BRPI0823004B8 - processo para preparação de compostos de insulina - Google Patents

processo para preparação de compostos de insulina

Info

Publication number
BRPI0823004B8
BRPI0823004B8 BRPI0823004A BRPI0823004A BRPI0823004B8 BR PI0823004 B8 BRPI0823004 B8 BR PI0823004B8 BR PI0823004 A BRPI0823004 A BR PI0823004A BR PI0823004 A BRPI0823004 A BR PI0823004A BR PI0823004 B8 BRPI0823004 B8 BR PI0823004B8
Authority
BR
Brazil
Prior art keywords
insulin compounds
preparing insulin
products
preparing
reaction
Prior art date
Application number
BRPI0823004A
Other languages
English (en)
Inventor
Partha Hazra
Harish Iyer
Kedarnath Nanjund Sastry
Srikanth Golarahosahalli Sathyanarayana
Manjunath Hadavanahalli Shivarudraiah
Suma Sreenivas
Original Assignee
Biocon Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocon Ltd filed Critical Biocon Ltd
Publication of BRPI0823004A2 publication Critical patent/BRPI0823004A2/pt
Publication of BRPI0823004B1 publication Critical patent/BRPI0823004B1/pt
Publication of BRPI0823004B8 publication Critical patent/BRPI0823004B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

processo para preparação de compostos de insulina. a presente invenção se relaciona à preparação de compostos de insulina incluindo seus análogos ou derivados de suas formas precursoras correspondentes por uma reação enzimática de uma etapa envolvendo o uso combinatório e concorrente de quantidades ótimas de tripsina e carboxipeptidase b que trabalham de forma sinérgica direcionando a reação de forma controlada para evitar a produção de subprodutos aleatórios indesejáveis. particu-larmente, as reações de conversão enzimática da invenção oferecem vantagens de redução no número de etapas operacionais, maior rendimento e pureza dos produtos finais desejados.
BRPI0823004A 2008-08-07 2008-09-19 processo para preparação de compostos de insulina BRPI0823004B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1904CH2008 2008-08-07
IN01904/CHE/2008 2008-08-07
PCT/IN2008/000598 WO2010016069A1 (en) 2008-08-07 2008-09-19 A process for preparation of insulin compounds

Publications (3)

Publication Number Publication Date
BRPI0823004A2 BRPI0823004A2 (pt) 2012-05-29
BRPI0823004B1 BRPI0823004B1 (pt) 2021-03-30
BRPI0823004B8 true BRPI0823004B8 (pt) 2021-05-25

Family

ID=41663319

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0823004A BRPI0823004B8 (pt) 2008-08-07 2008-09-19 processo para preparação de compostos de insulina

Country Status (15)

Country Link
US (1) US9090705B2 (pt)
EP (1) EP2307441B1 (pt)
JP (2) JP5903269B2 (pt)
KR (1) KR20110059602A (pt)
CN (1) CN102159588B (pt)
BR (1) BRPI0823004B8 (pt)
DK (1) DK2307441T3 (pt)
ES (1) ES2570937T3 (pt)
HK (1) HK1156046A1 (pt)
IL (1) IL211053A (pt)
MX (1) MX2011001408A (pt)
MY (1) MY188456A (pt)
PL (1) PL2307441T3 (pt)
RU (1) RU2458989C1 (pt)
WO (1) WO2010016069A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2515061C1 (ru) * 2013-04-29 2014-05-10 Общество с ограниченной ответственностью "БиоКлонТек" РЕКОМБИНАТНАЯ ПЛАЗМИДНАЯ ДНК рНI03 КОДИРУЮЩАЯ, ГИБРИДНЫЙ БЕЛОК С ПРОИНСУЛИНОМ ЧЕЛОВЕКА, КЛЕТКА Escherichia coli, ТРАНСФОРМИРОВАННАЯ РЕКОМБИНАНТНОЙ ПЛАЗМИДНОЙ ДНК рНI03, И ШТАММ БАКТЕРИЙ Escherichia coli JM109/pHI03-ПРОДУЦЕНТ ГИБРИДНОГО БЕЛКА-ПРЕДШЕСТВЕННИКА ИНСУЛИНА ЧЕЛОВЕКА
RU2514480C1 (ru) * 2013-04-29 2014-04-27 Общество с ограниченной ответственностью "БиоКлонТек" РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pHILP07, КОДИРУЮЩАЯ ГИБРИДНЫЙ БЕЛОК С ПРОИНСУЛИНОМ Lispro ЧЕЛОВЕКА, КЛЕТКА Escherichia coli, ТРАНСФОРМИРОВАННАЯ РЕКОМБИНАНТНОЙ ПЛАЗМИДНОЙ ДНК pHILP07, И ШТАММ БАКТЕРИЙ Escherichia coli JM109/pHILP07-ПРОДУЦЕНТ ГИБРИДНОГО БЕЛКА С ПРОИНСУЛИНОМ Lispro ЧЕЛОВЕКА
RU2514578C1 (ru) * 2013-04-29 2014-04-27 Общество с ограниченной ответственностью "БиоКлонТек" РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pHIASP03, КОДИРУЮЩАЯ ГИБРИДНЫЙ БЕЛОК С ПРОИНСУЛИНОМ Aspart ЧЕЛОВЕКА, КЛЕТКА Escherichia coli, ТРАНСФОРМИРОВАННАЯ РЕКОМБИНАНТНОЙ ПЛАЗМИДНОЙ ДНК pHIAsp03, И ШТАММ БАКТЕРИЙ Escherichia coli JM109/pHIAsp03-ПРОДУЦЕНТ ГИБРИДНОГО БЕЛКА С ПРОИНСУЛИНОМ Aspart ЧЕЛОВЕКА
US20180291077A1 (en) * 2015-09-24 2018-10-11 Hanmi Pharm. Co., Ltd Method of insulin production
CN109843904A (zh) * 2016-10-17 2019-06-04 恩泽生物科学有限公司 用于降低治疗性蛋白的异质性的连续方法
CN108164594B (zh) * 2017-12-08 2020-03-31 珠海冀百康生物科技有限公司 一种去b链30位氨基酸残基的胰岛素前体沉淀的回收方法
CN112105635A (zh) * 2018-06-18 2020-12-18 联合化学实验室有限公司 用于重组蛋白的更高表达的前导序列
KR20200080747A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 인슐린 전구체의 인슐린 효소 전환용 조성물 및 이를 이용하여 인슐린 전구체를 인슐린으로 전환하는 방법
RU2729737C1 (ru) * 2019-05-24 2020-08-11 Закрытое акционерное общество "ФАРМ-ХОЛДИНГ" РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pF882, КОДИРУЮЩАЯ ГИБРИДНЫЙ ПОЛИПЕПТИД, СОДЕРЖАЩИЙ В30-ДЕЗТРЕОНИН-ИНСУЛИН, И ШТАММ БАКТЕРИЙ Escherichia coli - ПРОДУЦЕНТ ГИБРИДНОГО ПОЛИПЕПТИДА, СОДЕРЖАЩЕГО В30-ДЕЗТРЕОНИН-ИНСУЛИН
CN114805544B (zh) * 2022-06-23 2022-09-09 北京惠之衡生物科技有限公司 一种赖脯胰岛素前体、其重组基因工程菌及其构建方法

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US2819999A (en) * 1953-11-13 1958-01-14 Novo Terapeutisk Labor As Process for crystallization of insulin using freeze dried insulin as seeding material
US3069323A (en) 1959-09-14 1962-12-18 Armour Pharma Insulin recovery process
DE3209184A1 (de) 1982-03-13 1983-09-15 Hoechst Ag, 6230 Frankfurt Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
DE3440988A1 (de) 1984-11-09 1986-07-10 Hoechst Ag, 6230 Frankfurt Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung
DK347086D0 (da) 1986-07-21 1986-07-21 Novo Industri As Novel peptides
DK129385A (da) 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
IL84110A (en) * 1986-10-14 1992-11-15 Lilly Co Eli Process for transforming a human insulin precursor to a human insulin
JP2606915B2 (ja) 1987-02-25 1997-05-07 ノボ ノルディスク アクティーゼルスカブ 新規インシュリン誘導体
ES2061797T3 (es) 1988-06-23 1994-12-16 Hoechst Ag Mini-proinsulina, su preparacion y empleo.
ATE132531T1 (de) 1988-11-03 1996-01-15 Hoechst Ag Verfahren zur herstellung eines insulin- vorprodukts in streptomyceten
AU682061B2 (en) 1993-09-17 1997-09-18 Novo Nordisk A/S Acylated insulin
US6011007A (en) 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
US6001604A (en) * 1993-12-29 1999-12-14 Bio-Technology General Corp. Refolding of proinsulins without addition of reducing agents
AU2003236201A1 (en) * 2002-05-07 2003-11-11 Novo Nordisk A/S Soluble formulations comprising monomeric insulin and acylated insulin
WO2004044206A1 (en) 2002-11-12 2004-05-27 Ckd Bio Corp. Plasmids expressing human insulin and the preparation method for human insuling thereby
CN101291952B (zh) * 2005-10-13 2016-02-03 拜奥康有限公司 制备胰岛素缀合物的方法
AR072563A1 (es) * 2009-07-15 2010-09-08 Beta Lab Sa Un procedimiento para obtener insulina aspartica que utiliza una cepa de levaduras de pichia pastoris

Also Published As

Publication number Publication date
ES2570937T3 (es) 2016-05-23
RU2458989C1 (ru) 2012-08-20
HK1156046A1 (zh) 2012-06-01
KR20110059602A (ko) 2011-06-02
BRPI0823004B1 (pt) 2021-03-30
IL211053A (en) 2016-08-31
EP2307441A4 (en) 2012-08-22
BRPI0823004A2 (pt) 2012-05-29
CN102159588B (zh) 2015-09-02
CN102159588A (zh) 2011-08-17
JP5909478B2 (ja) 2016-04-26
EP2307441A1 (en) 2011-04-13
MY188456A (en) 2021-12-10
MX2011001408A (es) 2011-05-02
IL211053A0 (en) 2011-04-28
EP2307441B1 (en) 2016-03-23
US20110159538A1 (en) 2011-06-30
US9090705B2 (en) 2015-07-28
WO2010016069A1 (en) 2010-02-11
DK2307441T3 (da) 2016-05-23
PL2307441T3 (pl) 2016-09-30
JP5903269B2 (ja) 2016-04-13
WO2010016069A9 (en) 2011-08-11
JP2014050402A (ja) 2014-03-20
JP2011530501A (ja) 2011-12-22

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