KR890700673A - 돼지 성장호르몬 아날로그 - Google Patents

돼지 성장호르몬 아날로그

Info

Publication number
KR890700673A
KR890700673A KR1019880701465A KR880701465A KR890700673A KR 890700673 A KR890700673 A KR 890700673A KR 1019880701465 A KR1019880701465 A KR 1019880701465A KR 880701465 A KR880701465 A KR 880701465A KR 890700673 A KR890700673 A KR 890700673A
Authority
KR
South Korea
Prior art keywords
ala
growth hormone
glu
pig growth
met
Prior art date
Application number
KR1019880701465A
Other languages
English (en)
Other versions
KR970009158B1 (ko
Inventor
엠.소우자 로오렌스
Original Assignee
원본 미기재
암젠 인코포레이티드
스미스클라인 벡크만 코퍼레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 원본 미기재, 암젠 인코포레이티드, 스미스클라인 벡크만 코퍼레이션 filed Critical 원본 미기재
Publication of KR890700673A publication Critical patent/KR890700673A/ko
Application granted granted Critical
Publication of KR970009158B1 publication Critical patent/KR970009158B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

내용 없음.

Description

돼지 성장호르몬 아날로그
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 pBR322-Trp-pGH 플라스미드 제조에 대한 설명도.

Claims (15)

  1. 다음과 같은 아미노산 사슬을 포함하고 있는 돼지 성장호르몬 아날로그로서
    Z - pGH1-31-(X)n-pGH39-191
    n:0 또는 1 z:수소, MET, ALA 또는 MET-ALA X:-GLU-ARG-ALA-TYR-ILE-PRO-GLU-여기서 아미노산 잔기의 하나이상이 제거되고 상대형질로 변환된 돼지 성장호르몬 아날로그.
  2. 제1항에 있어서, n이 0인 돼지 성장호르몬 아날로그.
  3. 제2항에 있어서, Z가 ALA 또는 MET-ALA인 돼지 성장호르몬 아날로그.
  4. 제3항에 있어서, Z가 ALA인 돼지 성장호르몬 아날로그.
  5. 제1항에 있어서, n이 l이고, X가 -GLU-ARG-THR-GLU-; THR-TYR-ILE-PRO-: -GLU-ARG-THR-TYR-ILE--GLU: 또는 -GLU-THR-TYR-ILE-PRO-GLU인 돼지 성장호르몬 아날로그.
  6. 제5항에 있어서, Z가 ALA 또는 MET-ALA인 돼지 성장호르몬 아날로그.
  7. 제6항에 있어서, Z가 ALA인 돼지 성장호르몬 아날로그.
  8. 다음과 같은 식으로서 표현되는 돼지 성장호르몬을 암호화하는 사슬을 포함하고 있는 DNA 사슬로서
    Z-pGH1-31-(X)n-pGH39-191
    n:0 또는 1 z:수소, MET, ALA 또는 MET-ALA X:-GLU-ARG-ALA-TYR-ILE-PRO-
    GLU-를 포함하고 있는 아미노산 잔기로 이루어진 펩티드 여기서 아미노산의 하나이상이 제거되고 상대형질변환된 DNA사슬.
  9. 제8항에 있어서, DNA 사슬을 발현하는 전이된 모든 배양체에 있어서의 발현 운반체.
  10. 다음과 같은 아미노산 사슬에 의해 발현된 돼지 성장호르몬을 포함하고 있는 조성물로서
    Z - pGH1-31-(X)n-pGH39-191
    n:0 또는 1 z:수소, MET, ALA, 또는 MET-ALA X:-GLU-ARG-ALA-TYR- ILE-PRO-GLU-를 포함하고 있는 아미노산 잔기로 이루어진 펩티드 여기서 아미노산의 하나이상이 제거되고 상대형질 변환되고. 돼지로부터 발생되는 다른 단백질에 대해 영향을 받지 않는 조성물.
  11. 제1항의 돼지 성장호르몬 아날로그의 효과적인 투여를 실시한 동물에 있어서의 성장촉진에 대한 방법.
  12. 다음과 같은 아미노산 사슬을 포함하고 있는 돼지 성장호르몬 아날로그로서
    (Met)n- ALa-pGH3-190
    n:O 또는l이고 상대형질 변환된 돼지 성장호르몬 아날로그.
  13. 제12항에 있어서, m이 0인 돼지 성장호르몬 아날로그.
  14. 돼지의 다른 단백질로부터 자유로운 제12항의 돼지 성장호르몬 아날로그를 포함하고 있는 조성물.
  15. 제12항의 돼지 성장호르몬의 효과적인 투여량을 투여한 동물에 있어서 성장촉진에 대한 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880701465A 1987-03-12 1988-03-07 돼지 성장호르몬 동족체 KR970009158B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US024,837 1987-03-12
US07/024,837 US5104806A (en) 1987-03-12 1987-03-12 Porcine growth hormone analogs encoding dna
US024837 1987-03-12
PCT/US1988/000700 WO1988007091A1 (en) 1987-03-12 1988-03-07 Porcine growth hormone analogs

Publications (2)

Publication Number Publication Date
KR890700673A true KR890700673A (ko) 1989-04-26
KR970009158B1 KR970009158B1 (ko) 1997-06-07

Family

ID=21822658

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019880701465A KR970009158B1 (ko) 1987-03-12 1988-03-07 돼지 성장호르몬 동족체
KR1019970701872A KR970009159B1 (ko) 1987-03-12 1997-03-18 돼지 성장호르몬 동족체를 암호화하는 디엔에이

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019970701872A KR970009159B1 (ko) 1987-03-12 1997-03-18 돼지 성장호르몬 동족체를 암호화하는 디엔에이

Country Status (14)

Country Link
US (2) US5104806A (ko)
EP (1) EP0282319B1 (ko)
JP (1) JP2619036B2 (ko)
KR (2) KR970009158B1 (ko)
CN (1) CN1033759C (ko)
AT (1) ATE94903T1 (ko)
AU (1) AU614956B2 (ko)
CA (1) CA1277933C (ko)
DE (1) DE3884241T2 (ko)
ES (1) ES2059504T3 (ko)
MY (1) MY103229A (ko)
PH (1) PH23502A (ko)
WO (1) WO1988007091A1 (ko)
ZA (1) ZA881751B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104806A (en) * 1987-03-12 1992-04-14 Amgen, Inc. Porcine growth hormone analogs encoding dna
AU634517B2 (en) * 1989-01-19 1993-02-25 Pharmacia & Upjohn Company Somatotropin analogs
US5338836A (en) * 1992-07-29 1994-08-16 American Cyanamid Company Biologically active porcine somatotropin polypeptides and methods of using the same
DE4303744A1 (de) * 1993-02-09 1994-08-11 Univ Autonoma De Nuevo Leon Mo Hundewachstumshormon
CN101665788B (zh) * 2009-09-21 2011-11-09 山西大学 人工合成猪生长激素基因及其表达纯化方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0103395A3 (en) * 1982-08-17 1985-05-22 Biogen N.V. Dna sequences, recombinant dna molecules and processes for producing bovine growth hormone-like polypeptides in high yield
CA1341012C (en) * 1982-09-27 2000-06-06 Biogen, Inc. Dna sequences, recombinant dna molecules and processes for producing swine growth hormone-like polypeptides
AU2092983A (en) * 1982-11-08 1984-05-17 Genentech Inc. Porcine growth hormone produced by recombinant dna technology
US4699897A (en) * 1983-06-04 1987-10-13 Amgen Biologically active peptides structurally related to regions within growth hormones
US4558033A (en) * 1983-06-06 1985-12-10 Amgen Potentiation of the effects of insulin by peptides
US5134120A (en) * 1984-08-03 1992-07-28 Cornell Research Foundation, Inc. Use of growth hormone to enhance porcine weight gain
US4861868A (en) * 1985-02-22 1989-08-29 Monsanto Company Production of proteins in procaryotes
US5037806A (en) * 1985-02-22 1991-08-06 Monsanto Company Biologically active method using somatotropins
US4670249A (en) * 1985-04-12 1987-06-02 International Minerals & Chemical Corp. Growth-promoting compositions
EP0206783A3 (en) * 1985-06-20 1988-10-05 The Salk Institute Biotechnology Industrial Associates, Inc. Expression and secretion of polypeptides from saccharomyces cerevisiae
US4765980A (en) * 1986-04-28 1988-08-23 International Minerals & Chemical Corp. Stabilized porcine growth hormone
US4792546A (en) * 1986-12-05 1988-12-20 American Cyanamid Company Method for increasing weight gains and reducing deposition of fat in animals
GB8701848D0 (en) * 1987-01-28 1987-03-04 Celltech Ltd Polypeptides
JP2580303B2 (ja) * 1987-02-19 1997-02-12 ジ・アップジョン・カンパニー 異種蛋白をコ−ド付けするｃＤＮＡ類、発現ベクタ−類および宿主類
US5104806A (en) * 1987-03-12 1992-04-14 Amgen, Inc. Porcine growth hormone analogs encoding dna

Also Published As

Publication number Publication date
CN1033759C (zh) 1997-01-08
JPH01502480A (ja) 1989-08-31
PH23502A (en) 1989-08-16
US5104806A (en) 1992-04-14
CA1277933C (en) 1990-12-18
JP2619036B2 (ja) 1997-06-11
CN88102023A (zh) 1988-11-02
AU1496988A (en) 1988-10-10
ZA881751B (en) 1988-09-01
US5356877A (en) 1994-10-18
KR970009158B1 (ko) 1997-06-07
DE3884241T2 (de) 1994-01-13
EP0282319B1 (en) 1993-09-22
EP0282319A3 (en) 1989-05-31
AU614956B2 (en) 1991-09-19
WO1988007091A1 (en) 1988-09-22
DE3884241D1 (de) 1993-10-28
MY103229A (en) 1993-05-29
ATE94903T1 (de) 1993-10-15
KR970009159B1 (ko) 1997-06-07
ES2059504T3 (es) 1994-11-16
EP0282319A2 (en) 1988-09-14

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