RO85071B - Procedeu pentru prepararea unui derivat de alanilprolina - Google Patents

Procedeu pentru prepararea unui derivat de alanilprolina

Info

Publication number
RO85071B
RO85071B RO108578A RO10857879A RO85071B RO 85071 B RO85071 B RO 85071B RO 108578 A RO108578 A RO 108578A RO 10857879 A RO10857879 A RO 10857879A RO 85071 B RO85071 B RO 85071B
Authority
RO
Romania
Prior art keywords
formula
ethyl acetate
ethanol
extracted
dissolved
Prior art date
Application number
RO108578A
Other languages
English (en)
Romanian (ro)
Other versions
RO85071A (ro
Inventor
A. Arthur Patchett
E. Elbert Harris
J. Matthew Wyvratt
W. Edward Tristram
Original Assignee
Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25513965&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RO85071(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.
Publication of RO85071A publication Critical patent/RO85071A/ro
Publication of RO85071B publication Critical patent/RO85071B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/80—Antihypertensive peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
RO108578A 1978-12-11 1979-12-08 Procedeu pentru prepararea unui derivat de alanilprolina RO85071B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96824978A 1978-12-11 1978-12-11

Publications (2)

Publication Number Publication Date
RO85071A RO85071A (ro) 1984-09-24
RO85071B true RO85071B (ro) 1984-10-30

Family

ID=25513965

Family Applications (4)

Application Number Title Priority Date Filing Date
RO108578A RO85071B (ro) 1978-12-11 1979-12-08 Procedeu pentru prepararea unui derivat de alanilprolina
RO7999486A RO80264A (ro) 1978-12-11 1979-12-08 Procedeu pentru prepararea unui derivat de alanilprolina
RO108580A RO85073B (ro) 1978-12-11 1979-12-08 Procedeu pentru prepararea unor derivati de aminoacizi
RO108579A RO85072B (ro) 1978-12-11 1979-12-08 Procedeu pentru prepararea n-(1-carboxi-3-fenilpropil)-l-alanil-l-prolinei

Family Applications After (3)

Application Number Title Priority Date Filing Date
RO7999486A RO80264A (ro) 1978-12-11 1979-12-08 Procedeu pentru prepararea unui derivat de alanilprolina
RO108580A RO85073B (ro) 1978-12-11 1979-12-08 Procedeu pentru prepararea unor derivati de aminoacizi
RO108579A RO85072B (ro) 1978-12-11 1979-12-08 Procedeu pentru prepararea n-(1-carboxi-3-fenilpropil)-l-alanil-l-prolinei

Country Status (33)

Country Link
US (2) US4374829A (en, 2012)
EP (1) EP0012401B1 (en, 2012)
JP (3) JPS5581845A (en, 2012)
KR (3) KR850000847B1 (en, 2012)
AR (1) AR231971A1 (en, 2012)
AU (1) AU530380B2 (en, 2012)
BG (6) BG39295A3 (en, 2012)
CA (4) CA1302005C (en, 2012)
CS (1) CS237311B2 (en, 2012)
DD (1) DD148770A5 (en, 2012)
DE (2) DE2966767D1 (en, 2012)
DK (1) DK165455C (en, 2012)
EG (1) EG14182A (en, 2012)
ES (2) ES8101540A1 (en, 2012)
FI (1) FI68405C (en, 2012)
GR (1) GR72251B (en, 2012)
HK (1) HK27487A (en, 2012)
HU (1) HU182902B (en, 2012)
IE (1) IE48922B1 (en, 2012)
IL (1) IL58849A (en, 2012)
LU (1) LU90173I2 (en, 2012)
MA (1) MA18664A1 (en, 2012)
NL (4) NL930007I2 (en, 2012)
NO (3) NO151622C (en, 2012)
NZ (1) NZ192312A (en, 2012)
PH (1) PH24268A (en, 2012)
PL (2) PL131140B1 (en, 2012)
PT (1) PT70542A (en, 2012)
RO (4) RO85071B (en, 2012)
SU (1) SU1287756A3 (en, 2012)
YU (3) YU42655B (en, 2012)
ZA (1) ZA796688B (en, 2012)
ZW (1) ZW24479A1 (en, 2012)

Families Citing this family (397)

* Cited by examiner, † Cited by third party
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