ATE120762T1 - Hepatospezifische insulin-analoga. - Google Patents

Hepatospezifische insulin-analoga.

Info

Publication number
ATE120762T1
ATE120762T1 AT90908000T AT90908000T ATE120762T1 AT E120762 T1 ATE120762 T1 AT E120762T1 AT 90908000 T AT90908000 T AT 90908000T AT 90908000 T AT90908000 T AT 90908000T AT E120762 T1 ATE120762 T1 AT E120762T1
Authority
AT
Austria
Prior art keywords
hepato
insulin analogue
specific insulin
insulin analogues
hepatospecific
Prior art date
Application number
AT90908000T
Other languages
English (en)
Inventor
Panayotis G Katsoyannis
Original Assignee
Sinai School Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sinai School Medicine filed Critical Sinai School Medicine
Application granted granted Critical
Publication of ATE120762T1 publication Critical patent/ATE120762T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
AT90908000T 1989-04-20 1990-04-17 Hepatospezifische insulin-analoga. ATE120762T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34092989A 1989-04-20 1989-04-20

Publications (1)

Publication Number Publication Date
ATE120762T1 true ATE120762T1 (de) 1995-04-15

Family

ID=23335524

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90908000T ATE120762T1 (de) 1989-04-20 1990-04-17 Hepatospezifische insulin-analoga.

Country Status (15)

Country Link
EP (1) EP0469084B1 (de)
JP (1) JPH04504858A (de)
AT (1) ATE120762T1 (de)
AU (1) AU631868B2 (de)
CA (1) CA2014896A1 (de)
DE (1) DE69018461T2 (de)
FI (1) FI914898A0 (de)
GR (1) GR1000908B (de)
HU (1) HU210142B (de)
IE (1) IE67353B1 (de)
IL (1) IL94163A (de)
NO (1) NO301544B1 (de)
PT (1) PT93832B (de)
WO (1) WO1990012814A1 (de)
ZA (1) ZA902965B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK158390D0 (da) * 1990-07-02 1990-07-02 Novo Nordisk As Nye peptider
DK33591D0 (de) * 1991-02-27 1991-02-27 Novo Nordisk As
US5268453A (en) * 1991-08-08 1993-12-07 Scios Inc. Tissue-selective insulin analogs
GB9316895D0 (en) * 1993-08-13 1993-09-29 Guy S And St Thomas Hospitals Hepatoselective insulin analogues
US5873358A (en) * 1993-01-29 1999-02-23 Aradigm Corporation Method of maintaining a diabetic patient's blood glucose level in a desired range
US5888477A (en) * 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
US5970973A (en) * 1993-01-29 1999-10-26 Aradigm Corporation Method of delivering insulin lispro
US5915378A (en) * 1993-01-29 1999-06-29 Aradigm Corporation Creating an aerosolized formulation of insulin
US6131567A (en) * 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
US5743250A (en) 1993-01-29 1998-04-28 Aradigm Corporation Insulin delivery enhanced by coached breathing
US6024090A (en) * 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
TW404844B (en) * 1993-04-08 2000-09-11 Oxford Biosciences Ltd Needleless syringe
US6342225B1 (en) 1993-08-13 2002-01-29 Deutshces Wollforschungsinstitut Pharmaceutical active conjugates
US6933272B1 (en) 1998-09-22 2005-08-23 Erik Helmerhorst Use of non-peptidyl compounds for the treatment of insulin related ailments
AUPP609198A0 (en) * 1998-09-22 1998-10-15 Curtin University Of Technology Use of non-peptidyl compounds for the treatment of insulin related ailments
KR100679878B1 (ko) * 1999-04-26 2007-02-07 아지노모토 가부시키가이샤 멜라노사이트-자극 호르몬 억제제
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
ATE433995T1 (de) * 2004-08-18 2009-07-15 Kaneka Corp Zur bindung an insulinbindendes protein fähiges peptid und adsorbens
CN102660614A (zh) 2005-08-16 2012-09-12 诺沃-诺迪斯克有限公司 制备成熟胰岛素多肽的方法
JP5864834B2 (ja) 2006-09-22 2016-02-17 ノボ・ノルデイスク・エー／エス プロテアーゼ耐性のインスリンアナログ
WO2008037735A1 (en) 2006-09-27 2008-04-03 Novo Nordisk A/S Method for making maturated insulin polypeptides
CA2713348C (en) 2008-01-30 2018-10-09 Indiana University Research And Technology Corporation Ester-based peptide prodrugs
JP5762001B2 (ja) 2008-03-14 2015-08-12 ノボ・ノルデイスク・エー／エス プロテアーゼ安定化インスリンアナログ
PT2254906T (pt) 2008-03-18 2017-01-03 Novo Nordisk As Análogos de insulina acilados, estabilizados contra proteases
US20110294729A1 (en) * 2008-12-09 2011-12-01 Novo Nordisk A/S Novel Insulin Analogues
US8481485B2 (en) 2008-12-19 2013-07-09 Indiana University Research And Technology Corporation Insulin analogs
AU2009335715B2 (en) * 2008-12-19 2016-09-15 Indiana University Research And Technology Corporation Amide-based insulin prodrugs
US8940860B2 (en) 2010-06-16 2015-01-27 Indiana University Research And Technology Corporation Single-chain insulin agonists exhibiting high activity at the insulin receptor
WO2011163462A2 (en) 2010-06-24 2011-12-29 Indiana University Research And Technology Corporation Amide-based insulin prodrugs
EP2793932B1 (de) 2011-12-20 2018-10-03 Indiana University Research and Technology Corporation Insulinanaloga auf ctp-basis zur behandlung von diabetes
CA2886228A1 (en) 2012-09-26 2014-04-03 Indiana University Research And Technology Corporation Insulin analog dimers
EP2970124B1 (de) 2013-03-14 2019-05-22 The Board of Trustees of the Leland Stanford Junior University Mitochondriale aldehyd-dehydrogenase-2-modulatoren und verfahren zur verwendung davon
CA2904332A1 (en) 2013-03-14 2014-10-02 Indiana University Research And Technology Corporation Insulin-incretin conjugates
AU2014333979B2 (en) 2013-10-07 2018-02-15 Novo Nordisk A/S Novel derivative of an insulin analogue
ES2947409T3 (es) 2014-09-24 2023-08-08 Univ Indiana Res & Tech Corp Profármacos de insulina a base de amida lipídica
EP3206710B1 (de) 2014-09-24 2020-05-06 Indiana University Research & Technology Corporation Inkretininsulinkonjugate
CN110087674B (zh) 2016-12-16 2023-01-03 诺和诺德股份有限公司 含胰岛素的药物组合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation

Also Published As

Publication number Publication date
IE67353B1 (en) 1996-03-20
ZA902965B (en) 1991-02-27
CA2014896A1 (en) 1990-10-20
HUT59941A (en) 1992-07-28
FI914898A0 (fi) 1991-10-17
PT93832A (pt) 1990-11-20
IE901404L (en) 1990-10-20
AU5541590A (en) 1990-11-16
AU631868B2 (en) 1992-12-10
HU903398D0 (en) 1991-12-30
WO1990012814A1 (en) 1990-11-01
EP0469084A1 (de) 1992-02-05
PT93832B (pt) 1996-09-30
HU210142B (en) 1995-02-28
GR900100290A (en) 1991-09-27
EP0469084B1 (de) 1995-04-05
IL94163A (en) 1995-08-31
NO914085D0 (no) 1991-10-17
NO301544B1 (no) 1997-11-10
DE69018461T2 (de) 1995-08-03
GR1000908B (el) 1993-03-16
JPH04504858A (ja) 1992-08-27
NO914085L (no) 1991-11-28
DE69018461D1 (de) 1995-05-11
IL94163A0 (en) 1991-01-31

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties