatic polyester; polyanhydride; polyethylene; polyorthoester; polyphosphazene; polyurethane; polycarbonate urethane; aliphatic polycarbonate; silicone; a silicone-containing polymer; polyolefin; polyamide; polycaprolactam; polyamide; polyvinyl alcohol; acrylic polymer; acrylate; polystyrene; epoxy; polyethers; cellulosics; expanded polytetrafluoroethylene; phosphorylcholine; polyethylene-terephthalate; polymethylmethacrylate; poly(ethylmethacrylate/n-butylmethacrylate); parylene C; polyethylene-co-vinyl acetate; polyalkyl methacrylates; polyalkylene-co-vinyl acetate; polyalkylene; polyalkyl siloxanes; polyhydroxyalkanoate;
- time-released drugs are delivered to a wall of a vascular vessel (e.g., an artery) within a host or patient using a coating comprised of one or more coating layers.
- Coating layers can include various therapeutic agents in various combinations including, e.g., biosorbable polymers and drugs that are deposited onto the surface of, e.g., expandable polymer devices (e.g., a medical balloon). The expandable polymer device is subsequently transferred to, and deployed within the vascular system of a host or patient as detailed herein.
- Drugs used in conjunction with various embodiments include, but are not limited to, e.g., antibiotics (e.g., Rapamycin [CAS No. 53123-88-9], LC Laboratories, Woburn, Mass., USA, anticoagulants (e.g., Heparin [CAS No. 9005-49-6]; antithrombotic agents (e.g., clopidogrel); antiplatelet drugs (e.g., aspirin); immunosuppressive drugs; antiproliferative drugs; chemotherapeutic agents (e.g., paclitaxel also known by the tradename TAXOL® [CAS No.
- antibiotics e.g., Rapamycin [CAS No. 53123-88-9], LC Laboratories, Woburn, Mass., USA
- anticoagulants e.g., Heparin [CAS No. 9005-49-6]
- antithrombotic agents e.g., clopidogrel
- antiplatelet drugs e.g., aspirin
- antibiotics include, but are not limited to, e.g., amikacin, amoxicillin, gentamicin, kanamycin, neomycin, netilmicin, paromomycin, tobramycin, geldanamycin, herbimycin, carbacephem (loracarbef), ertapenem, doripenem, imipenem, cefadroxil, cefazolin, cefalotin, cephalexin, cefaclor, cefamandole, cefoxitin, cefprozil, cefuroxime, cefixime, cefdinir, cefditoren, cefoperazone, cefotaxime, cefpodoxime, ceftazidime, cefti
- Antibiotics can also be grouped into classes of related drugs, for example, aminoglycosides (e.g., amikacin, gentamicin, kanamycin, neomycin, netilmicin, paromomycin, streptomycin, tobramycin), ansamycins (e.g., geldanamycin, herbimycin), carbacephem (loracarbef) carbapenems (e.g., ertapenem, doripenem, imipenem, meropenem), first generation cephalosporins (e.g., cefadroxil, cefazolin, cefalotin, cefalexin), second generation cephalosporins (e.g., cefaclor, cefamandole, cefoxitin, cefprozil, cefuroxime), third generation cephalosporins (e.g., cefixime, cefdinir, cefditoren, cefoperazone, cef
- Drugs used in some embodiments described herein include, but are not limited to, e.g., immunosuppressive drugs such as a macrolide immunosuppressive drug, which may comprise one or more of: rapamycin; biolimus (biolimus A9); 40-O-(2-Hydroxyethyl)rapamycin (everolimus); 40-O-Benzyl-rapamycin; 40-O-(4′-Hydroxymethyl)benzyl-rapamycin; 40-O-[4′-(1,2-Dihydroxyethyl)]benzyl-rapamycin; 40-O-Allyl-rapamycin; 40-O-[3′-(2,2-Dimethyl-1,3-dioxolan-4(S)-yl)-prop-2′-en-1′-yl]-rapamycin; (2′:E,4′S)-40-O-(4′,5′-Dihydroxypent-2′-en-1′-yl)-rapamycin; 40
- Drugs used in various embodiments described further herein include, but are not limited to, e.g., Acarbose; acetylsalicylic acid; acyclovir; allopurinol; alprostadil; prostaglandins; amantadine; ambroxol; amlodipine; S-amino salicylic acid; amitriptyline; atenolol; azathioprine; balsalazide; beclomethasone; betahistine; bezafibrate; diazepam and diazepam derivatives; budesonide; bufexamac; buprenorphine; butizine; methadone; calcium salts; potassium salts; magnesium salts; candesartan; carbamazepine; captopril; cetirizine; chenodeoxycholic acid; theophylline and theophylline derivatives; trypsins; cimetidine; clo
- Anti-thrombotic agents are also contemplated for use in the methods and devices described herein.
- Use of anti-platelet drugs e.g., aspirin
- Anti-platelet agents include “GpIIb/IIIa inhibitors” (e.g., abciximab, eptifibatide, tirofiban, RheoPro) and “ADP receptor blockers” (prasugrel, clopidogrel, ticlopidine).
- dipyridamole which has local vascular effects that improve endothelial function (e.g., by causing local release oft-PA, that will break up clots or prevent clot formation) and reduce the likelihood of platelets and inflammatory cells binding to damaged endothelium
- cAMP phosphodiesterase inhibitors e.g., cilostazol
- Chemotherapeutic agents may also be used.
- chemotherapeutic agents include, but are not limited to, e.g., angiostatin; DNA topoisomerase; endostatin; genistein; ornithine decarboxylase inhibitors; chlormethine; melphalan; pipobroman; triethylene-melamine; triethylenethiophosphoramine; busulfan; carmustine (BCNU); streptozocin; 6-mercaptopurine; 6-thioguanine; deoxyco-formycin; IFN- ⁇ ; 17 ⁇ -ethinylestradiol; diethylstilbestrol; testosterone; prednisone; fluoxymesterone; dromostanolone propionate; testolactone; megestrolacetate; methylprednisolone; methyl-testosterone; prednisolone; triamcinolone; chlorotrianisene; hydroxyprogesterone; estramustine; medroxypro
- EX-015 benzrabine, floxuridine, fludarabine, fludarabine phosphate, N-(2′-furanidyl)-5-fluorouracil, Daiichi Seiyaku FO-152, 5-FU-fibrinogen, isopropyl pyrrolizine, Lilly LY-188011, Lilly LY-264618, methobenzaprim, methotrexate, Wellcome MZPES, norspermidine, nolvadex, NCI NSC-127716, NCI NSC-264880, NCI NSC-39661, NCI NSC-612567, Warner-Lambert PALA, pentostatin, piritrexim, plicamycin, Asahi Chemical PL-AC, stearate, Takeda TAC-788, thioguanine, tiazofurin, Erbamont TIF, trimetrexate, tyrosine kinase inhibitors, tyrosine
- coatings on medical devices can include drugs used in time-release drug applications.
- Proteins may be coated according to these methods and coatings described herein may comprise proteins.
- Peptides may be coated according to these methods and coatings described herein may comprise peptides.
- coating particles can include releasing agents, which may include low-energy releasing agents (also called low-energy release agents). Releasing agents may also be called a “release agent.” These materials find use in coatings that are applied to, e.g., medical devices (e.g., medical balloons) and medical implant devices (e.g., drug-eluting stents), but are not limited thereto. Choice for near-critical or supercritical fluid is based on the solubility of the selected solute(s) of interest, which is not limited.
- a release agent may comprise: hydrophilic or hydrophobic chemicals or polymers that lower the interfacial energy between the surface of the medical device and the coating layers, water soluble chemicals or polymers that dissolve to eliminate adhesion between coatings layers and the medical device surface, brittle or friable coatings that lose mechanical cohesion upon, Polyethylene glycols (PEG), Hydrogels, Polyesters, Polyacrylates, Polysaccharides, Silicones, Silanes, Tocopherol, Glycerin, Sucrose, Cellulose, and Shellac.
- a low-energy releasing agents may be a subset of the larger set of releasing agents.
- a releasing agent that is “low-energy” may be defined as a releasing agent with surface energy of less than 35 dynes/cm or agents onto which a drop of water would experience a contact angle of greater than 90 degrees.
- Examples of low-energy releasing agents include (but are not limited to): Polyvinyl alcohols (PVA), Ethylene vinyl acetates (EVA), Polyolefins, Fluorosilanes, Fluoroacrylates, Fluorohydrocarbons, Paraffin, and Long chain hydrocarbons.
- coating particles can include adhesive agents that serve to affix the balloon coating to a receiving surface when the surface is contacted.
- Adhesive agents may comprise any one or more of the following: agents with cationic moieties that assist in cellular adhesion/uptake, shattering agents that penetrate tissue surface and promote adhesion through mechanical entanglement, viscous polymeric agents, and cationic polyamino acids.
- Cationic polyamino acids include, but are not limited to: polyarginine, polylysine, polyhistidine, and polyethyleneimine (PEI).
- Adhesive agents may comprise any one or more of the following: 3,4-dihydroxy-L-phenylalanine (dopa), (as in active component in mussel adhesive), laminins, and cationic surfactant molecules.
- Cationic surfactant molecules include, but are not limited to: didodecyldimethylammonium bromide (DMAB), ethylhexadecyldimethylammonium bromide, do decyltrimethyl ammonium bromide, tetradodecylammonium bromide, dimethylditetradecylammonium bromide, tetrabutylammonium iodide, DEAE-dextran hydrochloride, and hexadimethrine bromide.
- DMAB didodecyldimethylammonium bromide
- ethylhexadecyldimethylammonium bromide do decyltrimethyl am
- FIG. 4 presents exemplary process steps for generating e-RESS coating layers on expandable medical balloons that deliver transferable, drug-eluting deposits at target locations within a host or patient, according to an embodiment of the invention.
- a preselected solvent is intermixed with at least one coating material at a preselected pressure or temperature to form a supercritical solution.
- the selected coating material is discharged from the supercritical solution through a restrictor nozzle ( FIG. 1 ) as a RESS plume to form e-RESS charged coating particles at a preselected pressure and temperature.
- the e-RESS generated charged coating particles are delivered to the surface of the balloon to form a coating layer containing the charged coating particles.
- the particles are electrostatically attracted to the surface of the balloon either with or without the addition of an actively induced electrostatic field.
- the coating layer containing the charged coating particles is sintered to form a stable RESS film layer, e.g., on the surface of the balloon.
- Next ( 425 ) form one or more coating layers on the surface of the balloon using the e-RESS process.
- FIG. 5 presents exemplary process steps for generating e-STAT coating layers as a component of drug-eluting coatings formed in accordance with an embodiment of the invention.
- First ( 505 ) a potential is applied to the conductive element located within the expandable medical balloon to generate a selected potential on the surface of the balloon as described herein. A potential of ⁇ 15 kV is typical. However, potentials are not intended to be limited thereto.
- e-STAT dry charged
- the dry charged coating particles containing the preselected coating material are electrostatically attracted to the surface of the balloon to form a dry coating layer on the surface of the balloon.
- the electrostatic attraction between the particles and the balloon surface is performed with or without the addition of an actively induced electrostatic field.
- the coating layer containing the charged coating particles is sintered to form a stable e-STAT film layer on the surface of the balloon or to stabilize the e-STAT particles by fusing them to a previously deposited polymer layer.
- the e-STAT process is repeated as necessary to form one or more coating layers on the surface of the balloon.
- FIG. 6 presents exemplary process steps for generating combined e-RESS/e-STAT coating layers as a component of drug-eluting coatings formed in accordance with an embodiment of the invention.
- First ( 605 ) e-RESS generated charged coating particles and/or e-STAT generated charged coating particles containing a preselected coating material are discharged in respective plumes at a preselected pressure and temperature.
- the plumes containing the e-RESS and/or e-STAT generated charged coating particles can be discharged as separately in respective plumes or simultaneously in combined plumes in any order. No limitations are intended.
- the e-RESS and/or e-STAT charged coating particles containing the preselected coating material are delivered to the surface of the balloon to form one or more coating layers containing the charged coating particles on the surface of the balloon.
- the particles are electrostatically attracted to the surface of the balloon either with or without the addition of an actively induced electrostatic field.
- the e-RESS and/or e-STAT coating layers containing the charged coating particles are sintered to form stable coating layers on the surface of the balloon.
- one or more e-RESS and/or e-STAT coating layers are formed on the surface of the balloon using e-RESS and/or e-STAT processes performed individually, serially, or simultaneously.
- the transferable material or “portion of the coating” is delivered from the surface of the medical balloon to the target site within the vascular system of the patient or host by expanding the medical balloon within the receiving vessel (e.g., an artery or other vessel) at the location where the therapeutic drug or other therapeutic agent is needed.
- This process transfers the drug-eluting composite (or “material”) to the host vessel (e.g., artery or vein) providing treatment or medical intervention in the host or patient.
- coatings comprised of one or more layers including a biosorbable polymer and drug were successfully deployed within the vascular system of a host or patient.
- a cylindrical coating consisting of a therapeutic drug (e.g., rapamycin) encapsulated in a biosorbable polymer matrix (e.g., PLGA) into a blood vessel can provide long-term treatment of, e.g., arterial disease in patients.
- the drug-eluting composite/material remains deployed within the host vessel after deflation and removal of the medical balloon. Drug is continuously provided in a time-released manner by the drug-eluting composite/material without need for a permanent medical device to be present in the body.
- the drug-eluting coating can continue to deliver a needed drug benefit over time.
- FIG. 7 is a photomicrograph showing a polymer coating transferred from medical balloon onto the inner surface of medical-grade tubing (e.g., TYGON® medical tubing) that simulates transfer in an environment like those expected for delivery in mammalian hosts and human patients.
- the coating material was successfully transferred from the balloon surface to the inner wall (surface) of the medical tubing.
- the coating material on the surface of the medical balloon attaches to the host vessel upon expansion of the balloon. Removal and transfer of coating material from the balloon surface was effected in concert with a release layer composed of a low surface energy PTFE polymer (commercial-grade) that was deposited between the surface of the balloon and a first polymer layer prior to application of a subsequent PLGA polymer layer.
- a release layer composed of a low surface energy PTFE polymer (commercial-grade) that was deposited between the surface of the balloon and a first polymer layer prior to application of a subsequent PLGA polymer layer.
- release layers are preferably, but not exclusively used.
- release was accomplished by inserting the coated balloon into TYGON® tubing, expanding the balloon at a temperature of 37° C., and pressing the expanded balloon on the inner wall of the tubing for about 2 minutes at equilibrium, or for 1 minute at a pressure of about 250 psi while immersing in an aqueous bath. Pressure used in this test is comparable to pressures used to deploy medical balloons in typical medical procedures. Results showed the entire polymer coating deposited on the balloon surface was transferred to the inner wall of the tube, forming the polymer coating.
- the outermost layer of the transferable coating material that becomes the innermost layer of the transferred composite deposited in the vessel lumen is preferably, but not exclusively, a coherent layer.
- the transferred material may further consist of partial or incomplete layers.
- release and transfer of the transferable coating material from the surface of the medical device to the vessel wall of the host or patient may be further enhanced by adding a net positive or net negative charge to the outermost surface of the transferable coating.
- This enhanced charge can also enhance attraction or otherwise promote adhesion of the coating particles to the surface of the vessel wall to which the coating is delivered.
- Such charge can also promote uptake of the therapeutic agent present within the transferred coating material into various cells of the patient or host where tissue damage induced by balloon expansion can be treated.
- the outermost coating layer on the surface of the medical balloon is preferably, but not exclusively, charged with a net positive charge.
- a net positive charge enhances the attraction of the coating material on the surface of the expandable delivery device to the receiving surface of the host vessel. Although a positive net charge is described here, choice of charge is not limited. Tests on host vessel surrogates have demonstrated the ability to transfer polymer and drug coating materials at conditions similar to those found in a human body.
- a method for forming an implantable, drug-eluting coating on the surface of an expandable medical device characterized by the steps of: mounting an expandable delivery device with an internally disposed conducting member that maximizes conduction of charge on the surface of the device; delivering preselected potentials with the conducting member to the surface of the expandable delivery device to maximize collection of coating particles on the surface thereof; and coating the expandable delivery device with coating particles delivered via an e-RESS process, and e-STAT process, or a combined e-RESS process and e-STAT process to form one or more coating layers on the surface thereof.
- the expandable delivery device is a medical balloon.
- at least one coating layer of the expandable delivery device includes a drug-eluting component and at least one coating layer includes a biosorbable polymer forming the implantable drug eluting coating on the surface of the device.
- the medical balloon comprises nylon.
- the coating provides transfer of at least a portion of the one or more coating layers upon contact with a host vessel.
- the expandable delivery device is at least a portion of a medical implant device.
- the expandable delivery device is an interventional device.
- the expandable delivery device is a diagnostic device.
- the expandable delivery device is mounted to a delivery device prior to insertion into a host vessel.
- the delivery device is a catheter.
- the conduction of charge on the surface is via gas-phase conduction or surface conduction of charge.
- the delivering of preselected potentials includes delivering an active potential with the conducting component. In some embodiments, the delivering of preselected potentials does not include applying an active potential to the conducting component. In some embodiments, the delivering includes applying an electrostatic field potential on the surface of the expandable delivery device of at least about 15 kV prior to the coating step with the e-STAT process.
- the biosorbable polymer and drug eluting component are located within the same coating layer.
- the coating includes coating the surface simultaneously with the e-RESS process and the e-STAT process to encapsulate a drug and a biosorbable polymer in a single layer of the drug-eluting coating.
- the drug-eluting component includes a drug dispersed within a biosorbable polymer disposed in a single coating layer.
- the biosorbable polymer and drug-eluting component are located in different coating layers.
- at least one coating layer includes a binding component comprising polylactoglycolic acid (PLGA).
- the expandable delivery device is at least partially expanded during coating of same.
- the biosorbable polymer has a preselected molecular weight that enhances transferability of the drug-eluting coating to the receiving surface within the host vessel.
- the drug is a time-released drug that provides time-selectivity for treatment of a host or patient.
- the drug has a crystalline form.
- the drug comprises sirolimus.
- the coating includes masking one or more preselected portions of the expandable delivery device.
- the masking includes forming preselected shapes selected from: oval, square, rectangle, triangular, or cylindrical within the coating layers on the surface of the expandable delivery device that contain an active drug delivered in the drug-eluting coating when in contact with the receiving surface.
- At least one coating layer includes a releasing agent selected from the group consisting of hydrophilic or hydrophobic chemicals or polymers that lower the interfacial energy between the surface of the medical device and the coating layers, water soluble chemicals or polymers that dissolve to eliminate adhesion between coatings layers and the medical device surface, brittle or friable coatings that lose mechanical cohesion upon, polyethylene glycols (PEG), hydrogels, polyesters, polyacrylates, polysaccharides, silicones, silanes, tocopherol, glycerin, sucrose, cellulose, shellac, and combinations thereof providing release of the coating to the receiving surface upon contact with same.
- the releasing agent is located within a coating layer disposed between the surface of the expandable delivery device and a first layer comprising a biosorbable polymer.
- At least one coating layer on the surface of the expandable delivery device comprises a low-energy releasing agent selected from the group consisting of a releasing agent with surface energy of less than 35 dynes/cm or agents onto which a drop of water would experience a contact angle of greater than 90 degrees, polyvinyl alcohols (PVA), ethylene vinyl acetates (EVA), folyolefins, fluorosilanes, fluoroacrylates, fluorohydrocarbons, paraffin, long chain hydrocarbons, and combinations thereof.
- the low-energy releasing agent is located within a coating layer disposed between the surface of the expandable delivery device and a first layer comprising a biosorbable polymer.
- At least one coating layer on the surface of the expandable delivery device comprises an adhesive agent selected from the group consisting of agents with cationic moieties that assist in cellular adhesion/uptake, shattering agents that penetrate tissue surface and promote adhesion through mechanical entanglement, viscous polymeric agents, and cationic polyamino acids such as polyarginine, polylysine, polyhistidine, and polyethyleneimine (PEI), 3,4-dihydroxy-L-phenylalanine (dopa), (as in active component in mussel adhesive), laminins, cationic surfactant molecules such as didodecyldimethylammonium bromide (DMAB), ethylhexadecyldimethylammonium bromide, dodecyltrimethyl ammonium bromide, tetradodecylammonium bromide, dimethylditetradecylammonium bromide, detrabutylammonium iod
- At least one coating layer includes both the biosorbable polymer and a drug or therapeutic agent to provide timed-release delivery of the drug or therapeutic agent by dissolution of the biosorbable polymer layer within the coating material transferred to the host vessel.
- the leading layer of the transferable coating on the surface of the expandable delivery device contains therapeutic drug particles modified with a surface charge prior.
- the coating particles are of a size between about 0.01 micrometers and about 10 micrometers.
- the sintering includes sintering the transferable coating material in the presence of a solvent gas to form a dense, thermally stable film on the surface of the expandable delivery device.
- the method further includes the step of transferring at least a portion of the coating from the expandable delivery device to a receiving surface of a host vessel to form a drug-eluting deposit therein.
- the transferring includes expanding the expandable delivery device to transfer and implant at least a portion of the drug-eluting coating to the receiving surface of the host vessel.
- the step of expanding includes expanding the expandable delivery device using a fluid that maintains rigidity and integrity of along the external surface of same.
- the expanding includes at least partially deflating the expandable delivery device to reduce the physical dimensions of the expandable delivery device when inserting same into the host vessel prior to transferring the coating to the receiving surface of the host vessel.
- devices comprising the elements noted herein, which may be produced according to methods described herein.
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