ATE176482T1 - Asp-b28-insulinkristalle - Google Patents
Asp-b28-insulinkristalleInfo
- Publication number
- ATE176482T1 ATE176482T1 AT94918771T AT94918771T ATE176482T1 AT E176482 T1 ATE176482 T1 AT E176482T1 AT 94918771 T AT94918771 T AT 94918771T AT 94918771 T AT94918771 T AT 94918771T AT E176482 T1 ATE176482 T1 AT E176482T1
- Authority
- AT
- Austria
- Prior art keywords
- asp
- insulin crystals
- crystals
- insulin
- protamine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK93727A DK72793D0 (da) | 1993-06-21 | 1993-06-21 | Nyt produkt |
US08/127,672 US5547930A (en) | 1993-06-21 | 1993-09-28 | AspB28 insulin crystals |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE176482T1 true ATE176482T1 (de) | 1999-02-15 |
Family
ID=26064536
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT94918771T ATE176482T1 (de) | 1993-06-21 | 1994-06-21 | Asp-b28-insulinkristalle |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0705275B1 (de) |
JP (1) | JP2837956B2 (de) |
AT (1) | ATE176482T1 (de) |
AU (1) | AU6995794A (de) |
DE (4) | DE10199011I2 (de) |
DK (1) | DK0705275T3 (de) |
ES (1) | ES2130428T3 (de) |
GR (1) | GR3030130T3 (de) |
NL (3) | NL300021I2 (de) |
WO (1) | WO1995000550A1 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK72793D0 (da) * | 1993-06-21 | 1993-06-21 | Novo Nordisk As | Nyt produkt |
US5474978A (en) * | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
AU711428B2 (en) * | 1994-06-16 | 1999-10-14 | Eli Lilly And Company | Monomeric insulin analog formulations |
US5461031A (en) * | 1994-06-16 | 1995-10-24 | Eli Lilly And Company | Monomeric insulin analog formulations |
GB2327424B (en) * | 1994-06-16 | 1999-03-31 | Lilly Co Eli | Monomeric insulin analog formulations |
US5547929A (en) * | 1994-09-12 | 1996-08-20 | Eli Lilly And Company | Insulin analog formulations |
PL189964B1 (pl) * | 1996-06-20 | 2005-10-31 | Novo Nordisk As | Wodny preparat insuliny, środek farmaceutyczny dopodawania pozajelitowego oraz sposób poprawiania chemicznej stabilności preparatów insuliny |
WO1997048413A1 (en) * | 1996-06-20 | 1997-12-24 | Novo Nordisk A/S | Insulin preparations containing carbohydrates |
US5948751A (en) * | 1996-06-20 | 1999-09-07 | Novo Nordisk A/S | X14-mannitol |
US5866538A (en) * | 1996-06-20 | 1999-02-02 | Novo Nordisk A/S | Insulin preparations containing NaCl |
BE1013507A5 (fr) * | 1996-11-22 | 2002-03-05 | Lilly Co Eli | Formulations d'analogues de l'insuline. |
EP0969860B1 (de) * | 1997-03-20 | 2002-07-17 | Novo Nordisk A/S | Verfahren zur herstellung eines therapeutischen puders durch copräzipitation von insulin und einem absorptionsverstärker |
CA2306877A1 (en) | 1997-10-24 | 1999-05-06 | Eli Lilly And Company | Insoluble insulin compositions |
CO4970787A1 (es) | 1997-12-23 | 2000-11-07 | Lilly Co Eli | Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea |
US20010007853A1 (en) * | 1998-01-08 | 2001-07-12 | Dimarchi Richard Dennis | Method for administering monomeric insulin analogs |
EP1044016B1 (de) | 1998-01-09 | 2005-03-16 | Novo Nordisk A/S | Stabilisierte insulin-zubereitungen |
DE19825447A1 (de) * | 1998-06-06 | 1999-12-09 | Hoechst Marion Roussel De Gmbh | Neue Insulinanaloga mit erhöhter Zinkbildung |
WO2003031432A1 (en) | 2001-10-12 | 2003-04-17 | Novo Nordisk A/S | Substituted piperidines and their use for the treatment of diseases related to the histamine h3 receptor |
JP2006522746A (ja) | 2003-04-11 | 2006-10-05 | ノボ ノルディスク アクティーゼルスカブ | 置換されたアミドの薬学的使用 |
KR101243648B1 (ko) | 2003-11-20 | 2013-03-14 | 노보 노르디스크 에이/에스 | 제조 및 주사 장치용에 최적인 프로필렌 글리콜 함유펩티드 제제 |
EP2386554A1 (de) | 2005-07-04 | 2011-11-16 | High Point Pharmaceuticals, LLC | Histamine H3 Rezeptor aktive Verbindungen |
EP1910317B1 (de) | 2005-07-20 | 2013-07-03 | Eli Lilly And Company | 1-amino-verbundene verbindungen |
ES2393757T3 (es) | 2005-11-17 | 2012-12-27 | Eli Lilly & Company | Antagonistas de receptor de glucagón, preparación y usos terapéuticos |
JP5312054B2 (ja) | 2006-03-15 | 2013-10-09 | ノボ・ノルデイスク・エー/エス | アミリンとインスリンの混合物 |
US8394842B2 (en) | 2006-03-28 | 2013-03-12 | High Point Pharmaceuticals, Llc | Benzothiazoles having histamine H3 receptor activity |
DK2049475T3 (da) | 2006-04-24 | 2012-03-05 | Lilly Co Eli | Cyclohexyl-substituerede pyrrolidinoner som inhibitorer af 11-beta-hydroxysteroid dehydrogenase1 |
EP2079732B9 (de) | 2006-05-29 | 2012-03-21 | High Point Pharmaceuticals, LLC | 3-(1,3-benyodioxol-5-yl)-6- (4-cyclopropylpiperazin-1-yl)-pyridazin, dessen salze und solvate und dessen verwendung als histamin-h3-rezeptorantagonist |
WO2008145728A1 (en) | 2007-06-01 | 2008-12-04 | Novo Nordisk A/S | Spontaneously dispersible preconcentrates including a peptide drug in a solid or semisolid carrier |
BRPI0812354A2 (pt) | 2007-06-01 | 2015-01-27 | Novo Nordisk As | Composição farmacêutica não-aquosa. |
MX344293B (es) | 2008-10-17 | 2016-12-13 | Sanofi Aventis Deutschland | Combinacion de una insulina y un agonista de glp-1. |
EA020496B1 (ru) | 2008-11-21 | 2014-11-28 | ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Производное адамантилбензамида, фармацевтическая композиция, включающая его, и его применение |
BR112012011403B8 (pt) | 2009-11-13 | 2021-05-25 | Sanofi Aventis Deutschland | composição farmacêutica líquida compreendendo um agonista glp-1 e metionina e uso da mesma |
PT2498802E (pt) | 2009-11-13 | 2015-04-13 | Sanofi Aventis Deutschland | Composição farmacêutica que compreende um agonista de glp-1, uma insulina e metionina |
RU2546520C2 (ru) | 2010-08-30 | 2015-04-10 | Санофи-Авентис Дойчланд Гмбх | Применение ave0010 для производства лекарственного средства для лечения сахарного диабета 2 типа |
EP2670368A4 (de) | 2011-02-03 | 2015-04-15 | Pharmedica Ltd | Neue im mund zersetzbare filme zur insulinverabreichung zwecks behandlung von diabetes |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
US9408893B2 (en) | 2011-08-29 | 2016-08-09 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for use in glycemic control in diabetes type 2 patients |
TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
TWI641381B (zh) | 2013-02-04 | 2018-11-21 | 法商賽諾菲公司 | 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物 |
CN105899190B (zh) * | 2014-01-09 | 2022-06-14 | 赛诺菲 | 门冬胰岛素的稳定化药物制剂 |
WO2015104314A1 (en) | 2014-01-09 | 2015-07-16 | Sanofi | Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives |
JP2020143105A (ja) * | 2014-01-09 | 2020-09-10 | サノフイSanofi | インスリンアスパルトの安定化された医薬製剤 |
SG11201604708VA (en) | 2014-01-09 | 2016-07-28 | Sanofi Sa | Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives |
LT3229828T (lt) | 2014-12-12 | 2023-06-12 | Sanofi-Aventis Deutschland Gmbh | Insulino glargino/liksisenatido fiksuoto santykio kompozicija |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
WO2017163159A1 (en) * | 2016-03-21 | 2017-09-28 | Wockhardt Limited | Biphasic pharmaceutical composition of insulin human |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3327709A1 (de) * | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung |
PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
-
1994
- 1994-06-21 DK DK94918771T patent/DK0705275T3/da active
- 1994-06-21 AU AU69957/94A patent/AU6995794A/en not_active Abandoned
- 1994-06-21 AT AT94918771T patent/ATE176482T1/de active
- 1994-06-21 JP JP7502347A patent/JP2837956B2/ja not_active Expired - Lifetime
- 1994-06-21 DE DE2001199011 patent/DE10199011I2/de active Active
- 1994-06-21 DE DE200612000015 patent/DE122006000015I1/de active Pending
- 1994-06-21 ES ES94918771T patent/ES2130428T3/es not_active Expired - Lifetime
- 1994-06-21 EP EP94918771A patent/EP0705275B1/de not_active Expired - Lifetime
- 1994-06-21 DE DE200612000017 patent/DE122006000017I1/de active Pending
- 1994-06-21 DE DE69416409T patent/DE69416409T2/de not_active Expired - Lifetime
- 1994-06-21 WO PCT/DK1994/000246 patent/WO1995000550A1/en active IP Right Grant
-
1999
- 1999-04-30 GR GR990401212T patent/GR3030130T3/el unknown
-
2000
- 2000-10-16 NL NL300021C patent/NL300021I2/nl unknown
-
2005
- 2005-12-02 NL NL300212C patent/NL300212I1/nl unknown
- 2005-12-02 NL NL300211C patent/NL300211I1/nl unknown
Also Published As
Publication number | Publication date |
---|---|
DE122006000017I1 (de) | 2006-06-29 |
NL300212I1 (nl) | 2006-02-01 |
DE69416409T2 (de) | 1999-09-16 |
NL300021I2 (nl) | 2006-05-01 |
DE10199011I2 (de) | 2004-10-14 |
JP2837956B2 (ja) | 1998-12-16 |
JPH08511779A (ja) | 1996-12-10 |
WO1995000550A1 (en) | 1995-01-05 |
DE10199011I1 (de) | 2001-04-12 |
ES2130428T3 (es) | 1999-07-01 |
AU6995794A (en) | 1995-01-17 |
EP0705275A1 (de) | 1996-04-10 |
DE69416409D1 (de) | 1999-03-18 |
GR3030130T3 (en) | 1999-07-30 |
EP0705275B1 (de) | 1999-02-03 |
DE122006000015I1 (de) | 2006-06-29 |
NL300211I1 (nl) | 2006-02-01 |
DK0705275T3 (da) | 1999-09-20 |
NL300021I1 (nl) | 2000-12-01 |
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