WO1999003509A3 - Pharmazeutische mittel enthaltend perfluoralkylgruppenhaltige trijodaromaten und ihre verwendung in der tumortherapie und interventionellen radiologie - Google Patents

Pharmazeutische mittel enthaltend perfluoralkylgruppenhaltige trijodaromaten und ihre verwendung in der tumortherapie und interventionellen radiologie Download PDF

Info

Publication number
WO1999003509A3
WO1999003509A3 PCT/EP1998/004130 EP9804130W WO9903509A3 WO 1999003509 A3 WO1999003509 A3 WO 1999003509A3 EP 9804130 W EP9804130 W EP 9804130W WO 9903509 A3 WO9903509 A3 WO 9903509A3
Authority
WO
WIPO (PCT)
Prior art keywords
tumours
triiodoaromats
treatment
pharmaceutical products
perfluoroalkyl groups
Prior art date
Application number
PCT/EP1998/004130
Other languages
English (en)
French (fr)
Other versions
WO1999003509A2 (de
Inventor
Johannes Platzek
Ulrich Niedballa
Michael Bauer
Wolfgang Schlecker
Hanns-Joachim Weinmann
Thomas Frenzel
Werner Krause
Original Assignee
Schering Ag
Johannes Platzek
Ulrich Niedballa
Michael Bauer
Wolfgang Schlecker
Weinmann Hanns Joachim
Thomas Frenzel
Werner Krause
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag, Johannes Platzek, Ulrich Niedballa, Michael Bauer, Wolfgang Schlecker, Weinmann Hanns Joachim, Thomas Frenzel, Werner Krause filed Critical Schering Ag
Priority to AU88555/98A priority Critical patent/AU8855598A/en
Publication of WO1999003509A2 publication Critical patent/WO1999003509A2/de
Publication of WO1999003509A3 publication Critical patent/WO1999003509A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A61K31/03—Halogenated hydrocarbons carbocyclic aromatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Die Erfindung betrifft die in den Patentansprüchen gekennzeichneten Gegenstände, das heißt pharmazeutische Mittel enthaltend perfluoralkylgruppenhaltige Trijodaromaten der allgemeinen Formel (I) und deren Verwendung in der Tumortherapie und interventionellen Radiologie. Die Verbindungen der allgemeinen Formel (I) können vorzugsweise als Kombinationspräparate zusammen mit Chemotherapeutika bei der Chemoembolisation von Tumoren Anwendung finden.
PCT/EP1998/004130 1997-07-17 1998-07-06 Pharmazeutische mittel enthaltend perfluoralkylgruppenhaltige trijodaromaten und ihre verwendung in der tumortherapie und interventionellen radiologie WO1999003509A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU88555/98A AU8855598A (en) 1997-07-17 1998-07-06 Pharmaceutical products containing triiodoaromats containing perfluoroalkyl groups, and the use thereof in the treatment of tumours and interventional radiology

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19731591.7 1997-07-17
DE1997131591 DE19731591C2 (de) 1997-07-17 1997-07-17 Pharmazeutische Mittel enthaltend perfluoralkylgruppenhaltige Trijodaromaten und ihre Verwendung in der Tumortherapie und interventionellen Radiologie

Publications (2)

Publication Number Publication Date
WO1999003509A2 WO1999003509A2 (de) 1999-01-28
WO1999003509A3 true WO1999003509A3 (de) 1999-05-14

Family

ID=7836604

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/004130 WO1999003509A2 (de) 1997-07-17 1998-07-06 Pharmazeutische mittel enthaltend perfluoralkylgruppenhaltige trijodaromaten und ihre verwendung in der tumortherapie und interventionellen radiologie

Country Status (3)

Country Link
AU (1) AU8855598A (de)
DE (1) DE19731591C2 (de)
WO (1) WO1999003509A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1088559A3 (de) * 1999-09-29 2002-10-02 INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN Galenische Formulierungen
MXPA04001049A (es) * 2001-08-03 2004-05-20 Glaxo Group Ltd Compuestos surfactantes y usos de los mismos.
CN113816868B (zh) * 2021-09-28 2023-07-21 浙江海洲制药有限公司 一种碘海醇的合成方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4285928A (en) * 1979-01-25 1981-08-25 Juro Wada Contrast composition for angiography
WO1994016742A1 (en) * 1993-01-28 1994-08-04 S.A. A.T.T.A. Applications Et Transferts De Technologies Avancees Iodine-containing fluorocarbon contrast agents
DE4341478A1 (de) * 1993-12-02 1995-06-08 Max Delbrueck Centrum Mittel zur Antitumortherapie
WO1996014878A2 (en) * 1994-11-15 1996-05-23 Molecular Biosystems, Inc. Calixarene conjugates useful as mri and ct diagnostic imaging agents
WO1999002193A2 (de) * 1997-07-11 1999-01-21 Schering Aktiengesellschaft Perfluoralkylgruppenhaltige trijodaromaten, verfahren zu deren herstellung und deren verwendung als kontrastmittel

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA935164A (en) * 1968-12-06 1973-10-09 Sumimoto Shinzaburo Industrial process for iodinating aromatic compounds by using novel iodinating reagents
CA935153A (en) * 1969-06-27 1973-10-09 Nyegaard And Co. A/S 2,4,6-triiodobenzoyl amines used as x-ray contrast agents
AR207465A1 (es) * 1974-05-31 1976-10-08 Guerbet Lab Andre Procedimiento de preparacion de derivados de acido triiodoi2,4,6-(triiodo-2,4,6-benzoil)-amino-alcanoilaminobenzoico de acido triiodo-2,4,6-(triiodo-2,4,6-(triiodo-2,4,6-benzoil)-aminoalcanoilaminobenzoil)-amino-alcanoil-aminobenzoico y de acido triiodo-2,4,6-bis((triiodo-2,4,6-fenil)-carbamoil-metil)-aminoalcanoil-aminobenzoico
CH626873A5 (de) * 1977-03-28 1981-12-15 Bracco Ind Chimica Spa
DE2909439A1 (de) * 1979-03-08 1980-09-18 Schering Ag Neue nichtionische roentgenkontrastmittel
US4284620A (en) * 1979-03-23 1981-08-18 Mallinckrodt, Inc. N-(2-Hydroxyethyl)-2,4,6-triiodo-3,5-bis-(2-keto-L-gulonamido)benzamide and radiological compositions containing same
DE2926428A1 (de) * 1979-06-28 1981-01-08 Schering Ag Trijodierte 5-aminoisophthalsaeure- derivate
DE3001293A1 (de) * 1980-01-11 1981-07-16 Schering Ag Berlin Und Bergkamen, 1000 Berlin Ionische 5-c-substitiuerte 2,4,6-trijod-isophtalsaeure-derivete
US4341756A (en) * 1980-01-31 1982-07-27 The Regents Of The University Of California Novel amino-dioxepane intermediates for the synthesis of new non-ionic contrast media
US4564555A (en) * 1982-10-27 1986-01-14 Sermatech International Incorporated Coated part, coating therefor and method of forming same
US5191119A (en) * 1983-10-20 1993-03-02 Cook Imaging Corp. Process for producing non-ionic radiographic contrast media utilizing N-allylation
DE19875047I2 (de) * 1984-02-29 2001-08-09 Koehler Chemie Dr Franz N,N-(3,5-Diacetamido-2,4,6-triiodbenzoyl)-aminoacyl-N-methylglucamide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Röntgenkontrastmittel.
US4954348A (en) * 1985-08-09 1990-09-04 Cook Imaging Corporation Non-ionic polyol contrast media from ionic contrast media
US5141739A (en) * 1986-07-03 1992-08-25 Advanced Magnetics, Inc. Delivery of x-ray contrast agents using receptor mediated endocytosis
IL94718A (en) * 1989-07-05 1994-10-21 Schering Ag Non-ionic carboxamide contrast agent and method of preparation
DE3937118A1 (de) * 1989-11-03 1991-05-08 Schering Ag Nichtionische roentgenkontrastmittel mit hohem jodgehalt
IS1685B (is) * 1990-12-11 1998-02-24 Bracco International B.V. Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum
AU3273993A (en) * 1991-12-03 1993-06-28 Mallinckrodt Medical, Inc. Nonionic x-ray contrast agents, compositions and methods
DE19510864A1 (de) * 1995-03-16 1996-09-19 Schering Ag Röntgenkontrastmittel für die Computertomographie und Urographie
DE19608278A1 (de) * 1996-02-23 1997-08-28 Schering Ag Pharmazeutische Mittel enthaltend perfluoralkylhaltige Metallkomplexe, und ihre Verwendung in der Tumortherapie und interventioniellen Radiologie

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4285928A (en) * 1979-01-25 1981-08-25 Juro Wada Contrast composition for angiography
WO1994016742A1 (en) * 1993-01-28 1994-08-04 S.A. A.T.T.A. Applications Et Transferts De Technologies Avancees Iodine-containing fluorocarbon contrast agents
DE4341478A1 (de) * 1993-12-02 1995-06-08 Max Delbrueck Centrum Mittel zur Antitumortherapie
WO1996014878A2 (en) * 1994-11-15 1996-05-23 Molecular Biosystems, Inc. Calixarene conjugates useful as mri and ct diagnostic imaging agents
WO1999002193A2 (de) * 1997-07-11 1999-01-21 Schering Aktiengesellschaft Perfluoralkylgruppenhaltige trijodaromaten, verfahren zu deren herstellung und deren verwendung als kontrastmittel

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
LOWE K.C.: "Perfluorocarbons as oxygen-transport fluids", COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY - A PHYSIOLOGY, VOL. 87, NO. 4, PAGE(S) 825-838, 1987, XP002095316 *
LOWE K: "SYNTHETIC OXYGEN TRANSPORT FLUIDS BASED ON PERFLUOROCHEMICALS APPLICATIONS IN MEDICINE AND BIOLOGY", VOX SANGUINIS, vol. 60, no. 3, 1991, pages 129 - 140, XP002095317 *
MASON RP: "Non-invasive physiology: 19F NMR of perfluorocarbons.", ARTIF CELLS BLOOD SUBSTIT IMMOBIL BIOTECHNOL, 1994, VOL. 22, NO. 4, PAGE(S) 1141-53, XP002095318 *
PENG C T: "CHAPTER 61: RADIOPAQUES", M.E. WOLFF (ED.): BURGER'S MEDICINAL CHEMISTRY, EDITION 4, PART III, 1979, J. WILEY & SONS, NEW YORK, US, pages 1139 - 1203, XP002005069 *
SAKAS D.E. ET AL: "Perfluorocarbons: Recent developments and implications for neurosurgery", JOURNAL OF NEUROSURGERY, VOL. 85, NO. 2, PAGE(S) 248-254, August 1996 (1996-08-01), XP002095315 *

Also Published As

Publication number Publication date
DE19731591A1 (de) 1999-01-21
WO1999003509A2 (de) 1999-01-28
DE19731591C2 (de) 1999-09-16
AU8855598A (en) 1999-02-10

Similar Documents

Publication Publication Date Title
GEP20043375B (en) APRIL-Receptor (BCMA) and Use Thereof
PL350658A1 (en) Medical preparations for the treatment of alpha−galactosidase a deficiency
ZA948669B (en) New pyrazine carboxamide derivatives the preparation thereof and their use in pharmaceutical compositions
AU1937395A (en) Pharmaceutical compositions containing alkylthioalkanoic acids or derivatives thereof and their use in the treatment of mycobacterial infections and as antiseptic
HK1048986A1 (en) 2'-Substituted 1,1'-iphenyl-2-carbonamides, methodfor the production thereof, use thereof as medicament and pharmaceutical preparations containing said compounds.
IL122196A0 (en) Bicyclic-aromatic compounds
MX9805705A (es) Compuestos biaromaticos, composiciones farmaceuticas y cosmeticas que los contienen y utilizaciones.
WO1997004788A3 (en) Use of calendula glycosides for the treatment of psoriasis
MX9707668A (es) Compuestos biarilicos heterociclicos, composiciones farmaceuticas y cosmeticas que los contienen y uso de las mismas.
HUP9802897A3 (en) Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, the use thereof in the treatment of vascular diseases and pharmaceutical composition containing the compound as active ingredient
AU4789099A (en) Therapeutic composition based on flavonoids for use in the treatment of tumours with cytotoxic agents
GR1003490B (el) Νεες φαρμακευτικες συνθεσεις που περιεχουν αλας παροξετινης
WO1999003509A3 (de) Pharmazeutische mittel enthaltend perfluoralkylgruppenhaltige trijodaromaten und ihre verwendung in der tumortherapie und interventionellen radiologie
HUP0204208A2 (hu) Pruritus kezelésére szolgáló külsőleges gyógyszerkészítmény
AU3255295A (en) Hybrid molecules useful in the treatment of tumors, their preparation and use in pharmaceutical compositions
TW374085B (en) Novel piperidine derivatives, their preparation, pharmaceutical formulation and medical use
HK1050203A1 (en) Novel fusidic acid derivatives.
EP0190860A3 (de) 6-Chloro-3-methyl-1H-2,3,4,5-tetrahydro-3-benzazepin-N-oxyd und dieses enthaltende Arzneimittel
EP1232748A4 (de) Subsituierte nitrobenzol derivate mit medikamentöser oder anderer wirkung
AU6819898A (en) Oxygen anion radicals and/or therapeutic preparations containing their reaction or breakdown products, and use of such preparations in the treatment of parkinson's disease
WO2000066129A3 (en) Use of antiprogestagens in combined therapy
ITRM920516A0 (it) Composizione e suo uso per il trattamento terapeutico di affezioni dermatitiche, particolarmente la psoriasi.
MX9605916A (es) Compuestos bioaromaticos que llevan un grupo adamantilo en para, composiciones farmaceuticos y cosmeticas que los contienen y utilizaciones.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AU AZ BA BB BG BR BY CA CN CU CZ EE GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LV MD MG MK MN MW MX NO NZ PL RO RU SD SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AU AZ BA BB BG BR BY CA CN CU CZ EE GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LV MD MG MK MN MW MX NO NZ PL RO RU SD SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

NENP Non-entry into the national phase

Ref country code: KR

NENP Non-entry into the national phase

Ref country code: CA