SI1926749T1 - Cepitev prekurzorjev insulinov z varianto tripsina - Google Patents

Cepitev prekurzorjev insulinov z varianto tripsina

Info

Publication number
SI1926749T1
SI1926749T1 SI200631146T SI200631146T SI1926749T1 SI 1926749 T1 SI1926749 T1 SI 1926749T1 SI 200631146 T SI200631146 T SI 200631146T SI 200631146 T SI200631146 T SI 200631146T SI 1926749 T1 SI1926749 T1 SI 1926749T1
Authority
SI
Slovenia
Prior art keywords
insulins
trypsin
precursors
cleavage
variant
Prior art date
Application number
SI200631146T
Other languages
English (en)
Inventor
Frank Geipel
Stephan Glaser
Christoph Hoh
Erhard Kopetzki
Rainer Mueller
Frank Zocher
Original Assignee
Sanofi Aventis Deutschland
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland, Hoffmann La Roche filed Critical Sanofi Aventis Deutschland
Publication of SI1926749T1 publication Critical patent/SI1926749T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6427—Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)
SI200631146T 2005-09-14 2006-08-26 Cepitev prekurzorjev insulinov z varianto tripsina SI1926749T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05077086 2005-09-14
EP06791678A EP1926749B1 (en) 2005-09-14 2006-08-26 Cleavage of precursors of insulins by a variant of trypsin
PCT/EP2006/008380 WO2007031187A1 (en) 2005-09-14 2006-08-26 Cleavage of precursors of insulins by a variant of trypsin

Publications (1)

Publication Number Publication Date
SI1926749T1 true SI1926749T1 (sl) 2011-11-30

Family

ID=36190640

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200631146T SI1926749T1 (sl) 2005-09-14 2006-08-26 Cepitev prekurzorjev insulinov z varianto tripsina

Country Status (20)

Country Link
US (1) US7981635B2 (sl)
EP (1) EP1926749B1 (sl)
JP (1) JP5027812B2 (sl)
KR (1) KR101304958B1 (sl)
CN (1) CN101253196B (sl)
AR (1) AR055428A1 (sl)
AT (1) ATE517919T1 (sl)
AU (1) AU2006291780B2 (sl)
BR (1) BRPI0616054B8 (sl)
CA (1) CA2621344C (sl)
CY (1) CY1112667T1 (sl)
ES (1) ES2370657T3 (sl)
HK (1) HK1124341A1 (sl)
IL (1) IL189887A (sl)
MX (1) MX2008003362A (sl)
MY (1) MY146082A (sl)
PL (1) PL1926749T3 (sl)
PT (1) PT1926749E (sl)
SI (1) SI1926749T1 (sl)
WO (1) WO2007031187A1 (sl)

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DE102008025007A1 (de) 2008-05-24 2009-11-26 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008025008A1 (de) 2008-05-24 2009-11-26 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
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PT3228320T (pt) 2008-10-17 2020-03-26 Sanofi Aventis Deutschland Combinação de uma insulina e de um agonista do glp-1
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US10029011B2 (en) 2009-11-13 2018-07-24 Sanofi-Aventis Deutschland Gmbh Pharmaceutical composition comprising a GLP-1 agonist, an insulin and methionine
PT2498801T (pt) 2009-11-13 2018-05-02 Sanofi Aventis Deutschland Composição farmacêutica compreendendo despro36exendin-4(1-39)-lys6-nh2 e metionina
SG187904A1 (en) 2010-08-30 2013-04-30 Sanofi Aventis Deutschland Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
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AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
US9388227B2 (en) * 2012-03-29 2016-07-12 Biocon Limited Process of expressing a fully folded functional two chain insulin glargine
CN102816785B (zh) * 2012-05-24 2016-03-09 上海仁会生物制药股份有限公司 一种甘精胰岛素及其类似物的制备方法
CN102994600A (zh) * 2012-12-11 2013-03-27 鲁南新时代生物技术有限公司 甘精胰岛素前体的酶切转化方法
NZ733670A (en) 2014-12-12 2021-12-24 Sanofi Aventis Deutschland Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
CN108018277A (zh) * 2016-11-04 2018-05-11 江苏万邦生化医药股份有限公司 重组牛胰蛋白酶突变体及其制备方法
KR20190036956A (ko) 2017-09-28 2019-04-05 한미약품 주식회사 지속형 단쇄 인슐린 아날로그 및 이의 결합체
AU2019225972A1 (en) * 2018-02-22 2020-10-15 Sanofi-Aventis Deutschland Gmbh Variants of porcine trypsin
EP3650541A1 (en) * 2018-11-08 2020-05-13 BioPharma Translationsinstitut Dessau Forschungs GmbH Trypsin mutant for c- and n-terminal modification of polypeptides
KR20200080747A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 인슐린 전구체의 인슐린 효소 전환용 조성물 및 이를 이용하여 인슐린 전구체를 인슐린으로 전환하는 방법
IL293635A (en) 2019-12-10 2022-08-01 Sanofi Sa A method for preparing a conjugate of a sulfonamide and a polypeptide
CN113773391B (zh) * 2020-06-09 2023-10-20 宁波鲲鹏生物科技有限公司 一种门冬胰岛素的制备方法

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Also Published As

Publication number Publication date
BRPI0616054A2 (pt) 2011-06-07
IL189887A (en) 2012-02-29
KR20080055843A (ko) 2008-06-19
CN101253196B (zh) 2012-09-05
CA2621344C (en) 2014-12-16
ATE517919T1 (de) 2011-08-15
AU2006291780B2 (en) 2011-12-08
US20100196953A1 (en) 2010-08-05
KR101304958B1 (ko) 2013-09-17
WO2007031187A1 (en) 2007-03-22
AU2006291780A1 (en) 2007-03-22
BRPI0616054B1 (pt) 2019-08-06
CA2621344A1 (en) 2007-03-22
US7981635B2 (en) 2011-07-19
CY1112667T1 (el) 2016-02-10
JP2009507500A (ja) 2009-02-26
PL1926749T3 (pl) 2011-12-30
HK1124341A1 (en) 2009-07-10
MX2008003362A (es) 2008-03-25
EP1926749B1 (en) 2011-07-27
WO2007031187A8 (en) 2007-08-16
EP1926749A1 (en) 2008-06-04
CN101253196A (zh) 2008-08-27
PT1926749E (pt) 2011-09-29
JP5027812B2 (ja) 2012-09-19
BRPI0616054B8 (pt) 2021-05-25
MY146082A (en) 2012-06-29
IL189887A0 (en) 2008-11-03
AR055428A1 (es) 2007-08-22
ES2370657T3 (es) 2011-12-21

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