BR112012026205A2 - processo para produção enzimática de um produto de fosfinotricina ou um precursor do mesmo - Google Patents

processo para produção enzimática de um produto de fosfinotricina ou um precursor do mesmo

Info

Publication number
BR112012026205A2
BR112012026205A2 BR112012026205A BR112012026205A BR112012026205A2 BR 112012026205 A2 BR112012026205 A2 BR 112012026205A2 BR 112012026205 A BR112012026205 A BR 112012026205A BR 112012026205 A BR112012026205 A BR 112012026205A BR 112012026205 A2 BR112012026205 A2 BR 112012026205A2
Authority
BR
Brazil
Prior art keywords
precursor
enzymatic production
phosphinothricin product
phosphinothricin
product
Prior art date
Application number
BR112012026205A
Other languages
English (en)
Inventor
Alan Grubbs
Bennett C Borer
Kim F Albizati
Spiros Kambourakis
Original Assignee
Strategic Enzyme Applic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Strategic Enzyme Applic Inc filed Critical Strategic Enzyme Applic Inc
Publication of BR112012026205A2 publication Critical patent/BR112012026205A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32—Esters thereof
    • C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/36—Amides thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/002—Nitriles (-CN)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/05—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in nitriles (3.5.5)
    • C12Y305/05001—Nitrilase (3.5.5.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

processo para produção enzimática de um produto de fosfinotricina ou um precursor do mesmo. a presente invenção refere-se de um modo geral a processos para a produção enzimática de um produto fosfinotricina ou um precursor do mesmo a partir de um substrato contendo nitrila.
BR112012026205A 2010-04-14 2010-04-14 processo para produção enzimática de um produto de fosfinotricina ou um precursor do mesmo BR112012026205A2 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2010/031007 WO2011129820A1 (en) 2010-04-14 2010-04-14 Process for producing phosphinothricin employing nitrilases

Publications (1)

Publication Number Publication Date
BR112012026205A2 true BR112012026205A2 (pt) 2015-11-03

Family

ID=43383593

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012026205A BR112012026205A2 (pt) 2010-04-14 2010-04-14 processo para produção enzimática de um produto de fosfinotricina ou um precursor do mesmo

Country Status (4)

Country Link
US (3) US8981142B2 (pt)
BR (1) BR112012026205A2 (pt)
CA (1) CA2796158C (pt)
WO (1) WO2011129820A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2796158C (en) 2010-04-14 2022-06-14 Strategic Enzyme Applications, Inc. Process for producing phosphinothricin employing nitrilases
CN103827127B (zh) * 2011-09-30 2016-02-03 明治制果药业株式会社 草铵膦p游离酸的制造方法
CU20160168A7 (es) * 2014-05-13 2017-06-05 Bayer Cropscience Ag Proceso para preparar cianhidrinas que contienen fósforo
CN105567780A (zh) * 2016-01-14 2016-05-11 重庆惠健生物科技有限公司 一种l-草铵膦的酶-化学催化去消旋化制备方法
AU2017227553B2 (en) 2016-03-02 2021-03-25 Basf Se Methods for making L-glufosinate
CN114805433B (zh) * 2021-05-13 2023-11-28 永农生物科学有限公司 不含结晶水的l-草铵膦铵盐晶体形式及固体粉末

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2717440C2 (de) 1976-05-17 1984-04-05 Hoechst Ag, 6230 Frankfurt Unkrautbekämpfung mit [(3-Amino-3-carboxy)-propyl-1]-methylphosphinsäure-Derivaten
DE3149937A1 (de) 1981-12-17 1983-06-30 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von methyldichlorphosphan
DE3508573A1 (de) 1985-03-11 1986-09-11 Hoechst Ag, 6230 Frankfurt Phosphorhaltige (alpha)-aminonitrile und verfahren zu ihrer herstellung
DE3903446A1 (de) 1989-02-06 1990-10-18 Hoechst Ag Verfahren zur enzymatischen trennung von 2-amino-4-methylphosphinobuttersaeurederivaten
US5051525A (en) 1989-02-06 1991-09-24 Hoechst Aktiengesellschaft N-acyl-2-amino acid amides containing phosphinic esters, process for their preparation, and N-acyl-2-amino acids nitriles as precursors
FR2708936B1 (fr) 1993-08-10 1995-11-10 Rhone Poulenc Chimie Enzymes à activité nitrile-hydratase, outils génétiques et micro-organismes hôtes permettant leur obtention et procédé d'hydrolyse mettant en Óoeuvre lesdites enzymes.
DE4422045A1 (de) 1994-06-26 1996-01-04 Hoechst Schering Agrevo Gmbh Verfahren zur enzymatischen Spaltung von 2-Amino-4-methylphosphinobutansäureamid-Derivaten
DE19736125A1 (de) 1997-08-20 1999-02-25 Hoechst Schering Agrevo Gmbh Verfahren zur Herstellung von Glufosinate und phosphorhaltige alpha-Aminonitrile als Zwischenprodukte
DE19919848A1 (de) 1999-04-30 2000-11-02 Aventis Cropscience Gmbh Verfahren zur Herstellung von L-Phosphinothricin durch enzymatische Transaminierung mit Aspartat
FR2829490A1 (fr) 2001-09-12 2003-03-14 Rhodia Chimie Sa Procede pour transformer un cycle epoxyde 1,2 disubstitue en son derive alpha-dicetone
JP2009511624A (ja) 2005-10-18 2009-03-19 サーントゥル ナシオナル ドゥ ラ ルシェルシュ シャーンティフィク （セ エン エール エス） 次亜リン酸誘導体及びその治療的用途
US9217164B2 (en) * 2007-03-01 2015-12-22 Basf Enzymes Llc Nitrilases, nucleic acids encoding them and methods for making and using them
US7741088B2 (en) * 2007-10-31 2010-06-22 E.I. Dupont De Nemours And Company Immobilized microbial nitrilase for production of glycolic acid
CA2796158C (en) 2010-04-14 2022-06-14 Strategic Enzyme Applications, Inc. Process for producing phosphinothricin employing nitrilases

Also Published As

Publication number Publication date
US20130204031A1 (en) 2013-08-08
US20150239917A1 (en) 2015-08-27
US9683001B2 (en) 2017-06-20
US8981142B2 (en) 2015-03-17
CA2796158A1 (en) 2011-10-20
US20170247399A1 (en) 2017-08-31
WO2011129820A9 (en) 2012-04-19
US10428092B2 (en) 2019-10-01
CA2796158C (en) 2022-06-14
WO2011129820A1 (en) 2011-10-20

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]