BR0108077A - Processo para reduzir placas ateroscleróticas em um mamìfero, método para tratamento da aterosclerose em um mamìfero, composição, métodos para prover proteìna ou polipeptìdeo hidrolisante de lipìdeo biologicamente ativo ou mistura deles, para células de um mamìfero tendo deficiência na proteìna ou polipeptìdeo hidrolisante de lipìdeo biologicamente ativo , para prover lipase de ácido lisossomal biologicamente ativa para células de um mamìfero tendo deficiência de lipase de ácido lisossomal biologicamente ativa, para prover lipase de ácido lisossoal biologicamente ativa para células de um mamìfero com aterosclerose, para tratamento da doença de wolman em um mamìfero, para tratamento de doença de armazenagem de colesteril éster em um mamìfero, e, para tratamento da aterosclerose em um mamìfero - Google Patents
Processo para reduzir placas ateroscleróticas em um mamìfero, método para tratamento da aterosclerose em um mamìfero, composição, métodos para prover proteìna ou polipeptìdeo hidrolisante de lipìdeo biologicamente ativo ou mistura deles, para células de um mamìfero tendo deficiência na proteìna ou polipeptìdeo hidrolisante de lipìdeo biologicamente ativo , para prover lipase de ácido lisossomal biologicamente ativa para células de um mamìfero tendo deficiência de lipase de ácido lisossomal biologicamente ativa, para prover lipase de ácido lisossoal biologicamente ativa para células de um mamìfero com aterosclerose, para tratamento da doença de wolman em um mamìfero, para tratamento de doença de armazenagem de colesteril éster em um mamìfero, e, para tratamento da aterosclerose em um mamìferoInfo
- Publication number
- BR0108077A BR0108077A BR0108077-6A BR0108077A BR0108077A BR 0108077 A BR0108077 A BR 0108077A BR 0108077 A BR0108077 A BR 0108077A BR 0108077 A BR0108077 A BR 0108077A
- Authority
- BR
- Brazil
- Prior art keywords
- mammal
- biologically active
- cells
- atherosclerosis
- acid lipase
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01013—Sterol esterase (3.1.1.13)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/04—Uses of viruses as vector in vivo
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
Abstract
"PROCESSO PARA REDUZIR PLACAS ATEROSCLERóTICAS EM UM MAMìFERO, MéTODO PARA TRATAMENTO DA ATEROSCLEROSE EM UM MAMìFERO, COMPOSIçãO, MéTODOS PARA PROVER PROTEìNA OU POLIPEPTìDEO HIDROLISANTE DE LIPìDEO BIOLOGICAMENTE ATIVO OU MISTURA DELES, PARA CéLULAS DE UM MAMìFERO TENDO DEFICIêNCIA NA PROTEìNA OU POLIPEPTìDEO HIDROLISANTE DE LIPìDEO BIOLOGICAMENTE ATIVO, PARA PROVER LIPASE DE áCIDO LISOSSOMAL BIOLOGICAMENTE ATIVA PARA CéLULAS DE UM MAMìFERO TENDO DEFICIêNCIA DE LIPASE DE áCIDO LISOSSOMAL BIOLOGICAMENTE ATIVA, PARA PROVER LIPASE DE áCIDO LISOSSOMAL BIOLOGICAMENTE ATIVA PARA CéLULAS DE UM MAMìFERO COM ATEROSCLEROSE, PARA TRATAMENTO DA DOENçA DE WOLMAN EM UM MAMìFERO, PARA TRATAMENTO DE DOENçA DE ARMAZENAGEM DE COLESTERIL éSTER EM UM MAMìFERO, E, PARA TRATAMENTO DA ATEROSCLEROSE EM UM MAMìFERO". A presente invenção compreende um método para diminuir e/ou eliminar placas ateroscleróticas, em mamíferos, através de tratamento direto e indireto destas placas, in situ, usando-se substâncias adequadas, que são capazes de remover lipídeo, principalmente através de hidrólise, por um processo catalítico ou estequiométrico, em que a substância alveja receptores dentro e/ou sobre a célula, o que conduz à captação para dentro do lisossoma. Tais substâncias usadas para diminuir e/ou eliminar placas ateroscleróticas são geralmente compreendidas de proteínas e/ou polipeptídeos hidrolizantes de lipídeo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18036200P | 2000-02-04 | 2000-02-04 | |
PCT/US2001/003481 WO2001056596A1 (en) | 2000-02-04 | 2001-02-02 | Use of lysosomal acid lipase for treating atherosclerosis and related diseases |
US09/775,517 US6849257B2 (en) | 2000-02-04 | 2001-02-02 | Lipid hydrolysis therapy for atherosclerosis and related diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0108077A true BR0108077A (pt) | 2002-10-22 |
Family
ID=26876237
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0108077-6A BR0108077A (pt) | 2000-02-04 | 2001-02-02 | Processo para reduzir placas ateroscleróticas em um mamìfero, método para tratamento da aterosclerose em um mamìfero, composição, métodos para prover proteìna ou polipeptìdeo hidrolisante de lipìdeo biologicamente ativo ou mistura deles, para células de um mamìfero tendo deficiência na proteìna ou polipeptìdeo hidrolisante de lipìdeo biologicamente ativo , para prover lipase de ácido lisossomal biologicamente ativa para células de um mamìfero tendo deficiência de lipase de ácido lisossomal biologicamente ativa, para prover lipase de ácido lisossoal biologicamente ativa para células de um mamìfero com aterosclerose, para tratamento da doença de wolman em um mamìfero, para tratamento de doença de armazenagem de colesteril éster em um mamìfero, e, para tratamento da aterosclerose em um mamìfero |
Country Status (10)
Country | Link |
---|---|
US (6) | US6849257B2 (pt) |
EP (1) | EP1267914B2 (pt) |
JP (1) | JP2003523330A (pt) |
AT (1) | ATE429927T1 (pt) |
BR (1) | BR0108077A (pt) |
CA (1) | CA2398995C (pt) |
DE (1) | DE60138535D1 (pt) |
ES (1) | ES2328446T5 (pt) |
FR (1) | FR15C0091I2 (pt) |
WO (1) | WO2001056596A1 (pt) |
Families Citing this family (17)
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US6579974B1 (en) * | 1998-06-23 | 2003-06-17 | The Regents Of The University Of California | Acyl CoA:cholesterol acyltransferase (ACAT-2) |
ES2328446T5 (es) * | 2000-02-04 | 2014-02-27 | Children's Hospital Research Foundation | Uso de lipasa ácida lisosomal para tratar la aterosclerosis y enfermedades asociadas |
WO2002036754A2 (en) * | 2000-10-31 | 2002-05-10 | Bayer Aktiengesellschaft | Nucleotide and polypeptide sequence of human lysosomal acid lipase |
US20090297496A1 (en) * | 2005-09-08 | 2009-12-03 | Childrens Hospital Medical Center | Lysosomal Acid Lipase Therapy for NAFLD and Related Diseases |
US20070116755A1 (en) * | 2005-11-22 | 2007-05-24 | Zadini Filiberto P | Dissolution of arterial cholesterol plaques by pharmacological preparation |
US20090035348A1 (en) * | 2005-11-22 | 2009-02-05 | Z & Z Medical Holdings, Inc. | Dissolution of arterial plaque |
US8304383B2 (en) | 2005-11-22 | 2012-11-06 | Atheronova Operations, Inc. | Dissolution of arterial plaque |
WO2008144458A1 (en) * | 2007-05-15 | 2008-11-27 | Z & Z Medical Holdings, Inc. | Dissolution of arterial cholesterol plaques by pharmacologically induced elevation of endogenous bile salts |
EP3205351B1 (en) * | 2010-04-23 | 2023-04-12 | Alexion Pharmaceuticals, Inc. | Lysosomal storage disease enzyme |
AU2015249135A1 (en) * | 2010-04-23 | 2015-11-19 | Synageva Biopharma Corp. | Lysosomal storage disease enzyme |
MX365007B (es) * | 2010-09-09 | 2019-05-20 | Alexion Pharmaceuticals Inc Star | Uso de acido lipasa lisosomal para tratar la dificiencia de acido lipasa lisosomal en pacientes. |
AU2015218427B2 (en) * | 2010-09-09 | 2017-09-21 | Alexion Pharmaceuticals, Inc. | Use of lysosomal acid lipase for treating lysosomal acid lipase deficiency in patients |
KR20140006037A (ko) | 2011-02-15 | 2014-01-15 | 시나게바 바이오파르마, 코포레이션 | 리소좀의 산 리파제 결핍을 치료하는 방법들 |
US20130046283A1 (en) * | 2011-05-05 | 2013-02-21 | Medtronic Vascular, Inc. | Methods and intravascular treatment devices for treatment of atherosclerosis |
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US11396499B2 (en) | 2018-12-12 | 2022-07-26 | University Of Washington | Lysosomal acid lipase assay |
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- 2001-02-02 BR BR0108077-6A patent/BR0108077A/pt not_active Application Discontinuation
- 2001-02-02 CA CA2398995A patent/CA2398995C/en not_active Expired - Lifetime
- 2001-02-02 US US09/775,517 patent/US6849257B2/en not_active Expired - Lifetime
- 2001-02-02 AT AT01906927T patent/ATE429927T1/de not_active IP Right Cessation
- 2001-02-02 JP JP2001556495A patent/JP2003523330A/ja not_active Withdrawn
- 2001-02-02 DE DE60138535T patent/DE60138535D1/de not_active Expired - Lifetime
- 2001-02-02 EP EP01906927.7A patent/EP1267914B2/en not_active Expired - Lifetime
- 2001-02-02 WO PCT/US2001/003481 patent/WO2001056596A1/en active Search and Examination
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2004
- 2004-02-11 US US10/776,797 patent/US20040223960A1/en not_active Abandoned
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2007
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2010
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2015
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2017
- 2017-02-13 US US15/430,815 patent/US10864255B2/en not_active Expired - Lifetime
- 2017-04-20 US US15/492,650 patent/US20170296631A1/en not_active Abandoned
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US20100239558A1 (en) | 2010-09-23 |
US20070264249A1 (en) | 2007-11-15 |
WO2001056596A1 (en) | 2001-08-09 |
ES2328446T3 (es) | 2009-11-13 |
DE60138535D1 (de) | 2009-06-10 |
JP2003523330A (ja) | 2003-08-05 |
US6849257B2 (en) | 2005-02-01 |
US20170296631A1 (en) | 2017-10-19 |
ATE429927T1 (de) | 2009-05-15 |
US20040223960A1 (en) | 2004-11-11 |
EP1267914A1 (en) | 2003-01-02 |
WO2001056596A8 (en) | 2001-10-25 |
US20170151313A1 (en) | 2017-06-01 |
ES2328446T5 (es) | 2014-02-27 |
FR15C0091I2 (fr) | 2018-08-31 |
EP1267914B1 (en) | 2009-04-29 |
CA2398995A1 (en) | 2001-08-09 |
US10864255B2 (en) | 2020-12-15 |
FR15C0091I1 (fr) | 2016-01-22 |
CA2398995C (en) | 2014-09-23 |
EP1267914B2 (en) | 2013-11-06 |
US20030059420A1 (en) | 2003-03-27 |
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