AR064620A1 - Anticuerpos contra el receptor del factor de crecimiento similar a la insulina i y l a utilizacion de los mismos - Google Patents

Anticuerpos contra el receptor del factor de crecimiento similar a la insulina i y l a utilizacion de los mismos

Info

Publication number
AR064620A1
AR064620A1 ARP070105785A ARP070105785A AR064620A1 AR 064620 A1 AR064620 A1 AR 064620A1 AR P070105785 A ARP070105785 A AR P070105785A AR P070105785 A ARP070105785 A AR P070105785A AR 064620 A1 AR064620 A1 AR 064620A1
Authority
AR
Argentina
Prior art keywords
insulin
receiver
same
growth factor
antibodies against
Prior art date
Application number
ARP070105785A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR064620A1 publication Critical patent/AR064620A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification

Abstract

Un anticuerpo que se une al IGF-IR que está glicosilado con una cadena de azucares en la Asn297, y dicho anticuerpo que se caracteriza porque la cantidad de fucosa dentro de dicha cadena de azucares está entre un 20% y un 50%, presenta propiedades mejoradas en la terapia antitumoral.
ARP070105785A 2006-12-22 2007-12-20 Anticuerpos contra el receptor del factor de crecimiento similar a la insulina i y l a utilizacion de los mismos AR064620A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06026651 2006-12-22

Publications (1)

Publication Number Publication Date
AR064620A1 true AR064620A1 (es) 2009-04-15

Family

ID=37989161

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070105785A AR064620A1 (es) 2006-12-22 2007-12-20 Anticuerpos contra el receptor del factor de crecimiento similar a la insulina i y l a utilizacion de los mismos

Country Status (21)

Country Link
US (2) US20080226635A1 (es)
EP (1) EP2102242A1 (es)
JP (1) JP2010513352A (es)
KR (2) KR20090088911A (es)
CN (1) CN101611059A (es)
AR (1) AR064620A1 (es)
AU (1) AU2007338402A1 (es)
BR (1) BRPI0722062A2 (es)
CA (1) CA2672715A1 (es)
CL (1) CL2007003726A1 (es)
CR (1) CR10810A (es)
EC (1) ECSP099440A (es)
IL (1) IL198778A0 (es)
MA (1) MA31066B1 (es)
MX (1) MX2009006333A (es)
NZ (1) NZ576956A (es)
PE (1) PE20081832A1 (es)
RU (1) RU2009127846A (es)
TW (1) TW200833712A (es)
WO (1) WO2008077546A1 (es)
ZA (1) ZA200904324B (es)

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