ATE517919T1 - Spaltung von insulinvorstufen durch eine trypsinvariante - Google Patents

Spaltung von insulinvorstufen durch eine trypsinvariante

Info

Publication number
ATE517919T1
ATE517919T1 AT06791678T AT06791678T ATE517919T1 AT E517919 T1 ATE517919 T1 AT E517919T1 AT 06791678 T AT06791678 T AT 06791678T AT 06791678 T AT06791678 T AT 06791678T AT E517919 T1 ATE517919 T1 AT E517919T1
Authority
AT
Austria
Prior art keywords
classification
insulin precursors
trypsin variant
trypsin
variant
Prior art date
Application number
AT06791678T
Other languages
English (en)
Inventor
Frank Geipel
Stephan Glaser
Christoph Hoh
Erhard Kopetzki
Rainer Mueller
Frank Zocher
Original Assignee
Sanofi Aventis Deutschland
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland, Hoffmann La Roche filed Critical Sanofi Aventis Deutschland
Application granted granted Critical
Publication of ATE517919T1 publication Critical patent/ATE517919T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6427—Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
AT06791678T 2005-09-14 2006-08-26 Spaltung von insulinvorstufen durch eine trypsinvariante ATE517919T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05077086 2005-09-14
PCT/EP2006/008380 WO2007031187A1 (en) 2005-09-14 2006-08-26 Cleavage of precursors of insulins by a variant of trypsin

Publications (1)

Publication Number Publication Date
ATE517919T1 true ATE517919T1 (de) 2011-08-15

Family

ID=36190640

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06791678T ATE517919T1 (de) 2005-09-14 2006-08-26 Spaltung von insulinvorstufen durch eine trypsinvariante

Country Status (20)

Country Link
US (1) US7981635B2 (de)
EP (1) EP1926749B1 (de)
JP (1) JP5027812B2 (de)
KR (1) KR101304958B1 (de)
CN (1) CN101253196B (de)
AR (1) AR055428A1 (de)
AT (1) ATE517919T1 (de)
AU (1) AU2006291780B2 (de)
BR (1) BRPI0616054B8 (de)
CA (1) CA2621344C (de)
CY (1) CY1112667T1 (de)
ES (1) ES2370657T3 (de)
HK (1) HK1124341A1 (de)
IL (1) IL189887A (de)
MX (1) MX2008003362A (de)
MY (1) MY146082A (de)
PL (1) PL1926749T3 (de)
PT (1) PT1926749E (de)
SI (1) SI1926749T1 (de)
WO (1) WO2007031187A1 (de)

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DE102008025007A1 (de) 2008-05-24 2009-11-26 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008025008A1 (de) 2008-05-24 2009-11-26 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008003566A1 (de) 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
CA2711749A1 (en) 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Novel insulin derivatives having an extremely delayed time-action profile
DE102008003568A1 (de) 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
CN102015762B (zh) * 2008-02-19 2015-03-18 百康有限公司 获得纯化的生物活性异源蛋白的方法
RS56632B1 (sr) 2008-10-17 2018-03-30 Sanofi Aventis Deutschland Kombinacija insulina i glp-1-agonista
WO2011030347A1 (en) * 2009-09-10 2011-03-17 Biocon Limited Novel prolipase-bovine trypsinogen fusion proteins
CN102711804B (zh) 2009-11-13 2015-09-16 赛诺菲-安万特德国有限公司 包含glp-1激动剂和甲硫氨酸的药物组合物
AU2010317995B2 (en) 2009-11-13 2014-04-17 Sanofi-Aventis Deutschland Gmbh Pharmaceutical composition comprising a GLP-1 agonist, an insulin, and methionine
JP6199186B2 (ja) 2010-08-30 2017-09-20 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ２型糖尿病の治療用の医薬の製造のためのａｖｅ００１０の使用
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
WO2013015697A1 (en) * 2011-07-28 2013-01-31 Mabion S.A. A recombinant protein, a polynucleotide encoding it as well as a method of obtaining insulin or its an analogue
JP6367115B2 (ja) 2011-08-29 2018-08-01 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ２型糖尿病患者の血糖コントロールに使用する組合せ医薬
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
DK2831262T3 (en) * 2012-03-29 2018-05-28 Biocon Ltd SECRETION OF FUNCTIONAL INSULIN GLARGIN DIRECTLY IN THE CULTIVATION MEDIUM THROUGH INTRACELLULAR OVERPRESSION OF KEX2P
CN102816785B (zh) * 2012-05-24 2016-03-09 上海仁会生物制药股份有限公司 一种甘精胰岛素及其类似物的制备方法
CN102994600A (zh) * 2012-12-11 2013-03-27 鲁南新时代生物技术有限公司 甘精胰岛素前体的酶切转化方法
MX2017007699A (es) 2014-12-12 2017-09-18 Sanofi Aventis Deutschland Formulacion de proporcion fija de insulina glargina/lixisenatida.
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
CN108018277A (zh) * 2016-11-04 2018-05-11 江苏万邦生化医药股份有限公司 重组牛胰蛋白酶突变体及其制备方法
KR20190036956A (ko) 2017-09-28 2019-04-05 한미약품 주식회사 지속형 단쇄 인슐린 아날로그 및 이의 결합체
CA3091943A1 (en) * 2018-02-22 2019-08-29 Sanofi-Aventis Deutschland Gmbh Variants of porcine trypsin
EP3650541A1 (de) * 2018-11-08 2020-05-13 BioPharma Translationsinstitut Dessau Forschungs GmbH Trypsin-mutante zur c- und n-terminalen modifizierung von polypeptiden
KR20200080747A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 인슐린 전구체의 인슐린 효소 전환용 조성물 및 이를 이용하여 인슐린 전구체를 인슐린으로 전환하는 방법
AU2020399194A1 (en) 2019-12-10 2022-07-28 Sanofi A method of forming a conjugate of a sulfonamide and a polypeptide
CN113773391B (zh) * 2020-06-09 2023-10-20 宁波鲲鹏生物科技有限公司 一种门冬胰岛素的制备方法

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Also Published As

Publication number Publication date
ES2370657T3 (es) 2011-12-21
KR20080055843A (ko) 2008-06-19
KR101304958B1 (ko) 2013-09-17
EP1926749A1 (de) 2008-06-04
JP2009507500A (ja) 2009-02-26
AU2006291780A1 (en) 2007-03-22
BRPI0616054B1 (pt) 2019-08-06
CA2621344A1 (en) 2007-03-22
MX2008003362A (es) 2008-03-25
US20100196953A1 (en) 2010-08-05
WO2007031187A8 (en) 2007-08-16
HK1124341A1 (en) 2009-07-10
CA2621344C (en) 2014-12-16
CN101253196A (zh) 2008-08-27
EP1926749B1 (de) 2011-07-27
PT1926749E (pt) 2011-09-29
US7981635B2 (en) 2011-07-19
AU2006291780B2 (en) 2011-12-08
MY146082A (en) 2012-06-29
IL189887A (en) 2012-02-29
SI1926749T1 (sl) 2011-11-30
JP5027812B2 (ja) 2012-09-19
AR055428A1 (es) 2007-08-22
CN101253196B (zh) 2012-09-05
PL1926749T3 (pl) 2011-12-30
IL189887A0 (en) 2008-11-03
CY1112667T1 (el) 2016-02-10
BRPI0616054A2 (pt) 2011-06-07
BRPI0616054B8 (pt) 2021-05-25
WO2007031187A1 (en) 2007-03-22

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