SI1569912T1 - Derivati 2-(2-hidroksibifenil-3-il)-1h-benzoimidazol-5-karboksamidina kot inhibitorji faktorja viia - Google Patents

Derivati 2-(2-hidroksibifenil-3-il)-1h-benzoimidazol-5-karboksamidina kot inhibitorji faktorja viia

Info

Publication number
SI1569912T1
SI1569912T1 SI200332439T SI200332439T SI1569912T1 SI 1569912 T1 SI1569912 T1 SI 1569912T1 SI 200332439 T SI200332439 T SI 200332439T SI 200332439 T SI200332439 T SI 200332439T SI 1569912 T1 SI1569912 T1 SI 1569912T1
Authority
SI
Slovenia
Prior art keywords
hydroxybiphenyl
benzoimidazole
factor viia
viia inhibitors
carboxamidine derivatives
Prior art date
Application number
SI200332439T
Other languages
English (en)
Inventor
Aleksandr Kolesnikov
Roopa Rai
William Dvorak Shrader
Steven M. Torkelson
Kieron E. Wesson
Wendy B. Young
Original Assignee
Pharmacyclics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacyclics Llc filed Critical Pharmacyclics Llc
Publication of SI1569912T1 publication Critical patent/SI1569912T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/094—Esters of phosphoric acids with arylalkanols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65128—Six-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
SI200332439T 2002-12-03 2003-12-03 Derivati 2-(2-hidroksibifenil-3-il)-1h-benzoimidazol-5-karboksamidina kot inhibitorji faktorja viia SI1569912T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43098102P 2002-12-03 2002-12-03
EP03810056.6A EP1569912B1 (en) 2002-12-03 2003-12-03 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
PCT/US2003/038635 WO2004050637A2 (en) 2002-12-03 2003-12-03 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors

Publications (1)

Publication Number Publication Date
SI1569912T1 true SI1569912T1 (sl) 2015-09-30

Family

ID=32469576

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200332439T SI1569912T1 (sl) 2002-12-03 2003-12-03 Derivati 2-(2-hidroksibifenil-3-il)-1h-benzoimidazol-5-karboksamidina kot inhibitorji faktorja viia

Country Status (12)

Country Link
US (5) US7479502B2 (sl)
EP (2) EP2982668A3 (sl)
JP (3) JP4744149B2 (sl)
CN (1) CN100513398C (sl)
AU (1) AU2003302238A1 (sl)
CA (1) CA2507707C (sl)
DK (1) DK1569912T3 (sl)
ES (1) ES2543588T3 (sl)
HU (1) HUE025683T2 (sl)
PT (1) PT1569912E (sl)
SI (1) SI1569912T1 (sl)
WO (1) WO2004050637A2 (sl)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004050637A2 (en) 2002-12-03 2004-06-17 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
US7129264B2 (en) 2003-04-16 2006-10-31 Bristol-Myers Squibb Company Biarylmethyl indolines and indoles as antithromboembolic agents
JP5653572B2 (ja) 2003-08-14 2015-01-14 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 第ｖｉｉ因子ポリペプチドの液状水性医薬組成物
US7417063B2 (en) 2004-04-13 2008-08-26 Bristol-Myers Squibb Company Bicyclic heterocycles useful as serine protease inhibitors
JP2008501702A (ja) * 2004-06-02 2008-01-24 ファーマサイクリックス，インコーポレイティド 第ＶＩＩａ因子阻害剤
US8729117B2 (en) 2004-06-02 2014-05-20 Pharmacyclics, Inc. Factor VIIa inhibitor
EP1761504A2 (en) * 2004-06-02 2007-03-14 Pharmacyclics, Inc. Factor viia inhibitor
JP5236293B2 (ja) 2005-01-13 2013-07-17 ブリストル−マイヤーズ スクイブ カンパニー Ｘｉａ因子阻害剤としての置換ビアリール化合物
RU2435778C2 (ru) * 2005-07-04 2011-12-10 Заннан Сайтех Ко., Лтд. Лиганд комплекса рутения, комплекс рутения, катализатор комплекса рутения и способы его получения и применения
US20100285516A1 (en) * 2007-04-13 2010-11-11 Pharmacyclics, Inc. Calcium flux as a pharmacoefficacy biomarker for inhibitors of histone deacetylase
EP3150589A1 (en) * 2007-06-08 2017-04-05 MannKind Corporation Ire-1a inhibitors
US8552046B2 (en) * 2007-10-16 2013-10-08 Pharmacyclics, Inc. Manufacture, compositions and uses of coagulation factor VIIa modulator
ES2570628T3 (es) * 2007-12-17 2016-05-19 Hoffmann La Roche Nuevas arilamidas con sustitución imidazol
WO2014057069A1 (en) * 2012-10-10 2014-04-17 Novo Nordisk Health Care Ag Liquid pharmaceutical composition of factor vii polypeptide
FR2996845A1 (fr) * 2012-10-12 2014-04-18 Servier Lab Nouveau procede de synthese du 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
WO2016094260A1 (en) * 2014-12-10 2016-06-16 Merck Sharp & Dohme Corp. Factor ixa inhibitors
WO2018193387A1 (en) 2017-04-19 2018-10-25 Pi Industries Ltd. Heterocyclic compounds with microbiocidal properties
MX2020002449A (es) 2017-09-08 2020-11-06 Pi Industries Ltd Nuevos compuestos heterociclicos fungicidas.
WO2019048988A1 (en) 2017-09-08 2019-03-14 Pi Industries Ltd. NOVEL FUNGICIDE HETEROCYCLIC COMPOUNDS
AR120375A1 (es) 2019-11-11 2022-02-09 Pi Industries Ltd Piridiniloxi piperidiniletanonas sustituidas
UY38941A (es) 2019-11-11 2021-06-30 Pi Industries Ltd Nuevas sulfiliminas o sulfoximinas que contienen compuestos heterocíclicos fungicidas
AR120376A1 (es) 2019-11-11 2022-02-09 Pi Industries Ltd Heteroaril piperidiniletanonas sustituidas con actividad fungicida
CN113683480B (zh) * 2021-08-28 2024-02-27 山东三牧新材料科技有限公司 一种4-乙基苄氯的制备方法
CN114195640B (zh) * 2021-12-27 2024-03-12 攀枝花学院 羟基酪醇及其中间体的合成工艺

Family Cites Families (245)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4107288A (en) 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
DE3369355D1 (en) * 1983-10-19 1987-02-26 Sulzer Ag Vibration isolating and damping support for a loom
CA2024697A1 (en) 1989-09-07 1991-03-08 George P. Vlasuk Protein having anticoagulant properties
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
IL102758A (en) 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
ZA928276B (en) 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
JP3194953B2 (ja) 1992-02-14 2001-08-06 コルバス・インターナショナル、インコーポレイテッド 血栓症抑制剤
ATE177752T1 (de) 1992-12-15 1999-04-15 Corvas Int Inc Neue inhibitoren von faktor xa
CA2155931C (en) 1993-02-12 2002-11-19 George Phillip Vlasuk Inhibitors of thrombosis
US5563127A (en) 1993-03-24 1996-10-08 The Dupont Merck Pharmaceutical Company Boronic acid and ester inhibitors of thrombin
US5656600A (en) 1993-03-25 1997-08-12 Corvas International, Inc. α-ketoamide derivatives as inhibitors of thrombosis
US5863534A (en) 1993-04-09 1999-01-26 Bio-Technology General Corp. Polypeptide having factor Xa inhibitory method of reducing blood coagulation with a novel polypeptide having factor Xa inhibitory activity
JP3388803B2 (ja) 1993-05-20 2003-03-24 第一製薬株式会社 光学活性７−アミジノナフタレン誘導体の製造法
SE9301916D0 (sv) 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US5681844A (en) 1994-04-18 1997-10-28 Corvas International, Inc. Methionine sulfone and s-substituted cysteine sulfone derivatives as enzyme inhibitors
NZ284977A (en) 1994-04-26 1998-09-24 Selectide Corp Factor xa enzyme inhibitor
US5561146A (en) 1994-06-10 1996-10-01 Bristol-Myers Squibb Company Modified guanidino and amidino thrombin inhibitors
US5633381A (en) 1994-07-05 1997-05-27 Berlex Laboratories, Inc. (Z,Z), (Z,E) and (E,Z) isomers of substituted bis(phenylmethylene)cycloketones
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
ES2276396T3 (es) 1994-10-18 2007-06-16 Dendreon Corporation Proteinas anticoagulantes e inhibidores de la serina proteasa extraidos de nematodos.
SE504185C2 (sv) 1994-11-08 1996-12-02 Astra Ab Lagringsstabil vattenlösning för infusion av trombininhibitorer
KR100383161B1 (ko) 1994-12-02 2003-12-24 야마노우치세이야쿠 가부시키가이샤 신규한아미디노나프틸유도체또는이의염
SE9404196D0 (sv) 1994-12-02 1994-12-02 Astra Ab New antithrombotic formulation
US5656645A (en) 1994-12-13 1997-08-12 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
NZ298699A (en) 1994-12-13 2001-03-30 Corvas Int Inc 3-amino-1,2-dihydropyrid-1-yl(and 5-amino-1,6-dihydro-6-oxo(and 5,6-dioxo)pyrimidin-1-yl)-acetyl-argininal derivatives, useful for the treatment of blood coagulation and thrombosis
US5658930A (en) 1994-12-13 1997-08-19 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
US6025472A (en) 1994-12-21 2000-02-15 Corvas International, Inc. N-substituted glycine derivatives as enzyme inhibitors
ATE252100T1 (de) 1995-02-27 2003-11-15 Hoffmann La Roche Dioxopyrrolo-pyrrolderivate
DK0813525T3 (da) 1995-03-10 2004-02-16 Berlex Lab Benzamidinderivater, deres fremstilling og anvendelse som antikoagulanter
US5639739A (en) 1995-03-24 1997-06-17 The Dupont Merck Pharmaceutical Company Imidazole containing aminoboronic acids
US5612363A (en) 1995-06-02 1997-03-18 Berlex Laboratories, Inc. N,N-di(aryl) cyclic urea derivatives as anti-coagulants
US5612378A (en) 1995-06-06 1997-03-18 3-Dimensional Pharmaceuticals, Inc. Bis-arylsulfonylaminobenzamide derivatives and the use thereof as factor Xa inhibitors
US5741819A (en) 1995-06-07 1998-04-21 3-Dimensional Pharmaceuticals, Inc. Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors
US5721214A (en) 1995-06-07 1998-02-24 Cor Therapeutics, Inc. Inhibitors of factor Xa
US5612353A (en) 1995-06-07 1997-03-18 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds
US6069130A (en) 1995-06-07 2000-05-30 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US5919765A (en) 1995-06-07 1999-07-06 Cor Therapeutics, Inc. Inhibitors of factor XA
US6034093A (en) 1995-06-07 2000-03-07 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted sulfonic acid N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds
US5731315A (en) 1995-06-07 1998-03-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted sulfonic acid n- (aminoiminomethyl)phenylalkyl!-azaheterocyclamide compounds
GB9515489D0 (en) 1995-07-28 1995-09-27 Sandoz Ltd Organic compounds
DE19530996A1 (de) 1995-08-23 1997-02-27 Boehringer Mannheim Gmbh Cyclische Guanidine, Verfahren zu ihrer Herstellung und Arzneimittel
HUP9802764A3 (en) 1995-09-29 2000-03-28 Dimensional Pharm Inc Guanidino protease inhibitors
US5849759A (en) 1995-12-08 1998-12-15 Berlex Laboratories, Inc. Naphthyl-substituted benzimidazole derivatives as anti-coagulants
DE69623038T2 (de) 1995-12-20 2002-12-12 Aventis Pharma Inc Verfahren zur herstellung von n-acetyl(l)-4-cyanophenylalanin ac-(l)-phe(4-cn)-phe(4-cn)-oh und n-acetyl-(l)-p-amidinophenylalanin-cyclohexylglycin-beta-(3-n-methylpyridinium)-alanin ac-(l)-paph-chg-palme(3)-nh2
AR005245A1 (es) 1995-12-21 1999-04-28 Astrazeneca Ab Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion
WO1997023212A1 (en) 1995-12-21 1997-07-03 The Du Pont Merck Pharmaceutical Company ISOXAZOLINE, ISOTHIAZOLINE AND PYRAZOLINE FACTOR Xa INHIBITORS
IL124883A0 (en) 1995-12-29 1999-01-26 Dimensional Pharm Inc Amidino protease inhibitors and pharmaceutical compositions containing the same
SI0906094T1 (sl) 1996-01-02 2003-12-31 Aventis Pharmaceuticals Inc. Substituirani N-/(aminoiminometil ali aminometil)fenil/propil amidi
US6080767A (en) 1996-01-02 2000-06-27 Aventis Pharmaceuticals Products Inc. Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides
GB9602166D0 (en) 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
GB9602294D0 (en) 1996-02-05 1996-04-03 Zeneca Ltd Heterocyclic compounds
US5994375A (en) 1996-02-12 1999-11-30 Berlex Laboratories, Inc. Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
TR199801569T2 (xx) 1996-02-13 1998-10-21 Akzo Nobel N.V. Serin proteaz inhibit�rleri.
ES2186874T3 (es) 1996-02-22 2003-05-16 Bristol Myers Squibb Pharma Co Analogos de m-amidinofenilo como inhibidores del factor xa.
CA2250426C (en) 1996-03-29 2006-05-02 3-Dimensional Pharmaceuticals, Inc. Amidinohydrazones as protease inhibitors
DE19612828C1 (de) 1996-03-30 1997-02-27 Boehringer Mannheim Gmbh Verfahren zur Herstellung von Naphthonitrilderivaten und deren Verwendung zur Herstellung von Faktor-Xa-Inhibitoren
FR2754260B1 (fr) * 1996-10-04 1998-10-30 Adir Nouveaux derives substitues de biphenyle ou de phenylpyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IL126610A0 (en) 1996-04-17 1999-08-17 Du Pont Pharm Co N-(amidinophenyl)-n'-(subst.)-3h-2,4-benzodiazepin-3- one derivatives as factor xa inhibitors
SE9601556D0 (sv) 1996-04-24 1996-04-24 Astra Ab New pharmaceutical formulation of a thrombin inhibitor for parenteral use
SE9602145D0 (sv) 1996-05-31 1996-05-31 Astra Ab New improved formulation for treatment of thromboembolism
HU224315B1 (hu) 1996-06-05 2005-07-28 Gyógyszerkutató Intézet Kft. Véralvadásgátló hatású peptidil-arginin-aldehid-származékok és a vegyületeket tartalmazó gyógyszerkészítmények
HU222199B1 (hu) 1996-06-05 2003-05-28 Gyógyszerkutató Intézet Kft. Véralvadásgátló hatású peptid-aldehid-származékok és a vegyületeket tartalmazó gyógyszerkészítmények
JPH101467A (ja) 1996-06-13 1998-01-06 Banyu Pharmaceut Co Ltd ビフェニルアミジン誘導体
US6124291A (en) 1996-06-18 2000-09-26 Warner-Lambert Company Pyrrolo[1,2-a]pyrazine-1,4-dione serine protease inhibitors
CA2253835A1 (en) 1996-06-18 1997-12-24 Kent Alan Berryman Process for the preparation of chiral keto-heterocycles of basic amino acids
US6200967B1 (en) 1996-06-25 2001-03-13 Eli Lilly And Company Anticoagulant agents
JPH1017549A (ja) 1996-07-02 1998-01-20 Banyu Pharmaceut Co Ltd 二環性芳香族アミジン誘導体
AU3645697A (en) 1996-07-08 1998-02-02 Du Pont Pharmaceuticals Company Amidinoindoles, amidinoazoles, and analogs thereof as inhibitors of factor xa and of thrombin
WO1998006694A1 (en) 1996-08-16 1998-02-19 Du Pont Pharmaceuticals Company Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof
US5753635A (en) 1996-08-16 1998-05-19 Berlex Laboratories, Inc. Purine derivatives and their use as anti-coagulants
US5693641A (en) 1996-08-16 1997-12-02 Berlex Laboratories Inc. Bicyclic pyrimidine derivatives and their use as anti-coagulants
US6057342A (en) 1996-08-16 2000-05-02 Dupont Pharmaceutical Co. Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof
WO1998009987A1 (en) 1996-09-06 1998-03-12 Biochem Pharma, Inc. Lactam inhibitors of thrombin
KR20000036017A (ko) 1996-09-12 2000-06-26 에바-마리아 시마-메이어, 얼설라 멜져, 마거, 하르트만 시클릭 아미노산 및 시클릭 히드록시산 유도체로 치환된 벤즈아
US6004985A (en) 1996-10-09 1999-12-21 Berlex Laboratories, Inc. Thio acid derived monocylic N-heterocyclics as anticoagulants
US6369080B2 (en) 1996-10-11 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
EP0937073A2 (en) 1996-10-11 1999-08-25 Cor Therapeutics, Inc. Selective factor xa inhibitors
JP2001502674A (ja) 1996-10-11 2001-02-27 シーオーアール・セラピューティックス・インコーポレーテッド 選択的Ｘａ因子阻害物質
WO1998016547A1 (en) 1996-10-11 1998-04-23 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
SE9603724D0 (sv) 1996-10-11 1996-10-11 Astra Ab New pharmaceutical parenteral formulation of a thrombin inhibitor
WO1998016524A1 (en) 1996-10-11 1998-04-23 Cor Therapeutics, Inc. HETEROCYCLIC DERIVATIVES AS FACTOR Xa INHIBITORS
UA56197C2 (uk) 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
EP0842941A1 (de) 1996-11-16 1998-05-20 Roche Diagnostics GmbH Neue Phosphonate, Verfahren zu ihrer Herstellung und Arzneimittel
US6602864B1 (en) 1996-12-13 2003-08-05 Aventis Pharma Deutschland Gmbh Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds
KR20000057528A (ko) 1996-12-13 2000-09-25 오흘러 로스 제이. 설폰산 또는 설포닐아미노 ｎ-(헤테로아르알킬)-아자헤테로사이클릴아미드 화합물
JP2001506271A (ja) 1996-12-23 2001-05-15 デュポン ファーマシューティカルズ カンパニー Ｘａ因子阻害剤としての酸素またはイオウを含む複素環式芳香族化合物
PL334250A1 (en) 1996-12-23 2000-02-14 Du Pont Pharm Co Nitrogen containing hetero-aromatic compounds and inhibitors of xa factor
US6020357A (en) 1996-12-23 2000-02-01 Dupont Pharmaceuticals Company Nitrogen containing heteroaromatics as factor Xa inhibitors
TW542822B (en) 1997-01-17 2003-07-21 Ajinomoto Kk Benzamidine derivatives
JP2001521524A (ja) 1997-04-14 2001-11-06 シーオーアール セラピューティクス インコーポレイテッド 選択的Ｘａ因子阻害剤
NZ500352A (en) 1997-04-14 2001-10-26 Cor Therapeutics Inc Cyclic diaza selective factor Xa inhibitors
NZ500353A (en) 1997-04-14 2002-02-01 Cor Therapeutics Inc Cyclic diaza compounds that are selective inhibitors of factor Xa
AU747531B2 (en) 1997-04-14 2002-05-16 Millennium Pharmaceuticals, Inc. Selective factor Xa inhibitors
JP2001525823A (ja) 1997-05-15 2001-12-11 イーライ・リリー・アンド・カンパニー 抗血栓化合物
CA2287292A1 (en) 1997-05-30 1998-12-03 Takeda Chemical Industries, Ltd. Sulfonamide derivatives, their production and use
TW513402B (en) 1997-05-30 2002-12-11 Daiichi Seiyaku Co Process for preparing 3-(7-amidino-2-naphthyl)-2-phenylpropionic acid derivatives
US20010046974A1 (en) 1997-06-06 2001-11-29 Hamilton Civic Hospitals Res Dev., Inc. Modified low molecular weight heparin that inhibits clot associated coagulation factors
DE69830403T2 (de) 1997-06-19 2006-02-02 Bristol-Myers Squibb Pharma Co. Inhibitoren des faktors xa mit einer neutralen gruppe mit p1-spezifität
ZA985247B (en) 1997-06-19 1999-12-17 Du Pont Merck Pharma Guanidine mimics as factor Xa inhibitors.
AU7976998A (en) 1997-06-19 1999-01-04 Du Pont Merck Pharmaceutical Company, The (amidino)6-membered aromatics as factor xa inhibitors
US6060491A (en) 1997-06-19 2000-05-09 Dupont Pharmaceuticals 6-membered aromatics as factor Xa inhibitors
US6339099B1 (en) 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors
US6417200B1 (en) 1997-06-26 2002-07-09 Eli Lilly And Company Antithrombotic agents
ES2241151T3 (es) 1997-06-26 2005-10-16 Eli Lilly And Company Agentes antitromboticos.
IL133621A0 (en) 1997-06-26 2001-04-30 Lilly Co Eli Antithrombotic agents
EP0999834B1 (en) 1997-06-26 2005-10-12 Eli Lilly And Company Antithrombotic agents
AU735144B2 (en) 1997-07-23 2001-07-05 Yamanouchi Pharmaceutical Co., Ltd. Novel hexahydro-1,4-diazepine derivatives or their salts
GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
GB9715894D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic derivatives
JP2001512742A (ja) 1997-08-11 2001-08-28 シーオーアール セラピューティクス インコーポレイテッド 選択的Ｘａ因子阻害剤
EP0994894A1 (en) 1997-08-11 2000-04-26 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
CA2299612A1 (en) 1997-08-11 1999-02-18 Cor Therapeutics, Inc. Selective factor xa inhibitors containing a fused azepinone structure
US5886191A (en) 1997-08-18 1999-03-23 Dupont Pharmaceuticals Company Amidinoindoles, amidinoazoles, and analogs thereof
WO1999010316A1 (fr) 1997-08-27 1999-03-04 Kissei Pharmaceutical Co., Ltd. Derives de 3-amidinoaniline, inhibiteurs du facteur x de coagulation sanguine activee, et intermediaires de production de ces derives et de ces inhibiteurs
US6740682B2 (en) 1997-08-29 2004-05-25 Tularik Limited Meta-benzamidine derivatives as serine protease inhibitors
EP1012166B1 (en) 1997-08-29 2003-10-29 Tularik Limited 1-amino-7-isoquinoline derivatives as serine protease inhibitors
AU8886698A (en) 1997-09-01 1999-03-22 Yamanouchi Pharmaceutical Co., Ltd. Novel naphthamide derivatives or salts thereof
EP1015429B1 (en) 1997-09-09 2004-05-12 Bristol-Myers Squibb Pharma Company Benzimidazolinones, benzoxazolinones, benzopiperazinones, indanones, and derivatives thereof as inhibitors of factor xa
GB9719161D0 (en) 1997-09-09 1997-11-12 Glaxo Group Ltd New therapeutic method
KR20010015639A (ko) 1997-09-30 2001-02-26 스즈키 다다시 술포닐 유도체
DE19743435A1 (de) 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidinderivate
US6693075B1 (en) 1997-10-23 2004-02-17 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
JPH11140040A (ja) 1997-11-06 1999-05-25 Kissei Pharmaceut Co Ltd ３−アミジノフェニルエーテル誘導体、活性化血液凝固第ｘ因子阻害剤およびそれらの製造中間体
IL126893A (en) 1997-11-19 2003-05-29 Akzo Nobel Nv Sulfated pentasaccharide derivatives and pharmaceutical compositions containing them
JPH11152269A (ja) 1997-11-20 1999-06-08 Teijin Ltd ビフェニルアミジン誘導体
AU736112B2 (en) 1997-11-20 2001-07-26 Teijin Limited Biphenylamidine derivatives
HUP0100085A3 (en) 1997-11-20 2002-12-28 Teijin Ltd Biphenylamidine derivatives and pharmaceutical compositions containing them
PL340560A1 (en) 1997-11-26 2001-02-12 Dimensional Pharmaceuticals 3 Heteroaryl aminoguanidines and alkoxyguanidines and their application as protease inhibitors
US6150379A (en) 1997-11-26 2000-11-21 Axys Pharmaceuticals, Inc. Compounds and compositions as anticoagulants
WO1999026932A1 (en) 1997-11-26 1999-06-03 Axys Pharmaceuticals, Inc. By amidino group substituted heterocyclic derivatives and their use as anticoagulants
WO1999026933A1 (en) 1997-11-26 1999-06-03 Axys Pharmaceuticals, Inc. Substituted amidinoaryl derivatives and their use as anticoagulants
SE9704400D0 (sv) 1997-11-28 1997-11-28 Astra Ab Porous inorganic particles as carriers for drug substances
SE9704401D0 (sv) 1997-11-28 1997-11-28 Astra Ab Matrix pellets for greasy, oily or sticky drug substances
US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
DE19755268A1 (de) 1997-12-12 1999-06-17 Merck Patent Gmbh Benzamidinderivate
US6140351A (en) 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
EP1040108B1 (en) 1997-12-19 2004-02-25 Schering Aktiengesellschaft Ortho-anthranilamide derivatives as anti-coagulants
EP1042299A1 (en) 1997-12-22 2000-10-11 Du Pont Pharmaceuticals Company Nitrogen containing heteroaromatics with ortho-substituted p1's as factor xa inhibitors
US6271237B1 (en) 1997-12-22 2001-08-07 Dupont Pharmaceuticals Company Nitrogen containing heteromatics with ortho-substituted P1s as factor Xa inhabitors
CA2316172C (en) 1997-12-24 2010-02-02 Aventis Pharma Deutschland Gmbh Indole derivatives as inhibitors of factor xa
AU1689999A (en) 1997-12-25 1999-07-19 Daiichi Pharmaceutical Co., Ltd. Medicinal composition for percutaneous administration
AU1692399A (en) 1997-12-26 1999-07-19 Mochida Pharmaceutical Co., Ltd. Aromatic compounds having cyclic amino or salts thereof
FR2773801B1 (fr) 1998-01-19 2000-05-12 Sanofi Sa Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
WO1999037643A1 (fr) 1998-01-26 1999-07-29 Yamanouchi Pharmaceutical Co., Ltd. Nouveaux derives heterocycliques a fusion benzenique ou sels de ceux-ci
ATE346050T1 (de) 1998-01-27 2006-12-15 Aventis Pharma Inc Substituierte oxoazaheterocyclyl faktor xa hemmer
WO1999040072A1 (de) 1998-02-03 1999-08-12 Boehringer Ingelheim Pharma Kg 5-gliedrige benzokondensierte heterocyclen als antithrombotika
AU2298899A (en) 1998-02-05 1999-08-23 Takeda Chemical Industries Ltd. Sulfonamide derivatives, process for producing the same and utilization thereof
JP2000204081A (ja) 1998-02-05 2000-07-25 Takeda Chem Ind Ltd スルホンアミド誘導体、その製造法及び用途
EP0937711A1 (de) 1998-02-18 1999-08-25 Roche Diagnostics GmbH Neue Thiobenzamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
EP0937723A1 (de) 1998-02-18 1999-08-25 Roche Diagnostics GmbH Neue Sulfonamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
WO1999047503A1 (fr) 1998-03-19 1999-09-23 Ajinomoto Co., Inc. Derives d'aminoisoquinoleine
CA2325471C (en) 1998-03-23 2010-08-17 Aventis Pharmaceuticals Products Inc. Piperididinyl and n-amidinopiperidinyl derivatives
ES2230841T3 (es) 1998-03-27 2005-05-01 Bristol-Myers Squibb Pharma Company Pirazolinas y triazolinas disustituidas como inhibidores del factor xa.
JP2002509923A (ja) 1998-03-31 2002-04-02 ワーナー−ランバート・カンパニー Ｘａ因子およびトロンビンのようなセリンプロテアーゼ阻害剤としてのキノキサリノン
US6509335B1 (en) 1998-03-31 2003-01-21 Warner-Lambert Company Benzoxazinoes/benzothiazinones as serine protease inhibitors
BR9815786A (pt) 1998-03-31 2000-11-21 Warner Lambert Co Quinolonas como inibidores de protease de serina
US6344486B1 (en) 1998-04-03 2002-02-05 3-Dimensional Pharmaceuticals, Inc. Benzamide and sulfonamide substituted aminoguanidines and alkoxyguanidines as protease inhibitors
US20020061842A1 (en) 1998-04-10 2002-05-23 Octapharma Ag Method for sterilizing a native collagen in liquid medium, sterile native collagen obtained, compositions containing it and uses
KR100416111B1 (ko) 1998-04-10 2004-01-31 니뽄 다바코 산교 가부시키가이샤 아미딘 화합물
US6417161B1 (en) 1998-04-24 2002-07-09 3-Dimensional Pharmaceuticals, Inc. Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors
DE19819548A1 (de) 1998-04-30 1999-11-04 Merck Patent Gmbh Biphenylderivate
GB9809349D0 (en) 1998-05-02 1998-07-01 Zeneca Ltd Heterocyclic derivatives
GB9809350D0 (en) 1998-05-02 1998-07-01 Zeneca Ltd Novel salt
PL343706A1 (en) 1998-05-02 2001-08-27 Astrazeneca Ab Heterocyclic derivatives which inhibit factor xa
WO1999064392A1 (fr) 1998-06-08 1999-12-16 Ajinomoto Co., Inc. Derive de benzamidine
DE69926884T2 (de) 1998-06-11 2006-06-14 Johnson & Johnson Pharm Res Pyrazine protease inhibitore
DE19829964A1 (de) 1998-07-04 2000-01-05 Boehringer Ingelheim Pharma Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel
TWI248435B (en) 1998-07-04 2006-02-01 Boehringer Ingelheim Pharma Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions
DE19834751A1 (de) 1998-08-01 2000-02-03 Boehringer Ingelheim Pharma Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
DE19835950A1 (de) 1998-08-08 2000-02-10 Merck Patent Gmbh Piperazinonderivate
US6747023B1 (en) 1998-08-11 2004-06-08 Daiichi Pharmaceutical Co., Ltd. Sulfonyl derivatives
JP2000143623A (ja) 1998-08-28 2000-05-26 Dai Ichi Seiyaku Co Ltd 新規なスルホニル誘導体およびその塩
DE19839499A1 (de) 1998-08-29 2000-03-02 Merck Patent Gmbh 2-Oxo-2H-chinolinderivate
SE9802938D0 (sv) 1998-09-01 1998-09-01 Astra Ab Improved stability for injection solutions
JP2000080046A (ja) 1998-09-03 2000-03-21 Dai Ichi Seiyaku Co Ltd 多臓器障害の予防・治療剤
SE9802973D0 (sv) 1998-09-03 1998-09-03 Astra Ab Immediate release tablet
DE19845153A1 (de) 1998-10-01 2000-04-06 Merck Patent Gmbh Imidazo[4,5]-pyridin-4-on-derivate
TW575567B (en) 1998-10-23 2004-02-11 Akzo Nobel Nv Serine protease inhibitor
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
JP2003529531A (ja) 1998-11-25 2003-10-07 アヴェンティス ファーマシューティカルズ インコーポレイテッド 置換オキソアザへテロシクリルＸａ因子阻害剤
US6127376A (en) 1998-12-04 2000-10-03 Berlex Laboratories, Inc. Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
JP2000178243A (ja) 1998-12-14 2000-06-27 Teijin Ltd ビフェニルアミジン誘導体
JP3827530B2 (ja) 1998-12-16 2006-09-27 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 置換アリール誘導体及び置換ヘテロアリール誘導体、それらの調製及び薬物としてのそれらの使用
HUP0104987A3 (en) * 1998-12-18 2002-09-30 Axys Pharmaceuticals Inc South Benzimidazole or indole derivatives protease inhibitors, and pharmaceutical compositions containing them
AU2381600A (en) 1998-12-23 2000-07-31 Du Pont Pharmaceuticals Company Thrombin or factor xa inhibitors
ES2226485T3 (es) 1998-12-23 2005-03-16 Eli Lilly And Company Amidas aromaticas.
WO2000039117A1 (en) 1998-12-23 2000-07-06 Eli Lilly And Company HETEROROAROMATIC AMIDES AS INHIBITOR OF FACTOR Xa
ES2232202T3 (es) 1998-12-23 2005-05-16 Bristol-Myers Squibb Pharma Company Heterobiciclos que contienen nitrogeno como inhibidores del factor xa.
US6610704B1 (en) 1998-12-23 2003-08-26 Eli Lilly And Company Antithrombotic amides
ATE261941T1 (de) 1998-12-24 2004-04-15 Lilly Co Eli Heterocyclische amide als inhibitoren von faktor xa
EP1140901A2 (en) 1998-12-24 2001-10-10 Aventis Pharmaceuticals Products Inc. Substituted (aminoiminomethyl or aminomethyl)benzoheteroaryl compounds as factor xa inhibitors
AU2844800A (en) 1998-12-30 2000-07-24 Aventis Pharmaceuticals Products Inc. Process for preparing a stable non-hygroscopic crystalline n-(n-(n- piperdin- 4-yl)butanoyl)- n.ethylglycyl)- (l)-aspartyl) -ss-cyclohexylalanine amide
EP1016663A1 (en) 1999-01-02 2000-07-05 Aventis Pharma Deutschland GmbH Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor Xa activity)
CA2358581C (en) 1999-01-02 2010-02-02 Aventis Pharma Deutschland Gmbh Arylalkanoyl derivatives, processes for their preparation, their use and pharmaceutical compositions containing them
CA2358578A1 (en) 1999-01-02 2000-07-13 Aventis Pharma Deutschland Gmbh Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor xa activity)
DE19900355A1 (de) 1999-01-07 2000-07-13 Merck Patent Gmbh Benzimidazolderivate
DE19900471A1 (de) 1999-01-08 2000-07-13 Merck Patent Gmbh Imidazo[4,5c]-pyridin-4-on-derivate
SK11422001A3 (sk) 1999-02-09 2002-04-04 3-Dimensional Pharmaceuticals Inc. Heteroarylamidíny, metylamidíny a guanidíny ako inhibítory proteázy
WO2000047207A1 (en) 1999-02-09 2000-08-17 Bristol-Myers Squibb Company LACTAM INHIBITORS OF FXa AND METHOD
AU756174B2 (en) 1999-02-09 2003-01-09 Bristol-Myers Squibb Company Lactam inhibitors of FXa and method
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
AU3857300A (en) 1999-02-11 2000-08-29 Cor Therapeutics, Inc. Inhibitors of factor xa
DE19909237A1 (de) 1999-03-03 2000-09-07 Merck Patent Gmbh Pyrazol-3-on-derivate
CN1346292A (zh) 1999-03-11 2002-04-24 杜邦药品公司 凝血因子Xa抑制剂与阿司匹林、组织纤溶酶原激活物(TPA)、GPⅡb/Ⅲa拮抗剂、低分子量肝素或肝素联合用于治疗血栓形成
AU3329400A (en) 1999-03-31 2000-10-23 Kissei Pharmaceutical Co. Ltd. 3-amidinobenzenesulfonamide derivatives, medicinal compositions containing the same and intermediates in the production thereof
ES2197092T3 (es) 1999-04-02 2004-01-01 Bristol-Myers Squibb Pharma Company Sulfonil arilos como inhibidores del factor xa.
JP4390024B2 (ja) 1999-04-23 2009-12-24 アステラス製薬株式会社 新規なジアゼパン誘導体又はその塩
US6545055B1 (en) 1999-05-24 2003-04-08 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
AU5283600A (en) 1999-05-24 2000-12-12 Cor Therapeutics, Inc. Inhibitors of factor xa
JP2003500387A (ja) 1999-05-24 2003-01-07 シーオーアール セラピューティクス インコーポレイテッド Ｘａ因子の阻害剤
US6638980B1 (en) 1999-05-24 2003-10-28 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
AU5546000A (en) 1999-06-14 2001-01-02 Protherics Molecular Design Limited Compounds
EP1192132B1 (en) 1999-06-14 2005-09-07 Eli Lilly And Company Serine protease inhibitors
GB9914342D0 (en) 1999-06-19 1999-08-18 Zeneca Ltd Compound
CA2383492A1 (en) 1999-06-22 2000-12-28 Takeda Chemical Industries, Ltd. Acylhydrazine derivatives, their production and use
WO2001002397A1 (fr) 1999-06-30 2001-01-11 Mochida Pharmaceutical Co., Ltd. Composes tricycliques presentant une jonction spiro
WO2001002356A1 (fr) 1999-07-01 2001-01-11 Sankyo Company, Limited Dérivés d'indoline ou tétrahydroquinoline
JP2004507439A (ja) 1999-07-16 2004-03-11 ブリストル−マイヤーズ　スクイブ　ファーマ　カンパニー Ｘａ因子阻害剤としての窒素含有ヘテロ二環式化合物
US6350761B1 (en) 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants
AU6762400A (en) 1999-08-12 2001-03-13 Cor Therapeutics, Inc. Inhibitors of factor xa
US6469029B1 (en) 1999-09-13 2002-10-22 3-Dimensional Pharmaceuticals, Inc. Azacycloalkanone serine protease inhibitors
MX226123B (es) 1999-09-17 2005-02-07 Millennium Pharm Inc Benzamidas e inhibidores del factor xa relacionadas.
CA2385589A1 (en) 1999-09-17 2001-03-22 Bing-Yan Zhu Inhibitors of factor xa
JP2003515560A (ja) 1999-12-06 2003-05-07 スミスクライン・ビーチャム・コーポレイション トロンボポイエチン模倣物
AU2001234705A1 (en) 2000-02-01 2001-08-14 Cor Therapeutics, Inc. Indalone and benzimidazolone inhibitors of factor xa
US20020065303A1 (en) 2000-02-01 2002-05-30 Bing-Yan Zhu Bivalent phenylene inhibitors of factor Xa
US20020013314A1 (en) 2000-02-01 2002-01-31 Bing-Yan Zhu 3,4-dihydro-2H-benzo[1,4]oxazine inhibitors of factor Xa
US6777413B2 (en) 2000-02-01 2004-08-17 Millennium Pharmaceuticals, Inc. 2-[1H]-quinolone and 2-[1H]-quinoxalone inhibitors of factor Xa
AU2001245353A1 (en) 2000-02-29 2001-09-12 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
WO2001072708A2 (en) 2000-03-24 2001-10-04 Cor Therapeutics, Inc. OXINDOLE INHIBITORS OF FACTOR Xa
US20020019394A1 (en) 2000-03-24 2002-02-14 Wenhao Li Bicyclic sulfonyl amino inhibitors of factor Xa
US6469026B2 (en) 2000-03-24 2002-10-22 Millennium Pharmaceuticals, Inc. Isoquinolone inhibitors of factor Xa
US20020037912A1 (en) * 2000-08-11 2002-03-28 Leahy Ellen M. Factor viia inhibitors
US6465503B2 (en) 2000-08-11 2002-10-15 Axys Pharmaceuticals, Inc. Selective urokinase inhibitors
CA2421548C (en) 2000-09-11 2007-10-30 Genentech, Inc. Amidine inhibitors of serine proteases
CA2452391A1 (en) 2001-07-09 2003-01-23 Axys Pharmaceuticals, Inc. 2-[5-(5-carbamimidoyl-1h-heteroaryl)-6-hydroxybiphenyl-3-yl]-succinic acid derivatives as factor viia inhibitors
KR20040065278A (ko) 2001-12-21 2004-07-21 노보 노르디스크 에이/에스 변경된 인자 ⅶ 폴리펩티드의 액체 조성물
WO2003068756A1 (en) 2002-02-13 2003-08-21 Axys Pharmaceuticals, Inc. 2-[5-(5-carbamimidoyl-1h-heteroaryl)]-6-hydroxybiphenyl-3-yl derivatives as factor viia inhibitors
MXPA04009703A (es) 2002-04-08 2004-12-13 Guilford Pharm Inc Composiciones farmaceuticas que contienen promedicamentos solubles en agua de propofol y metodoss para administrar los mismos.
WO2004050637A2 (en) 2002-12-03 2004-06-17 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
AU2003300106A1 (en) 2003-01-08 2004-08-10 Axys Pharmaceuticals, Inc. 2-'5-(5-carbamimidoyl-1h-heteroaryl)-6-hydroxybiphenyl-3-yl!- carboxylic acid derivatives as factor viia inhibitors
US8729117B2 (en) 2004-06-02 2014-05-20 Pharmacyclics, Inc. Factor VIIa inhibitor
EP1761504A2 (en) 2004-06-02 2007-03-14 Pharmacyclics, Inc. Factor viia inhibitor
JP2008501702A (ja) 2004-06-02 2008-01-24 ファーマサイクリックス，インコーポレイティド 第ＶＩＩａ因子阻害剤
US8552046B2 (en) 2007-10-16 2013-10-08 Pharmacyclics, Inc. Manufacture, compositions and uses of coagulation factor VIIa modulator

Also Published As

Publication number Publication date
EP2982668A3 (en) 2016-04-13
US9162986B2 (en) 2015-10-20
US8778625B2 (en) 2014-07-15
CA2507707C (en) 2011-06-21
US8299110B2 (en) 2012-10-30
US20140378453A1 (en) 2014-12-25
US20110269806A1 (en) 2011-11-03
WO2004050637A2 (en) 2004-06-17
CA2507707A1 (en) 2004-06-17
JP4744149B2 (ja) 2011-08-10
HUE025683T2 (hu) 2016-04-28
EP2982668A2 (en) 2016-02-10
EP1569912A2 (en) 2005-09-07
DK1569912T3 (en) 2015-06-29
JP2014088446A (ja) 2014-05-15
JP2011157362A (ja) 2011-08-18
US20060205942A1 (en) 2006-09-14
ES2543588T3 (es) 2015-08-20
CN100513398C (zh) 2009-07-15
AU2003302238A8 (en) 2004-06-23
US7479502B2 (en) 2009-01-20
EP1569912B1 (en) 2015-04-29
WO2004050637A3 (en) 2004-09-02
US20130157298A1 (en) 2013-06-20
AU2003302238A1 (en) 2004-06-23
PT1569912E (pt) 2015-09-15
JP2006515839A (ja) 2006-06-08
US20090054432A1 (en) 2009-02-26
CN1745070A (zh) 2006-03-08

Similar Documents

Publication Publication Date Title
AU2003302238A8 (en) 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
IL165515A0 (en) Bisindolyl-maleimid derivatives as kinase inhibitors
HK1071360A1 (en) 2-hydroxy-3-heteroarylindole derivatives as gsk3 inhibitors
TWI319387B (en) Benzamide derivatives
AU2003260345A1 (en) 2-phenylpyridin-4-yl derivatives as alk5 inhibitors
EG25482A (en) Inhibitors
AP1850A (en) Spiroindolineplperidine derivatives
AU2003293356A8 (en) Dihydropyridinone derivatives as hne inhibitors
IL169323A0 (en) Pyrazole-derivatives as factor xa inhibitors
AP2005003343A0 (en) Substituted pyrrolo-pyrazole derivatives as kinaseinhibitors
IL165810A0 (en) Novel benzimidazole derivatives
HK1080745A1 (en) Angiogenesis inhibitors
AU2003271566A8 (en) Pyrrolopyrazines as kinase inhibitors
PL370478A1 (en) Aminoindazole derivatives as protein-kinase inhibitors
IL173484A0 (en) Quinazoline derivatives as angiogenesis inhibitors
GB0315870D0 (en) Heterocyclic derivatives
EP1532133A4 (en) NF-: B INHIBITORS
IL164898A0 (en) Heterotricyclyl 6-alkylidene-penems as beta-lactamase inhibitors
AU2003222659A8 (en) 23-o-substituted 5-o-mycaminosyltylonide derivatives
AU2003215635A1 (en) Thiazol-2-yl-imine compounds as pde-7 inhibitors
AU2003215158A1 (en) 2-(5-(5-carbamimidoyl-1h-heteroaryl))-6-hydroxybiphenyl-3-yl derivatives as factor viia inhibitors
AU2003232362A8 (en) 4-pyrazol-phenylalanine derivatives as ace-nep inhibitors
PL376540A1 (pl) Pochodne diazepanów stosowane jako inhibitory LFA
GB0220962D0 (en) Heterocyclic derivatives
GB0311957D0 (en) Heterocyclic derivatives