YU46857B - Postupak za dobijanje novih analoga insulina - Google Patents

Postupak za dobijanje novih analoga insulina

Info

Publication number
YU46857B
YU46857B YU4188A YU4188A YU46857B YU 46857 B YU46857 B YU 46857B YU 4188 A YU4188 A YU 4188A YU 4188 A YU4188 A YU 4188A YU 46857 B YU46857 B YU 46857B
Authority
YU
Yugoslavia
Prior art keywords
amino acid
acid residues
insulin
human insulin
molecule
Prior art date
Application number
YU4188A
Other languages
English (en)
Serbian (sr)
Other versions
YU4188A (en
Inventor
J.J.V. Brange
K. Norris
M.T. Hansen
Original Assignee
Novo Nordisk A/S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK395685A external-priority patent/DK395685D0/da
Priority claimed from DK467785A external-priority patent/DK467785D0/da
Application filed by Novo Nordisk A/S. filed Critical Novo Nordisk A/S.
Publication of YU4188A publication Critical patent/YU4188A/xx
Publication of YU46857B publication Critical patent/YU46857B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

POSTUPAK ZA DOBIJANJE NOVIH ANALOGA INSULINA, naznačen time, što imaju opštu formulu I u kojoj su sa X obeleženi ostaci amino-kiselina ljudskog insulina ili isti ili drukčiji ostaci supstituišućih amino-kiselina, čiste korisne funkcije, koji molekulu daju istu naboj ili veći negativni naboj pri neutralnom pH nego ljudski insulin, pod uslovom da se najmanje jedan X razlikuje od ostataka amino-kiselina ljudskog insulina na odgovarajućem mestu u molekulu insulina i da se onda kada je X na mestu A(8) His ili Phe, X na mestu A(21) Asp, X na mestu B(5) Ala, X na mestu B(9) Leu, X na mestu B(10) Asn ili Leu, X na mestu B(12) Asn ili S na mestu B(26) Ala, najmanje jedan od preostalih X razlikuje od ostataka amino-kiselina ljudskog insulina na odgovarajućem mestu u molekulu insulina, a takodje i pod uslovom da se jedan ili više ostataka amino-kiselina može ukloniti sa N- i/ili C-završetaka A- i/ili B-lanca. Prijava sadrži još 9 zavisnih zahteva.
YU4188A 1985-08-30 1988-01-11 Postupak za dobijanje novih analoga insulina YU46857B (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK395685A DK395685D0 (da) 1985-08-30 1985-08-30 Peptider
DK467785A DK467785D0 (da) 1985-10-14 1985-10-14 Peptider

Publications (2)

Publication Number Publication Date
YU4188A YU4188A (en) 1990-06-30
YU46857B true YU46857B (sh) 1994-06-24

Family

ID=26067291

Family Applications (2)

Application Number Title Priority Date Filing Date
YU148486A YU46023B (sh) 1985-08-30 1986-08-26 Postupak za dobijanje novih analoga insulina
YU4188A YU46857B (sh) 1985-08-30 1988-01-11 Postupak za dobijanje novih analoga insulina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
YU148486A YU46023B (sh) 1985-08-30 1986-08-26 Postupak za dobijanje novih analoga insulina

Country Status (25)

Country Link
US (1) US5618913A (sh)
EP (1) EP0214826B1 (sh)
JP (1) JP2662390B2 (sh)
KR (1) KR940000756B1 (sh)
CN (1) CN1029977C (sh)
AR (1) AR241801A1 (sh)
AT (1) ATE113061T1 (sh)
AU (1) AU593274B2 (sh)
CA (1) CA1306212C (sh)
CS (1) CS275613B6 (sh)
DD (1) DD268976A5 (sh)
DE (2) DE10075008I2 (sh)
ES (1) ES2001624A6 (sh)
FI (1) FI102182B1 (sh)
GR (1) GR862233B (sh)
HU (1) HU206518B (sh)
IE (1) IE66138B1 (sh)
IL (1) IL79887A (sh)
LU (1) LU90484I2 (sh)
NL (1) NL990042I2 (sh)
NO (2) NO177009C (sh)
NZ (1) NZ217406A (sh)
PH (1) PH25772A (sh)
PT (1) PT83278B (sh)
YU (2) YU46023B (sh)

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